AUB ScholarWorks

Effects of selenium and exendin-4 on glucagon-like peptide-1 receptor, IRS-1, and Raf-1 in the liver of diabetic rats

Show simple item record

dc.contributor.author Barakat G.M.
dc.contributor.author Moustafa M.E.
dc.contributor.author Bikhazi A.B.
dc.contributor.editor
dc.date Dec-2012
dc.date.accessioned 2017-09-07T06:59:57Z
dc.date.available 2017-09-07T06:59:57Z
dc.date.issued 2012
dc.identifier 10.1007/s10528-012-9532-2
dc.identifier.isbn
dc.identifier.issn 00062928
dc.identifier.uri http://hdl.handle.net/10938/11221
dc.description.abstract Selenium and exendin-4 exert antidiabetic effects by unknown mechanisms. Herein, we investigated their effects on the expression of glucagon-like peptide-1 receptor (GLP-1R), insulin receptor substrate-1 (IRS-1), and Raf-1 in the livers of rats with streptozotocin-induced diabetes. Diabetic rats were injected intraperitoneally with exendin-4 (0.03 lg-kg body weight) twice daily or treated with 5 ppm selenium as sodium selenite in drinking water for 4 weeks. Both selenium and exendin-4 reduced the hyperglycemia in diabetic rats. Induction of diabetes mellitus resulted in decreased level of GLP-1R and increased levels of IRS- 1 and Raf-1 in the liver. Treatment of diabetic rats with selenium or exendin-4 resulted in increased level of GLP-1R and decreased levels of IRS-1 and Raf-1 in the liver, compared with the levels in diabetic rats. Therefore, the antidiabetic actions of selenium and exendin-4 involve their effects on GLP-1R, IRS-1, and Raf-1 levels in the liver. © Springer Science+Business Media, LLC 2012.
dc.format.extent
dc.format.extent Pages: (922-935)
dc.language English
dc.publisher NEW YORK
dc.relation.ispartof Publication Name: Biochemical Genetics; Publication Year: 2012; Volume: 50; no. 41955; Pages: (922-935);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Effects of selenium and exendin-4 on glucagon-like peptide-1 receptor, IRS-1, and Raf-1 in the liver of diabetic rats
dc.type Article
dc.contributor.affiliation Barakat, G.M., Department of Biological and Environmental Sciences, Faculty of Science, Beirut Arab University, Beirut, Lebanon
dc.contributor.affiliation Moustafa, M.E., Department of Biological and Environmental Sciences, Faculty of Science, Beirut Arab University, Beirut, Lebanon, Department of Biochemistry, Faculty of Science, Alexandria University, Alexandria 21511, Egypt
dc.contributor.affiliation Bikhazi, A.B., Department of Physiology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon
dc.contributor.authorAddress Moustafa, M.E.; Department of Biological and Environmental Sciences, Faculty of Science, Beirut Arab University, Beirut, Lebanon; email: mohamed.mostafa@alex-sci.edu.eg
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Anatomy, Cell Biology and Physiological Sciences;
dc.contributor.authorDepartment Anatomy, Cell Biology and Physiological Sciences
dc.contributor.authorDivision
dc.contributor.authorEmail mohamed.mostafa@alex-sci.edu.eg
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Barakat, GM
dc.contributor.authorInitials Moustafa, ME
dc.contributor.authorInitials Bikhazi, AB
