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Browsing Biochemistry and Molecular Genetics by Author "Kadara, Humam N."

Browsing Biochemistry and Molecular Genetics by Author "Kadara, Humam N."

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  • Augmented Lipocalin-2 Is Associated with Chronic Obstructive Pulmonary Disease and Counteracts Lung Adenocarcinoma Development 
    Treekitkarnmongkol, Warapen; Hassane, Maya; Sinjab, Ansam; Chang, Kyle; Hara, Kieko; Rahal, Zahraa; Zhang, Jiexin; Lu, Wei; Sivakumar, Smruthy; McDowell, Tina L.; Kantrowitz, Jacob J.; Zhou, Jianling; Lang, Wenhua; Xu, Li; Kapere Ochieng, Joshua; Nunomura-Nakamura, Sayuri; Deng, Shanshan; Behrens, Carmen; Raso, Maria Gabriela; Fukuoka, Junya; Reuben, Alexandre; Ostrin, Edwin Justin; Parra, Edwin Roger C.; Solís, Luisa Maren; Spira, Avrum E.; McAllister, Florencia M.; Cascone, Tina; Wistuba, Ignacio Ivans; Moghaddam, Seyed Javad Mirhasani; Scheet, Paul A.; Fujimoto, Jyunya; Kadara, Humam N. (American Thoracic Society, 2021)
    Rationale: Early pathogenesis of lung adenocarcinoma (LUAD) remains largely unknown. We found that, relative to wild-type littermates, the innate immunomodulator Lcn2 (lipocalin-2) was increased in normal airways from mice ...
  • Deep targeted sequencing analysis of hot spot mutations in non-small cell lung cancer patients from the Middle Eastern population 
    Khoueiry, Pierre H.; Fakhri, Ghina B.; Akel, Reem S.; Assaad, Majd Al; Mahfouz, Rami A.R.; Khuri, Fadlo R.; Chami, Hassan A.; Petersen, Jason L.; Viet, Sarah; Davies, Gareth E.; Kadara, Humam N.; Tfayli, Arafat Hussein (AME Publishing Company, 2019)
    Background: The overall 5-year survival of lung cancer remains dismal despite the current treatment regimens. Testing for driver mutations has become routine practice for oncologists due to the presence of targeted therapy ...
  • Defining genome-wide expression and phenotypic contextual cues in macrophages generated by granulocyte/macrophage colony-stimulating factor, macrophage colony-stimulating factor, and heat-killed mycobacteria 
    Bazzi, Samer I.; El-Darzi, Emale; McDowell, Tina L.; Modjtahedi, Helmout; Mudan, Satvinder Singh; Achkar, Marcel; Akle, Charles A.; Kadara, Humam N.; Bahr, Georges Michel (Frontiers Media S.A., 2017)
    Heat-killed (HK) Mycobacterium obuense (NCTC13365) is currently being evaluated in the clinic as an immunotherapeutic agent for cancer treatment. Yet, the molecular underpinnings underlying immunomodulatory properties of ...
  • Development of Kras mutant lung adenocarcinoma in mice with knockout of the airway lineage-specific gene Gprc5a 
    Fujimoto, Jyunya; Nunomura-Nakamura, Sayuri; Liu, Yihua; Lang, Wenhua; McDowell, Tina L.; Jakubek, Yasminka A.; Ezzeddine, Dalia; Kapere Ochieng, Joshua; Petersen, Jason L.; Davies, Gareth E.; Fukuoka, Junya; Wistuba, Ignacio Ivans; Ehli, Erik A.; Fowler, Jerry; Scheet, Paul A.; Kadara, Humam N. (Wiley-Liss Inc., 2017)
    Despite the urgency for prevention and treatment of lung adenocarcinoma (LUAD), we still do not know drivers in pathogenesis of the disease. Earlier work revealed that mice with knockout of the G-protein coupled receptor ...
