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Modeling and analysis of gene expression mechanisms: A communication theory approach

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dc.contributor.author Dawy Z.
dc.contributor.author Gonzalez F.M.
dc.contributor.author Hagenauer J.
dc.contributor.author Mueller J.C.
dc.contributor.editor
dc.date 2005
dc.date.accessioned 2017-10-04T11:07:13Z
dc.date.available 2017-10-04T11:07:13Z
dc.date.issued 2005
dc.identifier
dc.identifier.isbn
dc.identifier.issn 05361486
dc.identifier.uri http://hdl.handle.net/10938/14432
dc.description.abstract The increase in the availability of genetic data in the last years is prompting the efforts to use tools from communications engineering for the understanding of genetic information. Processes in molecular biology can be modeled through the use of these tools. A communication theory based model for the process of translation in gene expression is proposed. The model is based on the assumption that the ribosome decodes the mRNA sequences using the 3' end of the 16SrRNA molecule as a one dimensional codebook. The biological consistency of the model is proven in the detection of the Shine-Dalgarno signal and the initiation codon for translation initiation. Furthermore, implications on the role of the 16SrRNA 3' end in the complete process of prokaryotic translation are presented and discussed. Interestingly, the obtained results lay out the possibility of an interaction of this part of the ribosome in the process of translation termination. Finally, results obtained via the proposed model are compared with published experimental results for different mutations of the rRNA molecule. Total agreement between both sets of results prove the validity of the proposed model. By means of simulated mutations in the last 13 bases of the 16SrRNA, a global analysis of this part of the ribosome in the process of translation is established. This work illustrates the relevance of communication theory based models for genetic regulatory systems. © 2005 IEEE.
dc.format.extent
dc.format.extent Pages: (815-819)
dc.language English
dc.relation.ispartof Publication Name: IEEE International Conference on Communications; Conference Title: 2005 IEEE International Conference on Communications, ICC 2005; Conference Date: 16 May 2005 through 20 May 2005; Conference Location: Seoul; Publication Year: 2005; Volume: 2; Pages: (815-819);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Modeling and analysis of gene expression mechanisms: A communication theory approach
dc.type Conference Paper
dc.contributor.affiliation Dawy, Z., Munich University of Technology, Institute for Communications Engineering (LNT), Arcisstr. 21, 80290 Munich, Germany, American University of Beirut, Department of Electrical and Computer Engineering, Beirut, Lebanon
dc.contributor.affiliation González, F.M., Munich University of Technology, Institute for Communications Engineering (LNT), Arcisstr. 21, 80290 Munich, Germany
dc.contributor.affiliation Hagenauer, J., Munich University of Technology, Institute for Communications Engineering (LNT), Arcisstr. 21, 80290 Munich, Germany
dc.contributor.affiliation Mueller, J.C., National Research Center for Environment and Health (GSF), Ingolstaedter Landstr. 1, 85764 Neuherberg, Germany
dc.contributor.authorAddress Dawy, Z.; Munich University of Technology, Institute for Communications Engineering (LNT), Arcisstr. 21, 80290 Munich, Germany; email: zaher.dawy@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut; Faculty: Faculty of Engineering and Architecture; Department: Electrical and Computer Engineering;
dc.contributor.authorDepartment Electrical and Computer Engineering
dc.contributor.authorDivision
dc.contributor.authorEmail
dc.contributor.authorFaculty Faculty of Engineering and Architecture
dc.contributor.authorInitials
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut
dc.description.cited
dc.description.citedCount 4
dc.description.citedTotWOSCount
dc.description.citedWOSCount
dc.format.extentCount 5
dc.identifier.articleNo
dc.identifier.coden
dc.identifier.pubmedID
dc.identifier.scopusID 24344465334
dc.identifier.url
dc.publisher.address
dc.relation.ispartofConference Conference Title: 2005 IEEE International Conference on Communications, ICC 2005 : Conference Date: 16 May 2005 through 20 May 2005 , Conference Location: Seoul.
dc.relation.ispartofConferenceCode 65541
dc.relation.ispartofConferenceDate 16 May 2005 through 20 May 2005
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc Seoul
dc.relation.ispartofConferenceSponsor IEEE Communications Society
dc.relation.ispartofConferenceTitle 2005 IEEE International Conference on Communications, ICC 2005
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr
dc.relation.ispartOfIssue
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle IEEE International Conference on Communications
dc.relation.ispartofPubTitleAbbr IEEE Int Conf Commun
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 2
dc.source.ID
dc.type.publication Series
dc.subject.otherAuthKeyword
dc.subject.otherChemCAS
dc.subject.otherIndex Communication systems
dc.subject.otherIndex Computer simulation
dc.subject.otherIndex Mathematical models
dc.subject.otherIndex Molecular biology
dc.subject.otherIndex Mutagenesis
dc.subject.otherIndex RNA
dc.subject.otherIndex Codebooks
dc.subject.otherIndex Gene expressions
dc.subject.otherIndex Genetic information
dc.subject.otherIndex Ribosomes
dc.subject.otherIndex Genetic engineering
dc.subject.otherKeywordPlus
dc.subject.otherWOS


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