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Browsing Biochemistry and Molecular Genetics by Issue Date

Browsing Biochemistry and Molecular Genetics by Issue Date

Now showing items 21-40 of 421

The Mutation P.T613a in the Pore Helix of the Kv11.1 Potassium Channel is Associated with Long QT Syndrome

Poulsen, Kristian Lundgaard; Hotait, Mostafa; Calloe, Kirstine; Klaerke, Dan Arne; Rebeiz, Abdallah G.; Nemer, Georges M.; Tejada, Maria De Los Angeles; Refaat, Marwan M. (Blackwell Publishing Inc., 2015)

Background Loss-of-function mutations in the voltage gated potassium channel Kv11.1 have been associated with the Long QT Syndrome (LQTS) type 2. We identified the p.T613A mutation in Kv11.1 in a family with LQTS. T613A ...
Nanotheragnostic Applications for Ischemic and Hemorrhagic Strokes: Improved Delivery for a Better Prognosis

Mouhieddine, Tarek H.; Itani, Muhieddine M.; Nokkari, Amaly; Ren, Changhong; Daoud, Georges E.; Zeidan, Asad; Mondello, Stefania; Kobeissy, Firas H. (Current Medicine Group LLC 1, 2015)

Stroke is the second leading cause of death worldwide and a major cause of long-term severe disability representing a global health burden and one of the highly researched medical conditions. Nanostructured material synthesis ...
Proteomics studies in inner ear disorders: Pathophysiology and biomarkers

Alawieh, Ali Mostafa; Mondello, Stefania; Kobeissy, Firas H.; Shibbani, Kamel; Bassim, Marc Kaissar (Expert Reviews Ltd., 2015)

Although proteomics has been exploited in a wide range of diseases for identification of biomarkers and pathophysiological mechanisms, there are still biomedical disciplines such as otology where proteomics platforms are ...
A novel nonsense mutation in NPHS1: is aortic stenosis associated with congenital nephropathy?

Gharibeh, Lara; El-Rassy, Inaam; Soubra, Ayman; Safa, Raya; Fahed, A. K.L.; Tanos, Rachel; Arabi, Mariam Toufic; Kambris, Zakaria; Bitar, Fadi Fouad; Nemer, Georges M. (Springer India, 2015)
Inhibition of sphingosine kinase 1 ameliorates angiotensin ii-induced hypertension and inhibits transmembrane calcium entry via store-operated calcium channel

Wilson, Parker C.; Fitzgibbon, Wayne R.; Garrett, Sara M.; Jaffa, Ayad A.; Luttrell, Louis M.; Brands, Michael W.; El-Shewy, Hesham M. (Endocrine Society, 2015)

Angiotensin II (AngII) plays a critical role in the regulation of vascular tone and blood pressure mainly via regulation of Ca2+ mobilization. Several reports have implicated sphingosine kinase 1 (SK1)/sphingosine 1-phosphate ...
Retinoic acid and arsenic trioxide trigger degradation of mutated NPM1, resulting in apoptosis of AML cells

El-Hajj, Hiba Ahmad; Dassouki, Zeina; Berthier, Caroline P.; Raffoux, Emmanuel; Adès, Lionel; Legrand, Ollivier; Hleihel, Rita S.; Sahin, Umut; Tawil, Nadim M.; Salameh, Ala; Zibara, Kazem; Darwiche, Nadine D.; Mohty, Mohamad; Dombret, Hervè; Fénaux, Pierre; de Thȩ, Hugues B.; Bazarbachi, Ali Abdul Hamid (American Society of Hematology, 2015)

Nucleophosmin-1 (NPM1) is the most frequently mutated gene in acute myeloid leukemia (AML). Addition of retinoic acid (RA) to chemotherapy was proposed to improve survival of some of these patients. Here, we found that RA ...
Mechanical stretch-induced vascular hypertrophy occurs through modulation of leptin synthesis-mediated ROS formation and GATA-4 nuclear translocation

Ghantous, Crystal M.; Kobeissy, Firas H.; Soudani, Nadia Y.; Rahman, Farah Abdel; Al Hariri, Moustafa; Itani, Hana A.; Sabra, Ramzi F.; Zeidan, Asad (Frontiers Research Foundation, 2015)