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Moustafa, ME (reprint author), Univ Alexandria, Dept Biochem, Fac Sci, Alexandria 21511, Egypt.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited Akbaraly TN, 2010, NUTR METAB, V7, DOI 10.1186-1743-7075-7-21; Algotar AM, 2011, NUTR CANCER, V63, P1, DOI 10.1080-01635581.2010.516476; Ban K, 2008, CIRCULATION, V117, P2340, DOI 10.1161-CIRCULATIONAHA.107.739938; Bergmann U, 1996, BIOCHEM BIOPH RES CO, V220, P886, DOI 10.1006-bbrc.1996.0500; Bjorkhem-Bergman L, 2005, CARCINOGENESIS, V26, P125, DOI 10.1093-carcin-bgh290; Bleys J, 2007, DIABETES CARE, V30, P829, DOI 10.2337-dc06-1726; Campbell SC, 2008, FEBS LETT, V582, P2333, DOI 10.1016-j.febslet.2008.05.038; Douillet C, 1999, J TRACE ELEM EXP MED, V12, P379, DOI 10.1002-(SICI)1520-670X(1999)12:4379::AID-JTRA123.0.CO;2-C; Drucker DJ, 2003, ENDOCRINOLOGY, V144, P5145, DOI 10.1210-en.2003-1147; Drucker DJ, 2007, J CLIN INVEST, V117, P24, DOI 10.1172-JCI30076; ELLIOTT RM, 1993, J ENDOCRINOL, V138, P159, DOI 10.1677-joe.0.1380159; FEHMANN HC, 1992, MOL CELL ENDOCRINOL, V85, pC39, DOI 10.1016-0303-7207(92)90118-P; Furnsinn C, 1996, LIFE SCI, V59, P1989, DOI 10.1016-S0024-3205(96)00550-4; Ghosh R, 1994, Diabetes Res, V25, P165; GOKE R, 1993, J BIOL CHEM, V268, P19650; GRANKVIST K, 1981, BIOCHEM J, V199, P393; HARA K, 1994, P NATL ACAD SCI USA, V91, P7415, DOI 10.1073-pnas.91.16.7415; Harmon JS, 2009, ENDOCRINOLOGY, V150, P4855, DOI 10.1210-en.2009-0708; Hei YJ, 1998, MOL CELL BIOCHEM, V178, P367, DOI 10.1023-A:1006819906820; Hong G, 2007, ENDOCRINE, V32, P90; IIZUKA Y, 1993, YAKUGAKU ZASSHI, V113, P525; Kljai K, 2001, BIOL TRACE ELEM RES, V83, P223, DOI 10.1385-BTER:83:3:223; LAAKSO M, 1994, J CLIN INVEST, V94, P1141, DOI 10.1172-JCI117429; Labunskyy VM, 2011, ANTIOXID REDOX SIGN, V14, P2327, DOI 10.1089-ars.2010.3526; Lei XG, 2005, J NUTR, V135, P2295; Lippman SM, 2009, JAMA-J AM MED ASSOC, V301, P39, DOI 10.1001-jama.2008.864; Lortz S, 2000, DIABETES, V49, P1123, DOI 10.2337-diabetes.49.7.1123; Maiese K, 2007, CURR NEUROVASC RES, V4, P63, DOI 10.2174-156720207779940653; McClung JP, 2004, P NATL ACAD SCI USA, V101, P8852, DOI 10.1073-pnas.0308026101; MCNEILL JH, 1991, DIABETES, V40, P1675, DOI 10.2337-diabetes.40.12.1675; Moriscot C, 2003, DIABETES METAB, V29, P145, DOI 10.1016-S1262-3636(07)70021-6; Mukherjee B, 1998, BIOMED PHARMACOTHER, V52, P89, DOI 10.1016-S0753-3322(98)80008-5; Mysore TB, 2005, DIABETES, V54, P2109, DOI 10.2337-diabetes.54.7.2109; Navarro-Alarcon M, 1999, SCI TOTAL ENVIRON, V228, P79, DOI 10.1016-S0048-9697(99)00034-0; Rajpathak S, 2005, J AM COLL NUTR, V24, P250; RASEKH HR, 1991, TOXICOL LETT, V58, P199, DOI 10.1016-0378-4274(91)90174-5; SCHNEDL WJ, 1994, DIABETES, V43, P1326, DOI 10.2337-diabetes.43.11.1326; Sesti G, 2001, FASEB J, V15, P2099, DOI 10.1096-fj.01-0009rev; Stapleton SR, 2000, CELL MOL LIFE SCI, V57, P1874, DOI 10.1007-PL00000669; Stranges S, 2007, ANN INTERN MED, V147, P217; Trumper A, 2002, J ENDOCRINOL, V174, DOI 10.1677-joe.0.1740233; Wang XD, 2008, DIABETOLOGIA, V51, P1515, DOI 10.1007-s00125-008-1055-3
dc.description.citedCount
dc.description.citedTotWOSCount 1
dc.description.citedWOSCount 0
dc.format.extentCount 14
dc.identifier.articleNo
dc.identifier.coden BIGEB
dc.identifier.pubmedID 22983684
dc.identifier.scopusID 84871229527
dc.identifier.url
dc.publisher.address 233 SPRING ST, NEW YORK, NY 10013 USA
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Biochem. Genet.
dc.relation.ispartOfIssue 41955
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Biochemical Genetics
dc.relation.ispartofPubTitleAbbr Biochem. Genet.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 50
dc.source.ID WOS:000310887500010
dc.type.publication Journal
