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Effects of selenium and exendin-4 on glucagon-like peptide-1 receptor, IRS-1, and Raf-1 in the liver of diabetic rats

Show simple item record Barakat G.M. Moustafa M.E. Bikhazi A.B.
dc.contributor.editor Dec-2012 2017-09-07T06:59:57Z 2017-09-07T06:59:57Z 2012
dc.identifier 10.1007/s10528-012-9532-2
dc.identifier.issn 00062928
dc.description.abstract Selenium and exendin-4 exert antidiabetic effects by unknown mechanisms. Herein, we investigated their effects on the expression of glucagon-like peptide-1 receptor (GLP-1R), insulin receptor substrate-1 (IRS-1), and Raf-1 in the livers of rats with streptozotocin-induced diabetes. Diabetic rats were injected intraperitoneally with exendin-4 (0.03 lg-kg body weight) twice daily or treated with 5 ppm selenium as sodium selenite in drinking water for 4 weeks. Both selenium and exendin-4 reduced the hyperglycemia in diabetic rats. Induction of diabetes mellitus resulted in decreased level of GLP-1R and increased levels of IRS- 1 and Raf-1 in the liver. Treatment of diabetic rats with selenium or exendin-4 resulted in increased level of GLP-1R and decreased levels of IRS-1 and Raf-1 in the liver, compared with the levels in diabetic rats. Therefore, the antidiabetic actions of selenium and exendin-4 involve their effects on GLP-1R, IRS-1, and Raf-1 levels in the liver. © Springer Science+Business Media, LLC 2012.
dc.format.extent Pages: (922-935)
dc.language English
dc.publisher NEW YORK
dc.relation.ispartof Publication Name: Biochemical Genetics; Publication Year: 2012; Volume: 50; no. 41955; Pages: (922-935);
dc.source Scopus
dc.title Effects of selenium and exendin-4 on glucagon-like peptide-1 receptor, IRS-1, and Raf-1 in the liver of diabetic rats
dc.type Article
dc.contributor.affiliation Barakat, G.M., Department of Biological and Environmental Sciences, Faculty of Science, Beirut Arab University, Beirut, Lebanon
dc.contributor.affiliation Moustafa, M.E., Department of Biological and Environmental Sciences, Faculty of Science, Beirut Arab University, Beirut, Lebanon, Department of Biochemistry, Faculty of Science, Alexandria University, Alexandria 21511, Egypt
dc.contributor.affiliation Bikhazi, A.B., Department of Physiology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon
dc.contributor.authorAddress Moustafa, M.E.; Department of Biological and Environmental Sciences, Faculty of Science, Beirut Arab University, Beirut, Lebanon; email:
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Anatomy, Cell Biology and Physiological Sciences;
dc.contributor.authorDepartment Anatomy, Cell Biology and Physiological Sciences
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Barakat, GM
dc.contributor.authorInitials Moustafa, ME
dc.contributor.authorInitials Bikhazi, AB
dc.contributor.authorReprintAddress Moustafa, ME (reprint author), Univ Alexandria, Dept Biochem, Fac Sci, Alexandria 21511, Egypt.
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedTotWOSCount 1
dc.description.citedWOSCount 0
dc.format.extentCount 14
dc.identifier.coden BIGEB
dc.identifier.pubmedID 22983684
dc.identifier.scopusID 84871229527
dc.publisher.address 233 SPRING ST, NEW YORK, NY 10013 USA
dc.relation.ispartOfISOAbbr Biochem. Genet.
dc.relation.ispartOfIssue 41955
dc.relation.ispartofPubTitle Biochemical Genetics
dc.relation.ispartofPubTitleAbbr Biochem. Genet.
