dc.contributor.author |
Atallah, Hala Michel, |
dc.date.accessioned |
2017-08-30T14:28:33Z |
dc.date.available |
2017-08-30T14:28:33Z |
dc.date.issued |
2016 |
dc.date.submitted |
2016 |
dc.identifier.other |
b19027606 |
dc.identifier.uri |
http://hdl.handle.net/10938/11085 |
dc.description |
Thesis. M.S. American University of Beirut. Department of Chemistry, 2016. T:6515 |
dc.description |
Advisor : Dr. Kamal Bouhadir, Professor, Chemistry ; Co-Advisor : Dr. Jomana El Aridi, Assistant Professor, Chemistry, LAU ; Committee members : Dr. Makhlouf Haddadin, Professor, Chemistry ; Dr. Tarek Ghaddar, Professor, Chemistry. |
dc.description |
Includes bibliographical references (leaves 209-213) |
dc.description.abstract |
1,4-Naphthoquinone possesses the quinone core which is reportedly essential for biological activity. Naphthoquinones, in general, have been reported to possess a variety of pharmacological properties including antibacterial, antifungal, antiviral, anti-inflammatory, anti-artherosclerotic and anticancer effects. Our interest in 1,4-naphthoquinone was fortified by literature reports that describe the anticancer activity of several thymoquinone derivatives. In this study, we report the synthesis of a new series of novel menadione-hydrazone conjugates by reaction of naphthoquinones with several aliphatic hydrazides. We synthesized a series of analogous menadione hydrazones and aim to evaluate their biological activity in comparison to the parent naphthoquinone molecule. Modified oligonucleotides have a plethora of industrial and synthetic applications. The hypothesis underlying this research project is that N,N-diallyl-N’-acylhydrazine derivatives can be cyclopolymerized more efficiently in comparison to the diallylamine derivatives. We successfully synthesized hydrazidoethyl-methyl-pyrimidine based (uracil, thymine) derivatives of N,N-diallyl-N’-hydrazine. |
dc.format.extent |
1 online resource (xiv, 213 leaves) : illustrations (some color) |
dc.language.iso |
eng |
dc.relation.ispartof |
Theses, Dissertations, and Projects |
dc.subject.classification |
T:006515 |
dc.subject.lcsh |
Naphthoquinone. |
dc.subject.lcsh |
Polymerization. |
dc.subject.lcsh |
Quinone. |
dc.title |
Synthesis and characterization of menadione analogues and hydrazidoethyl-methyl-pyrimidine derivatives - |
dc.type |
Thesis |
dc.contributor.department |
Faculty of Arts and Sciences. |
dc.contributor.department |
Department of Chemistry, |
dc.contributor.institution |
American University of Beirut. |