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Epigallocatechin-3-gallate induces apoptosis and cell cycle arrest in HTLV-1-positive and -negative leukemia cells

Show simple item record Harakeh S. Abu-El-Ardat K. Diab-Assaf M. Niedzwiecki A. El-Sabban M. Rath M.
dc.contributor.editor Mar-2008 2017-10-03T15:43:40Z 2017-10-03T15:43:40Z 2008
dc.identifier 10.1007/s12032-007-0036-6
dc.identifier.issn 13570560
dc.description.abstract The objective of this study is to evaluate the efficacy of epigallocatechin gallate against ATL cells. The anti-proliferative and pro-apoptotic effects of EGCG were evaluated in HTLV-1-positive and -negative cells. EGCG exhibited a marked decrease in proliferation of ATL cells at 96 h of treatment. The results indicated that TGF-α was down-regulated whereas levels of TGF-β2 increased. Cell cycle distribution analysis revealed an increase in cells in the pre-G1 phase which was confirmed by ELISA. The results on proteins showed an up-regulation of p53, Bax and p21 protein levels while the levels of Bcl-2α were down-regulated. © 2007 Humana Press Inc.
dc.format.extent Pages: (30-39)
dc.language English
dc.publisher TOTOWA
dc.relation.ispartof Publication Name: Medical Oncology; Publication Year: 2008; Volume: 25; no. 1; Pages: (30-39);
dc.source Scopus
dc.title Epigallocatechin-3-gallate induces apoptosis and cell cycle arrest in HTLV-1-positive and -negative leukemia cells
dc.type Article
dc.contributor.affiliation Harakeh, S., Biology Department, American University of Beirut, Beirut 11-0236, Lebanon
dc.contributor.affiliation Abu-El-Ardat, K., Biology Department, American University of Beirut, Beirut 11-0236, Lebanon
dc.contributor.affiliation Diab-Assaf, M., Biology Department, American University of Beirut, Beirut 11-0236, Lebanon
dc.contributor.affiliation Niedzwiecki, A., Dr. Rath Research Insitute, Santa Clara, CA, United States
dc.contributor.affiliation El-Sabban, M., Human Morphology Department, American University of Beirut, Beirut 11-0236, Lebanon
dc.contributor.affiliation Rath, M., Dr. Rath Research Insitute, Santa Clara, CA, United States
dc.contributor.authorAddress Harakeh, S.; Biology Department, American University of Beirut, Beirut 11-0236, Lebanon; email:
dc.contributor.authorCorporate University: American University of Beirut; Faculty: Faculty of Arts and Sciences; Department: Biology;
dc.contributor.authorDepartment Biology
dc.contributor.faculty Faculty of Arts and Sciences
dc.contributor.authorInitials Harakeh, S
dc.contributor.authorInitials Abu-El-Ardat, K
dc.contributor.authorInitials Diab-Assaf, M
dc.contributor.authorInitials Niedzwiecki, A
dc.contributor.authorInitials El-Sabban, M
dc.contributor.authorInitials Rath, M
dc.contributor.authorReprintAddress Harakeh, S (reprint author), Amer Univ Beirut, Dept Biol, Beirut 110236, Lebanon.
dc.contributor.authorResearcherID Harakeh, Steve-K-5709-2012
dc.contributor.authorUniversity American University of Beirut
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dc.description.citedCount 22
dc.description.citedTotWOSCount 24
dc.description.citedWOSCount 22
dc.format.extentCount 10
dc.identifier.coden MONCE
dc.identifier.pubmedID 18188712
dc.identifier.scopusID 42949123220
dc.publisher.address 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
dc.relation.ispartOfISOAbbr Med. Oncol.
dc.relation.ispartOfIssue 1
dc.relation.ispartofPubTitle Medical Oncology
dc.relation.ispartofPubTitleAbbr Med. Oncol.
