AUB ScholarWorks

Thymulin related peptide attenuates inflammation in the brain induced by intracerebroventricular endotoxin injection

Show simple item record Safieh-Garabedian B. Jabbur S.J. Dardenne M. Saade N.E.
dc.contributor.editor Feb-2011 2017-09-07T06:59:55Z 2017-09-07T06:59:55Z 2011
dc.identifier 10.1016/j.neuropharm.2010.11.004
dc.identifier.issn 00283908
dc.description.abstract Based on significant amount of evidence, it is now generally believed, that one underlying cause for neurodegenerative diseases, could be dysregulation in inflammatory processes. The actual mechanisms involved are not yet well understood. Several studies have demonstrated the potent analgesic and anti-inflammatory actions of thymulin related peptide (PAT), in different animal pain models. In this study, we investigated the efficacy of PAT in a recently developed model of neuroinflammation, in conscious rats, caused by intracerbroventricular (ICV) injection of endotoxin (ET). Our results indicate that ICV injection of PAT alone did not elicit significant alteration of nociceptive thresholds, while ET injections produced significant thermal hyperalgesia and cold allodynia. Pretreatment with PAT resulted in significant alleviation of ET-induced hyperalgesia and increased body temperature. In other sets of experiments, ICV injection of ET resulted in a significant elevation in the concentration of pro-inflammatory mediators measured in different areas of the brain; this elevation was significantly following pretreatment with PAT. Taken together these results provide evidence in support of our hypothesis that as a potent anti-inflammatory and analgesic peptide, PAT might have potential therapeutic use for the treatment of neurodegenerative conditions induced by silent or overt inflammation. © 2010 Elsevier Ltd. All rights reserved.
dc.format.extent Pages: (496-504)
dc.language English
dc.publisher OXFORD
dc.relation.ispartof Publication Name: Neuropharmacology; Publication Year: 2011; Volume: 60; no. 41673; Pages: (496-504);
dc.source Scopus
dc.title Thymulin related peptide attenuates inflammation in the brain induced by intracerebroventricular endotoxin injection
dc.type Article
dc.contributor.affiliation Safieh-Garabedian, B., Department Natural Science and Public Health, Zayed University, Abu Dhabi, United Arab Emirates
dc.contributor.affiliation Jabbur, S.J., Department of Human Morphology, Faculty of Medicine, American University of Beirut, P. O. Box 110236-41, Riad El Solh, Beirut 1107-2020, Beirut, Lebanon, Department of Physiology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Dardenne, M., CNRS UMR 8603, Hôpital Necker, University of Paris v, Paris, France
dc.contributor.affiliation Saadé, N.E., Department of Human Morphology, Faculty of Medicine, American University of Beirut, P. O. Box 110236-41, Riad El Solh, Beirut 1107-2020, Beirut, Lebanon, Department of Physiology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon
dc.contributor.authorAddress Saadé, N. E.; Department of Human Morphology, Faculty of Medicine, American University of Beirut, P. O. Box 110236-41, Riad El Solh, Beirut 1107-2020, Beirut, Lebanon; email:
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Anatomy, Cell Biology and Physiological Sciences;
dc.contributor.authorDepartment Anatomy, Cell Biology and Physiological Sciences
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Safieh-Garabedian, B
dc.contributor.authorInitials Jabbur, SJ
dc.contributor.authorInitials Dardenne, M
dc.contributor.authorInitials Saade, NE
dc.contributor.authorReprintAddress Saade, NE (reprint author), Amer Univ Beirut, Dept Human Morphol, Fac Med, POB 110236-41, Beirut 11072020, Lebanon.
