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Photocrosslinked alginate hydrogels with tunable biodegradation rates and mechanical properties

Show simple item record Jeon O. Bouhadir K.H. Mansour J.M. Alsberg E.
dc.contributor.editor 2009 2017-10-03T15:45:40Z 2017-10-03T15:45:40Z 2009
dc.identifier 10.1016/j.biomaterials.2009.01.034
dc.identifier.issn 01429612
dc.description.abstract Photocrosslinked and biodegradable alginate hydrogels were engineered for biomedical applications. Photocrosslinkable alginate macromers were prepared by reacting sodium alginate and 2-aminoethyl methacrylate in the presence of 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride and N-hydroxysuccinimide. Methacrylated alginates were photocrosslinked using ultraviolet light with 0.05percent photoinitiator. The swelling behavior, elastic moduli, and degradation rates of photocrosslinked alginate hydrogels were quantified and could be controlled by varying the degree of alginate methacrylation. The methacrylated alginate macromer and photocrosslinked alginate hydrogels exhibited low cytotoxicity when cultured with primary bovine chondrocytes. In addition, chondrocytes encapsulated in these hydrogels remained viable and metabolically active as demonstrated by Live-Dead cell staining and MTS assay. These photocrosslinked alginate hydrogels, with tailorable mechanical properties and degradation rates, may find great utility as therapeutic materials in regenerative medicine and bioactive factor delivery. © 2009 Elsevier Ltd. All rights reserved.
dc.format.extent Pages: (2724-2734)
dc.language English
dc.publisher OXFORD
dc.relation.ispartof Publication Name: Biomaterials; Publication Year: 2009; Volume: 30; no. 14; Pages: (2724-2734);
dc.source Scopus
dc.title Photocrosslinked alginate hydrogels with tunable biodegradation rates and mechanical properties
dc.type Article
dc.contributor.affiliation Jeon, O., Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, United States
dc.contributor.affiliation Bouhadir, K.H., Department of Chemistry, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Mansour, J.M., Department of Mechanical and Aerospace Engineering, Case Western Reserve University, Cleveland, OH 44106, United States, Department of Orthopaedic Surgery, Case Western Reserve University, Cleveland, OH 44106, United States
dc.contributor.affiliation Alsberg, E., Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, United States, Department of Orthopaedic Surgery, Case Western Reserve University, Cleveland, OH 44106, United States
dc.contributor.authorAddress Alsberg, E.; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, United States; email:
dc.contributor.authorCorporate University: American University of Beirut; Faculty: Faculty of Arts and Sciences; Department: Chemistry;
dc.contributor.authorDepartment Chemistry
dc.contributor.faculty Faculty of Arts and Sciences
dc.contributor.authorInitials Jeon, O
dc.contributor.authorInitials Bouhadir, KH
dc.contributor.authorInitials Mansour, JM
dc.contributor.authorInitials Alsberg, E
dc.contributor.authorReprintAddress Alsberg, E (reprint author), Case Western Reserve Univ, Dept Biomed Engn, Cleveland, OH 44106 USA.
