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Pathology and Laboratory Medicine - Faculty Publications: Recent submissions

Now showing items 1-20 of 291

Plasminogen Activator Inhibitor-1 (PAI-1) gene 4G-5G alleles frequency distribution in the Lebanese population

Shammaa D.M.R.; Sabbagh A.S.; Taher A.T.; Zaatari G.S.; Mahfouz R.A.R. (DORDRECHTVAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS, 2008)

Plasminogen activator inhibitor-1 (PAI-1) is an inhibitor of fibrinolysis. Increased plasma PAI-1 levels play an essential role in the pathogenesis of cardiovascular risk and other diseases associated with thrombosis. The ...
Factor XIII gene V34L mutation in the Lebanese population: Another unique feature in this community?

Mahfouz R.A.R.; Sabbagh A.S.; Shammaa D.M.R.; Otrock Z.K.; Zaatari G.S.; Taher A.T. (DORDRECHTVAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS, 2008)

We studied the distribution of the Factor XIII gene V34L polymorphism in a sample of healthy Lebanese individuals to assess its prevalence and compare it with other populations. Factor XIII genotypes were determined using ...
Arsenic trioxide inhibits ATRA-induced prostaglandin E2 and cyclooxygenase-1 in NB4 cells, a model of acute promyelocytic leukemia

Habib A.; Hamade E.; Mahfouz R.; Nasrallah M.S.; de The H.; Bazarbachi A. (LONDONMACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND, 2008)

In acute promyelocytic leukemia (APL), all-trans retinoic acid (ATRA) triggers cell differentiation, while arsenic trioxide (As2 O3) generates partial differentiation and apoptosis. Animal and human studies suggest that ...
Thalassemia and hypercoagulability

Taher A.T.; Otrock Z.K.; Uthman I.; Cappellini M.D. (EDINBURGHJOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND, 2008)

Thalassemia is a congenital hemolytic disease caused by defective globin synthesis resulting in decreased quantity of globin chains. Although the life expectancy of β-thalassemia patients has markedly improved over the ...
Thrombophilic risk factors among 16 Lebanese patients with cerebral venous and sinus thrombosis

Otrock Z.K.; Taher A.T.; Shamseddeen W.A.; Mahfouz R.A. (DORDRECHTVAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS, 2008)

Cerebral venous and sinus thrombosis (CVST) is a multifaceted disorder. The frequency of inherited and acquired thrombophilia among 16 CVST patients was evaluated. The mean age of the patients was 22.9 years. Five out of ...
Frequency distribution of the G-A alleles of the β-fibrinogen gene in the Lebanese population

Shammaa D.M.R.; Sabbagh A.S.; Taher A.T.; Zaatari G.S.; Mahfouz R.A.R. (DORDRECHTVAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS, 2008)

Fibrinogen is a plasma protein that has been reported to be associated with an increased risk of atherothrombotic diseases and venous thrombosis. The most common polymorphism that has been studied so far in different ...
Plasmapheresis in asparaginase-induced hypertriglyceridemia

Kfoury-Baz E.M.; Nassar R.A.; Tanios R.F.; Otrock Z.K.; Youssef A.M.; Albany C.; Bazarbachi A.; Salem Z.M. (MALDENCOMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA, 2008)

BACKGROUND: Asparaginase is an essential component of the chemotherapy regimens during the induction and intensification phases for acute lymphoblastic leukemia and lymphoblastic lymphoma. The administration of asparaginase ...
MEFV gene mutations spectrum among Lebanese patients referred for Familial Mediterranean Fever work-up: Experience of a major tertiary care center

Sabbagh A.S.; Ghasham M.; Abdel Khalek R.; Greije L.; Shammaa D.M.R.; Zaatari G.S.; Mahfouz R.A.R. (DORDRECHTVAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS, 2008)

Familial Mediterranean Fever (FMF) is an autosomal recessive inflammatory disorder predominantly affecting people living in or originating from areas around the Mediterranean Sea, mainly Jews, Armenians, Turks, and Arabs. ...
Varying prevalence of embB codon 306 mutations in ethambutol-resistant clinical Mycobacterium tuberculosis isolates from Beirut and Dubai

Ahmad S.; Itani L.Y.; Fares E.; Araj G.F. (FLORENCEVIA CARLO DEL GRECO 36, 50141 FLORENCE, ITALY, 2008)

[No abstract available]
ABO blood group and gastric cancer: Rekindling an old fire? [3]

El Hajj I.I.; Hashash J.G.; Baz E.M.K.; Abdul-Baki H.; Sharara A.I. (, 2007)

