Browsing by Subject "S phase cell cycle checkpoint"

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Ajwa Date (Phoenix dactylifera L.) extract inhibits human breast adenocarcinoma (MCF7) cells in vitro by inducing apoptosis and cell cycle arrest

Khan, Fazal; Ahmed, Farid; Pushparaj, Peter Natesan; Abuzenadah, Adel Mohammad; Kumosani, Taha Abdullah; Barbour, Elie K.; Al-Qahtani, Mohammed Hussain; Gauthaman, Kalamegam (Public Library of Science, 2016)

Introduction Phoenix dactylifera L (Date palm) is a native plant of the Kingdom of Saudi Arabia (KSA) and other Middle Eastern countries. Ajwa date has been described in the traditional and alternative medicine to provide ...
Anti-proliferative and anti-inflammatory activities of the sea cucumber Holothuria polii aqueous extract

Kareh, Mike; El Nahas, Rana; Al-Aaraj, Lamis; Al-Ghadban, Sara I.; Naser Al Deen, Nataly; Saliba, Najat A.; El-Sabban, Marwan E.; Talhouk, Rabih S. (SAGE Publications Ltd, 2018)

Objective: Sea cucumbers are considered among the most important functional foods. Following bioassay guided fractionation, we assessed the anti-proliferative and anti-inflammatory activities of Holothuria polii (H. polii) ...
Antitumor activities of the synthetic retinoid ST1926 in two-dimensional and three-dimensional human breast cancer models

Aouad, Patrick; Saikali, Melody; Abdel-Samad, Rana; Fostok, Sabreen F.; El-Houjeiri, Leeanna; Pisano, Claudio C.P.; Talhouk, Rabih S.; Darwiche, Nadine D. (Lippincott Williams and Wilkins, 2017)

Despite recent advances in chemotherapy, aggressive and metastatic breast cancers remain refractory to targeted therapy and the development of novel drugs is urgently needed. Retinoids are crucial regulators of cellular ...
Cell Death by Gallotannin Is Associated with Inhibition of the JAK/STAT Pathway in Human Colon Cancer Cells

Houssein, Marwa; Abi Saab, Widian F.; Khalil, Mahmoud Ibrahim M.; Khalife, Hala K.; Fatfat, Maamoun (Excerpta Medica Inc., 2020)

Background: Gallotannin (GT) is a polyphenol that possesses interesting anticancer properties. However, the mechanisms underlying its antitumor effects have not been well defined. Objective: This study was designed to ...
The synthetic retinoid ST1926 as a novel therapeutic agent in rhabdomyosarcoma

Basma, Hussein A.; Ghayad, Sandra E.; Rammal, Ghina; Mancinelli, Angelo; Harajly, Mohamad; Ghamloush, Farah; Dweik, Loai M.; El-Eit, Rabab M.; Zalzali, Hassan; Rabeh, Wissam; Pisano, Claudio C.P.; Darwiche, Nadine D.; Saab, Raya H. (Wiley-Liss Inc., 2016)

Rhabdomyosarcoma (RMS) is the most frequent soft tissue sarcoma in children. Despite multiple attempts at intensifying chemotherapeutic approaches to treatment, only moderate improvements in survival have been made for ...
The synthetic retinoid ST1926 attenuates prostate cancer growth and potentially targets prostate cancer stem-like cells

Bahmad, Hisham F.; Samman, Houda; Monzer, Alissar; Hadadeh, Ola; Cheaito, Katia A.; Abdel-Samad, Rana; Hayar, Berthe; Pisano, Claudio C.P.; Msheik, Hiba; Liu, Yennien; Darwiche, Nadine D.; Abou-Kheir, Wassim G. (John Wiley and Sons Inc., 2019)

Retinoids are vitamin A derivatives that regulate crucial biological processes such as cellular proliferation, apoptosis, and differentiation. The use of natural retinoids in cancer therapy is limited due to their toxicity ...

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Browsing by Subject "S phase cell cycle checkpoint"

Browsing by Subject "S phase cell cycle checkpoint"

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