Comparative Antiproliferative activities of wood and seeds essential oils of Juniperus Oxycedrus L. against K562 human chronic myelogenous leukemia cells

Saab A.M.; Gali-Muhtasib H.; Maietti S.; Grandini A.; Rossi D.; Lampronti I.; Gallerani E.; Fabbri E.; Gambari R.

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dc.contributor.author	Saab A.M.
dc.contributor.author	Gali-Muhtasib H.
dc.contributor.author	Maietti S.
dc.contributor.author	Grandini A.
dc.contributor.author	Rossi D.
dc.contributor.author	Lampronti I.
dc.contributor.author	Gallerani E.
dc.contributor.author	Fabbri E.
dc.contributor.author	Gambari R.
dc.contributor.editor
dc.date	2014
dc.date.accessioned	2017-10-03T15:45:34Z
dc.date.available	2017-10-03T15:45:34Z
dc.date.issued	2014
dc.identifier	10.1080/10412905.2013.829006
dc.identifier.isbn
dc.identifier.issn	10412905
dc.identifier.uri	http://hdl.handle.net/10938/12725
dc.description.abstract	The species Juniperus oxycedrus L. is a member of Cupressaceae family. The chemical composition and antiproliferative activity of wood and seeds essential oils of J. oxycedrus, grown wild in Lebanon, were evaluated in order to investigate whether these products could be used as sources of functional compounds. The most abundant components of the seeds essential oils were pinene, β-myrcene, limonene and δ-cadinene, while wood oil components included δ-cadinene, cis-thujopsene, τ-muurolol, widdrol, epi-cubenol, β-caryophyllene and calacorene. Both wood and seeds essential oils inhibited the proliferation of K562 cell line with ic50 values of 39.8±2.7 and 147.7±3.6 g-mL, respectively. The J. oxycedrus wood oil showed erythroid differentiation of 16.0±2.0percent at a concentration of 5 g-mL, while the seeds essential oil showed erythroid differentiation of 25.0±2.8percent at a concentration of 50 g-mL. © 2013 © 2013 Taylor and Francis.
dc.format.extent
dc.format.extent	Pages: (301-307)
dc.language	English
dc.publisher	Taylor and Francis Inc.; PHILADELPHIA
dc.relation.ispartof	Publication Name: Journal of Essential Oil Research; Publication Year: 2014; Volume: 26; no. 4; Pages: (301-307);
dc.relation.ispartofseries
dc.relation.uri
dc.source	Scopus
dc.subject.other
dc.title	Comparative Antiproliferative activities of wood and seeds essential oils of Juniperus Oxycedrus L. against K562 human chronic myelogenous leukemia cells
dc.type	Article
dc.contributor.affiliation	Saab, A.M., Faculty of Sciences II, Chemistry Department, Lebanese University, Fanar, Beirut, Lebanon
dc.contributor.affiliation	Gali-Muhtasib, H., Department of Biology, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation	Maietti, S., Department of Life Sciences and Biotechnology (SVeB), University of Ferrara, Ferrara, Italy
dc.contributor.affiliation	Grandini, A., Department of Life Sciences and Biotechnology (SVeB), University of Ferrara, Ferrara, Italy
dc.contributor.affiliation	Rossi, D., Department of Life Sciences and Biotechnology (SVeB), University of Ferrara, Ferrara, Italy
dc.contributor.affiliation	Lampronti, I., Department of Life Sciences and Biotechnology (SVeB), University of Ferrara, Ferrara, Italy
dc.contributor.affiliation	Gallerani, E., Department of Life Sciences and Biotechnology (SVeB), University of Ferrara, Ferrara, Italy
dc.contributor.affiliation	Fabbri, E., Department of Life Sciences and Biotechnology (SVeB), University of Ferrara, Ferrara, Italy
dc.contributor.affiliation	Gambari, R., Department of Life Sciences and Biotechnology (SVeB), University of Ferrara, Ferrara, Italy
dc.contributor.authorAddress	Rossi, D.; Department of Life Sciences and Biotechnology (SVeB), University of Ferrara, Ferrara, Italy; email: damiano.rossi@unife.it
dc.contributor.authorCorporate	University: American University of Beirut; Faculty: Faculty of Arts and Sciences; Department: Chemistry;
dc.contributor.authorDepartment	Chemistry
dc.contributor.authorDivision
dc.contributor.authorEmail	damiano.rossi@unife.it
dc.contributor.faculty	Faculty of Arts and Sciences
dc.contributor.authorInitials	Saab, AM
dc.contributor.authorInitials	Gali-Muhtasib, H
dc.contributor.authorInitials	Maietti, S
dc.contributor.authorInitials	Grandini, A
