AUB ScholarWorks

Browsing by Subject "I-kappa B Kinase"

Browsing by Subject "I-kappa B Kinase"

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  • Gallotannin inhibits NFκB signaling and growth of human colon cancer xenografts 
    Al-Halabi R.; Chedid M.B.; Merhi R.A.; El-Hajj H.; Zahr H.; Schneider-Stock R.; Bazarbachi A.; Gali-Muhtasib H. (AUSTIN1806 RIO GRANDE ST, AUSTIN, TX 78702 USA, 2011)
    Gallotannin (GT), the polyphenolic hydrolyzable tannin, exhibits anti-inflammatory and anticancer activities through mechanisms that are not fully understood. Several effects modulated by GT have been shown to be linked ...
  • Low nuclear body formation and tax SUMOylation do not prevent NF-kappaB promoter activation 
    Bonnet A.; Randrianarison-Huetz V.; Nzounza P.; Nedelec M.; Chazal M.; Waast L.; Pene S.; Bazarbachi A.; Mahieux R.; Benit L.; Pique C. (LONDON236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND, 2012)
    Background: The Tax protein encoded by Human T-lymphotropic virus type 1 (HTLV-1) is a powerful activator of the NF-κB pathway, a property critical for HTLV-1-induced immortalization of CD4+ T lymphocytes. Tax permanently ...
  • Tax ubiquitylation and SUMOylation control the dynamic shuttling of Tax and NEMO between Ubc9 nuclear bodies and the centrosome 
    Kfoury Y.; Setterblad N.; El-Sabban M.; Zamborlini A.; Dassouki Z.; El Hajj H.; Hermine O.; Pique C.; De The H.; Saib A.; Bazarbachi A. (WASHINGTON1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA, 2011)
    The human T-lymphotropic virus type I oncoprotein Tax is critical for T-cell transformation, acting mainly through nuclear factor kappa B essential modulator (NEMO) binding and subsequent nuclear factor-κB activation. Tax ...
  • The role of NF-κB in mediating the anti-inflammatory effects of IL-10 in intestinal epithelial cells 
    Al-Ashy R.; Chakroun I.; El-Sabban M.E.; Homaidan F.R. (LONDON24-28 OVAL RD, LONDON NW1 7DX, ENGLAND, 2006)
    In inflammatory bowel disease, cells that infiltrate the mucosa regulate intestinal epithelial cell function partly through release of pro- and anti-inflammatory cytokines. The aim of this study is to evaluate the role of ...
  • Ubiquitylated Tax targets and binds the IKK signalosome at the centrosome 
    Kfoury Y.; Nasr R.; Favre-Bonvin A.; El-Sabban M.; Renault N.; Giron M.-L.; Setterblad N.; Hajj H.E.; Chiari E.; Mikati A.G.; Hermine O.; Saib A.; De The H.; Pique C.; Bazarbachi A. (LONDONMACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND, 2008)
    Constitutive activation of the NF-κB pathway by the Tax oncoprotein plays a crucial role in the proliferation and transformation of HTLV-I infected T lymphocytes. We have previously shown that Tax ubiquitylation on C-terminal ...

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