dc.contributor.authorUniversity American University of Beirut
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dc.description.citedCount 128
dc.description.citedTotWOSCount 132
dc.description.citedWOSCount 128
dc.format.extentCount 11
dc.identifier.coden BIMAD
dc.identifier.pubmedID 19201462
dc.identifier.scopusID 61549109884
dc.relation.ispartOfISOAbbr Biomaterials
dc.relation.ispartOfIssue 14
dc.relation.ispartofPubTitle Biomaterials
dc.relation.ispartofPubTitleAbbr Biomaterials
dc.relation.ispartOfVolume 30
dc.source.ID WOS:000264953900008
dc.type.publication Journal
dc.subject.otherAuthKeyword Alginate
dc.subject.otherAuthKeyword Biodegradable
dc.subject.otherAuthKeyword Biomaterial
dc.subject.otherAuthKeyword Hydrogel
dc.subject.otherAuthKeyword Photopolymerization
dc.subject.otherAuthKeyword Tissue engineering
dc.subject.otherChemCAS alginic acid, 28961-37-7, 29894-36-8, 9005-32-7, 9005-38-3
dc.subject.otherChemCAS Alginates
dc.subject.otherChemCAS Glucuronic Acid, 576-37-4
dc.subject.otherChemCAS Hexuronic Acids
dc.subject.otherChemCAS Hydrogels
dc.subject.otherChemCAS Water, 7732-18-5
dc.subject.otherChemCAS alginic acid, 9005-32-7
dc.subject.otherIndex Alginate hydrogels
dc.subject.otherIndex Bio-medical applications
dc.subject.otherIndex Bioactive factors
dc.subject.otherIndex Biodegradable
dc.subject.otherIndex Biodegradation rates
dc.subject.otherIndex Bovine chondrocytes
dc.subject.otherIndex Carbodiimide hydrochlorides
dc.subject.otherIndex Chondrocytes
dc.subject.otherIndex Degradation rates
dc.subject.otherIndex Macromer
dc.subject.otherIndex Macromers
dc.subject.otherIndex Methacrylation
dc.subject.otherIndex N-hydroxysuccinimide
dc.subject.otherIndex Photoinitiator
dc.subject.otherIndex Regenerative medicines
dc.subject.otherIndex Sodium alginates
dc.subject.otherIndex Swelling behaviors
dc.subject.otherIndex Therapeutic materials
dc.subject.otherIndex Ultra-violet lights
dc.subject.otherIndex Alginate
dc.subject.otherIndex Biochemistry
dc.subject.otherIndex Biodegradation
dc.subject.otherIndex Biomechanics
dc.subject.otherIndex Body fluids
dc.subject.otherIndex Catalyst activity
dc.subject.otherIndex Degradation
dc.subject.otherIndex Elastic moduli
dc.subject.otherIndex Mechanical properties
dc.subject.otherIndex Photopolymerization
dc.subject.otherIndex Sodium
dc.subject.otherIndex Tissue engineering
dc.subject.otherIndex Ultraviolet radiation
dc.subject.otherIndex Hydrogels
dc.subject.otherIndex alginic acid
dc.subject.otherIndex animal cell
dc.subject.otherIndex article
dc.subject.otherIndex biodegradability
dc.subject.otherIndex biomedical engineering
dc.subject.otherIndex cartilage cell
dc.subject.otherIndex cell adhesion
dc.subject.otherIndex cell structure
dc.subject.otherIndex controlled study
dc.subject.otherIndex cytotoxicity
dc.subject.otherIndex encapsulation
dc.subject.otherIndex hydrogel
dc.subject.otherIndex nonhuman
dc.subject.otherIndex priority journal
dc.subject.otherIndex synthesis
dc.subject.otherIndex Alginates
dc.subject.otherIndex Animals
dc.subject.otherIndex Cattle
dc.subject.otherIndex Cell Shape
dc.subject.otherIndex Cell Survival
dc.subject.otherIndex Cells, Cultured
dc.subject.otherIndex Chondrocytes
dc.subject.otherIndex Glucuronic Acid
dc.subject.otherIndex Hexuronic Acids
dc.subject.otherIndex Hydrogels
dc.subject.otherIndex Kinetics
dc.subject.otherIndex Magnetic Resonance Spectroscopy
dc.subject.otherIndex Molecular Structure
dc.subject.otherIndex Photochemical Processes
dc.subject.otherIndex Stress, Mechanical
dc.subject.otherIndex Water
dc.subject.otherIndex Bovinae
dc.subject.otherKeywordPlus IN-VIVO BONE
dc.subject.otherKeywordPlus DRUG-DELIVERY
dc.subject.otherKeywordPlus CELLS
dc.subject.otherKeywordPlus BIOMATERIALS
dc.subject.otherKeywordPlus CARTILAGE
dc.subject.otherKeywordPlus DIFFERENTIATION
dc.subject.otherKeywordPlus CHONDROCYTES
dc.subject.otherWOS Engineering, Biomedical
dc.subject.otherWOS Materials Science, Biomaterials

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