AUB ScholarWorks

Browsing Pediatrics and Adolescent Medicine by Author "Pathology and Laboratory Medicine"

Browsing Pediatrics and Adolescent Medicine by Author "Pathology and Laboratory Medicine"

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  • Full genome characterization of human influenza A/H3N2 isolates from asian countries reveals a rare amantadine resistance-conferring mutation and novel PB1-F2 polymorphisms 
    Zaraket, Hassan; Kondo, Hiroshi; Hibino, Akinobu; Yagami, Ren; Odagiri, Takashi; Takemae, Nobuhiro; Tsunekuni, Ryota; Saito, Takehiko Saito; Kimura, Shinji; Kawashima, Takashi; Sato, Isamu; Hibi, Shigeyoshi; Kodo, Naoki; Masaki, Hironori; Shirahige, Yutaka; Asoh, Norichika; Kita, Yoshiko; Kuroki, Reiki; Nawata, Yasuo; Ono, Yasuhiko; Makiya, Tomoko; Takefuta, Kiyotaka; Myint, Yi Yi; Kyaw, Yadanar; Oo, Khin Yi; Tin, Htay Htay; Lin, Nay; Anh, Nguyen Phuong; Hang, Nguyen Le Khanh; Mai, Le Quynh; Hassan, Mohd Rohaizat; Shobugawa, Yugo; Tang, Julians Wei Tze; Dbaibo, Ghassan S.; Saito, Reiko (Frontiers Media S.A., 2016)
    Influenza A viruses evolve at a high rate requiring continuous monitoring to maintain the efficacy of vaccines and antiviral drugs. We performed next generation sequencing analysis of 100 influenza A/H3N2 isolates collected ...
  • Gene expression profiling of breast cancer in Lebanese women 
    Makoukji, Joelle; Makhoul, Nadine J.; Khalil, Maya K.; El-Sitt, Sally Boulos; Saad Aldin, Ehab; Jabbour, Mark N.; Boulos, Fouad I.; Gadaleta, Emanuela; Sangaralingam, Ajanthah; Chelala, Claude; Boustany, Rose Mary Naaman; Tfayli, Arafat Hussein (Nature Publishing Group, 2016)
    Breast cancer is commonest cancer in women worldwide. Elucidation of underlying biology and molecular pathways is necessary for improving therapeutic options and clinical outcomes. Molecular alterations in breast cancer ...
  • Genomic surveillance of SARS-CoV-2 in COVID-19 vaccinated healthcare workers in Lebanon 
    Alkalamouni, Habib; Abou Hassan, Farouk F.; Bou Hamdan, Mirna A.; Page, Andrew J.; Lott, Martin; Matthews, Michaela; Ghosn, Nada; Rady, Alissar; Mahfouz, Rami A.R.; Araj, George F.; Dbaibo, Ghassan S.; Zaraket, Hassan; Melhem, Nada Mohamad; Matar, Ghassan (BioMed Central Ltd, 2023)
    Background: The emergence of SARS-CoV-2 variants including the Delta and Omicron along with waning of vaccine-induced immunity over time contributed to increased rates of breakthrough infection specifically among healthcare ...
  • Heritable cancer predisposition testing in pediatric cancer patients excluding retinoblastoma in a middle-income country 
    El Khatib, Omar; Yahya, Yasser; Mahfouz, Rami A.R.; Hamadeh, Lama N.; Basbous, Maya; Abboud, Miguel Raul; Muwakkit, Samar A.; Rodríguez-Galindo, Carlos; Jeha, Sima S.; Saab, Raya H. (John Wiley and Sons Inc, 2022)
    Resource-limited settings often have financial barriers to genetic testing for heritable cancer. This retrospective study investigated the pattern of heritable cancer predisposition testing in a middle-income country over ...
  • Incidence of alpha-globin gene defect in the lebanese population: A pilot study 
    Farra, Chantal G.; Daher, Rose T.; Badra, Rebecca; El Rafei, Rym C.; Bejjany, Rachelle; Charafeddine, Lama; Yunis, Khalid A. (Hindawi Publishing Corporation, 2015)
    Background. It is well established that the Mediterranean and Arab populations are at high risk for thalassemias in general and for alpha-thalassemia in particular. Yet, reports on alpha-thalassemia in Lebanon are still ...
  • Increased blaOXA-23-like prevalence in acinetobacter baumannii at a tertiary care center in Lebanon (2007-2013) 
    Kanj, Souha S.; Tayyar, Ralph; Shehab, Marwa; El Hafi, Bassam; Rasheed, Sari Shawki; Kissoyan, Kohar Annie B.; Kanafani, Zeina A.; Hanna-Wakim, Rima H.; Zahereddine, Nada Kara; Araj, George F.; Dbaibo, Ghassan S.; Matar, Ghassan (Journal of Infection in Developing Countries, 2018)
    Introduction: Acinetobacter baumannii has become one of the most feared organisms in hospital-acquired infections during the past decades. Their multi-drug resistant profiles have rendered many broad-spectrum antibiotics ...