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited Allan SM, 2003, PHILOS T ROY SOC B, V358, P1669, DOI 10.1098-rstb.2003.1358; Allan SM, 2001, NAT REV NEUROSCI, V2, P734, DOI 10.1038-35094583; Barada KA, 2007, CYTOKINE, V37, P236, DOI 10.1016-j.cyto.2007.04.005; Boutin H, 2001, J NEUROSCI, V21, P5528; Cao ZX, 2006, J NEUROSCI, V26, P5565, DOI 10.1523-JNEUROSCI.0815-06.2006; CHOI Y, 1994, PAIN, V59, P369; Cunha TM, 2005, P NATL ACAD SCI USA, V102, P1755, DOI 10.1073-pnas.0409225102; Cunningham C, 2005, J NEUROSCI, V25, P9275, DOI 10.1523-JNEUROSCI.2614-05.2005; di Mola FF, 2000, GUT, V46, P670, DOI 10.1136-gut.46.5.670; Fink KB, 1999, NEUROSCIENCE, V94, P1213, DOI 10.1016-S0306-4522(99)00345-0; Fontaine F., 2002, J NEUROSCI, V22, P2; Frank-Cannon TC, 2009, MOL NEURODEGENER, V4, DOI 10.1186-1750-1326-4-47; Golz G, 2006, EUR J NEUROSCI, V24, P2721, DOI 10.1111-j.1460-9568.2006.05155.x; Gonzalez-Scarano F, 1999, ANNU REV NEUROSCI, V22, P219, DOI 10.1146-annurev.neuro.22.1.219; HARGREAVES K, 1988, PAIN, V32, P77, DOI 10.1016-0304-3959(88)90026-7; Ignatowski TA, 1999, BRAIN RES, V841, P70, DOI 10.1016-S0006-8993(99)01782-5; Johnston LC, 2008, MOL THER, V16, P1392, DOI 10.1038-mt.2008.113; Kanaan SA, 1998, J NEUROIMMUNOL, V86, P142, DOI 10.1016-S0165-5728(98)00027-7; Lucas SM, 2006, BRIT J PHARMACOL, V147, pS232, DOI 10.1038-sj.bjp.0706400; Luheshi NM, 2009, BRIT J PHARMACOL, V157, P1318, DOI 10.1111-j.1476-5381.2009.00331.x; Ma DL, 2003, AM J PHYSIOL-REG I, V284, pR1323, DOI 10.1152-ajpregu.00756.2002; Marini H, 2004, EXP NEUROL, V188, P178, DOI 10.1016-j.expneurol.2004.03.023; Moore KW, 2001, ANNU REV IMMUNOL, V19, P683, DOI 10.1146-annurev.immunol.19.1.683; Nguyen MD, 2002, NAT REV NEUROSCI, V3, P216, DOI 10.1038-nrn752; Oka T, 1996, NEUROIMMUNOMODULAT, V3, P135, DOI 10.1159-000097238; Osamura N, 2005, EXP NEUROL, V195, P61, DOI 10.1016-j.expneurol.2005.03.019; Petty MA, 2002, PROG NEUROBIOL, V68, P311, DOI 10.1016-S0301-0082(02)00128-4; Pezet S, 2006, ANNU REV NEUROSCI, V29, P507, DOI 10.1146-annurev.neuro.29.051605.112929; Reale M, 2009, BRAIN BEHAV IMMUN, V23, P55, DOI 10.1016-j.bbi.2008.07.003; Rees GS, 1999, EUR CYTOKINE NETW, V10, P383; Rosas-Ballina M, 2009, J INTERN MED, V265, P663, DOI 10.1111-j.1365-2796.2009.02098.x; Rothwell NJ, 1999, J PHYSIOL-LONDON, V514, P3, DOI 10.1111-j.1469-7793.1999.003af.x; Saab CY, 2009, J NEUROIMMUNOL, V208, P94, DOI 10.1016-j.jneuroim.2009.01.011; Saade NE, 2008, BRAIN BEHAV IMMUN, V22, P245, DOI 10.1016-j.bbi.2007.08.002; Saade NE, 1998, J NEUROIMMUNOL, V91, P171, DOI 10.1016-S0165-5728(98)00176-3; Saade NE, 2000, BRIT J PHARMACOL, V131, P1317, DOI 10.1038-sj.bjp.0703699; Safieh-Garabedian B, 2002, BRIT J PHARMACOL, V136, P947, DOI 10.1038-sj.bjp.0704793; SafiehGarabedian B, 1997, BRIT J PHARMACOL, V121, P1619, DOI 10.1038-sj.bjp.0701313; SAFIEHGARABEDIAN B, 1995, BRIT J PHARMACOL, V115, P1265; Safieh-Garabedian B, 2003, NEUROSCIENCE, V121, P865, DOI 10.1016-S0306-4522(03)00500-1; Safieh-Garabedian Bared, 2004, Current Drug Targets - CNS and Neurological Disorders, V3, P271, DOI 10.2174-1568007043337300; Safieh-Garabedian B., 2010, SOC NEUROSCIENCE; Serou MJ, 1999, J NEUROSCI RES, V58, P593, DOI 10.1002-(SICI)1097-4547(19991115)58:4593::AID-JNR123.0.CO;2-4; Sommer C, 2004, NEUROSCI LETT, V361, P184, DOI 10.1016-j.neulet.2003.12.007; Stroemer RP, 1998, J CEREBR BLOOD F MET, V18, P833; Szelenyi J, 2001, BRAIN RES BULL, V54, P329, DOI 10.1016-S0361-9230(01)00428-2; Tamatani M, 1998, J NEUROCHEM, V71, P1588; Tansy M.G., 2008, FRONT BIOSCI, V1, P709; Wang H, 2003, NATURE, V421, P384, DOI 10.1038-nature01339; Won-Con K., 2000, J NEUROSCI, V20, P6309; Wyss-Coray T, 2002, NEURON, V35, P419, DOI 10.1016-S0896-6273(02)00794-8
