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Browsing Pediatrics and Adolescent Medicine by Author "Pediatrics and Adolescent Medicine"

Now showing items 1-20 of 475

13-valent pneumococcal conjugate vaccine (PCV13) is immunogenic and safe in children 6-17 years of age with sickle cell disease previously vaccinated with 23-valent pneumococcal polysaccharide vaccine (PPSV23): Results of a phase 3 study

de Montalembert, Marianne; Abboud, Miguel Raul; Fiquet, Anne; Inati, Adlette; Lebensburger, Jeffrey D.; Kaddah, Normeen A.H.; Mokhtar, Galila Mohamed; Piga, Antonio Giulio; Halasa, Natasha B.; Inusa, Baba Psalm Duniya; Rees, David C.; Heath, Paul Trafford; Telfer, Paul T.; Driscoll, Catherine C.; Al-Hajjar, Sami Hussain; Tozzi, Alberto Eugenio; Jiang, Qin; Emini, Emilio A.; Gruber, William C.; Gurtman, Alejandra C.; Scott, Daniel A. (John Wiley and Sons Inc., 2015)

Background: A large population of older children with sickle cell disease (SCD) is currently vaccinated with only 23-valent pneumococcal polysaccharide vaccine (PPSV23). In immunocompetent adults, PPSV23 vaccination reduces ...
A child with hyperekplexia and epileptic myoclonus

Wadi, Lara Carine; Medlej, Yasser; Obeid, Makram (Wiley Blackwell, 2018)

Hyperekplexia is a rare neurogenetic disorder characterized by startle. Accurate diagnosis of this notorious mimicker of epilepsy is important to prevent life-threatening apnoea. We report a novel case of concomitant ...
A complex breastfeeding promotion and support intervention in a developing country: Study protocol for a randomized clinical trial

Nabulsi, Mona M.; Hamade, Haya; Tamim, Hani Mohammed; Kabakian-Khasholian, Tamar; Charafeddine, Lama; Yehya, Nadine A.; Sinno, Durriyah; Sidani, Saadieh (2014)

Background: Breastfeeding has countless benefits to mothers, children and community at large, especially in developing countries. Studies from Lebanon report disappointingly low breastfeeding exclusivity and continuation ...
A GRIN3A polymorphism may be associated with glucocorticoid-induced symptomatic osteonecrosis in children with acute lymphoblastic leukemia

Khoueiry-Zgheib, Nathalie; El-Khoury, Habib; Maamari, Dimitri Jean Mickael; Basbous, Maya; Saab, Raya H.; Muwakkit, Samar A. (Future Medicine Ltd., 2021)

Aim: To evaluate the association between candidate genetic polymorphisms and glucocorticoid-induced osteonecrosis in Arab children treated for acute lymphoblastic leukemia. Methods: A total of 189 children treated for acute ...
A HAND to TBX5 Explains the Link between Thalidomide and Cardiac Diseases

Khalil, Athar A.; Tanos, Rachel; El Hachem, Nehme; Kurban, Mazen S.; Bouvagnet, Patrice F.; Bitar, Fadi Fouad; Nemer, Georges M. (Nature Publishing Group, 2017)

Congenital heart disease is the leading cause of death in the first year of life. Mutations only in few genes have been linked to some cases of CHD. Thalidomide was used by pregnant women for morning sickness but was removed ...
A Modified Two-Way Active Avoidance Test for Combined Contextual and Auditory Instrumental Conditioning

Salah, Houssein; Abdel-Rassoul, Ronza; Medlej, Yasser; Asdikian, Rita; Hajjar, Helene; Dagher, Sarah; Darwich, Mouhamad J.; Fakih, Christina; Obeid, Makram (Frontiers Media S.A., 2021)

Available two-way active avoidance paradigms do not provide contextual testing, likely due to challenges in performing repetitive trials of context exposure. To incorporate contextual conditioning in the two-way shuttle ...
A multi-component intervention to support breastfeeding in Lebanon: A randomized clinical trial

Nabulsi, Mona M.; Tamim, Hani Mohammed; Shamsedine, Lama; Charafeddine, Lama; Yehya, Nadine A.; Kabakian-Khasholian, Tamar; Masri, Saadieh; Nasser, Fatima; Ayash, Soumaya; Ghanem, Diane (Public Library of Science, 2019)

Background Effective evidence-based breastfeeding support interventions can bolster breastfeeding practices. This study investigated the effect of a multi-component breastfeeding support intervention delivered in hospital ...
A Multinational Trial of Prasugrel for Sickle Cell Vaso-Occlusive Events

