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Browsing Biochemistry and Molecular Genetics by Author "Faculty of Health Sciences (FHS)"

Now showing items 1-20 of 31

A Likelihood-Based Approach with Shared Latent Random Parameters for the Longitudinal Binary and Informative Censoring Processes

Jaffa, Miran A.; Jaffa, Ayad A. (Springer New York LLC, 2019)

Longitudinal studies with binary outcomes characterized by informative right censoring are commonly encountered in clinical, basic, behavioral, and health sciences. Approaches developed to analyze data with binary outcomes ...
Analysis of longitudinal semicontinuous data using marginalized two-part model

Jaffa, Miran A.; Gebregziabher, Mulugeta G.; Garrett, Sara M.; Luttrell, Deirdre K.; Lipson, Kenneth E.; Luttrell, Louis M.; Jaffa, Ayad A. (BioMed Central Ltd., 2018)

Background: Connective tissue growth factor (CTGF), is a secreted matricellular factor that has been linked to increased risk of cardiovascular disease in diabetic subjects. Despite the biological role of CTGF in diabetes, ...
Analysis of multivariate longitudinal kidney function outcomes using generalized linear mixed models

Jaffa, Miran A.; Gebregziabher, Mulugeta G.; Jaffa, Ayad A. (BioMed Central Ltd., 2015)

Background: Renal transplant patients are mandated to have continuous assessment of their kidney function over time to monitor disease progression determined by changes in blood urea nitrogen (BUN), serum creatinine (Cr), ...
Beirut Ammonium Nitrate Blast: Analysis, Review, and Recommendations

Al-Hajj, Samar; Dhaini, Hassan R.; Mondello, Stefania; Kaafarani, Haytham M.A.; Kobeissy, Firas H.; DePalma, Ralph George (Frontiers Media S.A., 2021)

A massive chemical detonation occurred on August 4, 2020 in the Port of Beirut, Lebanon. An uncontrolled fire in an adjacent warehouse ignited ~2,750 tons of Ammonium Nitrate (AN), producing one of the most devastating ...
Characterization of astrovirus-associated gastroenteritis in hospitalized children under five years of age

Zaraket, Hassan; Abou-El-Hassan, Hadi; Kreidieh, Khalil; Soudani, Nadia Y.; Ali, Zainab; Hammadi, Moza M.; Reslan, Lina; Ghanem, Soha T.; Hajar, Farah M.; Inati, Adlette; Rajab, Mariam El; Fakhouri, Hassan; Ghanem, Bassam; Baasiri, Ghassan M.; Melhem, Nada Mohamad; Dbaibo, Ghassan S. (Elsevier B.V., 2017)

Purpose The aim of this study was to determine the incidence and genetic diversity of astrovirus (AstV) detected in children hospitalized for gastroenteritis (GE). Methods A multi-center, hospital-based surveillance study ...
Characterization of Traumatic Brain Injury Research in the Middle East and North Africa Region: A Systematic Review

Al-Hajj, Samar; Hammoud, Zeinab; Colnaric, Jure M.; Ataya, Maya; Macaron, Marie Michele; Kadi, Kamil; Harati, Hayat; Phipps, Helen W.; Mondello, Stefania; Tamim, Hani Mohammed; Abou-Abbass, Hussein; Kobeissy, Firas H. (S. Karger AG, 2021)

Objectives: Traumatic brain injury (TBI) represents a major health concern worldwide with a large impact in the Middle East and North Africa (MENA) region as a consequence of protracted wars and conflicts that adversely ...
Consanguinity rates among Syrian refugees in Lebanon: A study on genetic awareness

El Sabeh, Malak; Kassir, Mohamed Faisal; Ghanem, Paola; Saifi, Omran; El Hadi, Dalia; Khalifeh, Ibrahim M.; Akkawi, Abdul Rahman; Ghabach, Marc M.; Shaya, Monique; Nemer, Georges M.; Abbas, Ossama M.; Kurban, Mazen S. (Cambridge University Press, 2020)

Consanguineous marriage is a deeply rooted tradition in the Arab world. Such marriages are linked to higher rates of recessive genetic diseases. During the Syrian conflict, which started in 2011, around one million Syrian ...
Exercise-Induced Ventricular Ectopy and Cardiovascular Mortality in Asymptomatic Individuals