Background: Obesity and hypertension are associated with increased leptin production contributing to cardiovascular remodeling. Mechanisms involving mechanical stretch-induced leptin production and the cross talk between ...
Molecular consequences of proprotein convertase 1/3 (PC1/3) inhibition in macrophages for application to cancer immunotherapy: A proteomic study

Duhamel, Marie; Rodet, Franck; Delhem, Nadira; Vanden-Abeele, Fabien; Kobeissy, Firas H.; Nataf, Serge; Pays, Laurent; Desjardins, Roxane; Gagnon, Hugo; Wisztorski, Maxence; Fournier, Isabelle; Day, Robert; SALZET, Michel (American Society for Biochemistry and Molecular Biology Inc., 2015)

Macrophages provide the first line of host immune defense. Their activation triggers the secretion of pro-inflammatory cytokines and chemokines recruiting other immune cells. In cancer, macrophages present an M2 anti-inflammatory ...
ST1926, an orally active synthetic retinoid, induces apoptosis in chronic myeloid leukemia cells and prolongs survival in a murine model

Nasr, Rihab R.; Hmadi, Raed A.; El-Eit, Rabab M.; Iskandarani, Ahmad N.; Jabbour, Mark N.; Zaatari, Ghazi S.; Mahon, François Xavier; Pisano, Claudio C.P.; Darwiche, Nadine D. (Wiley-Liss Inc., 2015)

The tyrosine kinase inhibitor, imatinib, is the first line of treatment for chronic myeloid leukemia (CML) patients. Unfortunately, patients develop resistance and relapse due to bcr-abl point mutations and the persistence ...
Identification of several mutations in ATP2C1 in Lebanese families: Insight into the pathogenesis of Hailey-Hailey disease

Btadini, Waed; Abou-Hassan, Ossama K.; Saade, Dana; Abbas, Ossama M.; Ballout, Farah; Kibbi, Abdul Ghani M.; Dbaibo, Ghassan S.; Darwiche, Nadine D.; Nemer, Georges M.; Kurban, Mazen S. (Public Library of Science, 2015)

Background: Hailey-Hailey disease (HHD) is an inherited blistering dermatosis characterized by recurrent erosions and erythematous plaques that generally manifest in intertriginous areas. Genetically, HHD is an autosomal ...
Analysis of multivariate longitudinal kidney function outcomes using generalized linear mixed models

Jaffa, Miran A.; Gebregziabher, Mulugeta G.; Jaffa, Ayad A. (BioMed Central Ltd., 2015)

Background: Renal transplant patients are mandated to have continuous assessment of their kidney function over time to monitor disease progression determined by changes in blood urea nitrogen (BUN), serum creatinine (Cr), ...
Assessment of serum UCH-L1 and GFAP in acute stroke patients

Ren, Changhong; Kobeissy, Firas H.; Alawieh, Ali Mostafa; Li, Na; Li, Ning; Zibara, Kazem; Zoltewicz, Susie; Guingab-Cagmat, Joy D.; Larner, Stephen F.; Ding, Yuchuan Chuan; Hayes, Ronald Lawrence; Ji, Xunming; Mondello, Stefania (Nature Publishing Group, 2016)

A rapid and reliable diagnostic test to distinguish ischemic from hemorrhagic stroke in patients presenting with stroke-like symptoms is essential to optimize management and triage for thrombolytic therapy. The present ...
Deciphering glycomics and neuroproteomic alterations in experimental traumatic brain injury: Comparative analysis of aspirin and clopidogrel treatment

Abou-Abbass, Hussein; Bahmad, Hisham F.; Abou-El-Hassan, Hadi; Zhu, Rui; Zhou, Shiyue; Dong, Xue; Hamade, Eva; Mallah, Khalil; Zebian, Abir; Ramadan, Naify; Mondello, Stefania; Fares, Jawad Y.; Comair, Youssef G.; Atweh, Samir F.; Darwish, Hala; Zibara, Kazem; Mechref, Yehia S.; Kobeissy, Firas H. (Wiley-VCH Verlag, 2016)

As populations age, the number of patients sustaining traumatic brain injury (TBI) and concomitantly receiving preinjury antiplatelet therapy such as aspirin (ASA) and clopidogrel (CLOP) is rising. These drugs have been ...
Brugada Syndrome