Heeney, Matthew M.; Hoppe, Carolyn C.; Abboud, Miguel Raul; Inusa, Baba Psalm Duniya; Kanter-Washko, Julie; Ogutu, Bernhards R.; Brown, Patricia B.; Heath, Lori Ellen; Jakubowski, Joseph A.; Zhou, Chunmei; Zamoryakhin, Dmitry; Agbenyega, Tsiri E.; Colombatti, Raffaella; Hassab, Hoda Mohammed Abo El Fotoh; Nduba, Videlis N.; Oyieko, Janet N.; Robitaille, Nancy Michelle; Segbefia, Catherine I.; Rees, David C. (Massachussetts Medical Society, 2016)

BACKGROUND: Sickle cell anemia is an inherited blood disorder that is characterized by painful vaso-occlusive crises, for which there are few treatment options. Platelets mediate intercellular adhesion and thrombosis during ...
A new measure for multi-professional medical team communication: design and methodology for multilingual measurement development

Malone, Sara M.; Rivera, Jocelyn; Puerto-Torres, Maria F.; Prewitt, Kim; Sakaan, Firas Mohamed; Counts, Lara; Al-Zebin, Zebin; Arias, Anita V.; Bhattacharyya, Parthasarathi S.; Gunasekera, Sanjeeva; Johnson, Sherry; Balagadde-Kambugu, Joyce; Kaye, Erica Carmen; Mandrell, Belinda N.; Mack, Jennifer W.; McArthur, Jennifer Ann; Méndez, Alejandra; Morrissey, Lisa K.; Sharara-Chami, Rana I.; Snaman, Jennifer M.; Sniderman, Elizabeth R.; Luke, Douglas A.; Graetz, Dylan Elizabeth; Agulnik, Asya L. (Frontiers Media S.A., 2023)

Background: As implementation science in global health continues to evolve, there is a need for valid and reliable measures that consider diverse linguistic and cultural contexts. A standardized, reproducible process for ...
A novel autism-associated UBLCP1 mutation impacts proteasome regulation/activity

Soueid, Jihane; Hamze, Zeinab; Bedran, Joe; Chahrour, Maria H.; Boustany, Rose Mary Naaman (Springer Nature, 2023)

The landscape of autism spectrum disorder (ASD) in Lebanon is unique because of high rates of consanguinity, shared ancestry, and increased remote consanguinity. ASD prevalence in Lebanon is 1 in 68 with a male-to-female ...
A novel homozygous mutation in RASGRP1 that predisposes to immune dysregulation and immunodeficiency associated with uncontrolled Epstein-Barr virus-induced B cell proliferation

Mansour, Rana; El-Orfali, Youmna; Saidu, Adam; Al-Kalamouni, Habib; Mardirossian, Hagop; Hanna-Wakim, Rima H.; Abboud, Miguel Raul; Massaad, Michel J. (Academic Press Inc., 2023)

Background: RASGRP1-deficiency results in an immune dysregulation and immunodeficiency that manifest as autoimmunity, lymphoproliferation, lymphopenia, defective T cell function, and increased incidence of Epstein-Bar Virus ...
A Novel Mutation in FOXC1 in a Lebanese Family with Congenital Heart Disease and Anterior Segment Dysgenesis: Potential Roles for NFATC1 and DPT in the Phenotypic Variations

Khalil, Athar A.; Al-Haddad, Christiane Elias; Hariri, Hadla; Shibbani, Kamel; Bitar, Fadi Fouad; Kurban, Mazen S.; Nemer, Georges M.; Arabi, Mariam Toufic (Frontiers Media S.A., 2017)

Congenital heart diseases (CHDs) are still the leading cause of death in neonates. Anterior segment dysgenesis is a broad clinical phenotype that affects the normal development of the eye, leading in most of the cases to ...
A novel nonsense mutation in NPHS1: is aortic stenosis associated with congenital nephropathy?

Gharibeh, Lara; El-Rassy, Inaam; Soubra, Ayman; Safa, Raya; Fahed, A. K.L.; Tanos, Rachel; Arabi, Mariam Toufic; Kambris, Zakaria; Bitar, Fadi Fouad; Nemer, Georges M. (Springer India, 2015)
A novel role for CSRP1 in a lebanese family with congenital cardiac defects

Kamar, Amina A.; Fahed, Akl C.; Shibbani, Kamel; El Hachem, Nehme; Bou-Slaiman, Salim; Arabi, Mariam Toufic; Kurban, Mazen S.; Seidman, Jonathan G.; Seidman, Christine E.; Haidar, Rachid K.; Baydoun, Elias Abdel Hasan; Nemer, Georges M.; Bitar, Fadi Fouad (Frontiers Media S.A., 2017)

