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Browsing Pediatrics and Adolescent Medicine by Author "Saab, Raya H."

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A GRIN3A polymorphism may be associated with glucocorticoid-induced symptomatic osteonecrosis in children with acute lymphoblastic leukemia

Khoueiry-Zgheib, Nathalie; El-Khoury, Habib; Maamari, Dimitri Jean Mickael; Basbous, Maya; Saab, Raya H.; Muwakkit, Samar A. (Future Medicine Ltd., 2021)

Aim: To evaluate the association between candidate genetic polymorphisms and glucocorticoid-induced osteonecrosis in Arab children treated for acute lymphoblastic leukemia. Methods: A total of 189 children treated for acute ...
A temporal in vivo catalog of chromatin accessibility and expression profiles in pineoblastoma reveals a prevalent role for repressor elements

Idriss, Salam; Hallal, Mohamad M.; El-Kurdi, Abdullah; Zalzali, Hassan; El-Rassi, Inaam; Ehli, Erik A.; Davis, Christel M.; Chung, Philip E.D.; Gendoo, Deena Mohamad Ameen; Zacksenhaus, Eldad; Saab, Raya H.; Khoueiry, Pierre H. (Cold Spring Harbor Laboratory Press, 2023)

Pediatric pineoblastomas (PBs) are rare and aggressive tumors of grade IV histology. Although some oncogenic drivers are characterized, including germline mutations in RB1 and DICER1, the role of epigenetic deregulation ...
Addressing the Gap in Research Methodologies Education in Pediatric Oncology in the Eastern Mediterranean Region

Saab, Raya H.; Santana, Victor M.; Obeid, Anas; Devidas, Meenakshi; Belgaumi, Asim Fakhruddin; Bhakta, Nickhill Hitesh; Naidu, Paula E.; Saha, Vaskar; Sultan, Iyad Y.; Arora, Ramandeep Singh; Mukoka, Lilly; Jeha, Sima S. (NLM (Medline), 2023)

PURPOSE: Formal training in clinical research methodologies is limited in limited-resource countries. Through collaboration among high- and middle-resource settings and in response to an identified need verbalized by ...
Approach to Non-Neutropenic Fever in Pediatric Oncology Patients-A Single Institution Study

Ali, Bilal Abou; Hirmas, Nader; Tamim, Hani Mohammed; Merabi, Zeina; Hanna-Wakim, Rima H.; Muwakkit, Samar A.; Abboud, Miguel Raul; El-Solh, Hassan; Saab, Raya H. (John Wiley and Sons Inc., 2015)

Background: Pediatric oncology patients with fever, even when not neutropenic, are known to be at an increased risk of bloodstream infections. However, there are no standard guidelines for management of fever in non-neutropenic ...
Cancer care for displaced children in Lebanon

Saab, Raya H.; Ghanem, Khaled M.; Jeha, Sima S. (Elsevier Ltd, 2021)
Cancer registration in the middle east, north africa, and turkey: Scope and challenges

Abdul-Sater, Zahi; Shamseddine, Ali I.; Taher, Ali T.; Fouad, Fouad Mohammad; Abu-Sittah, Ghassan S.; Fadhil, Ibtihal; Saab, Raya H.; Sullivan, Richard; Adib, Salim Maurice; Saleh, Shadi S.; Mukherji, Deborah M. (American Society of Clinical Oncology, 2021)

PURPOSE National cancer control strategies have been identified as essential tools for reducing and managing the growing burden of cancer in low- and middle-income countries. Cancer registration is an instrumental component ...
Caregivers' Perception of Drug Administration Safety for Pediatric Oncology Patients

Harris, Nariman; Kurdahi Badr, Lina Kurdahi; Saab, Raya H.; Khalidi, Aziza (SAGE Publications Inc., 2014)

Medication errors (MEs) are reported to be between 1.5% and 90% depending on many factors, such as type of the institution where data were collected and the method to identify the errors. More significantly, the risk for ...
CD147 Promotes Tumorigenesis via Exosome-Mediated Signaling in Rhabdomyosarcoma