Refaat, Marwan M.; Hotait, Mostafa; Scheinman, Melvin M. (W.B. Saunders, 2016)

Brugada syndrome might stay undetected in patients until surviving cardiac arrest. Despite the prominent advances in exploring the disease in the past 2 decades, many questions remain unanswered and the controversies ...
Characterization of influenza outbreaks in Lebanon during the 2013/14 and 2014/15 seasons

Saito, Reiko; Akinobu, H.; Shaker, Rouba A.; Akel, Imad S.; Assaf-Casals, Aia; Lteif, Mireille; Odagiri, Takashi; Inaba, R.; Soudani, Nadia Y.; Khafaja, Sarah A.; Ghanem, Soha T.; Rajab, Mariam El; Shobugawa, Yugo; Dbaibo, Ghassan S.; Zaraket, Hassan (World Health Organization, 2016)

Despite the significant burden of influenza outbreaks, active disease monitoring has been largely absent in the Middle East, including Lebanon. In this study we characterized influenza virus in 440 nasopharyngeal swabs ...
Pregnancy outcomes in Lebanese women with multiple sclerosis (the LeMS study): A prospective multicentre study

Fares, Jawad Y.; Nassar, Anwar H.; Gebeily, Souheil E.; Kobeissy, Firas H.; Fares, Youssef H. (BMJ Publishing Group, 2016)

Objective: The Lebanese Multiple Sclerosis (LeMS) study aims to assess the influence of pregnancy and delivery on the clinical course of multiple sclerosis (MS) in Lebanese women. Setting: This prospective multicentre study ...
Arrhythmogenic Right Ventricular Cardiomyopathy Caused by a Novel Frameshift Mutation

Refaat, Marwan M.; Tang, Paul Ling Fung; Harfouch, Nassier; Wojciak, Julianne; Kwok, Puiyan Yan; Scheinman, Melvin M. (W.B. Saunders, 2016)

Arrhythmogenic right ventricular cardiomyopathy is a rare cardiomyopathy that might be asymptomatic or symptomatic, causing palpations or syncope, and might lead to sudden cardiac death. It is recommended that physical ...
Proteomic analysis of the spatio-temporal based molecular kinetics of acute spinal cord injury identifies a Time-and segment-specific window for effective tissue repair

Devaux, Stéphanie; Čí̌zková, Dáša; Quanico, Jusal P.; Franck, Julien; Nataf, Serge; Pays, Laurent; Hauberg-Lotte, Lena; Maaß, Peter; Kobarg, Jan Hendrik; Kobeissy, Firas H.; Mériaux, Céline; Wisztorski, Maxence; Slovinská, Lucia; Blaško, Juraj; Cigánková, Viera; Fournier, Isabelle; SALZET, Michel (American Society for Biochemistry and Molecular Biology Inc., 2016)

Spinal cord injury (SCI) represents a major debilitating health issue with a direct socioeconomic burden on the public and private sectors worldwide. Although several studies have been conducted to identify the molecular ...
Moringa oleifera's Nutritious Aqueous Leaf Extract Has Anticancerous Effects by Compromising Mitochondrial Viability in an ROS-Dependent Manner

Madi, Niveen; Dany, Mohammed; Abdoun, Salah; Usta, Julnar A.R. (Routledge, 2016)

Introduction:Moringa oleifera (MO) is an important dietary component for many populations in West Africa and the Indian subcontinent. In addition to its highly nutritious value, almost all parts of this plant have been ...
Multivariate generalized linear mixed models with random intercepts to analyze cardiovascular risk markers in type-1 diabetic patients

Jaffa, Miran A.; Gebregziabher, Mulugeta G.; Luttrell, Deirdre K.; Luttrell, Louis M.; Jaffa, Ayad A. (Taylor and Francis Ltd., 2016)

Statistical approaches tailored to analyzing longitudinal data that have multiple outcomes with different distributions are scarce. This paucity is due to the non-availability of multivariate distributions that jointly ...

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Browsing Biochemistry and Molecular Genetics by Issue Date

Browsing Biochemistry and Molecular Genetics by Issue Date

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