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Amiloride and the regulation of NF-κB: An unsung crosstalk and missing link between fluid dynamics and oxidative stress-related inflammation - Controversy or pseudo-controversy?

Show simple item record Haddad J.J.
dc.contributor.editor 2005 2017-10-03T15:43:35Z 2017-10-03T15:43:35Z 2005
dc.identifier 10.1016/j.bbrc.2004.11.166
dc.description.abstract Understanding the biophysics of fluid dynamics within the context of transcriptional regulation, mediated by nuclear factor (NF)-κB, is crucial to developing a consensus on the molecular basis of fluid mechanics and imbalance. Amiloride, an antikaliuretic-diuretic agent, has recently entered the realm of NF-κB as a key player in regulating the molecular association of fluid dynamics with inflammation and oxidative stress. With the identification of flanking regions encoding the amiloride-sensitive channels that are NF-κB-responsive, a new theme emerges which underlies the significance of this association. What is the role of NF-κB in regulating fluid mechanics-is it a physiologic or immunologic function? Conversely, amiloride is purported as a major regulator of this transcriptional pathway. It is the mainstream of this survey, therefore, to outline current advances on the biophysics and nature of the interaction existing between amiloride, amiloride-sensitive channels, and NF-κB, while searching for potential molecular mechanisms. © 2004 Published by Elsevier Inc.
dc.format.extent Pages: (373-381)
dc.language English
dc.publisher SAN DIEGO
dc.relation.ispartof Publication Name: Biochemical and Biophysical Research Communications; Publication Year: 2005; Volume: 327; no. 2; Pages: (373-381);
dc.source Scopus
dc.title Amiloride and the regulation of NF-κB: An unsung crosstalk and missing link between fluid dynamics and oxidative stress-related inflammation - Controversy or pseudo-controversy?
dc.type Review
dc.contributor.affiliation Haddad, J.J., Department of Biology, Faculty of Arts and Sciences, Amer. Univ. Beirut, Beirut, Lebanon, United States, Depts. of Biol. and Biomed. Sciences, Faculty of Arts and Sciences, Lebanese Intl. Univ., Beirut, L., Lebanon
dc.contributor.authorAddress Department of Biology, Faculty of Arts and Sciences, Amer. Univ. Beirut, Beirut, LebanonUnited States; email:
dc.contributor.authorCorporate University: American University of Beirut; Faculty: Faculty of Arts and Sciences; Department: Biology;
dc.contributor.authorDepartment Biology
dc.contributor.faculty Faculty of Arts and Sciences
dc.contributor.authorInitials Haddad, JJ
dc.contributor.authorReprintAddress Haddad, JJ (reprint author), Amer Univ Beirut, Fac Arts and Sci, Dept Biol, Beirut, Lebanon.
dc.contributor.authorUniversity American University of Beirut
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dc.description.citedCount 10
dc.description.citedTotWOSCount 11
dc.description.citedWOSCount 10
dc.format.extentCount 9
dc.identifier.coden BBRCA
dc.identifier.pubmedID 15629126
dc.identifier.scopusID 11144300132
dc.publisher.address 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
dc.relation.ispartOfISOAbbr Biochem. Biophys. Res. Commun.
dc.relation.ispartOfIssue 2
dc.relation.ispartofPubTitle Biochemical and Biophysical Research Communications
dc.relation.ispartofPubTitleAbbr Biochem. Biophys. Res. Commun.