[No abstract available]
Genomics and premalignant breast lesions: Clues to the development and progression of lobular breast cancer

Mastracci T.L.; Boulos F.I.; Andrulis; Lam W.L. (, 2007)

Advances in genomic technology have improved our understanding of the genetic events that parallel breast cancer development. Because almost all mammary carcinomas develop in the terminal duct lobular units of the breast, ...
Increased microvessel density in involved organs from patients with HTLV-I associated adult T cell leukemia lymphoma

Kchour G.; Tarhini M.; Sharifi N.; Farid R.; Khooei A.R.; Shirdel A.; Afshari J.T.; Sadeghian A.; Otrock Z.; Hermine O.; El-Sabban M.; Bazarbachi A. (ABINGDON4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND, 2008)

Adult T-cell leukemia-lymphoma (ATLL) is a rapidly progressive lymphoproliferative disorder secondary to infection with the human T cell lymphotropic virus type I (HTLV-I). The role of angiogenesis in the development and ...
Restoration of normal insulinemia and insulin sensitivity in hyperinsulinemic normoglycemic men by a hypoenergetic high monounsaturated fat diet

Hwalla N.; Torbay N.; Andari N.; Adra N.; Azar S.T.; Habbal Z. (, 2004)

Purpose: To test the hypothesis that the macronutrient composition of hypoenergetic diets is an important consideration in weight-reducing regimens of hyperinsulinemic normoglycemic obese subjects. Design: A 4-week randomized ...
Prevalence of hepatitis B in a presumably healthy Lebanese population

Saab B.R.; Nassar N.T.; Musharrafieh U.; Araj G.F.; Khogali M. (, 2007)

OBJECTIVE : Policy makers need data on the prevalence of infection with HBV in order to determine the cost effectiveness of universal immunization against hepatitis B. This study aims at determining the prevalence rate of ...
Natural killer cell Immunoglobulin-like Receptors (KIR) genotypes in two Arab populations: Will KIR become a genetic landmark between nations?

Rayes R.; Bazarbachi A.; Khazen G.; Sabbagh A.; Zaatari G.; Mahfouz R. (DORDRECHTVAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS, 2008)

Genotypic profiles of the Natural killer cell Immunoglobulin-like Receptors (KIR) have been reported to vary among different ethnic groups and this study represents a comparative report on its distribution between two ...
Molecular and clinical description of a girl with a 46,X,t(Y;4)(q11.2;p16)- 45,X,der(4)t(Y;4)(q11.2;p16) karyotype and a small cryptic 4p subtelomeric deletion

Zahed L.; Sismani C.; Ioannides M.; Saleh M.; Koumbaris G.; Kenj M.; Abdallah A.; Ayyache M.; Patsalis P. (HOBOKENDIV JOHN WILEY and SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA, 2008)

We report on a 13-year-old female with short stature, minimal axillary and pubic hair, no breast development, absence of uterus and ovaries, with the following karyotype on lymphocyte cultures: 46,X,t(Y;4)(q11.2;p16) ...
High prevalence of MTHFR gene A1298C polymorphism in Lebanon

Sabbagh A.S.; Mahfoud Z.; Taher A.; Zaatari G.; Daher R.; Mahfouz R.A.R. (NEW ROCHELLE140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA, 2008)

Background: Mutations in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene could reduce the enzyme activity and lead to hyperhomocysteinemia, a condition that has been associated with several vascular conditions, ...
Molecular characterisation of extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella spp. isolates at a tertiary-care centre in Lebanon

Kanj S.S.; Corkill J.E.; Kanafani Z.A.; Araj G.F.; Hart C.A.; Jaafar R.; Matar G.M. (OXFORD9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND, 2008)

The prevalence of blaCTX-M, blaTEM and blaSHV genes among extended-spectrum β-lactamase (ESBL)-producing clinical isolates of Escherichia coli (n = 50) and Klebsiella spp. (n = 50) from Lebanon was 96percent, 57percent and ...
Understanding the biology of angiogenesis: Review of the most important molecular mechanisms

Otrock Z.K.; Mahfouz R.A.R.; Makarem J.A.; Shamseddine A.I. (SAN DIEGO525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA, 2007)

Angiogenesis is an important process for forming new blood vessels. It is fundamental in many biological processes including development, reproduction and wound repair. Under these conditions, angiogenesis is a highly ...
Antimicrobial susceptibility of respiratory pathogens at the American University of Beirut Medical Center

Kanj S.S.; El-Dbouni O.; Kanafani Z.A.; Araj G.F. (OXFORDTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND, 2007)

[No abstract available]

Now showing items 1-20 of 291

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