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Intracortical augmenting responses in networks of reduced compartmental models of tufted layer 5 cells

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dc.contributor.author Karameh F.N.
dc.contributor.author Massaquoi S.G.
dc.contributor.editor
dc.date 2009
dc.date.accessioned 2017-10-04T11:06:41Z
dc.date.available 2017-10-04T11:06:41Z
dc.date.issued 2009
dc.identifier 10.1152/jn.01280.2007
dc.identifier.isbn
dc.identifier.issn 00223077
dc.identifier.uri http://hdl.handle.net/10938/14062
dc.description.abstract Augmenting responses (ARs) are characteristic recruitment phenomena that can be generated in target neural populations by repetitive intracortical or thalamic stimulation and that may facilitate activity transmission from thalamic nuclei to the cortex or between cortical areas. Experimental evidence suggests a role for cortical layer 5 in initiating at least one form of augmentation. We present a three-compartment model of tufted layer 5 (TL5) cells that faithfully reproduces a wide range of dynamics in these neurons that previously has been achieved only partially and in much more complex models. Using this model, the simplest network exhibiting AR was a single pair of TL5 and inhibitory (IN5) neurons. Intracellularly, AR initiation was controlled by low-threshold Ca 2+ current (I T), which promoted TL5 rebound firing, whereas AR strength was dictated by inward-rectifying current (I h), which regulated TL5 multiple-spike firing and also prevented excessive firing under high-amplitude stimuli. Synaptically, AR was significantly more salient under concurrent stimulus delivery to superficial and deep dendritic zones of TL5 cells than under conventional single-zone stimuli. Moreover, slow GABA-B-mediated inhibition in TL5 cells controlled AR strength and frequency range. Finally, a network model of two cortical populations interacting across functional hierarchy showed that intracortical AR occurred prominently upon exciting superficial cortical layers either directly or via intrinsic connections, with AR frequency dictated by connection strength and background activity. Overall, the investigation supports a central role for a TL5-IN5 skeleton network in low-frequency cortical dynamics in vivo, particularly across functional hierarchies, and presents neuronal models that facilitate accurate large-scale simulations. Copyright © 2009 The American Physiological Society.
dc.format.extent
dc.format.extent Pages: (207-233)
dc.language English
dc.publisher BETHESDA
dc.relation.ispartof Publication Name: Journal of Neurophysiology; Publication Year: 2009; Volume: 101; no. 1; Pages: (207-233);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Intracortical augmenting responses in networks of reduced compartmental models of tufted layer 5 cells
dc.type Article
dc.contributor.affiliation Karameh, F.N., Department of Electrical and Computer Engineering, American University of Beirut, Beirut, Lebanon, Department of Electrical and Computer Engineering, American University of Beirut, Riad el Solh, 1107-2020, Beirut, Lebanon
dc.contributor.affiliation Massaquoi, S.G., Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States, Massachusetts Institute of Technology-Harvard Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States
dc.contributor.authorAddress Karameh, F. N.; Department of Electrical and Computer Engineering, American University of Beirut, Riad el Solh, 1107-2020, Beirut, Lebanon; email: fk14@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut; Faculty: Faculty of Engineering and Architecture; Department: Electrical and Computer Engineering;
dc.contributor.authorDepartment Electrical and Computer Engineering
dc.contributor.authorDivision
dc.contributor.authorEmail fk14@aub.edu.lb
dc.contributor.authorFaculty Faculty of Engineering and Architecture
dc.contributor.authorInitials Karameh, FN
dc.contributor.authorInitials Massaquoi, SG
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Karameh, FN (reprint author), American Univ, Dept Elect and Comp Engn, Beirut 11072020, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut
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dc.description.citedCount 1
dc.description.citedTotWOSCount 1
dc.description.citedWOSCount 1
dc.format.extentCount 27
dc.identifier.articleNo
dc.identifier.coden JONEA
dc.identifier.pubmedID 18922956
dc.identifier.scopusID 58849130698
dc.identifier.url
dc.publisher.address 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
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dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr J. Neurophysiol.
dc.relation.ispartOfIssue 1
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Journal of Neurophysiology
dc.relation.ispartofPubTitleAbbr J. Neurophysiol.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 101
dc.source.ID WOS:000262410800018
dc.type.publication Journal
dc.subject.otherAuthKeyword
dc.subject.otherChemCAS calcium, 14092-94-5, 7440-70-2
dc.subject.otherChemCAS Calcium Channels, T-Type
dc.subject.otherChemCAS Potassium Channels, Calcium-Activated
dc.subject.otherChemCAS Receptors, GABA-B
dc.subject.otherChemCAS Receptors, Muscarinic
dc.subject.otherChemCAS Sodium Channels
dc.subject.otherIndex calcium
dc.subject.otherIndex article
dc.subject.otherIndex brain cell
dc.subject.otherIndex brain cortex
dc.subject.otherIndex calcium current
dc.subject.otherIndex cell membrane potential
dc.subject.otherIndex controlled study
dc.subject.otherIndex electrostimulation
dc.subject.otherIndex human
dc.subject.otherIndex human cell
dc.subject.otherIndex hyperpolarization
dc.subject.otherIndex inhibitory postsynaptic potential
dc.subject.otherIndex interneuron
dc.subject.otherIndex priority journal
dc.subject.otherIndex Algorithms
dc.subject.otherIndex Attention
dc.subject.otherIndex Calcium Channels, T-Type
dc.subject.otherIndex Cerebral Cortex
dc.subject.otherIndex Dendrites
dc.subject.otherIndex Electrophysiology
dc.subject.otherIndex Interneurons
dc.subject.otherIndex Models, Neurological
dc.subject.otherIndex Neural Networks (Computer)
dc.subject.otherIndex Neurons
dc.subject.otherIndex Photic Stimulation
dc.subject.otherIndex Potassium Channels, Calcium-Activated
dc.subject.otherIndex Receptors, GABA-B
dc.subject.otherIndex Receptors, Muscarinic
dc.subject.otherIndex Recruitment, Neurophysiological
dc.subject.otherIndex Sodium Channels
dc.subject.otherIndex Thalamus
dc.subject.otherKeywordPlus NEOCORTICAL PYRAMIDAL NEURONS
dc.subject.otherKeywordPlus DUAL INTRACELLULAR-RECORDINGS
dc.subject.otherKeywordPlus SHORT-TERM PLASTICITY
dc.subject.otherKeywordPlus RAT VISUAL-CORTEX
dc.subject.otherKeywordPlus INHIBITORY POSTSYNAPTIC POTENTIALS
dc.subject.otherKeywordPlus PRIMARY SOMATOSENSORY CORTEX
dc.subject.otherKeywordPlus MEDIAL FRONTAL-CORTEX
dc.subject.otherKeywordPlus IN-VIVO
dc.subject.otherKeywordPlus SENSORIMOTOR CORTEX
dc.subject.otherKeywordPlus SYNAPTIC RESPONSES
dc.subject.otherWOS Neurosciences
dc.subject.otherWOS Physiology


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