AUB ScholarWorks

Browsing Biochemistry and Molecular Genetics by Issue Date

Browsing Biochemistry and Molecular Genetics by Issue Date

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  • Stem cells in neuroinjury and neurodegenerative disorders: Challenges and future neurotherapeutic prospects 
    Mouhieddine, Tarek H.; Kobeissy, Firas H.; Itani, Muhieddine M.; Nokkari, Amaly; Wang, Kevin Ka Wang (Editorial Board of Neural Regeneration Research, 2014)
    The prevalence of neurodegenerative diseases and neural injury disorders is increasing worldwide. Research is now focusing on improving current neurogenesis techniques including neural stem cell therapy and other biochemical ...
  • Low-density lipoprotein levels and not mutation status predict Intima-media thickness in familial hypercholesterolemia 
    Fahed, Akl C.; Habib, Robert H.; Nemer, Georges M.; Azar, Sami T.; Andary, Rabih R.; Arabi, Mariam Toufic; Moubarak, Elie M.; Bitar, Fadi Fouad; Haddad, Fady F. (2014)
    Background Intima-media thickness (IMT) is a well-described marker of cardiovascular disease. In this study we aim to determine whether low-density lipoprotein (LDL) levels and disease-related mutation status can predict ...
  • Passaging impact of H9N2 avian influenza virus in hamsters on its pathogenicity and genetic variability 
    Shaib, Houssam A.; Cochet, Nelly; Ribeiro, Thierry; Abdel Nour, Afif M.; Nemer, Georges M.; Azhar, Esam Ibraheem; Iyer, Archana P.; Kumosani, Taha Abdullah; Harakeh, Steve Mustapha; Barbour, Elie K. (Journal of Infection in Developing Countries, 2014)
    Introduction: Avian influenza viruses of the H9N2 subtype have been reported to cause human infections. This study demonstrates the impact of nasal viral passaging of avian H9N2 in hamsters on its cross species-pathogenic ...
  • Recent advances in application of biosensors in tissue engineering 
    Hasan, Anwarul Ul; Nurunnabi, Md; Morshed, Mahboob; Paul, Arghya; Polini, Alessandro; Kuila, Tapas; Al Hariri, Moustafa; Lee, Yong-kyu; Jaffa, Ayad A. (Hindawi Publishing Corporation, 2014)
    Biosensors research is a fast growing field in which tens of thousands of papers have been published over the years, and the industry is now worth billions of dollars. The biosensor products have found their applications ...
  • Recent updates on drug abuse analyzed by neuroproteomics studies: Cocaine, Methamphetamine and MDMA 
    Kobeissy, Firas H.; Mouhieddine, Tarek H.; Nokkari, Amaly; Itani, Muhieddine M.; Mouhieddine, Mohamed; Zhang, Zhiqun; Zhu, Rui; Gold, Mark S.; Wang, Kevin Ka Wang; Mechref, Yehia S. (Elsevier B.V., 2014)
    Currently, drug abuse and addiction represent a global public health concern with about 13.6 million people using illicit drugs in the USA alone. Substance abuse intervenes in normal brain functioning, causing alterations ...
  • Primary carnitine deficiency: Novel mutations and insights into the cardiac phenotype 
    Shibbani, Kamel; Fahed, Akl C.; Al-Shaar, Laila; Arabi, Mariam Toufic; Nemer, Georges M.; Bitar, Fadi Fouad; Majdalani, Marianne Nimah (2014)
    Solute carrier family 22 member 5 (SLC22A5) encodes a sodium-dependent ion transporter responsible for shuffling carnitine across the plasma membrane. This process provides energy for the heart, among other organs allowing ...
  • Stability of urinary thromboxane A2 metabolites and adaptation of the extraction method to small urine volume 
    Pagliaccia, Francesca; Habib, Aida A.; Pitocco, Dario; Petrucci, Giovanna; Zaccardi, Francesco; Di Stasio, Enrico; Rocca, Bianca (2014)
    Background: Thromboxane (TX) A2 is a pro-thrombotic prostanoid synthesized by activated platelets, biotransformed into 11-dehydro-TXB 2, measurable in urines. Eleven-dehydro-TXB2 excretion is increased in high risk ...