  • Distinct pattern of TP53 mutations in human immunodeficiency virus–related head and neck squamous cell carcinoma 
    Gleber-Netto, Frederico Omar; Zhao, Mei; Trivedi, Sanchit; Wang, Jiping; Jasser, Samar A.; McDowell, Christina L.; Kadara, Humam N.; Zhang, Jiexin; Wang, Jing; William, William Nassib; Lee, J. Jack; Nguyen, Minh Ly T.; Pai, Sara Isabel; Walline, Heather M.; Shin, Dongmoon; Ferris, Robert Louis; Carey, Thomas E.; Myers, Jeffrey N.; Pickering, Curtis R. (John Wiley and Sons Inc., 2018)
    BACKGROUND: Human immunodeficiency virus–infected individuals (HIVIIs) have a higher incidence of head and neck squamous cell carcinoma (HNSCC), and clinical and histopathological differences have been observed in their ...
  • Epigenetic suppression of the T-box subfamily 2 (TBX2) in human non-small cell lung cancer 
    Nehme, Eliana; Rahal, Zahraa; Sinjab, Ansam; Khalil, Athar A.; Chami, Hassan A.; Nemer, Georges M.; Kadara, Humam N. (MDPI AG, 2019)
    (1) The TBX2 subfamily of transcription factors (TBXs 2, 3, 4 and 5) are markedly down-regulated in human non-small cell lung cancer (NSCLC) and exert tumor suppressor effects in lung malignancy. Yet, mechanisms underlying ...
  • Erythropoietic protoporphyria a clinical and molecular study from Lebanon: Ferrochelatase a potential tumor suppressor gene in colon cancer 
    Kadara, Humam N.; Nemer, Georges M.; Safi, Rémi; Rebeiz, Nelly; Daou, Laetitia; Delbani, D.; Btadini, Waed; Abbas, Ossama M.; Tofaili, Mona; Bitar, Fadi Fouad; Kibbi, Abdul Ghani M.; Shimomura, Yutaka; Kurban, Mazen S. (Blackwell Publishing Ltd, 2017)
    Erythropoietic protoporphyria (EPP) is a rare cutaneous and systemic disease caused by mutations in the ferrochelatase gene (FECH). The molecular underpinnings of EPP in Middle Eastern populations and relative to other ...
  • Genome-wide and phenotypic evaluation of stem cell progenitors derived from GPRC5A-deficient murine lung adenocarcinoma with somatic KRAS mutations 
    Daouk, Reem; Hassane, Maya; Bahmad, Hisham F.; Sinjab, Ansam; Fujimoto, Jyunya; Abou-Kheir, Wassim G.; Kadara, Humam N. (Frontiers Media S.A., 2019)
    Lung adenocarcinomas (LUADs) with somatic mutations in the KRAS oncogene comprise the most common molecular subtype of lung cancer in smokers and present with overall dismal prognosis and resistance to most therapies. Our ...
  • Genome-wide gene expression changes in the normal-appearing airway during the evolution of smoking-associated lung adenocarcinoma 
    Kantrowitz, Jacob J.; Sinjab, Ansam; Xu, Li; McDowell, Tina L.; Sivakumar, Smruthy; Lang, Wenhua; Nunomura-Nakamura, Sayuri; Fukuoka, Junya; Nemer, Georges M.; Darwiche, Nadine D.; Chami, Hassan A.; Tfayli, Arafat Hussein; Wistuba, Ignacio Ivans; Scheet, Paul A.; Fujimoto, Jyunya; Spira, Avrum E.; Kadara, Humam N. (American Association for Cancer Research Inc., 2018)
    Smoking perpetuates in cytologically normal airways a molecular field of injury that is pertinent to lung cancer and early detection. The evolution of airway field changes prior to lung oncogenesis is poorly understood ...
  • Genomic landscape of atypical adenomatous hyperplasia reveals divergent modes to lung adenocarcinoma 
    Sivakumar, Smruthy; San Lucas, Francis Anthony; McDowell, Tina L.; Lang, Wenhua; Xu, Li; Fujimoto, Jyunya; Zhang, Jianjun; Futreal, Phillip Andrew; Fukuoka, Junya; Yatabe, Yasushi; Dubinett, Steven M.; Spira, Avrum E.; Fowler, Jerry; Hawk, Ernest T.; Wistuba, Ignacio Ivans; Scheet, Paul A.; Kadara, Humam N. (American Association for Cancer Research Inc., 2017)
    There is a dearth of knowledge about the pathogenesis of premalignant lung lesions, especially for atypical adenomatous hyperplasia (AAH), the only known precursor for the major lung cancer subtype adenocarcinoma (LUAD). ...