dc.description.citedCount 3
dc.description.citedTotWOSCount 3
dc.description.citedWOSCount 3
dc.format.extentCount 9
dc.identifier.coden NEPHB
dc.identifier.pubmedID 21059360
dc.identifier.scopusID 78650834290
dc.relation.ispartOfISOAbbr Neuropharmacology
dc.relation.ispartOfIssue 41673
dc.relation.ispartofPubTitle Neuropharmacology
dc.relation.ispartofPubTitleAbbr Neuropharmacology
dc.relation.ispartOfVolume 60
dc.source.ID WOS:000287054600038
dc.type.publication Journal
dc.subject.otherAuthKeyword Analgesia
dc.subject.otherAuthKeyword Cytokines
dc.subject.otherAuthKeyword Hyperalgesia
dc.subject.otherAuthKeyword Neuroinflammation
dc.subject.otherAuthKeyword Neurotrophins
dc.subject.otherAuthKeyword Thymulin
dc.subject.otherChemCAS nerve growth factor, 9061-61-4
dc.subject.otherChemCAS thymulin, 78922-62-0
dc.subject.otherChemCAS Anti-Inflammatory Agents, Non-Steroidal
dc.subject.otherChemCAS Endotoxins
dc.subject.otherChemCAS Thymic Factor, Circulating, 78922-62-0
dc.subject.otherIndex endotoxin
dc.subject.otherIndex interleukin 1beta
dc.subject.otherIndex interleukin 6
dc.subject.otherIndex nerve growth factor
dc.subject.otherIndex thymulin
dc.subject.otherIndex allodynia
dc.subject.otherIndex analgesic activity
dc.subject.otherIndex animal cell
dc.subject.otherIndex animal experiment
dc.subject.otherIndex animal model
dc.subject.otherIndex animal tissue
dc.subject.otherIndex antiinflammatory activity
dc.subject.otherIndex article
dc.subject.otherIndex brain stem
dc.subject.otherIndex controlled study
dc.subject.otherIndex cytokine production
dc.subject.otherIndex diencephalon
dc.subject.otherIndex dose response
dc.subject.otherIndex drug efficacy
dc.subject.otherIndex encephalitis
dc.subject.otherIndex fever
dc.subject.otherIndex hyperalgesia
dc.subject.otherIndex male
dc.subject.otherIndex nociception
dc.subject.otherIndex nonhuman
dc.subject.otherIndex priority journal
dc.subject.otherIndex rat
dc.subject.otherIndex upregulation
dc.subject.otherIndex Animals
dc.subject.otherIndex Anti-Inflammatory Agents, Non-Steroidal
dc.subject.otherIndex Brain
dc.subject.otherIndex Disease Models, Animal
dc.subject.otherIndex Endotoxins
dc.subject.otherIndex Inflammation
dc.subject.otherIndex Infusions, Intraventricular
dc.subject.otherIndex Male
dc.subject.otherIndex Neurodegenerative Diseases
dc.subject.otherIndex Pain Measurement
dc.subject.otherIndex Rats
dc.subject.otherIndex Rats, Sprague-Dawley
dc.subject.otherIndex Thymic Factor, Circulating
dc.subject.otherKeywordPlus NERVE GROWTH-FACTOR
dc.subject.otherKeywordPlus NECROSIS-FACTOR-ALPHA
dc.subject.otherKeywordPlus INDUCED HYPERALGESIA
dc.subject.otherKeywordPlus PARKINSONS-DISEASE
dc.subject.otherKeywordPlus NEUROPATHIC PAIN
dc.subject.otherKeywordPlus GENE-EXPRESSION
dc.subject.otherKeywordPlus UP-REGULATION
dc.subject.otherKeywordPlus RAT MODEL
dc.subject.otherKeywordPlus CYTOKINES
dc.subject.otherKeywordPlus INTERLEUKIN-10
dc.subject.otherWOS Neurosciences
dc.subject.otherWOS Pharmacology and Pharmacy

Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search AUB ScholarWorks


My Account