Despite an obvious role for consanguinity in congenital heart disease (CHD), most studies fail to document a monogenic model of inheritance except for few cases. We hereby describe a first-degree cousins consanguineous ...
A Novel Somatic Variant in HEY2 Unveils an Alternative Splicing Isoform Linked to Ventricular Septal Defect

Fardoun, Manal Muin; Dehaini, Hassan; Kamar, Amina A.; Bitar, Fadi Fouad; Majdalani, Marianne Nimah; El-Rassi, Issam M.; Nemer, Georges M.; Arabi, Mariam Toufic (Springer New York LLC, 2019)

Congenital heart defects (CHDs) are the leading cause of death in infants under 1 year of age. Aberrations in the expression and function of cardiac transcription factors (TFs) are a major contributor to CHDs. Despite the ...
A Quality improvement initiative to reduce central line-associated bloodstream infections in a neonatal intensive care unit in a low-and-middle-income country

Al Bizri, Ayah; Hanna-Wakim, Rima H.; Obeid, Alaa; Daaboul, Tania; Charafeddine, Lama; Mounla, Nabil A.; Nakad, Pascale E.; Yunis, Khalid A. (BMJ Publishing Group, 2023)

Background Premature and sick neonates in the neonatal intensive care unit (NICU) are in need of central lines placing them at high risk of contracting a central line-associated bloodstream infection (CLABSI). CLABSI extends ...
A review of prenatal HIV screening practices among physicians at a tertiary care center in Lebanon: is it culture?

Abi Zeid Daou, Christophe; Rizk, Nesrine A.; Mirza, Fadi Ghazi; Lakissian, Zavi; Banat, Rim; Chahine, Elsa; Sharara-Chami, Rana I. (Routledge, 2021)

HIV remains one of the major causes of mortality and morbidity among women of reproductive age; given the risk of vertical transmission to the fetus, timely prevention, monitoring and management are imperative (Melaku et ...
A snapshot of influenza surveillance, vaccine recommendations, and vaccine access, drivers, and barriers in selected Middle Eastern and North African countries

Al Awaidy, Salah T.; Althaqafi, Abdulhakeem O.; Dbaibo, Ghassan S.; Abuglia, Mohamed; Abusrewil, Suleiman; Aksakal, Fatma Nur Baran; Barakat, Amal; Dahbi, Zahra; Derrar, Morocco Fawzi; El-Hefnawy, M. Hesham; Esteghamati, Abdoulreza; Ghasemi, Massoud; Hadeed, Ibtisam; Hassan, Mohamed Badi; Idris, Omaima Abdel Fattah; Kara, Ateş; Mardani, Masoud; Nourlil, Jalal; Tarraf, Hesham N.; Slim, Amine Faouzi; Unal, Serhat Haluk; Hasan, Musallam Yunus Abu (Oman Medical Specialty Board, 2018)

Objectives: Influenza is a vaccine-preventable acute respiratory viral infection that causes epidemics annually around the globe. A regional influenza stakeholder network (MENA-ISN) comprised of experts assessed the status ...
A temporal in vivo catalog of chromatin accessibility and expression profiles in pineoblastoma reveals a prevalent role for repressor elements

Idriss, Salam; Hallal, Mohamad M.; El-Kurdi, Abdullah; Zalzali, Hassan; El-Rassi, Inaam; Ehli, Erik A.; Davis, Christel M.; Chung, Philip E.D.; Gendoo, Deena Mohamad Ameen; Zacksenhaus, Eldad; Saab, Raya H.; Khoueiry, Pierre H. (Cold Spring Harbor Laboratory Press, 2023)

Pediatric pineoblastomas (PBs) are rare and aggressive tumors of grade IV histology. Although some oncogenic drivers are characterized, including germline mutations in RB1 and DICER1, the role of epigenetic deregulation ...
A test of the epidemiological paradox in a context of forced migration: Low birthweight among Syrian newborns in Lebanon

Abdulrahim, Sawsan; El Rafei, Rym C.; Beydoun, Zahraa; El Hayek, Ghinwa Y.; Nakad, Pascale E.; Yunis, Khalid A. (Oxford University Press, 2019)

Background Studies on immigrants revealed an epidemiological paradox whereby low-socioeconomic status (SES) immigrant mothers exhibit favourable birth outcomes compared with native-born mothers. We tested the epidemiological ...

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Browsing Pediatrics and Adolescent Medicine by Author "Pediatrics and Adolescent Medicine"

Browsing Pediatrics and Adolescent Medicine by Author "Pediatrics and Adolescent Medicine"

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