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Browsing Biochemistry and Molecular Genetics by Author "Nasrallah, Leila"

Browsing Biochemistry and Molecular Genetics by Author "Nasrallah, Leila"

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  • Drug repurposing: Promises of edaravone target drug in traumatic brain injury 
    Shakkour, Zaynab; Issa, Hawraa; Ismail, Helene; Ashekyan, Ohanes; Habashy, Karl John; Nasrallah, Leila; Jourdi, Hussam; Hamade, Eva; Mondello, Stefania; Sabra, Mirna; Zibara, Kazem; Kobeissy, Firas H. (Bentham Science Publishers, 2021)
    Edaravone is a potent free-radical scavenger that has been in the market for more than 30 years. It was originally developed in Japan to treat strokes and has been used there since 2001. Aside from its anti-oxidative ...
  • Mitoquinone supplementation alleviates oxidative stress and pathologic outcomes following repetitive mild traumatic brain injury at a chronic time point 
    Tabet, Maha; El-Kurdi, Marya; Haidar, Muhammad Ali; Nasrallah, Leila; Reslan, Mohammad Amine; Shear, Deborah Ann; Pandya, Jignesh D.; El-Yazbi, Ahmed F.; Sabra, Mirna; Mondello, Stefania; Mechref, Yehia S.; Shaito, Abdullah A.; Wang, Kevin K.W.; El-Khoury, Riyad; Kobeissy, Firas H. (Academic Press Inc., 2022)
    Traumatic brain injury (TBI) is a major cause of disability and death. Mild TBI (mTBI) constitutes ~75% of all TBI cases. Repeated exposure to mTBI (rmTBI), leads to the exacerbation of the symptoms compared to single mTBI. ...
  • Modulation of Neuro-Inflammatory Signals in Microglia by Plasma Prekallikrein and Neuronal Cell Debris 
    Jaffa, Aneese A.; Jaffa, Miran A.; Moussa, Mayssam; Ahmed, Ibrahim A.; Karam, Mia; Aldeen, Kawthar Sharaf; Al Sayegh, Rola; El-Achkar, Ghewa A.; Nasrallah, Leila; Yehya, Yara; Habib, Aida A.; Ziyadeh, Fuad N.; Eid, Ali H.; Kobeissy, Firas H.; Jaffa, Ayad A. (Frontiers Media S.A., 2021)
    Microglia, the resident phagocytes of the central nervous system and one of the key modulators of the innate immune system, have been shown to play a major role in brain insults. Upon activation in response to neuroinflammation, ...
  • Potentiating hemorrhage in a periadolescent rat model of closed-head traumatic brain injury worsens hyperexcitability but not behavioral deficits 
    Jalloul, Dounya; Hajjar, Helene; Asdikian, Rita; Maawie, Mariam; Nasrallah, Leila; Medlej, Yasser; Darwich, Mouhamad J.; Karnib, Nabil; Lawand, Nada Bashir; Abdel-Rassoul, Ronza; Wang, Kevin K.W.; Kobeissy, Firas H.; Darwish, Hala; Obeid, Makram (MDPI, 2021)
    Post-traumatic epilepsy (PTE) and neurocognitive deficits are devastating sequelae of head injuries that are common in adolescents. Investigating desperately needed treatments is hindered by the difficulties in inducing ...
  • The effect of clopidogrel and aspirin on the severity of traumatic brain injury in a rat model 
    Kobeissy, Firas H.; Mallah, Khalil; Zibara, Kazem; Dakroub, Fatima; Dalloul, Zeinab; Nasser, Mohamad; Nasrallah, Leila; Mallah, Zahraa I.; El-Achkar, Ghewa A.; Ramadan, Naify; Mohamed, Wael My; Mondello, Stefania; Darwish, Hala; Hamade, Eva; Habib, Aida A. (Elsevier Ltd, 2022)
    Traumatic Brain Injury (TBI) is one of the leading causes of death and disability worldwide. Aspirin (ASA) and clopidogrel (CLOP) are antiplatelet agents that inhibit platelet aggregation. They are implicated in worsening ...
  • Traumatic brain injury: Oxidative stress and novel anti-oxidants such as mitoquinone and edaravone 
    Ismail, Helene; Shakkour, Zaynab; Tabet, Maha; Abdelhady, Samar; Kobaisi, Abir; Abedi, Reem; Nasrallah, Leila; Pintus, Gianfranco; Al-Dhaheri, Yusra; Mondello, Stefania; El-Khoury, Riyad; Eid, Ali H.; Kobeissy, Firas H.; Salameh, Johnny S. (MDPI, 2020)
    Traumatic brain injury (TBI) is a major health concern worldwide and is classified based on severity into mild, moderate, and severe. The mechanical injury in TBI leads to a metabolic and ionic imbalance, which eventually ...

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