Refaat, Marwan M.; Gharios, Charbel; Moorthy, Manickavasagar Vinayaga; Abdulhai, Farah A.; Blumenthal, Roger S.; Jaffa, Miran A.; Mora, Samia (Elsevier Inc., 2021)

Background: The prognosis of exercise-induced premature ventricular contractions (PVCs) in asymptomatic individuals is unclear. Objectives: This study sought to investigate whether high-grade PVCs during stress testing ...
Genomic and Proteomic Study of the Inflammatory Pathway in Patients With Atrial Fibrillation and Cardiometabolic Syndrome

Itani, Hana A.; Jaffa, Miran A.; Elias, Joseph; Sabra, Mohammad; Zakka, Patrick K.; Ballout, Jad A.; Bekdash, Amira M.; Ibrahim, Rand; Al Hariri, Moustafa; Ghemrawi, Mirna; Abi-Saleh, Bernard S.; Khoury, Maurice Y.; Alam, Samir E.; Mahfouz, Rami A.R.; Jaffa, Ayad A.; Azar, Sami T.; Refaat, Marwan M. (Frontiers Media S.A., 2020)

Atrial fibrillation (AF) and cardiometabolic syndrome (CMS) have been linked to inflammation and fibrosis. However, it is still unknown which inflammatory cytokines contribute to the pathogenesis of AF. Furthermore, ...
Heteromerization fingerprints between bradykinin B2 and thromboxane TP receptors in native cells

Dagher, Oula K.; Jaffa, Miran A.; Habib, Aida A.; Ziyadeh, Fuad N.; Jaffa, Ayad A. (Public Library of Science, 2019)

Bradykinin (BK) and thromboxane-A2 (TX-A2) are two vasoactive mediators that modulate vascular tone and inflammation via binding to their cognate “class A” G-protein coupled receptors (GPCRs), BK-B2 receptors (B2R) and ...
Interventions addressing genetic disease burdens within selected countries in the MENA region: a scoping review

Grant, Madison; Kabakian-Khasholian, Tamar; Yazbek, Soha N. (Springer Science and Business Media Deutschland GmbH, 2023)

Background: The MENA region is disproportionately affected by genetic disease. The aim of this research is to scope the region for evidence of genetic services and public health interventions to identify geographic gaps, ...
Joint modeling of covariates and censoring process assuming non-constant dropout hazard

Jaffa, Miran A.; Jaffa, Ayad A. (Springer Verlag, 2016)

In this manuscript we propose a novel approach for the analysis of longitudinal data that have informative dropout. We jointly model the slopes of covariates of interest and the censoring process for which we assume a ...
Longitudinal plasma kallikrein levels and their association with the risk of cardiovascular disease outcomes in type 1 diabetes in dcct/edic

Jaffa, Miran A.; Bebu, Ionut; Luttrell, Deirdre K.; Braffett, Barbara H.; Lachin, John M.; Hunt, Kelly J.; Lopes-Virella, Maria Fernanda L.; Luttrell, Louis M.; Lyons, Timothy J.; Jaffa, Ayad A. (American Diabetes Association Inc., 2020)

We determined the relationship between plasma kalli-krein and cardiovascular disease (CVD) outcomes as well as major adverse cardiovascular events (MACE) in the Diabetes Control and Complications Trial (DCCT)/ Epidemiology ...
Modulation of Neuro-Inflammatory Signals in Microglia by Plasma Prekallikrein and Neuronal Cell Debris

Jaffa, Aneese A.; Jaffa, Miran A.; Moussa, Mayssam; Ahmed, Ibrahim A.; Karam, Mia; Aldeen, Kawthar Sharaf; Al Sayegh, Rola; El-Achkar, Ghewa A.; Nasrallah, Leila; Yehya, Yara; Habib, Aida A.; Ziyadeh, Fuad N.; Eid, Ali H.; Kobeissy, Firas H.; Jaffa, Ayad A. (Frontiers Media S.A., 2021)

Microglia, the resident phagocytes of the central nervous system and one of the key modulators of the innate immune system, have been shown to play a major role in brain insults. Upon activation in response to neuroinflammation, ...
Modulation of proteomic and inflammatory signals by Bradykinin in podocytes

