AUB ScholarWorks

Browsing Biochemistry and Molecular Genetics by Author "Kadara, Humam N."

Browsing Biochemistry and Molecular Genetics by Author "Kadara, Humam N."

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  • SLURP-1 is mutated in Mal de Meleda, a potential molecular signature for melanoma and a putative squamous lineage tumor suppressor gene 
    Bergqvist, Christina; Kadara, Humam N.; Hamie, Lamiaa; Nemer, Georges M.; Safi, Rémi; Karouni, Mirna; Marrouche, Nadine; Abbas, Ossama M.; Hasbani, Divina Justina; Kibbi, Abdul Ghani M.; Nassar, Dany; Shimomura, Yutaka; Kurban, Mazen S. (Blackwell Publishing Ltd, 2018)
    Background: Mal de Meleda (MDM) is a rare inherited autosomal recessive genodermatosis characterized by palmoplantar keratoderma (PPK) with transgrediens and caused by mutations in the SLURP1 gene. Uncommonly, cutaneous ...
  • Smoking and lung cancer: A geo-regional perspective 
    Rahal, Zahraa; Nemr, Shaza El; Sinjab, Ansam; Chami, Hassan A.; Tfayli, Arafat Hussein; Kadara, Humam N. (Frontiers Media S.A., 2017)
    Lung cancer is the leading cause of cancer-related deaths worldwide. Non-small cell lung cancer (NSCLC) represents the most frequently diagnosed subtype of this morbid malignancy. NSCLC is causally linked to tobacco ...
  • Strategies for identification of somatic variants using the Ion Torrent deep targeted sequencing platform 
    Deshpande, Aditya S.; Lang, Wenhua; McDowell, Tina L.; Sivakumar, Smruthy; Zhang, Jiexin; Wang, Jing; San Lucas, Francis Anthony; Fowler, Jerry; Kadara, Humam N.; Scheet, Paul A. (BioMed Central Ltd., 2018)
    Background: 'Next-generation' (NGS) sequencing has wide application in medical genetics, including the detection of somatic variation in cancer. The Ion Torrent-based (IONT) platform is among NGS technologies employed in ...
  • TBX2 subfamily suppression in lung cancer pathogenesis: a high-potential marker for early detection 
    Khalil, Athar A.; Sivakumar, Smruthy; San Lucas, Francis Anthony; McDowell, Tina L.; Lang, Wenhua; Tabata, Kazuhiro; Fujimoto, Jyunya; Yatabe, Yasushi; Spira, Avrum E.; Scheet, Paul A.; Nemer, Georges M.; Kadara, Humam N. (NLM (Medline), 2017)
    The TBX2 subfamily (TBXs 2, 3, 4 and 5) transactivates or represses genes involved in lung organogenesis. Yet TBX2 subfamily expression in pathogenesis of non-small cell lung cancer (NSCLC), the most common lung malignancy, ...
  • The HGF/c-MET pathway is a driver and biomarker of VEGFR-inhibitor resistance and vascular remodeling in non–small cell lung cancer 
    Cascone, Tina; Xu, Li; Lin, Heather Yan; Liu, Wenbin; Tran, Hai T.; Liu, Yuan; Howells, Kathryn; Haddad, Vincent; Hanrahan, Emer O.; Nilsson, Monique B.; Cortez, Maria Angélica Abdalla De Freitas; Giri, Uma; Kadara, Humam N.; Saigal, Babita; Park, Yun-yong; Peng, Weiyi; Lee, Juseog Seong; Ryan, Anderson Joseph; Jüergensmeier, Juliane M.; Herbst, Roy S.; Wang, Jing; Langley, Robert R.; Wistuba, Ignacio Ivans; Lee, J. Jack; Heymach, John Victor (American Association for Cancer Research Inc., 2017)
    Purpose: Resistance to VEGFR inhibitors is a major obstacle in the treatment of non–small cell lung cancer (NSCLC). We investigated the cellular mechanisms mediating resistance of NSCLCs to VEGFR tyrosine kinase inhibitors. ...
  • Transcriptomic alterations in lung adenocarcinoma unveil new mechanisms targeted by the Tbx2 subfamily of tumor suppressor genes 
    Khalil, Athar A.; Dekmak, Batoul; Boulos, Fouad I.; Kantrowitz, Jacob J.; Spira, Avrum E.; Fujimoto, Jyunya; Kadara, Humam N.; El Hachem, Nehme; Nemer, Georges M. (Frontiers Media S.A., 2018)
    T-box (TBX) transcription factors are evolutionary conserved genes and master transcriptional regulators. In mammals, TBX2 subfamily (TBX2, TBX3, TBX4, and TBX5) genes are expressed in the developing lung bud and tracheae. ...
  • Whole-exome sequencing and immune profiling of early-stage lung adenocarcinoma with fully annotated clinical follow-up 
    Kadara, Humam N.; Choi, Murim; Zhang, Jiashan (Julia); Parra, Edwin Roger C.; Rodriguez-Canales, Jaime A.; Gaffney, Stephen G.; Zhao, Zi-Ming; Behrens, Carmen; Fujimoto, Jyunya; Chow, Chi Wan B.; Yoo, Yongjin; Kalhor, Neda; Moran, César A.; Rimm, David L.; Swisher, Stephen G.; Gibbons, Don Lynn; Heymach, John Victor; Kaftan, Edward J.; Townsend, Jeffrey P.; Lynch, Thomas J.; Schlessinger, Joseph; Lee, Jeffrey H.; Lifton, Richard P.; Wistuba, Ignacio Ivans; Herbst, Roy S. (Oxford University Press, 2017)
    Background: Lung adenocarcinomas (LUADs) lead to the majority of deaths attributable to lung cancer. We performed whole-exome sequencing (WES) and immune profiling analyses of a unique set of clinically annotated early-stage ...

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