dc.relation.ispartOfVolume 25
dc.source.ID WOS:000252280800004
dc.type.publication Journal
dc.subject.otherAuthKeyword Apoptosis
dc.subject.otherAuthKeyword Epigallocatechin-3- gallate (EGCG)
dc.subject.otherAuthKeyword Human T-cell Lymphotrophic Virus-1 (HTLV-1)
dc.subject.otherAuthKeyword p21
dc.subject.otherAuthKeyword p53
dc.subject.otherAuthKeyword Transforming Growth Factor (TGF)
dc.subject.otherChemCAS epigallocatechin gallate, 989-51-5
dc.subject.otherChemCAS protein bcl 2, 219306-68-0
dc.subject.otherChemCAS protein p21, 85306-28-1
dc.subject.otherChemCAS catechin, 13392-26-2, 154-23-4
dc.subject.otherChemCAS transforming growth factor, 76057-06-2
dc.subject.otherChemCAS Catechin, 154-23-4
dc.subject.otherChemCAS epigallocatechin gallate, 989-51-5
dc.subject.otherChemCAS RNA, Messenger
dc.subject.otherChemCAS Transforming Growth Factors, 76057-06-2
dc.subject.otherIndex epigallocatechin gallate
dc.subject.otherIndex protein Bax
dc.subject.otherIndex protein bcl 2
dc.subject.otherIndex protein p21
dc.subject.otherIndex protein p53
dc.subject.otherIndex transforming growth factor alpha
dc.subject.otherIndex transforming growth factor beta2
dc.subject.otherIndex catechin
dc.subject.otherIndex drug derivative
dc.subject.otherIndex epigallocatechin gallate
dc.subject.otherIndex messenger RNA
dc.subject.otherIndex transforming growth factor
dc.subject.otherIndex antineoplastic activity
dc.subject.otherIndex apoptosis
dc.subject.otherIndex article
dc.subject.otherIndex cell cycle arrest
dc.subject.otherIndex cell cycle G1 phase
dc.subject.otherIndex cell proliferation
dc.subject.otherIndex controlled study
dc.subject.otherIndex cytotoxicity
dc.subject.otherIndex down regulation
dc.subject.otherIndex drug efficacy
dc.subject.otherIndex enzyme linked immunosorbent assay
dc.subject.otherIndex flow cytometry
dc.subject.otherIndex human
dc.subject.otherIndex human cell
dc.subject.otherIndex Human T cell leukemia virus 1
dc.subject.otherIndex leukemia cell
dc.subject.otherIndex priority journal
dc.subject.otherIndex protein expression
dc.subject.otherIndex T cell leukemia
dc.subject.otherIndex upregulation
dc.subject.otherIndex apoptosis
dc.subject.otherIndex cell cycle
dc.subject.otherIndex drug effect
dc.subject.otherIndex genetics
dc.subject.otherIndex Human T cell leukemia virus 1
dc.subject.otherIndex isolation and purification
dc.subject.otherIndex pathology
dc.subject.otherIndex t cell leukemia lymphoma
dc.subject.otherIndex tumor cell line
dc.subject.otherIndex virology
dc.subject.otherIndex Apoptosis
dc.subject.otherIndex Catechin
dc.subject.otherIndex Cell Cycle
dc.subject.otherIndex Cell Line, Tumor
dc.subject.otherIndex Cell Proliferation
dc.subject.otherIndex Enzyme-Linked Immunosorbent Assay
dc.subject.otherIndex Flow Cytometry
dc.subject.otherIndex Human T-lymphotropic virus 1
dc.subject.otherIndex Humans
dc.subject.otherIndex Leukemia-Lymphoma, Adult T-Cell
dc.subject.otherIndex RNA, Messenger
dc.subject.otherIndex Transforming Growth Factors
dc.subject.otherKeywordPlus GREEN TEA EXTRACT
dc.subject.otherKeywordPlus PROSTATE CARCINOMA-CELLS
dc.subject.otherKeywordPlus HUMAN T-CELLS
dc.subject.otherKeywordPlus VIRUS TYPE-I
dc.subject.otherKeywordPlus TGF-BETA
dc.subject.otherKeywordPlus GROWTH-INHIBITION
dc.subject.otherKeywordPlus ASCORBIC-ACID
dc.subject.otherKeywordPlus KAPPA-B
dc.subject.otherKeywordPlus P53
dc.subject.otherWOS Oncology

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