  • Antioxidant activity of pomegranate juice reduces acute lung injury secondary to hyperoxia in an animal model 
    Husari, Ahmad W.; Khayat, Aline; Bitar, Hala; Hashem, Yasmine; Rizkallah, Alain; Zaatari, Ghazi S.; El-Sabban, Marwan E. (BioMed Central Ltd., 2014)
    Background: Hyperoxia triggers the release of toxic reactive oxygen species (ROS). Pomegranate Juice (PJ) is a rich source of potent antioxidants. We assessed the effects of PJ supplementation on Acute Lung Injury (ALI) ...
  • CSF and Plasma Amyloid-β Temporal Profiles and Relationships with Neurological Status and Mortality after Severe Traumatic Brain Injury 
    Mondello, Stefania; Büki, Andràs; Barzó, Pál; Randall, Jeffrey D.; Provuncher, Gail K.; Hanlon, David W.; Wilson, David H.; Kobeissy, Firas H.; Jeromin, Andreas (Nature Publishing Group, 2014)
    The role of amyloid-β (Aβ) neuropathology and its significant changes in biofluids after traumatic brain injury (TBI) is still debated. We used ultrasensitive digital ELISA approach to assess amyloid-β1-42 (Aβ42) concentrations ...
  • Cell death mechanisms of plant-derived anticancer drugs: Beyond apoptosis 
    Gali-Muhtasib, Hala Uthman; Hmadi, Raed A.; Kareh, Mike; Tohme, Rita; Darwiche, Nadine D. (Springer New York LLC, 2015)
    Despite remarkable progress in the discovery and development of novel cancer therapeutics, cancer remains the second leading cause of death in the world. For many years, compounds derived from plants have been at the ...
  • Genetics of Sudden Cardiac Death 
    Refaat, Marwan M.; Hotait, Mostafa; London, Barry (Current Medicine Group LLC 1, 2015)
    Sudden cardiac death (SCD) is defined by the World Health Organization (WHO) as death within 1 h of symptom onset (witnessed) or within 24 h of being observed alive and symptom free (unwitnessed). It affects more than ...
  • Association between CLN3 (neuronal ceroid lipofuscinosis, CLN3 type) gene expression and clinical characteristics of breast cancer patients 
    Makoukji, Joelle; Raad, Mohamad A.; Genadry, Katia Christina; El-Sitt, Sally Boulos; Makhoul, Nadine J.; Saad Aldin, Ehab; Nohra, Eden A.; Jabbour, Mark N.; Sangaralingam, Ajanthah; Chelala, Claude; Habib, Robert H.; Boulos, Fouad I.; Tfayli, Arafat Hussein; Boustany, Rose Mary Naaman (Frontiers Media S.A., 2015)
    Breast cancer is the most common cancer in women worldwide. Elucidation of underlying biology and molecular pathways is necessary for improving therapeutic options and clinical outcomes. CLN3 protein (CLN3p), deficient in ...
  • Epidemiology and characteristics of urinary tract infections in children and adolescents 
    Hanna-Wakim, Rima H.; Ghanem, Soha T.; El Helou, Mona W.; Khafaja, Sarah A.; Shaker, Rouba A.; Hassan, Sara A.; Saad, Randa K.; Hedari, Carine P.; Khinkarly, Rima W.; Hajar, Farah M.; Bakhash, Marwan; El Karah, Dima; Akel, Imad S.; Rajab, Mariam El; Khoury, Mireille Lteif; Dbaibo, Ghassan S. (Frontiers Research Foundation, 2015)
    Background: Urinary tract infections (UTIs) are among the most common infections in the pediatric population. Over the last two decades, antibiotic resistance is increasing significantly as extended spectrum beta lactamase ...
  • NKX2-5 mutations in an inbred consanguineous population: Genetic and phenotypic diversity 
    Abou-Hassan, Ossama K.; Fahed, Akl C.; Batrawi, Manal; Arabi, Mariam Toufic; Refaat, Marwan M.; DePalma, Steven R.; Seidman, Jonathan G.; Seidman, Christine E.; Bitar, Fadi Fouad; Nemer, Georges M. (Nature Publishing Group, 2015)
    NKX2-5 mutations are associated with different forms of congenital heart disease. Despite the knowledge gained from molecular and animal studies, genotype-phenotype correlations in humans are limited by the lack of large ...