  • Germline and somatic smoothened mutations in non-small-cell lung cancer are potentially responsive to hedgehog inhibitor vismodegib 
    Tsao, Anne S.; Wistuba, Ignacio Ivans; Xia, Dianren; Byers, Lauren Averett; Diao, Lixiao; Wang, Jing; Papadimitrakopoulou, Vassiliki A.; Tang, Ximing; Lu, Wei; Kadara, Humam N.; Grigoryev, Dimitry N.; Esai Selvan, Myvizhi Esai; Gümüş, Zeynep Hülya; Tan, Zhi; Zhang, Shuxing; Nilsson, Monique B.; Heymach, John Victor (American Society of Clinical Oncology, 2017)
  • IL22 promotes kras-mutant lung cancer by induction of a protumor immune response and protection of stemness properties 
    Khosravi, Nasim; Caetano, Maurício Silva; Cumpian, Amber M.; Ünver, Neşe; De la Garza-Ramos, Cynthia; Noble, Oscar; Daliri, Soudabeh; Hernandez, Belinda J.; Gutierrez, Berenice A.; Evans, Scott E.; Hanash, Samir M.; Alekseev, Andrei M.; Yang, Yi; Chang, Seonhee; Nurieva, Roza I.; Kadara, Humam N.; Chen, Jichao; Ostrin, Edwin Justin; Moghaddam, Seyed Javad Mirhasani (American Association for Cancer Research Inc., 2018)
    Somatic KRAS mutations are the most common oncogenic variants in lung cancer and are associated with poor prognosis. Using a Kras-induced lung cancer mouse model, CC-LR, we previously showed a role for inflammation in lung ...
  • Insights Into Lung Cancer Immune-Based Biology, Prevention, and Treatment 
    Saab, Sara; Zalzale, Hussein; Rahal, Zahraa; Khalifeh, Ibrahim M.; Sinjab, Ansam; Kadara, Humam N. (Frontiers Media S.A., 2020)
    Lung cancer is the number one cause of cancer-related deaths. The malignancy is characterized by dismal prognosis and poor clinical outcome mostly due to advanced-stage at diagnosis, thereby inflicting a heavy burden on ...
  • MicroRNA Expression in Ethnic Specific Early Stage Breast Cancer: An Integration and Comparative Analysis 
    Nassar, Farah J.; Talhouk, Rabih S.; Khoueiry-Zgheib, Nathalie; Tfayli, Arafat Hussein; El-Sabban, Marwan E.; El-Saghir, Nagi S.; Boulos, Fouad I.; Jabbour, Mark N.; Chalala, Claude; Boustany, Rose Mary Naaman; Kadara, Humam N.; Zhang, Zhou; Zheng, Yinan; Joyce, Brian Thomas; Hou, Lifang; Bazarbachi, Ali Abdul Hamid; Calin, George Adrian; Nasr, Rihab R. (Nature Publishing Group, 2017)
    Breast cancer (BC) has a higher incidence in young Lebanese woman as compared to the West. We assessed the microRNA (miRNA) microarray profile of tissues derived from Lebanese patients with early BC and performed mRNA-miRNA ...
  • Mutation profiles in early-stage lung squamous cell carcinoma with clinical follow-up and correlation with markers of immune function 
    Choi, Murim; Kadara, Humam N.; Zhang, Jianjun; Parra, Edwin Roger C.; Rodriguez-Canales, Jaime A.; Gaffney, Stephen G.; Zhao, Zi-Ming; Behrens, Carmen; Fujimoto, Jyunya; Chow, Chi Wan B.; Kim, Kwangsoo; Kalhor, Neda; Moran, César A.; Rimm, David L.; Swisher, Stephen G.; Gibbons, Don Lynn; Heymach, John Victor; Kaftan, Edward J.; Townsend, Jeffrey P.; Lynch, Thomas J.; Schlessinger, Joseph; Lee, J. Jack; Lifton, Richard P.; Herbst, Roy S.; Wistuba, Ignacio Ivans (Oxford University Press, 2017)
    Background: Lung squamous cell carcinoma (LUSC) accounts for 20-30% of non-small cell lung cancers (NSCLCs). There are limited treatment strategies for LUSC in part due to our inadequate understanding of the molecular ...
