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Browsing by Subject "B raf kinase"

Browsing by Subject "B raf kinase"

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  • Alternative lengthening of telomeres, ATRX loss and H3-K27M mutations in histologically defined pilocytic astrocytoma with anaplasia 
    Rodríguez, Fausto J.; Brosnan-Cashman, Jacqueline A.; Allen, Sariah J.; Vizcaíno, Maria Adelita; Giannini, Caterina; Camelo-Piragua, Sandra Ines; Webb, Milad; Matsushita, Marcus De Medeiros; Wadhwani, Nitin R.; Tabbarah, Abeer Z.; Hamideh, Dima; Jiang, Liqun; Chen, Liam L.; Arvanitis, Leonidas D.; Alnajar, Hussein H.; Barber, John R.; Rodríguez-Velasco, Alicia; Orr, Brent A.; Heaphy, Christopher M. (Blackwell Publishing Ltd, 2019)
    Anaplasia may be identified in a subset of tumors with a presumed pilocytic astrocytoma (PA) component or piloid features, which may be associated with aggressive behavior, but the biologic basis of this change remains ...
  • Ascorbic acid in colon cancer: From the basic to the clinical applications 
    Halabi, Ibrahim El; Bejjany, Rachelle; Nasr, Rihab R.; Mukherji, Deborah M.; Temraz, Sally N.; Nassar, Farah J.; Darsa, Haidar El; Shamseddine, Ali I. (MDPI AG, 2018)
    Given the safety and potential benefits of intravenous ascorbic acid (AA) administration in cancer patients, there is merit in further exploring this therapeutic concept. In this review, we discuss the potential benefits ...
  • B-type proto-oncogene-mutated tumors of colon cancer: Promising therapeutic approaches 
    Temraz, Sally N.; Alameddine, Raafat S.; Shamseddine, Ali I. (Lippincott Williams and Wilkins, 2015)
    Purpose of review B-type proto-oncogene (BRAF) mutations have been observed in about 10.8% of patients with colorectal cancer (CRC). These patients do not respond to standard therapy with anti-epidermal growth factor ...
  • BRAF analysis on a spectrum of melanocytic neoplasms: An epidemiological study across differing UV regions 
    Saroufim, Maya; Habib, Robert H.; Karram, Sarah; Youssef Massad, Cleo; Taraif, Suad H.; Loya, Asif; Houreih, Mohammad Adib; Sheikh, Salwa Shabbir; Amr, Samir Sami; Satti, Mohammed Bakhit; Oberkanins, Christian; Khalifeh, Ibrahim M. (2014)
    BRAF mutation has been linked to the development of melanocytic tumors in homogeneous Caucasian cohorts. The role of solar UV radiation (UVR) in BRAF mutation status is poorly understood. We studied the epidemiology of ...
  • BRAF and NRAS Mutations in Papillary Thyroid Carcinoma and Concordance in BRAF Mutations between Primary and Corresponding Lymph Node Metastases 
    Fakhruddin, Najla; Jabbour, Mark N.; Novy, Michael; Tamim, Hani Mohammed; Bahmad, Hisham F.; Farhat, Fadi Sami; Zaatari, Ghazi S.; Aridi, Tarek; Kriegshäuser, Gernot; Oberkanins, Christian; Mahfouz, Rami A.R. (Nature Publishing Group, 2017)
    Concordance between mutations in the primary papillary thyroid carcinoma (PTC) and the paired x lymph node metastasis may elucidate the potential role of molecular targeted therapy in advanced stages. BRAF and NRAS mutations ...
  • BRAF mutation status in primary and metastatic melanomas in two regions with differing potential ultraviolet radiation exposure 
    Massad, Cleo Y.; Loya, Asif; Taraif, Suad H.; Saroufim, Maya; Kibbi, Abdul Ghani M.; Habib, Robert H.; Novy, Michael; Rauscher, Bettina; Oberkanins, Christian; Khalifeh, Ibrahim M. (2014)
    Background Melanoma is seen as a heterogeneous molecular entity, with solar ultraviolet radiation (UVR) and BRAF mutation status being important determinants. Aim To study primary and metastatic melanomas from two UVR-distinct ...