Fahs, Assil; Hussein, Nader; Zalzali, Hassan; Ramadan, Farah; Ghamloush, Farah; Tamim, Hani Mohammed; El Homsi, Mahmoud; Badran, Bassam M.; Boulos, Fouad I.; Tawil, Ayman N.; Ghayad, Sandra E.; Saab, Raya H. (MDPI, 2022)

Rhabdomyosarcoma (RMS) is an aggressive childhood soft-tissue tumor, with propensity for local invasion and distant metastasis. Exosomes are secreted vesicles that mediate paracrine signaling by delivering functional ...
CDK2 transcriptional repression is an essential effector in p53-dependent cellular senescence - Implications for therapeutic intervention

Zalzali, Hassan; Nasr, Bilal N.; Harajly, Mohamad; Basma, Hussein A.; Ghamloush, Farah; Ghayad, Sandra E.; Ghanem, Noël; Evan, Gérard I.; Saab, Raya H. (American Association for Cancer Research Inc., 2015)

Cellular senescence, a form of cell-cycle arrest, is a tumor-suppressor mechanism triggered by multiple tumor-promoting insults, including oncogenic stress and DNA damage. The role of cyclin-dependent kinase 2 (CDK2) ...
Cerebral sinus venous thrombosis during childhood acute lymphoblastic leukemia therapy: Risk factors and management

Ghanem, Khaled M.; Dhayni, Raghida M.; Al-Aridi, Carol; Tarek, Nidale; Tamim, Hani Mohammed; Chan, Anthony Kam Chuen; Saab, Raya H.; Abboud, Miguel Raul; El-Solh, Hassan; Muwakkit, Samar A. (John Wiley and Sons Inc., 2017)

Background: Cerebral sinus venous thrombosis (CSVT) is a rare but serious complication of childhood acute lymphoblastic leukemia (ALL) therapy. No available consensus exists regarding its risk factors and appropriate ...
Childhood cancer care in the Middle East, North Africa, and West/Central Asia: A snapshot across five countries from the POEM network

Basbous, Maya; Al-Jadiry, Mazin Faisal Farhan; Belgaumi, Asim Fakhruddin; Sultan, Iyad Y.; Al-Haddad, Alaa; Jeha, Sima S.; Saab, Raya H. (Elsevier Ltd, 2021)

Background: The Pediatric Oncology East and Mediterranean (POEM) network, through this report, provides a snapshot view of an expected child's treatment journey in five countries in the region. Methods: Pediatric oncologists ...
Circulating tumor cell detection technologies and clinical utility: Challenges and opportunities

Habli, Zeina S.; AlChamaa, Walid; Saab, Raya H.; Kadara, Humam N.; Khraiche, Massoud Louis (MDPI AG, 2020)

The potential clinical utility of circulating tumor cells (CTCs) in the diagnosis and management of cancer has drawn a lot of attention in the past 10 years. CTCs disseminate from tumors into the bloodstream and are believed ...
Clinical prognostic factors and outcome in pediatric osteosarcoma: Effect of delay in local control and degree of necrosis in a multidisciplinary setting in Lebanon

Ali, Bilal Abou; Salman, Mayssaa; Ghanem, Khaled M.; Boulos, Fouad I.; Haidar, Rachid K.; Saghieh, Saïd S.; Akel, Samir R.; Muwakkit, Samar A.; El-Solh, Hassan; Saab, Raya H.; Tamim, Hani Mohammed; Abboud, Miguel Raul (American Society of Clinical Oncology, 2019)

PURPOSE Outcomes in pediatric osteosarcoma have dramatically improved over the past few decades, with overall survival rates of 70% and 30% for patients with localized and metastatic disease, respectively. PATIENTS AND ...
Displaced children with cancer in Lebanon: A sustained response to an unprecedented crisis

Saab, Raya H.; Jeha, Sima S.; Khalifeh, Haifaa; Zahreddine, Lama T.; Bayram, Layal; Merabi, Zeina; Abboud, Miguel Raul; Muwakkit, Samar A.; Tarek, Nidale; Rodríguez-Galindo, Carlos; El-Solh, Hassan (John Wiley and Sons Inc., 2018)