  • Infantile myofibromatosis: review of imaging findings and emphasis on correlation between MRI and histopathological findings 
    Naffaa, Lena N.; Khalifeh, Ibrahim M.; Salman, Rida; Itani, Malak; Saab, Raya H.; Al-Kutoubi, Aghiad O. (Elsevier Inc., 2019)
    Background: Infantile myofibromatosis (IM) is the most common fibrous tumor of infancy. MRI is considered the gold standard in IM evaluation. Very little has been published about IM with histopathology correlation in the ...
  • KIR genotype distribution among Lebanese patients with Hodgkin's lymphoma 
    Hoteit, Rouba M.; Abboud, Miguel Raul; Bazarbachi, Ali Abdul Hamid; Salem, Ziad M.; Shammaa, Dina M.R.; Zaatari, Ghazi S.; Mahfouz, Rami A.R. (Elsevier, 2015)
    Introduction: In addition to their important role in fighting infection, natural killer cells are cytotoxic to cancer cells. Studies demonstrated that some KIR genes were responsible for the reduction of the risk of Hodgkin's ...
  • Mandibular melanotic neuroectodermal tumor of infancy: a role for neoadjuvant chemotherapy 
    Maroun, Christopher A.; Khalifeh, Ibrahim M.; Alam, Elie S.; Akl, Pierre Abi; Saab, Raya H.; Moukarbel, Roger V. (Springer Verlag, 2016)
    Melanotic Neuroectodermal Tumor of Infancy (MNTI) is a rare, locally aggressive neoplasm with a predilection for the head and neck area, most commonly occurring in the maxilla. The vast majority of treatment modalities for ...
  • MicroRNA Expression in Ethnic Specific Early Stage Breast Cancer: An Integration and Comparative Analysis 
    Nassar, Farah J.; Talhouk, Rabih S.; Khoueiry-Zgheib, Nathalie; Tfayli, Arafat Hussein; El-Sabban, Marwan E.; El-Saghir, Nagi S.; Boulos, Fouad I.; Jabbour, Mark N.; Chalala, Claude; Boustany, Rose Mary Naaman; Kadara, Humam N.; Zhang, Zhou; Zheng, Yinan; Joyce, Brian Thomas; Hou, Lifang; Bazarbachi, Ali Abdul Hamid; Calin, George Adrian; Nasr, Rihab R. (Nature Publishing Group, 2017)
    Breast cancer (BC) has a higher incidence in young Lebanese woman as compared to the West. We assessed the microRNA (miRNA) microarray profile of tissues derived from Lebanese patients with early BC and performed mRNA-miRNA ...
  • Molecular Characterization of Candida auris Isolates at a Major Tertiary Care Center in Lebanon 
    Reslan, Lina; Araj, George F.; Finianos, Marc; El Asmar, Rima G.; Hrabák, Jaroslav; Dbaibo, Ghassan S.; Bitar, Ibrahim (Frontiers Media S.A., 2022)
    Background: The globally emerging Candida auris pathogens poses heavy burden to the healthcare system. Their molecular analyses assist in understanding their epidemiology, dissemination, treatment, and control. This study ...
  • Novel trans-2,3-enoyl-CoA reductase–like variant associated with catecholaminergic polymorphic ventricular tachycardia type 3 
    Charafeddine, Fatme; Assaf, Nada P.; Ismail, Ali; Bulbul, Ziad R. (Elsevier Inc., 2023)
  • NUDT15 and TPMT genetic polymorphisms are related to 6-mercaptopurine intolerance in children treated for acute lymphoblastic leukemia at the Children's Cancer Center of Lebanon 
    Khoueiry-Zgheib, Nathalie; Akika, Reem; Mahfouz, Rami A.R.; Al-Aridi, Carol; Ghanem, Khaled M.; Saab, Raya H.; Abboud, Miguel Raul; Tarek, Nidale; El-Solh, Hassan; Muwakkit, Samar A. (John Wiley and Sons Inc., 2017)
    Background: Interindividual variability in thiopurine-related toxicity could not be completely explained by thiopurine S-methyltransferase (TPMT) polymorphisms, as a number of patients who are homozygous wild type or normal ...
  • Osteoma-like melorheostosis: a rare type of skeletal dysplasia depicted on FDG PET/CT 
    Abi-Ghanem, Alain S.; Asmar, Karl; Boulos, Fouad I.; Muwakkit, Samar A. (Springer Verlag, 2019)
    Melorheostosis, also known as Leri’s disease, is a rare benign form of mesodermal mixed sclerosing bone dysplasia. We report the unusual case of a 14-year-old boy with melorheostosis in the lower extremity that went ...