  • BRAF mutational epidemiology in dysplastic nevi: Does different solar UV radiation exposure matter? 
    Saroufim, Maya; Novy, Michael; Taraif, Suad H.; Habib, Robert H.; Loya, Asif; Rauscher, Bettina; Kriegshäuser, Gernot; Oberkanins, Christian; Khalifeh, Ibrahim M. (Blackwell Publishing Ltd, 2014)
    Background Proto-oncogene B-Raf (BRAF) mutation rates have been reported in nevi and melanomas of homogeneous Caucasian cohorts. Objective To study the demographics of BRAF mutations in dysplastic nevi of populations with ...
  • Current Status and Future Perspectives of Immunotherapy in Middle-Income Countries: A Single-Center Early Experience 
    Bou-Akl, Imad J.; Berro, Juliett; Tfayli, Arafat Hussein; Shamseddine, Ali I.; Mukherji, Deborah M.; Temraz, Sally N.; El-Cheikh, Jean; Alameh, Ibrahim A.; Assi, Hazem I. (Elmer Press, 2020)
    Background: Immunotherapy agents offer novel treatment options in advanced cancers. However, their use is limited in developing countries lacking unifying guidelines and can be followed by a financial burden. In this study, ...
  • Cutaneous malignant melanoma: Update on diagnostic and prognostic biomarkers 
    Abbas, Ossama M.; Miller, Daniel D.; Bhawan, Jag (Lippincott Williams and Wilkins, 2014)
    The incidence of cutaneous malignant melanoma has rapidly increased in recent years in all parts of the world, and melanoma is a leading cause of cancer death. As even relatively small melanomas may have metastatic potential, ...
  • Dual inhibition of MEK and PI3K pathway in KRAS and BRAF mutated colorectal cancers 
    Temraz, Sally N.; Mukherji, Deborah M.; Shamseddine, Ali I. (MDPI AG, 2015)
    Colorectal cancer (CRC) is a heterogeneous disease with multiple underlying causative genetic mutations. Genetic mutations in the phosphatidylinositol-3 kinase (PI3K) and the mitogen activated protein kinase (MAPK) pathways ...
  • Effect of adoptive t cell therapy on vegf signaling pathway in dmh-induced colon cancer in balb/c mice 
    Bou Hamdan, Mirna A.; Massaad, Michel J.; Usta, Julnar A.R.; Borjac, Jamila Mohamad (Medical Project Poland, 2021)
    Colon cancer is the fourth most leading causes of cancer-related deaths worldwide accounting for nearly 7-10% of all cancers. Adoptive T Cell Therapy (ACT), a type of immunotherapy, was first developed using Tumor-Infiltrating ...
  • Emerging genetic biomarkers in lung adenocarcinoma 
    Barbar, Jawad; Armach, Maria; Hodroj, Mohammad Hassan; Assi, Sahar; El Nakib, Clara; Chamseddine, Nathalie; Assi, Hazem I. (SAGE Publications Ltd, 2022)
    Comprehensive genomic profiling is a next-generation sequencing approach used to detect several known and emerging genomic alterations. Many genomic variants detected by comprehensive genomic profiling have become recognized ...
  • Genomic landscape of atypical adenomatous hyperplasia reveals divergent modes to lung adenocarcinoma 
    Sivakumar, Smruthy; San Lucas, Francis Anthony; McDowell, Tina L.; Lang, Wenhua; Xu, Li; Fujimoto, Jyunya; Zhang, Jianjun; Futreal, Phillip Andrew; Fukuoka, Junya; Yatabe, Yasushi; Dubinett, Steven M.; Spira, Avrum E.; Fowler, Jerry; Hawk, Ernest T.; Wistuba, Ignacio Ivans; Scheet, Paul A.; Kadara, Humam N. (American Association for Cancer Research Inc., 2017)
    There is a dearth of knowledge about the pathogenesis of premalignant lung lesions, especially for atypical adenomatous hyperplasia (AAH), the only known precursor for the major lung cancer subtype adenocarcinoma (LUAD). ...
