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Chemopreventive effects of wild carrot oil against 7,12-dimethyl benz(a)anthracene-induced squamous cell carcinoma in mice

Show simple item record Zeinab R.A. Mroueh M. Diab-Assaf M. Jurjus A. Wex B. Sakr A. Daher C.F.
dc.contributor.editor Sep-2011 2017-09-07T06:59:55Z 2017-09-07T06:59:55Z 2011
dc.identifier 10.3109/13880209.2011.559250
dc.identifier.issn 13880209
dc.description.abstract Context: Daucus carota L. ssp. carota (Apiacea) is widely distributed throughout the world and has many uses in traditional medicine. Objective: The present study investigates the chemopreventive effects of oil extract of D. carota umbels on 7,12-dimethyl benz(a)anthracene (DMBA)-induced skin cancer in mice. Materials and methods: D. carota oil extract (DCOE) was prepared by extracting the dried umbels with 50:50 acetone:methanol. Skin papilloma were initiated by DMBA and promoted by 12-O-tetradecanoyl phorobol-13-acetate (TPA). The extract was administered to animals via gavage (0.02 mL of 100percent oil), intraperitoneal (0.3 mL of 2percent oil), and topical (0.2 mL of 5, 50, and 100percent oil) routes for 20 weeks. Tumor appearance, incidence, yield, and volume were compared with those of a non-treated control group. Results: Topical 100percent treatment delayed tumor appearance, and inhibited tumor incidence and yield by 40 and 89percent, respectively. Topical 50percent treatment inhibited tumor incidence and yield by 30 and 83percent, respectively, whereas the 5percent treatment inhibited tumor yield by 36percent. Tumor volume was decreased by 99, 91, and 70percent following topical treatments with 100, 50, and 5percent oil, respectively. Intraperitoneal treatment inhibited tumor yield by 43percent, and decreased tumor volume by 85percent, whereas gavage treatment showed minimal effects on both. Intraperitoneal and topical treatment decreased infiltration and hyperplasia with an increase in the level of hyperkeratosis. Conclusion: These findings demonstrate that DCOE has remarkable antitumor activity against DMBA-induced skin cancer compared with non-treated animals paving the ground for further investigations. © 2011 Informa Healthcare USA, Inc.
dc.format.extent Pages: (955-961)
dc.language English
dc.publisher LONDON
dc.relation.ispartof Publication Name: Pharmaceutical Biology; Publication Year: 2011; Volume: 49; no. 9; Pages: (955-961);
dc.source Scopus
dc.title Chemopreventive effects of wild carrot oil against 7,12-dimethyl benz(a)anthracene-induced squamous cell carcinoma in mice
dc.type Article
dc.contributor.affiliation Zeinab, R.A., Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, P.O. Box 36, Byblos, Lebanon
dc.contributor.affiliation Mroueh, M., School of Pharmacy, Lebanese American University, Byblos, Lebanon
dc.contributor.affiliation Diab-Assaf, M., Faculty of Sciences, Lebanese University, Fanar, Beirut, Lebanon
dc.contributor.affiliation Jurjus, A., School of Medicine, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Wex, B., Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, P.O. Box 36, Byblos, Lebanon
dc.contributor.affiliation Sakr, A., Analytical Testing Laboratories, Achrafieh, Beirut, Lebanon
dc.contributor.affiliation Daher, C.F., Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, P.O. Box 36, Byblos, Lebanon
dc.contributor.authorAddress Daher, C.F.; Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, P.O. Box 36, Byblos, Lebanon; email:
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Anatomy, Cell Biology and Physiological Sciences;
dc.contributor.authorDepartment Anatomy, Cell Biology and Physiological Sciences
dc.contributor.faculty Faculty of Medicine
dc.contributor.authorInitials Abu Zeinab, R
dc.contributor.authorInitials Mroueh, M
dc.contributor.authorInitials Diab-Assaf, M
dc.contributor.authorInitials Jurjus, A
dc.contributor.authorInitials Wex, B
dc.contributor.authorInitials Sakr, A
dc.contributor.authorInitials Daher, CF
dc.contributor.authorReprintAddress Daher, CF (reprint author), Lebanese Amer Univ, Sch Arts and Sci, Dept Nat Sci, POB 36, Byblos, Lebanon.