dc.subject.otherAuthKeyword Antidiabetic
dc.subject.otherAuthKeyword Diabetes mellitus
dc.subject.otherAuthKeyword Exendin-4
dc.subject.otherAuthKeyword GLP-1 receptor
dc.subject.otherAuthKeyword Glutathione peroxidase-1
dc.subject.otherChemCAS bovine insulin, 11070-73-8
dc.subject.otherChemCAS exendin 4, 141732-76-5, 141758-74-9
dc.subject.otherChemCAS glucose, 50-99-7, 84778-64-3
dc.subject.otherChemCAS insulin receptor substrate 1, 175335-32-7
dc.subject.otherChemCAS sodium selenite, 10102-18-8
dc.subject.otherChemCAS Blood Glucose
dc.subject.otherChemCAS Hypoglycemic Agents
dc.subject.otherChemCAS Insulin
dc.subject.otherChemCAS Insulin Receptor Substrate Proteins
dc.subject.otherChemCAS Irs1 protein, rat
dc.subject.otherChemCAS MAP Kinase Kinase Kinases, 2.7.11.25
dc.subject.otherChemCAS Peptides
dc.subject.otherChemCAS RNA, Messenger
dc.subject.otherChemCAS Raf-1 protein, rat, 2.7.11.1
dc.subject.otherChemCAS Receptors, Glucagon
dc.subject.otherChemCAS Selenium, 7782-49-2
dc.subject.otherChemCAS Sodium Selenite, 10102-18-8
dc.subject.otherChemCAS Streptozocin, 18883-66-4
dc.subject.otherChemCAS Venoms
dc.subject.otherChemCAS exenatide, 141732-76-5
dc.subject.otherChemCAS glucagon-like peptide-1 receptor
dc.subject.otherIndex bovine insulin
dc.subject.otherIndex exendin 4
dc.subject.otherIndex glucagon like peptide 1 receptor
dc.subject.otherIndex glucose
dc.subject.otherIndex insulin receptor substrate 1
dc.subject.otherIndex Raf protein
dc.subject.otherIndex sodium selenite
dc.subject.otherIndex animal experiment
dc.subject.otherIndex animal model
dc.subject.otherIndex animal tissue
dc.subject.otherIndex article
dc.subject.otherIndex controlled study
dc.subject.otherIndex diabetes mellitus
dc.subject.otherIndex glucose blood level
dc.subject.otherIndex hyperglycemia
dc.subject.otherIndex liver
dc.subject.otherIndex male
dc.subject.otherIndex nonhuman
dc.subject.otherIndex protein blood level
dc.subject.otherIndex protein expression
dc.subject.otherIndex rat
dc.subject.otherIndex streptozocin diabetes
dc.subject.otherIndex Animals
dc.subject.otherIndex Blood Glucose
dc.subject.otherIndex Blotting, Western
dc.subject.otherIndex Diabetes Mellitus, Experimental
dc.subject.otherIndex Hypoglycemic Agents
dc.subject.otherIndex Insulin
dc.subject.otherIndex Insulin Receptor Substrate Proteins
dc.subject.otherIndex Liver
dc.subject.otherIndex Male
dc.subject.otherIndex MAP Kinase Kinase Kinases
dc.subject.otherIndex Peptides
dc.subject.otherIndex Rats
dc.subject.otherIndex Rats, Sprague-Dawley
dc.subject.otherIndex Receptors, Glucagon
dc.subject.otherIndex RNA, Messenger
dc.subject.otherIndex Selenium
dc.subject.otherIndex Sodium Selenite
dc.subject.otherIndex Streptozocin
dc.subject.otherIndex Time Factors
dc.subject.otherIndex Venoms
dc.subject.otherIndex Rattus
dc.subject.otherKeywordPlus DEPENDENT INSULINOTROPIC POLYPEPTIDE
dc.subject.otherKeywordPlus GLUTATHIONE-PEROXIDASE
dc.subject.otherKeywordPlus SUPEROXIDE-DISMUTASE
dc.subject.otherKeywordPlus OXIDATIVE STRESS
dc.subject.otherKeywordPlus PROSTATE-CANCER
dc.subject.otherKeywordPlus BETA-CELL
dc.subject.otherKeywordPlus GLUCOSE
dc.subject.otherKeywordPlus MICE
dc.subject.otherKeywordPlus OVEREXPRESSION
dc.subject.otherKeywordPlus STIMULATION
dc.subject.otherWOS Biochemistry and Molecular Biology
dc.subject.otherWOS Genetics and Heredity


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search AUB ScholarWorks


Browse

My Account