  • The Novel PKCθ from Benchtop to Clinic 
    Hage-Sleiman, Rouba; Hamze, Asmaa B.; Reslan, Lina; Kobeissy, Hadile; Dbaibo, Ghassan S. (Hindawi Limited, 2015)
    The protein kinases C (PKCs) are a family of serine/threonine kinases involved in regulating multiple essential cellular processes such as survival, proliferation, and differentiation. Of particular interest is the novel, ...
  • Leptin inhibits the Na+/K+ ATPase in Caco-2 cells via PKC and p38MAPK 
    El Zein, Ola; Usta, Julnar A.R.; El Moussawi, Layla; Kreydiyyeh, Sawsan Ibrahim (Elsevier Inc., 2015)
    We demonstrated previously an inhibitory effect of luminal leptin on glucose absorption in differentiated Caco-2 cells. Since this process is dependent on the Na+ gradient established by the Na+/K+ATPase this work was ...
  • Retinoic acid and arsenic trioxide trigger degradation of mutated NPM1, resulting in apoptosis of AML cells 
    El-Hajj, Hiba Ahmad; Dassouki, Zeina; Berthier, Caroline P.; Raffoux, Emmanuel; Adès, Lionel; Legrand, Ollivier; Hleihel, Rita S.; Sahin, Umut; Tawil, Nadim M.; Salameh, Ala; Zibara, Kazem; Darwiche, Nadine D.; Mohty, Mohamad; Dombret, Hervè; Fénaux, Pierre; de Thȩ, Hugues B.; Bazarbachi, Ali Abdul Hamid (American Society of Hematology, 2015)
    Nucleophosmin-1 (NPM1) is the most frequently mutated gene in acute myeloid leukemia (AML). Addition of retinoic acid (RA) to chemotherapy was proposed to improve survival of some of these patients. Here, we found that RA ...
  • Molecular consequences of proprotein convertase 1/3 (PC1/3) inhibition in macrophages for application to cancer immunotherapy: A proteomic study 
    Duhamel, Marie; Rodet, Franck; Delhem, Nadira; Vanden-Abeele, Fabien; Kobeissy, Firas H.; Nataf, Serge; Pays, Laurent; Desjardins, Roxane; Gagnon, Hugo; Wisztorski, Maxence; Fournier, Isabelle; Day, Robert; SALZET, Michel (American Society for Biochemistry and Molecular Biology Inc., 2015)
    Macrophages provide the first line of host immune defense. Their activation triggers the secretion of pro-inflammatory cytokines and chemokines recruiting other immune cells. In cancer, macrophages present an M2 anti-inflammatory ...
  • Thiazole derivatives as inhibitors of cyclooxygenases in vitro and in vivo 
    El-Achkar, Ghewa A.; Jouni, Mariam; Mrad, May F.; Hirz, Taghreed; El Hachem, Nehme; Khalaf, Ali Ali; Hammoud, Soukaina; Fayyad-kazan, Hussein; Eid, Assaad A.; Badran, Bassam M.; Abou-Merhi, Raghida; Hachem, Ali; Hamade, Eva; Habib, Aida A. (Elsevier, 2015)
    Cyclooxygenases (COXs) are important membrane-bound heme containing enzymes important in platelet activation and inflammation. COX-1 is constitutively expressed in most cells whereas COX-2 is an inducible isoform highly ...
  • Nanotheragnostic Applications for Ischemic and Hemorrhagic Strokes: Improved Delivery for a Better Prognosis 
    Mouhieddine, Tarek H.; Itani, Muhieddine M.; Nokkari, Amaly; Ren, Changhong; Daoud, Georges E.; Zeidan, Asad; Mondello, Stefania; Kobeissy, Firas H. (Current Medicine Group LLC 1, 2015)
    Stroke is the second leading cause of death worldwide and a major cause of long-term severe disability representing a global health burden and one of the highly researched medical conditions. Nanostructured material synthesis ...

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