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Browsing Biochemistry and Molecular Genetics by Issue Date

Browsing Biochemistry and Molecular Genetics by Issue Date

Now showing items 41-60 of 421

Deciphering glycomics and neuroproteomic alterations in experimental traumatic brain injury: Comparative analysis of aspirin and clopidogrel treatment

Abou-Abbass, Hussein; Bahmad, Hisham F.; Abou-El-Hassan, Hadi; Zhu, Rui; Zhou, Shiyue; Dong, Xue; Hamade, Eva; Mallah, Khalil; Zebian, Abir; Ramadan, Naify; Mondello, Stefania; Fares, Jawad Y.; Comair, Youssef G.; Atweh, Samir F.; Darwish, Hala; Zibara, Kazem; Mechref, Yehia S.; Kobeissy, Firas H. (Wiley-VCH Verlag, 2016)

As populations age, the number of patients sustaining traumatic brain injury (TBI) and concomitantly receiving preinjury antiplatelet therapy such as aspirin (ASA) and clopidogrel (CLOP) is rising. These drugs have been ...
Moringa oleifera's Nutritious Aqueous Leaf Extract Has Anticancerous Effects by Compromising Mitochondrial Viability in an ROS-Dependent Manner

Madi, Niveen; Dany, Mohammed; Abdoun, Salah; Usta, Julnar A.R. (Routledge, 2016)

Introduction:Moringa oleifera (MO) is an important dietary component for many populations in West Africa and the Indian subcontinent. In addition to its highly nutritious value, almost all parts of this plant have been ...
Multivariate generalized linear mixed models with random intercepts to analyze cardiovascular risk markers in type-1 diabetic patients

Jaffa, Miran A.; Gebregziabher, Mulugeta G.; Luttrell, Deirdre K.; Luttrell, Louis M.; Jaffa, Ayad A. (Taylor and Francis Ltd., 2016)

Statistical approaches tailored to analyzing longitudinal data that have multiple outcomes with different distributions are scarce. This paucity is due to the non-availability of multivariate distributions that jointly ...
Traumatic Brain Injury and Blood-Brain Barrier Cross-Talk

Nasser, Mohamad; Bejjani, Fabienne; Raad, Mohamad A.; Abou-El-Hassan, Hadi; Mantash, Sarah; Nokkari, Amaly; Ramadan, Naify; Kassem, Nouhad A.; Mondello, Stefania; Hamade, Eva; Darwish, Hala; Zibara, Kazem; Kobeissy, Firas H. (Bentham Science Publishers, 2016)

Traumatic brain injury, often referred to as the silent epidemic, is a nondegenerative, non-congenital insult to the brain due to a blow or penetrating object that disrupts the function of the brain leading to permanent ...
Pregnancy outcomes in Lebanese women with multiple sclerosis (the LeMS study): A prospective multicentre study

Fares, Jawad Y.; Nassar, Anwar H.; Gebeily, Souheil E.; Kobeissy, Firas H.; Fares, Youssef H. (BMJ Publishing Group, 2016)

Objective: The Lebanese Multiple Sclerosis (LeMS) study aims to assess the influence of pregnancy and delivery on the clinical course of multiple sclerosis (MS) in Lebanese women. Setting: This prospective multicentre study ...
Arrhythmogenic Right Ventricular Cardiomyopathy Caused by a Novel Frameshift Mutation

Refaat, Marwan M.; Tang, Paul Ling Fung; Harfouch, Nassier; Wojciak, Julianne; Kwok, Puiyan Yan; Scheinman, Melvin M. (W.B. Saunders, 2016)

Arrhythmogenic right ventricular cardiomyopathy is a rare cardiomyopathy that might be asymptomatic or symptomatic, causing palpations or syncope, and might lead to sudden cardiac death. It is recommended that physical ...
Variable expressivity and co-occurrence of LDLR and LDLRAP1 mutations in familial hypercholesterolemia: Failure of the dominant and recessive dichotomy

Fahed, Akl C.; Khalaf, Ruby I.; Salloum, Rony H.; Andary, Rabih R.; Safa, Raya; El-Rassy, Inaam; Moubarak, Elie M.; Azar, Sami T.; Bitar, Fadi Fouad; Nemer, Georges M. (Wiley-Blackwell, 2016)