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 2
dc.description.citedTotWOSCount 1
dc.description.citedWOSCount 1
dc.format.extentCount 7
dc.identifier.coden PHBIF
dc.identifier.pubmedID 21777042
dc.identifier.scopusID 80051517710
dc.relation.ispartOfISOAbbr Pharm. Biol.
dc.relation.ispartOfIssue 9
dc.relation.ispartofPubTitle Pharmaceutical Biology
dc.relation.ispartofPubTitleAbbr Pharm. Biol.
dc.relation.ispartOfVolume 49
dc.source.ID WOS:000293600900010
dc.type.publication Journal
dc.subject.otherAuthKeyword antitumor
dc.subject.otherAuthKeyword Daucus carota L. ssp. carota (Apiacae)
dc.subject.otherAuthKeyword dermal infiltration
dc.subject.otherAuthKeyword hyperkeratosis
dc.subject.otherAuthKeyword skin papilloma
dc.subject.otherChemCAS 7,12 dimethylbenz[a]anthracene, 57-97-6
dc.subject.otherChemCAS acetone, 67-64-1
dc.subject.otherChemCAS methanol, 67-56-1
dc.subject.otherChemCAS phorbol 13 acetate 12 myristate, 16561-29-8
dc.subject.otherChemCAS 9,10-Dimethyl-1,2-benzanthracene, 57-97-6
dc.subject.otherChemCAS Anticarcinogenic Agents
dc.subject.otherChemCAS Carcinogens
dc.subject.otherChemCAS Oils
dc.subject.otherChemCAS Plant Extracts
dc.subject.otherIndex 7,12 dimethylbenz[a]anthracene
dc.subject.otherIndex acetone
dc.subject.otherIndex antineoplastic agent
dc.subject.otherIndex daucus carota extract
dc.subject.otherIndex methanol
dc.subject.otherIndex phorbol 13 acetate 12 myristate
dc.subject.otherIndex plant extract
dc.subject.otherIndex unclassified drug
dc.subject.otherIndex animal experiment
dc.subject.otherIndex animal model
dc.subject.otherIndex animal tissue
dc.subject.otherIndex antineoplastic activity
dc.subject.otherIndex article
dc.subject.otherIndex cancer inhibition
dc.subject.otherIndex cancer prevention
dc.subject.otherIndex cancer survival
dc.subject.otherIndex carrot
dc.subject.otherIndex chemoprophylaxis
dc.subject.otherIndex controlled study
dc.subject.otherIndex dose response
dc.subject.otherIndex drug efficacy
dc.subject.otherIndex epidermis hyperplasia
dc.subject.otherIndex histopathology
dc.subject.otherIndex hyperkeratosis
dc.subject.otherIndex mouse
dc.subject.otherIndex nonhuman
dc.subject.otherIndex skin cancer
dc.subject.otherIndex skin infiltrate
dc.subject.otherIndex skin papilloma
dc.subject.otherIndex squamous cell carcinoma
dc.subject.otherIndex tumor biopsy
dc.subject.otherIndex tumor volume
dc.subject.otherIndex 9,10-Dimethyl-1,2-benzanthracene
dc.subject.otherIndex Animals
dc.subject.otherIndex Anticarcinogenic Agents
dc.subject.otherIndex Carcinogens
dc.subject.otherIndex Carcinoma, Squamous Cell
dc.subject.otherIndex Chemoprevention
dc.subject.otherIndex Daucus carota
dc.subject.otherIndex Flowers
dc.subject.otherIndex Mice
dc.subject.otherIndex Mice, Inbred BALB C
dc.subject.otherIndex Oils
dc.subject.otherIndex Papilloma
dc.subject.otherIndex Phytotherapy
dc.subject.otherIndex Plant Extracts
dc.subject.otherIndex Skin Neoplasms
dc.subject.otherIndex Tumor Burden
dc.subject.otherIndex Animalia
dc.subject.otherIndex Daucus
dc.subject.otherIndex Daucus carota
dc.subject.otherIndex Mus
dc.subject.otherKeywordPlus ANTICANCER ACTIVITY
dc.subject.otherKeywordPlus ALPHA-HUMULENE
dc.subject.otherKeywordPlus IN-VITRO
dc.subject.otherKeywordPlus CANCER
dc.subject.otherKeywordPlus SKIN
dc.subject.otherKeywordPlus PAPILLOMAS
dc.subject.otherKeywordPlus L.
dc.subject.otherWOS Plant Sciences
dc.subject.otherWOS Medical Laboratory Technology
dc.subject.otherWOS Pharmacology and Pharmacy

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