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Alcoholism and neuro-immune-endocrine interactions: Physiochemical aspects

Show simple item record Haddad J.J.
dc.contributor.editor 2004 2017-10-03T15:43:30Z 2017-10-03T15:43:30Z 2004
dc.identifier 10.1016/j.bbrc.2004.08.119
dc.description.abstract The role of alcohol consumption and alcoholism as an addiction in regulating the chemistry of the brain and its physiology has gained a backlog of interest over the past few decades. Besides the notion that alcohol acts as a brain depressant, the molecular mechanisms and neuronal interactions are not well understood. Emerging evidence implicates alcohol as a neurochemical messenger that influences a cross talk amongst the nervous, immune, and endocrine systems. Specifically, alcohol acts as a crucial regulator of the hypothalamic-pituitary-adrenal (HPA) axis, thereby modulating the release of hormones, particularly adrenocorticotropic hormone (ACTH) and corticosterone (CORT). It is the aim of this review, therefore, to investigate current concepts on how alcohol, particularly ethanol, and alcoholism affect neuro-immune-endocrine neurochemical interactions via the regulation of the HPA axis, taking into consideration bio-behavioral and physiochemical aspects. © 2004 Published by Elsevier Inc.
dc.format.extent Pages: (361-371)
dc.language English
dc.publisher SAN DIEGO
dc.relation.ispartof Publication Name: Biochemical and Biophysical Research Communications; Publication Year: 2004; Volume: 323; no. 2; Pages: (361-371);
dc.source Scopus
dc.title Alcoholism and neuro-immune-endocrine interactions: Physiochemical aspects
dc.type Review
dc.contributor.affiliation Haddad, J.J., Department of Biology, Faculty of Arts and Sciences, Amer. Univ. Beirut, Beirut, Lebanon, United States
dc.contributor.authorAddress Department of Biology, Faculty of Arts and Sciences, Amer. Univ. Beirut, Beirut, LebanonUnited States; email:
dc.contributor.authorCorporate University: American University of Beirut; Faculty: Faculty of Arts and Sciences; Department: Biology;
dc.contributor.authorDepartment Biology
dc.contributor.faculty Faculty of Arts and Sciences
dc.contributor.authorInitials Haddad, JJ
dc.contributor.authorReprintAddress Haddad, JJ (reprint author), Amer Univ Beirut, Fac Arts and Sci, Dept Biol, Beirut, Lebanon.
dc.contributor.authorUniversity American University of Beirut
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dc.description.citedCount 23
dc.description.citedTotWOSCount 26
dc.description.citedWOSCount 21
dc.format.extentCount 11
dc.identifier.coden BBRCA
dc.identifier.pubmedID 15369760
dc.identifier.scopusID 4544349406
dc.publisher.address 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
dc.relation.ispartOfISOAbbr Biochem. Biophys. Res. Commun.
dc.relation.ispartOfIssue 2
dc.relation.ispartofPubTitle Biochemical and Biophysical Research Communications
dc.relation.ispartofPubTitleAbbr Biochem. Biophys. Res. Commun.
dc.relation.ispartOfVolume 323
dc.source.ID WOS:000224076900001
dc.type.publication Journal
dc.subject.otherAuthKeyword ACTH
dc.subject.otherAuthKeyword Alcohol
dc.subject.otherAuthKeyword CNS
dc.subject.otherAuthKeyword CORT
dc.subject.otherAuthKeyword Cytokine
dc.subject.otherAuthKeyword HPA
dc.subject.otherAuthKeyword Inflammation
dc.subject.otherAuthKeyword Neuro-immune-endocrine system
dc.subject.otherChemCAS alcohol, 64-17-5
dc.subject.otherChemCAS nitric oxide, 10102-43-9
dc.subject.otherChemCAS Adrenocorticotropic Hormone, 9002-60-2
dc.subject.otherChemCAS Corticosterone, 50-22-6
dc.subject.otherChemCAS Ethanol, 64-17-5
dc.subject.otherIndex alcohol
dc.subject.otherIndex hormone
dc.subject.otherIndex leptin
dc.subject.otherIndex nitric oxide
dc.subject.otherIndex steroid
dc.subject.otherIndex alcoholism
dc.subject.otherIndex behavior
dc.subject.otherIndex brain
dc.subject.otherIndex endocrine system
dc.subject.otherIndex hippocampus
dc.subject.otherIndex human
dc.subject.otherIndex hypothalamus hypophysis system
dc.subject.otherIndex immune system
dc.subject.otherIndex immunology
dc.subject.otherIndex limbic system
dc.subject.otherIndex neurochemistry
dc.subject.otherIndex physical chemistry
dc.subject.otherIndex priority journal
dc.subject.otherIndex regulatory mechanism
dc.subject.otherIndex review
dc.subject.otherIndex signal transduction
dc.subject.otherIndex Adrenocorticotropic Hormone
dc.subject.otherIndex Alcoholism
dc.subject.otherIndex Animals
dc.subject.otherIndex Corticosterone
dc.subject.otherIndex Ethanol
dc.subject.otherIndex Humans
dc.subject.otherIndex Hypothalamo-Hypophyseal System
dc.subject.otherIndex Neuroimmunomodulation
dc.subject.otherIndex Neurosecretory Systems
dc.subject.otherIndex Pituitary-Adrenal System
dc.subject.otherKeywordPlus PITUITARY-ADRENAL AXIS
dc.subject.otherKeywordPlus BETA-ENDORPHIN
dc.subject.otherKeywordPlus ETHANOL WITHDRAWAL
dc.subject.otherKeywordPlus FAMILY-HISTORY
dc.subject.otherKeywordPlus CORTISOL RESPONSES
dc.subject.otherKeywordPlus STIMULATION TEST
dc.subject.otherKeywordPlus EXPOSURE ALTERS
dc.subject.otherKeywordPlus ACTH-SECRETION
dc.subject.otherWOS Biochemistry and Molecular Biology
dc.subject.otherWOS Biophysics

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