Background The familial inherited genetic disorder of lipoprotein metabolism affects more than 10 million individuals around the world. Lebanon is one of the several endemic areas for familial hypercholesterolemia (FH) ...
Antioxidant activity of pomegranate juice reduces emphysematous changes and injury secondary to cigarette smoke in an animal model and human alveolar cells

Husari, Ahmad W.; Hashem, Yasmine; Bitar, Hala; Dbaibo, Ghassan S.; Zaatari, Ghazi S.; El-Sabban, Marwan E. (Dove Medical Press Ltd., 2016)

Background: Cigarette smoke (CS) increases oxidative stress (OS) in the lungs. Pomegranate juice (PJ) possesses potent antioxidant activities, attributed to its polyphenols. This study investigates the effects of PJ on the ...
Rotavirus genotypes and vaccine effectiveness from a sentinel, hospital-based, surveillance study for three consecutive rotavirus seasons in Lebanon

Ali, Zainab; Harastani, Houda H.; Hammadi, Moza M.; Reslan, Lina; Ghanem, Soha T.; Hajar, Farah M.; Sabra, Ahmad H.; Haidar, Amjad; Inati, Adlette; Rajab, Mariam El; Fakhouri, Hassan; Ghanem, Bassam; Baasiri, Ghassan M.; Gerbaka, Bernard J.; Zaraket, Hassan; Matar, Ghassan; Dbaibo, Ghassan S. (Public Library of Science, 2016)

Introduction Globally, rotavirus (RV) is the leading cause of gastroenteritis (GE) in children. Longitudinal data about changes in RV genotype distribution and vaccine effectiveness (VE) are scarce. This study was conducted ...
The synthetic retinoid ST1926 as a novel therapeutic agent in rhabdomyosarcoma

Basma, Hussein A.; Ghayad, Sandra E.; Rammal, Ghina; Mancinelli, Angelo; Harajly, Mohamad; Ghamloush, Farah; Dweik, Loai M.; El-Eit, Rabab M.; Zalzali, Hassan; Rabeh, Wissam; Pisano, Claudio C.P.; Darwiche, Nadine D.; Saab, Raya H. (Wiley-Liss Inc., 2016)

Rhabdomyosarcoma (RMS) is the most frequent soft tissue sarcoma in children. Despite multiple attempts at intensifying chemotherapeutic approaches to treatment, only moderate improvements in survival have been made for ...
Iron Overload Leading to Torsades de Pointes in β-Thalassemia and Long QT Syndrome

Refaat, Marwan M.; El-Hage, Lea; Steffensen, Annette Buur; Hotait, Mostafa; Schmitt, Nicole; Scheinman, Melvin M.; Badhwar, Nitish (W.B. Saunders, 2016)

The authors present a unique case of torsades de pointes in a b-thalassemia patient with early iron overload in the absence of any structural abnormalities as seen in hemochromatosis. Genetic testing showed a novel KCNQ1 ...
Inflammation and elevation of interleukin-12p40 in patients with schizophrenia

Bedrossian, Nora; Haidar, Mariam; Fares, Jawad Y.; Kobeissy, Firas H.; Fares, Youssef H. (Frontiers Research Foundation, 2016)

Schizophrenia is a serious mental illness with chronic symptoms and significant impairment in psychosocial functioning, which suggests that it likely has neurodegenerative characteristics. Inflammatory markers such as ...
Gene expression profiling of breast cancer in Lebanese women

Makoukji, Joelle; Makhoul, Nadine J.; Khalil, Maya K.; El-Sitt, Sally Boulos; Saad Aldin, Ehab; Jabbour, Mark N.; Boulos, Fouad I.; Gadaleta, Emanuela; Sangaralingam, Ajanthah; Chelala, Claude; Boustany, Rose Mary Naaman; Tfayli, Arafat Hussein (Nature Publishing Group, 2016)

Breast cancer is commonest cancer in women worldwide. Elucidation of underlying biology and molecular pathways is necessary for improving therapeutic options and clinical outcomes. Molecular alterations in breast cancer ...
Linezolid toxicity and mitochondrial susceptibility: A novel neurological complication in a lebanese patient