  • Outcome of Ewing sarcoma in a multidisciplinary setting in Lebanon 
    Abou Ali, Bilal; Nader, Ralph; Tamim, Hani Mohammed; Eid, Toufic A.; Boulos, Fouad I.; Khoury, Nabil El; Akel, Samir R.; Haidar, Rachid K.; Saghieh, Saïd S.; Abboud, Miguel Raul; Muwakkit, Samar A.; El-Solh, Hassan; Saab, Raya H. (John Wiley and Sons Inc, 2014)
    Treatment of Ewing sarcoma (ES) necessitates coordinated multi-disciplinary care. We analyzed outcome for 39 patients treated at a single institution in Lebanon, a developing country with available multidisciplinary treatment ...
  • Outcome of Nonketotic Hyperglycinemia in Lebanon: 14-Year Retrospective Review 
    Shbarou, Rolla M.; Boustany, Rose Mary Naaman; Daher, Rose T.; Pakdel, Parisa; Noureddine, Abir; Karam, Pascale E. (Hippokrates Verlag GmbH, 2019)
    Nonketotic hyperglycinemia is a rare inborn error of glycine metabolism characterized by a severe metabolic encephalopathy with drug-resistant seizures. Here, we report the outcome of nonketotic hyperglycinemia in a cohort ...
  • p53 restoration in induction and maintenance of senescence: Differential effects in premalignant and malignant tumor cells 
    Harajly, Mohamad; Zalzali, Hassan; Nawaz, Zafar; Ghayad, Sandra E.; Ghamloush, Farah; Basma, Hussein A.; Zainedin, Samiha; Rabeh, Wissam; Jabbour, Mark N.; Tawil, Ayman N.; BADRO, Danielle A.; Evan, Gérard I.; Saab, Raya H. (American Society for Microbiology, 2016)
    The restoration of p53 has been suggested as a therapeutic approach in tumors. However, the timing of p53 restoration in relation to its efficacy during tumor progression still is unclear. We now show that the restoration ...
  • Prognostic significance of O6-methylguanine-DNA-methyltransferase (MGMT) promoter methylation and isocitrate dehydrogenase-1 (IDH-1) mutation in glioblastoma multiforme patients: A single-center experience in the Middle East region 
    Ayoub, Zeina A.; Geara, Fady B.; Najjar, Marwan W.; Comair, Youssef G.; Khoueiry-Zgheib, Nathalie; Khoueiry, Pierre H.; Mahfouz, Rami A.R.; Boulos, Fouad I.; Kamar, Francois G.; Andraos, Therese Youssef; Saadeh, Fadi S.; Kreidieh, Firas Y.; Abboud, Miguel Raul; Skaf, Ghassan S.; Assi, Hazem I. (Elsevier B.V., 2019)
    Objectives: To determine the prevalence and prognostic value of MGMT promoter methylation and IDH1 mutation in glioblastoma multiforme (GBM) patients from the Middle East. Patients and methods: Records of patients diagnosed ...
  • Spoligotyping of Mycobacterium tuberculosis isolates using Luminex®based method in Lebanon 
    Masoud, Khaldoun; Araj, George F.; Reslan, Lina; Fadlallah, Sukayna M.; Wehbe, Michel; Itani, Lina Y.; Avedissian, Aline Z.; Dbaibo, Ghassan S.; Saade, Antoine; Réfrégier, Guislaine; Sola, Christophe Noel; Matar, Ghassan (Journal of Infection in Developing Countries, 2020)
    Introduction: Data about the genotypes of circulating Mycobacterium tuberculosis isolates (MTB) in Lebanon are scarce. This study was undertaken to reveal the spoligotypes of MTB isolates recovered from patients in Lebanon. ...
  • The burden of laboratory-confirmed influenza infection in Lebanon between 2008 and 2016: A single tertiary care center experience 
    Assaf-Casals, Aia; Saleh, Zeina M.; Khafaja, Sarah A.; Fayad, Danielle; Ezzeddine, Hady; Saleh, Mohammad; Chamseddine, Sarah; Sayegh, Rouba; Sharara, Sima Lynn; Chmaisse, Ahmad; Kanj, Souha S.; Kanafani, Zeina A.; Hanna-Wakim, Rima H.; Araj, George F.; Mahfouz, Rami A.R.; Saito, Reiko; Suzuki, Hiroshi; Zaraket, Hassan; Dbaibo, Ghassan S. (BioMed Central Ltd., 2020)
    Background: Influenza is a major cause of morbidity and mortality worldwide. Following the 2009 pandemic, there was widened interest in studying influenza burden in all regions. However, since data from the World Health ...

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