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Frequency of the CCR5-delta 32 chemokine receptor gene mutation in the Lebanese population

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dc.contributor.author Karam W.
dc.contributor.author Jurjus R.
dc.contributor.author Khoury N.
dc.contributor.author Khansa H.
dc.contributor.author Assad C.
dc.contributor.author Zalloua P.
dc.contributor.author Jurjus A.
dc.contributor.editor
dc.date Jul-2004
dc.date.accessioned 2017-09-07T06:59:59Z
dc.date.available 2017-09-07T06:59:59Z
dc.date.issued 2004
dc.identifier
dc.identifier.isbn
dc.identifier.issn 10203397
dc.identifier.uri http://hdl.handle.net/10938/11226
dc.description.abstract A direct correlation between HIV infection and mutation in the chemokine receptor (CCR5) gene has been established. However, such correlation has never been investigated in Lebanon. We report the frequency of the CCR5-delta 32 mutation in a random sample of 209 healthy, HIV-1 seronegative Lebanese aged 19-68. Overall, 4.8percent were heterozygous for the mutation. Homozygosity was absent from our sample. The frequency for the CCR5-delta 32 allele was 2.5percent. Distribution of the mutation was unaffected by sex, age, religion or educational level. The frequency in the Lebanese population is consistent with that in the origin of the mutation in northern Europe. This could be attributed to a gene flow into the Middle East from northern Europe.
dc.format.extent
dc.format.extent Pages: (671-675)
dc.language English
dc.relation.ispartof Publication Name: Eastern Mediterranean Health Journal; Publication Year: 2004; Volume: 10; no. 41734; Pages: (671-675);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other GENBANK: X91492
dc.title Frequency of the CCR5-delta 32 chemokine receptor gene mutation in the Lebanese population
dc.type Article
dc.contributor.affiliation Karam, W., Faculty of Public Health, Balamand University, Beirut, Lebanon
dc.contributor.affiliation Jurjus, R., Faculty of Medicine, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Khoury, N., Faculty of Public Health, Lebanese University, Beirut, Lebanon
dc.contributor.affiliation Khansa, H., Faculty of Public Health, Lebanese University, Beirut, Lebanon
dc.contributor.affiliation Assad, C., Division of Medical Sciences and Public Health, Lebanese Council for Scientific Research, Beirut, Lebanon
dc.contributor.affiliation Zalloua, P., Chronic Care Centre, Hazmieh, Lebanon
dc.contributor.affiliation Jurjus, A., Faculty of Medicine, American University of Beirut, Beirut, Lebanon
dc.contributor.authorAddress Karam, W.; Faculty of Public Health, Balamand University, Beirut, Lebanon
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Anatomy, Cell Biology and Physiological Sciences;
dc.contributor.authorDepartment Anatomy, Cell Biology and Physiological Sciences
dc.contributor.authorDivision
dc.contributor.authorEmail
dc.contributor.faculty Faculty of Medicine
dc.contributor.authorInitials empty
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited
dc.description.citedCount 4
dc.description.citedTotWOSCount
dc.description.citedWOSCount
dc.format.extentCount 5
dc.identifier.articleNo
dc.identifier.coden EMHJA
dc.identifier.pubmedID 16335661
dc.identifier.scopusID 28444491074
dc.identifier.url
dc.publisher.address
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr
dc.relation.ispartOfIssue 41734
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Eastern Mediterranean Health Journal
dc.relation.ispartofPubTitleAbbr East. Mediterr. Health J.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 10
dc.source.ID
dc.type.publication Journal
dc.subject.otherAuthKeyword
dc.subject.otherChemCAS Receptors, CCR5
dc.subject.otherIndex chemokine receptor CCR5
dc.subject.otherIndex adult
dc.subject.otherIndex age
dc.subject.otherIndex article
dc.subject.otherIndex controlled study
dc.subject.otherIndex correlation analysis
dc.subject.otherIndex education
dc.subject.otherIndex Europe
dc.subject.otherIndex female
dc.subject.otherIndex gene flow
dc.subject.otherIndex gene frequency
dc.subject.otherIndex gene mutation
dc.subject.otherIndex heterozygosity
dc.subject.otherIndex homozygosity
dc.subject.otherIndex human
dc.subject.otherIndex Human immunodeficiency virus infection
dc.subject.otherIndex Lebanon
dc.subject.otherIndex male
dc.subject.otherIndex Middle East
dc.subject.otherIndex nucleotide sequence
dc.subject.otherIndex population genetics
dc.subject.otherIndex religion
dc.subject.otherIndex serodiagnosis
dc.subject.otherIndex sex
dc.subject.otherIndex Adult
dc.subject.otherIndex Aged
dc.subject.otherIndex Analysis of Variance
dc.subject.otherIndex Blood Donors
dc.subject.otherIndex Female
dc.subject.otherIndex Frameshift Mutation
dc.subject.otherIndex Gene Deletion
dc.subject.otherIndex Gene Flow
dc.subject.otherIndex Gene Frequency
dc.subject.otherIndex Genetics, Population
dc.subject.otherIndex Genotype
dc.subject.otherIndex Heterozygote
dc.subject.otherIndex HIV Seronegativity
dc.subject.otherIndex Homozygote
dc.subject.otherIndex Hospitals, Teaching
dc.subject.otherIndex Humans
dc.subject.otherIndex Lebanon
dc.subject.otherIndex Male
dc.subject.otherIndex Middle Aged
dc.subject.otherIndex Mutation
dc.subject.otherIndex Polymerase Chain Reaction
dc.subject.otherIndex Population Surveillance
dc.subject.otherIndex Questionnaires
dc.subject.otherIndex Receptors, CCR5
dc.subject.otherKeywordPlus
dc.subject.otherWOS


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