Saoud, Richard; Jaffa, Miran A.; Habib, Aida A.; Zhao, Jingfu; Al Hariri, Moustafa; Zhu, Rui; Hasan, Anwarul Ul; Ziyadeh, Fuad N.; Kobeissy, Firas H.; Mechref, Yehia S.; Jaffa, Ayad A. (Elsevier B.V., 2020)

Podocyte damage is one of the hallmarks of diabetic nephropathy leading to proteinuria and kidney damage. The underlying mechanisms of podocyte injury are not well defined. Bradykinin (BK) was shown to contribute to diabetic ...
Multivariate generalized linear mixed models with random intercepts to analyze cardiovascular risk markers in type-1 diabetic patients

Jaffa, Miran A.; Gebregziabher, Mulugeta G.; Luttrell, Deirdre K.; Luttrell, Louis M.; Jaffa, Ayad A. (Taylor and Francis Ltd., 2016)

Statistical approaches tailored to analyzing longitudinal data that have multiple outcomes with different distributions are scarce. This paucity is due to the non-availability of multivariate distributions that jointly ...
Mutations in SDR9C7 gene encoding an enzyme for vitamin A metabolism underlie autosomal recessive congenital ichthyosis

Shigehara, Y.; Okuda, Shujiro; Nemer, Georges M.; Chedraoui, Adele; Hayashi, Ryota; Bitar, Fadi Fouad; Nakai, Hiroyuki; Abbas, Ossama M.; Daou, Laetitia; Abe, Riichiro; Sleiman, Maria Bou; Kibbi, Abdul Ghani M.; Kurban, Mazen S.; Shimomura, Yutaka (Oxford University Press, 2016)

Autosomal recessive congenital ichthyosis (ARCI) is a heterogeneous group of hereditary skin disorder characterized by an aberrant cornification of the epidermis. ARCI is classified into a total of 11 subtypes (ARCI1-ARCI11) ...
Pediatric Traumatic Brain Injury in the Middle East and North Africa Region: A Systematic Review and Meta-Analysis to Assess Characteristics, Mechanisms, and Risk Factors

Al-Hajj, Samar; Farran, Sarah H.; Dekmak, Batoul; Hneiny, Layal; Abbas, Hussein Abou; Hassoun, Aya; Youness, Nadine; Ghalayini, Sarah; Khalil, Nour Abou; Lecky, Fiona Elizabeth; Shahjouieh, Shima; Ghamlouche, Layal; Nasrallah, Zainab A.; Kobeissy, Firas H. (Mary Ann Liebert Inc., 2023)

Pediatric traumatic brain injury (pTBI) represents a major cause of child injuries in the Middle East and North Africa (MENA) region. This review aims to assess pTBIs in the MENA region and reports their clinical severity ...
Plasma connective tissue growth factor (CTGF/CCN2) levels predict myocardial infarction in the veterans affairs diabetes trial (VADT) cohort

Hunt, Kelly J.; Jaffa, Miran A.; Garrett, Sara M.; Luttrell, Deirdre K.; Lipson, Kenneth E.; Lopes-Virella, Maria Fernanda L.; Luttrell, Louis M.; Jaffa, Ayad A. (American Diabetes Association Inc., 2018)

OBJECTIVE Connective tissue growth factor (CTGF), also known as CCN2, is a potent chemotactic and extracellular matrix-inducing matricellular protein that has been implicated in progression of inflammatory and fibroproliferative ...
Plasma prekallikrein is associated with carotid intima-media thickness in type 1 diabetes

Jaffa, Miran A.; Luttrell, Deirdre K.; Schmaier, Alvin H.; Klein, Richard L.; Lopes-Virella, Maria Fernanda L.; Luttrell, Louis M.; Jaffa, Ayad A. (American Diabetes Association Inc., 2016)

The hypothesis that plasma prekallikrein (PK) is a risk factor for the development of vascular complications was assessed in a study using the Diabetes Control and Complications Trial (DCCT)/Epidemiology and Diabetes ...

Now showing items 1-20 of 31

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Browsing Biochemistry and Molecular Genetics by Author "Faculty of Health Sciences (FHS)"

Browsing Biochemistry and Molecular Genetics by Author "Faculty of Health Sciences (FHS)"

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