Abou-Hassan, Ossama K.; Karnib, Mohamad; El-Khoury, Riyad; Nemer, Georges M.; Barmada, Mamdouha Abdab; Bou-Khalil, Pierre (Frontiers Media S.A., 2016)

The recent rise in the use of linezolid to treat a variety of resistant pathogens has uncovered many side effects. Some patients develop lactic acidosis, myelosuppression, optic or peripheral neuropathies, and myopathies. ...
Patient-independent variables affecting the assessment of aspirin responsiveness by serum thromboxane measurement

Petrucci, Giovanna; Rizzi, Alessandro L.; Cavalca, Viviana; Habib, Aida A.; Pitocco, Dario; Veglia, Fabrizio; Ranalli, Paola; Zaccardi, Francesco; Pagliaccia, Francesca; Tremoli, Elena; Patrono, Carlo; Rocca, Bianca (Schattauer GmbH, 2016)

The serum TXB(2) (sTXB(2)) assay reflects the pharmacodynamics of platelet inhibition by low-dose aspirin. However, different studies reported variable sTXB(2) values. sTXB(2) assay requires whole blood incubation at 37 ...
The effect of chronic methamphetamine exposure on the hippocampal and olfactory bulb neuroproteomes of rats

Zhu, Rui; Yang, Tianjiao; Kobeissy, Firas H.; Mouhieddine, Tarek H.; Raad, Mohamad A.; Nokkari, Amaly; Gold, Mark S.; Wang, Kevin Ka Wang; Mechref, Yehia S. (Public Library of Science, 2016)

Nowadays, drug abuse and addiction are serious public health problems in the USA. Methamphetamine (METH) is one of the most abused drugs and is known to cause brain damage after repeated exposure. In this paper, we conducted ...
Restless leg syndrome in hospitalized psychiatric patients in Lebanon: A pilot study

Talih, Farid Ramzi; Aajaltouni, Jean; Kobeissy, Firas H. (Dove Medical Press Ltd, 2016)

Objectives: To characterize and describe the prevalence of restless leg syndrome (RLS) in hospitalized psychiatric patients and to investigate the correlations between patient profile and RLS. Methods: Demographic information, ...
Catecholaminergic Polymorphic Ventricular Tachycardia

Refaat, Marwan M.; Hassanieh, Sylvana; Scheinman, Melvin M. (W.B. Saunders, 2016)

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a challenging and serious disease with a high incidence of sudden cardiac deaths. Patients with CPVT should not be exposed to physical or emotional exertion ...
Mutations in SDR9C7 gene encoding an enzyme for vitamin A metabolism underlie autosomal recessive congenital ichthyosis

Shigehara, Y.; Okuda, Shujiro; Nemer, Georges M.; Chedraoui, Adele; Hayashi, Ryota; Bitar, Fadi Fouad; Nakai, Hiroyuki; Abbas, Ossama M.; Daou, Laetitia; Abe, Riichiro; Sleiman, Maria Bou; Kibbi, Abdul Ghani M.; Kurban, Mazen S.; Shimomura, Yutaka (Oxford University Press, 2016)

Autosomal recessive congenital ichthyosis (ARCI) is a heterogeneous group of hereditary skin disorder characterized by an aberrant cornification of the epidermis. ARCI is classified into a total of 11 subtypes (ARCI1-ARCI11) ...
Cigarette smoking-induced cardiac hypertrophy, vascular inflammation and injury are attenuated by antioxidant supplementation in an animal model

Al Hariri, Moustafa; Zibara, Kazem; Farhat, Wissam; Hashem, Yasmine; Soudani, Nadia Y.; Al Ibrahim, Farah; Hamade, Eva; Zeidan, Asad; Husari, Ahmad W.; Kobeissy, Firas H. (Frontiers Media S.A., 2016)

Background: Cardiovascular diseases are the leading causes of morbidity and mortality worldwide. Cigarette smoking remains a global health epidemic with associated detrimental effects on the cardiovascular system. In this ...

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Browsing Biochemistry and Molecular Genetics by Issue Date

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