dc.relation.ispartOfVolume 327
dc.source.ID WOS:000226364000001
dc.type.publication Journal
dc.subject.otherAuthKeyword Amiloride
dc.subject.otherAuthKeyword Anti-diuretic
dc.subject.otherAuthKeyword Cytokine
dc.subject.otherAuthKeyword ENaC
dc.subject.otherAuthKeyword Fluid
dc.subject.otherAuthKeyword NF-κB
dc.subject.otherAuthKeyword Transcription
dc.subject.otherChemCAS (3 methylsulfonyl 4 piperidinobenzoyl)guanidine methanesulfonate, 141923-47-9
dc.subject.otherChemCAS 21 [4 [2,6 bis(1 pyrrolidinyl) 4 pyrimidinyl] 1 piperazinyl]pregna 1,4,9(11) triene 3,20 dione, 111668-89-4
dc.subject.otherChemCAS amiloride, 2016-88-8, 2609-46-3
dc.subject.otherChemCAS bafilomycin A1, 88899-55-2
dc.subject.otherChemCAS cimetidine, 51481-61-9, 70059-30-2
dc.subject.otherChemCAS clonidine, 4205-90-7, 4205-91-8, 57066-25-8
dc.subject.otherChemCAS harmaline, 304-21-2
dc.subject.otherChemCAS ibuprofen, 15687-27-1, 79261-49-7
dc.subject.otherChemCAS mitogen activated protein kinase, 142243-02-5
dc.subject.otherChemCAS trolox C, 56305-04-5
dc.subject.otherChemCAS urokinase, 139639-24-0
dc.subject.otherChemCAS Amiloride, 2609-46-3
dc.subject.otherChemCAS Diuretics
dc.subject.otherChemCAS NF-kappa B
dc.subject.otherIndex (3 methylsulfonyl 4 piperidinobenzoyl)guanidine methanesulfonate
dc.subject.otherIndex 21 [4 [2,6 bis(1 pyrrolidinyl) 4 pyrimidinyl] 1 piperazinyl]pregna 1,4,9(11) triene 3,20 dione
dc.subject.otherIndex amiloride
dc.subject.otherIndex bafilomycin A1
dc.subject.otherIndex cimetidine
dc.subject.otherIndex clonidine
dc.subject.otherIndex cytokine
dc.subject.otherIndex diuretic agent
dc.subject.otherIndex harmaline
dc.subject.otherIndex ibuprofen
dc.subject.otherIndex immunoglobulin enhancer binding protein
dc.subject.otherIndex ion channel
dc.subject.otherIndex mitogen activated protein kinase
dc.subject.otherIndex trolox C
dc.subject.otherIndex urokinase
dc.subject.otherIndex acidity
dc.subject.otherIndex biosynthesis
dc.subject.otherIndex concentration response
dc.subject.otherIndex cytokine production
dc.subject.otherIndex drug activity
dc.subject.otherIndex drug effect
dc.subject.otherIndex drug mechanism
dc.subject.otherIndex drug specificity
dc.subject.otherIndex dynamics
dc.subject.otherIndex enzyme activity
dc.subject.otherIndex enzyme regulation
dc.subject.otherIndex human
dc.subject.otherIndex immune system
dc.subject.otherIndex immunoregulation
dc.subject.otherIndex inflammation
dc.subject.otherIndex inhibition kinetics
dc.subject.otherIndex kidney interstitium
dc.subject.otherIndex liquid
dc.subject.otherIndex microenvironment
dc.subject.otherIndex molecular dynamics
dc.subject.otherIndex molecular interaction
dc.subject.otherIndex molecular mechanics
dc.subject.otherIndex nonhuman
dc.subject.otherIndex oxidative stress
dc.subject.otherIndex pH
dc.subject.otherIndex physics
dc.subject.otherIndex priority journal
dc.subject.otherIndex protein analysis
dc.subject.otherIndex protein function
dc.subject.otherIndex regulatory mechanism
dc.subject.otherIndex review
dc.subject.otherIndex Rhinovirus
dc.subject.otherIndex transcription regulation
dc.subject.otherIndex Amiloride
dc.subject.otherIndex Animals
dc.subject.otherIndex Diuretics
dc.subject.otherIndex Humans
dc.subject.otherIndex Inflammation
dc.subject.otherIndex NF-kappa B
dc.subject.otherIndex Oxidative Stress
dc.subject.otherKeywordPlus NITRIC-OXIDE SYNTHASE
dc.subject.otherKeywordPlus ENDOTHELIAL-CELLS
dc.subject.otherKeywordPlus NA+-H+ EXCHANGER
dc.subject.otherKeywordPlus EPITHELIAL-CELLS
dc.subject.otherKeywordPlus SODIUM-CHANNEL
dc.subject.otherKeywordPlus ACTIVATION
dc.subject.otherKeywordPlus LIPOPOLYSACCHARIDE
dc.subject.otherKeywordPlus MACROPHAGES
dc.subject.otherKeywordPlus INVOLVEMENT
dc.subject.otherKeywordPlus INHIBITION
dc.subject.otherWOS Biochemistry and Molecular Biology
dc.subject.otherWOS Biophysics

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