dc.relation.ispartOfVolume 50
dc.source.ID WOS:000310887500010
dc.type.publication Journal
dc.subject.otherAuthKeyword Antidiabetic
dc.subject.otherAuthKeyword Diabetes mellitus
dc.subject.otherAuthKeyword Exendin-4
dc.subject.otherAuthKeyword GLP-1 receptor
dc.subject.otherAuthKeyword Glutathione peroxidase-1
dc.subject.otherChemCAS bovine insulin, 11070-73-8
dc.subject.otherChemCAS exendin 4, 141732-76-5, 141758-74-9
dc.subject.otherChemCAS glucose, 50-99-7, 84778-64-3
dc.subject.otherChemCAS insulin receptor substrate 1, 175335-32-7
dc.subject.otherChemCAS sodium selenite, 10102-18-8
dc.subject.otherChemCAS Blood Glucose
dc.subject.otherChemCAS Hypoglycemic Agents
dc.subject.otherChemCAS Insulin
dc.subject.otherChemCAS Insulin Receptor Substrate Proteins
dc.subject.otherChemCAS Irs1 protein, rat
dc.subject.otherChemCAS MAP Kinase Kinase Kinases,
dc.subject.otherChemCAS Peptides
dc.subject.otherChemCAS RNA, Messenger
dc.subject.otherChemCAS Raf-1 protein, rat,
dc.subject.otherChemCAS Receptors, Glucagon
dc.subject.otherChemCAS Selenium, 7782-49-2
dc.subject.otherChemCAS Sodium Selenite, 10102-18-8
dc.subject.otherChemCAS Streptozocin, 18883-66-4
dc.subject.otherChemCAS Venoms
dc.subject.otherChemCAS exenatide, 141732-76-5
dc.subject.otherChemCAS glucagon-like peptide-1 receptor
dc.subject.otherIndex bovine insulin
dc.subject.otherIndex exendin 4
dc.subject.otherIndex glucagon like peptide 1 receptor
dc.subject.otherIndex glucose
dc.subject.otherIndex insulin receptor substrate 1
dc.subject.otherIndex Raf protein
dc.subject.otherIndex sodium selenite
dc.subject.otherIndex animal experiment
dc.subject.otherIndex animal model
dc.subject.otherIndex animal tissue
dc.subject.otherIndex article
dc.subject.otherIndex controlled study
dc.subject.otherIndex diabetes mellitus
dc.subject.otherIndex glucose blood level
dc.subject.otherIndex hyperglycemia
dc.subject.otherIndex liver
dc.subject.otherIndex male
dc.subject.otherIndex nonhuman
dc.subject.otherIndex protein blood level
dc.subject.otherIndex protein expression
dc.subject.otherIndex rat
dc.subject.otherIndex streptozocin diabetes
dc.subject.otherIndex Animals
dc.subject.otherIndex Blood Glucose
dc.subject.otherIndex Blotting, Western
dc.subject.otherIndex Diabetes Mellitus, Experimental
dc.subject.otherIndex Hypoglycemic Agents
dc.subject.otherIndex Insulin
dc.subject.otherIndex Insulin Receptor Substrate Proteins
dc.subject.otherIndex Liver
dc.subject.otherIndex Male
dc.subject.otherIndex MAP Kinase Kinase Kinases
dc.subject.otherIndex Peptides
dc.subject.otherIndex Rats
dc.subject.otherIndex Rats, Sprague-Dawley
dc.subject.otherIndex Receptors, Glucagon
dc.subject.otherIndex RNA, Messenger
dc.subject.otherIndex Selenium
dc.subject.otherIndex Sodium Selenite
dc.subject.otherIndex Streptozocin
dc.subject.otherIndex Time Factors
dc.subject.otherIndex Venoms
dc.subject.otherIndex Rattus
dc.subject.otherKeywordPlus GLUTATHIONE-PEROXIDASE
dc.subject.otherKeywordPlus SUPEROXIDE-DISMUTASE
dc.subject.otherKeywordPlus OXIDATIVE STRESS
dc.subject.otherKeywordPlus PROSTATE-CANCER
dc.subject.otherKeywordPlus BETA-CELL
dc.subject.otherKeywordPlus GLUCOSE
dc.subject.otherKeywordPlus MICE
dc.subject.otherKeywordPlus OVEREXPRESSION
dc.subject.otherKeywordPlus STIMULATION
dc.subject.otherWOS Biochemistry and Molecular Biology
dc.subject.otherWOS Genetics and Heredity

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