  • Pathogenesis of Tobacco-Associated Lung Adenocarcinoma Is Closely Coupled with Changes in the Gut and Lung Microbiomes 
    Finnicum, Casey T.; Rahal, Zahraa; Hassane, Maya; Treekitkarnmongkol, Warapen; Sinjab, Ansam; Morris, Rhiannon; Liu, Yuejiang; Tang, Elizabeth L.; Viet, Sarah; Petersen, Jason L.; Lorenzi, Philip L.; Tan, Lin; Petrosino, Joseph F.; Hoffman, Kristi Louise; Fujimoto, Jyunya; Moghaddam, Seyed Javad Mirhasani; Kadara, Humam N. (MDPI, 2022)
    Microbial dysbiosis has emerged as a modulator of oncogenesis and response to therapy, particularly in lung cancer. Here, we investigate the evolution of the gut and lung microbiomes following exposure to a tobacco carcinogen. ...
  • Prevalence of programmed death ligand-1 in patients diagnosed with non-small cell lung cancer in Lebanon 
    Fakhri, Ghina B.; Akel, Reem S.; Khalifeh, Ibrahim M.; Chami, Hassan A.; Hajj-Ali, Adel M.; Assaad, Majd Al; Atwi, Hanine; Kadara, Humam N.; Tfayli, Arafat Hussein (SAGE Publications Ltd, 2021)
    Introduction: Programmed death ligand-1 expression has been shown to be a good predictor of response to cancer therapy with checkpoint inhibitors. Its expression varies among different tumor types and among non-small cell ...
  • Requirement for MUC5AC in KRAS-dependent lung carcinogenesis 
    Bauer, Alison K.; Umer, Misha; Richardson, Vanessa L.; Cumpian, Amber M.; Harder, Anna Q.; Khosravi, Nasim; Azzegagh, Zoulikha; Hara, Naoko M.; Ehré, Camille; Mohebnasab, Maedeh; Caetano, Maurício Silva; Merrick, Daniel T.; van Bokhoven, Adrie; Wistuba, Ignacio Ivans; Kadara, Humam N.; Dickey, Burton F.; Velmurugan, Kalpana; Mann, Patrick R.; Lu, Xian; Barõn, Anna E.; Evans, Christopher M.; Moghaddam, Seyed Javad Mirhasani (NLM (Medline), 2018)
    With more than 150,000 deaths per year in the US alone, lung cancer has the highest number of deaths for any cancer. These poor outcomes reflect a lack of treatment for the most common form of lung cancer, non-small cell ...
  • Sex differences in gene expression with galactosylceramide treatment in Cln3Δex7/8 mice 
    Makoukji, Joelle; El-Sitt, Sally Boulos; Makhoul, Nadine J.; Soueid, Jihane; Kadara, Humam N.; Boustany, Rose Mary Naaman (Public Library of Science, 2020)
    Background CLN3 disease is caused by mutations in the CLN3 gene. The purpose of this study is to discern global expression patterns reflecting therapeutic targets in CLN3 disease. Methods Differential gene expression in ...
  • Sex specific function of epithelial STAT3 signaling in pathogenesis of K-ras mutant lung cancer 
    Caetano, Maurício Silva; Hassane, Maya; Van, Hieu T.; Bugarin, Emmanuel; Cumpian, Amber M.; McDowell, Christina L.; Cavazos, Carolina Gonzalez; Zhang, Huiyuan; Deng, Shanshan; Diao, Lixiao; Wang, Jing; Evans, Scott E.; Behrens, Carmen; Wistuba, Ignacio Ivans; Fuqua, Susan A.W.; Lin, Huang; Stabile, Laura P.; Watowich, Stephanie S.; Kadara, Humam N.; Moghaddam, Seyed Javad Mirhasani (Nature Publishing Group, 2018)
    Lung adenocarcinomas (LUADs) with mutations in the K-ras oncogene display dismal prognosis. Proinflammatory and immunomodulatory events that drive development of K-ras mutant LUAD are poorly understood. Here, we develop a ...

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