dc.contributor.authorInitials	Rossi, D
dc.contributor.authorInitials	Lampronti, I
dc.contributor.authorInitials	Gallerani, E
dc.contributor.authorInitials	Fabbri, E
dc.contributor.authorInitials	Gambari, R
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress	Rossi, D (reprint author), Univ Ferrara, Dept Life Sci and Biotechnol SVeB, I-44100 Ferrara, Italy.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity	American University of Beirut
dc.description.cited	Adams R. P., 2007, IDENTIFICATION ESSEN; Barrero Alejandro F., 1993, Flavour and Fragrance Journal, V8, P185, DOI 10.1002-ffj.2730080404; Bianchi N, 2000, BIOCHEM PHARMACOL, V60, P31, DOI 10.1016-S0006-2952(00)00297-5; Bianchi N, 2001, BRIT J HAEMATOL, V113, P951, DOI 10.1046-j.1365-2141.2001.02843.x; Bouhlal K., 1988, PARFUMS COSMETIQUES, V83, P73; Catelani G, 2002, BIOORGAN MED CHEM, V10, P347, DOI 10.1016-S0968-0896(01)00285-1; Cavaleiro C, 2006, J APPL MICROBIOL, V100, P1333, DOI 10.1111-j.1365-2672.2006.02862.x; Chiarabelli C, 2003, HAEMATOLOGICA, V88, P826; Cortesi R, 1998, EUR J HAEMATOL, V61, P295; Sanchez De Medina F., 1994, Planta Medica, V60, P197, DOI 10.1055-s-2006-959457; Fibach E, 2003, BLOOD, V102, P1276, DOI 10.1182-blood-2002-10-3095; Franco J.A., 1964, FLORA EUROPAEA, V1; Gambari R, 2007, CURR MED CHEM, V14, P199, DOI 10.2174-092986707779313318; Guerrini A, 2009, J AGR FOOD CHEM, V57, P4103, DOI 10.1021-jf803489p; Hanene M, 2012, NAT PROD RES, V26, P810, DOI 10.1080-14786419.2011.558014; Iyama E.W., 2003, J EXP HAEMATOL, V31, P592; Lampronti D., 2003, PHYTOMEDICINE, V10, P300; Lampronti I, 2006, INT J ONCOL, V29, P989; Loizzo MR, 2007, FOOD CHEM, V105, P572, DOI 10.1016-j.foodchem.2007.04.015; Loizzo M.R., 2008, CHEM BIODIVERS, V5, P481; Moreno L, 1998, PHARMACOL TOXICOL, V82, P108; Perrine SP, 2011, J CLIN PHARMACOL, V51, P1186, DOI 10.1177-0091270010379810; Puissant A, 2008, FASEB J, V22, P1894, DOI 10.1096-fj.07-101394; Rathore Ritesh, 2003, Med Health R I, V86, P240; Saab A.M., 2012, PLANTA MED, V78, P1; Salido S, 2002, J ETHNOPHARMACOL, V81, P129, DOI 10.1016-S0378-8741(02)00045-4; Tohme G., 2000, 1001 FLOWERS LEBANON, P309
dc.description.citedCount
dc.description.citedTotWOSCount	0
dc.description.citedWOSCount	0
dc.format.extentCount	7
dc.identifier.articleNo
dc.identifier.coden	JEORE
dc.identifier.pubmedID
dc.identifier.scopusID	84903272450
dc.identifier.url
dc.publisher.address	530 CHESTNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr	J. Essent. Oil Res.
dc.relation.ispartOfIssue	4
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle	Journal of Essential Oil Research
dc.relation.ispartofPubTitleAbbr	J. Essent. Oil Res.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume	26
dc.source.ID	WOS:000338021700010
dc.type.publication	Journal
dc.subject.otherAuthKeyword	antiproliferative activity
dc.subject.otherAuthKeyword	essential oils
dc.subject.otherAuthKeyword	GC-MS
dc.subject.otherAuthKeyword	Juniperus oxycedrus L
dc.subject.otherAuthKeyword	K562 cells
dc.subject.otherChemCAS
dc.subject.otherIndex	Cell culture
dc.subject.otherIndex	Monoterpenes
dc.subject.otherIndex	Anti-proliferative activities
dc.subject.otherIndex	Chemical compositions
dc.subject.otherIndex	Chronic Myelogenous Leukemia
dc.subject.otherIndex	Erythroid differentiation
dc.subject.otherIndex	Functional compounds
dc.subject.otherIndex	GC-MS
dc.subject.otherIndex	Juniperus oxycedrus L
dc.subject.otherIndex	K562 cells
dc.subject.otherIndex	Essential oils
dc.subject.otherIndex	Cupressaceae
dc.subject.otherIndex	Juniperus
dc.subject.otherIndex	Juniperus oxycedrus
dc.subject.otherKeywordPlus	GLOBIN GENE-EXPRESSION
dc.subject.otherKeywordPlus	ERYTHROID-DIFFERENTIATION
dc.subject.otherKeywordPlus	CHEMICAL-COMPOSITION
dc.subject.otherKeywordPlus	INDUCTION
dc.subject.otherKeywordPlus	TALLIMUSTINE
dc.subject.otherKeywordPlus	ANTIOXIDANT
dc.subject.otherKeywordPlus	EXTRACTS
dc.subject.otherKeywordPlus	INDUCERS
dc.subject.otherKeywordPlus	ANALOGS
dc.subject.otherKeywordPlus	ACID
dc.subject.otherWOS	Chemistry, Applied
dc.subject.otherWOS	Food Science and Technology

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