  • Malignant melanoma with metaplastic cartilaginous transdifferentiation: A case report 
    Berro, Juliett; Abdul Halim, Nour; Khaled, Chirine S.; Assi, Hazem I. (Blackwell Publishing Ltd, 2019)
    Malignant melanoma is notorious for its remarkable morphological variation and aberrant histopathological patterns. However, melanoma with prominent cartilaginous transdifferentiation simulating chondrosarcoma is extremely ...
  • Methods of overcoming treatment resistance in colorectal cancer 
    Temraz, Sally N.; Mukherji, Deborah M.; Alameddine, Raafat S.; Shamseddine, Ali I. (2014)
    Metastatic colorectal cancer remains a lethal disease with a poor prognosis in the majority of patients. Multiple drug combinations have been developed in recent years that have significantly improved response rates and ...
  • Molecular mechanisms targeting drug-resistance and metastasis in colorectal cancer: Updates and beyond 
    Bitar, Sara Al; El-Sabban, Marwan E.; Doughan, Samer; Abou-Kheir, Wassim G. (Baishideng Publishing Group Inc, 2023)
    Colorectal cancer (CRC) is the third most diagnosed malignancy and a major leading cause of cancer-related deaths worldwide. Despite advances in therapeutic regimens, the number of patients presenting with metastatic CRC ...
  • Non-random aneuploidy specifies subgroups of pilocytic astrocytoma and correlates with older age 
    Fontebasso, Adam M.; Shirinian, Margret; Khuong-Quang, Dong Anh; Bechet, Denise; Gayden, Tenzin; Kool, Marcel; de Jay, Nicolas; Jacob, Karine; Gerges, Noha; Hutter, Barbara; Şeker-Cin, Huriye; Witt, Hendrik; Montpetit, Alexandre; Brunet, Sébastien; Lepage, Pierre; Bourret, Geneviève; Klekner, Álmos P.; Bognár, László; Hauser, Péter; Garami, Miklós; Farmer, Jean Pierre; Montes, José Luis Temes; Atkinson, Jeffrey D.; Lambert, Sally R.; Kwan, Tony; Korshunov, Andrey G.; Tabori, Uri; Peter Collins, V.; Albrecht, Steffen; Faury, Damien; Pfister, Stefan M.; Paulus, Werner; Hasselblatt, Martin; Jones, David T.W.; Jabado, Nada (Impact Journals LLC, 2015)
    Pilocytic astrocytoma (PA) is the most common brain tumor in children but is rare in adults, and hence poorly studied in this age group. We investigated 222 PA and report increased aneuploidy in older patients. Aneuploid ...
  • Pediatric cancer pathology review from a single institution: Neuropathology expert opinion is essential for accurate diagnosis of pediatric brain tumors 
    Merabi, Zeina; Boulos, Fouad I.; Santiago, Teresa C.B.; Jenkins, Jesse Jay; Abboud, Miguel Raul; Muwakkit, Samar A.; Tarek, Nidale; Zaatari, Ghazi S.; Jeha, Sima S.; El-Solh, Hassan; Saab, Raya H. (John Wiley and Sons Inc., 2018)
    Background and objectives: Second pathology review has been reported to improve accuracy in oncologic diagnoses, including pediatric malignancies. We assessed the impact of second review on the diagnosis of pediatric ...
  • Prioritizing mutational profiling for targeted therapy of lung adenocarcinoma 
    Sinjab, Ansam; Tfayli, Arafat Hussein (AME Publishing Company, 2019)
  • Recent progress in mutation-driven therapy, immunotherapy and combination therapy for the treatment of Melanoma 
    Assi, Hazem I.; Assi, Rita E. (Bentham Science Publishers B.V., 2017)
    With increases in our understanding of the human genome and immune system, the treatment armamentarium for melanoma has benefitted from the development and approval of BRAF inhibitors, MEK inhibitors, immune checkpoint ...

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