BACKGROUND: The unrest in Syria has resulted in an escalating refugee crisis. The postwar lack of health care infrastructure in Iraq has also resulted in Iraqis seeking health care in neighboring countries. Pediatric cancer ...
Effect of malnutrition at diagnosis on clinical outcomes of children with acute lymphoblastic leukemia

Yazbeck, Nadine H.; Samia, Loma; Saab, Raya H.; Abboud, Miguel Raul; El-Solh, Hassan; Muwakkit, Samar A. (Lippincott Williams and Wilkins, 2016)

Acute lymphoblastic leukemia (ALL) is the most common malignancy among children. Although studies have shown that malnutrition can negatively affect treatment outcome, results are controversial. This retrospective study ...
Effects of the oncoprotein PAX3-FOXO1 on modulation of exosomes function and protein content: Implications on oxidative stress protection and enhanced plasticity

Fahs, Assil; Ramadan, Farah; Ghamloush, Farah; Ayoub, Abeer J.; Ali Ahmad, Fatima; Kobeissy, Firas H.; Mechref, Yehia S.; Zhao, Jingfu; Zhu, Rui; Hussein, Nader; Saab, Raya H.; Ghayad, Sandra E. (Frontiers Media S.A., 2020)

Rhabdomyosarcoma (RMS) is a highly malignant soft tissue sarcoma classified into two major histologic subtypes: embryonal (ERMS) and alveolar (ARMS). ARMS subtype is clinically more aggressive, and characterized by an ...
Estimated incidence, prevalence, mortality, and registration of childhood cancer (ages 0–14 years) in the WHO Eastern Mediterranean region: an analysis of GLOBOCAN 2020 data

Fadhil, Ibtihal; Soliman, Ranin M.; Jaffar, Sawsan; Al Madhi, Sawsan Abdul Salam; Saab, Raya H.; Belgaumi, Asim Fakhruddin; ElHaddad, Alaa M. (Elsevier B.V., 2022)

Background: There is little evidence about childhood cancer burden in the WHO Eastern Mediterranean region (EMR). We aimed to provide an estimate of childhood cancer burden in the EMR, examine the connection between ...
Exosomes derived from embryonal and alveolar rhabdomyosarcoma carry differential miRNA cargo and promote invasion of recipient fibroblasts

Ghayad, Sandra E.; Rammal, Ghina; Ghamloush, Farah; Basma, Hussein A.; Nasr, Rihab R.; Diab-Assaf, Mona; Chelala, Claude; Saab, Raya H. (Nature Publishing Group, 2016)

Rhabdomyosarcoma (RMS) is an aggressive childhood soft tissue tumor, which exists in oncoprotein PAX-FOXO1 fusion positive and fusion negative subtypes, with the fusion-positive RMS being characterized by a more aggressive ...
Extraskeletal Ewing sarcoma: Diagnosis, management and prognosis (Review)

Abboud, Abdallah; Masrouha, Karim Z.; Saliba, Maelle; Haidar, Rachid K.; Saab, Raya H.; Khoury, Nabil El; Tawil, Ayman N.; Saghieh, Saïd S. (Spandidos Publications, 2021)

Extraskeletal Ewing sarcoma (EES) is a relatively uncommon primary tumor of the soft tissues, which accounts for 20‑30% of all reported cases of ES. Being uncommon, all members of the ES family tumors are treated following ...
Fludarabine-based reduced intensity regimen for matched related donor hematopoietic stem cell transplantation in acquired severe aplastic anemia

Ghanem, Khaled M.; Kharfan-Dabaja, M. A.; El-Solh, Hassan; Harris, Nariman; Kreidieh, Nabeela M.A.; Nehme, Rita; Muwakkit, Samar A.; Saab, Raya H.; Bazarbachi, Ali Abdul Hamid; Abboud, Miguel Raul (Elsevier Masson SAS, 2017)

Different conditioning regimens have been evaluated in matched-related donor allogeneic hematopoietic stem cell transplantation (allo-HSCT) for acquired severe aplastic anemia (SAA) with varying results. In this manuscript, ...

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Browsing Pediatrics and Adolescent Medicine by Author "Saab, Raya H."

Browsing Pediatrics and Adolescent Medicine by Author "Saab, Raya H."

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