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A randomized trial comparing colloid preload to coload during spinal anesthesia for elective cesarean delivery

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dc.contributor.author Siddik-Sayyid S.M.
dc.contributor.author Nasr V.G.
dc.contributor.author Taha S.K.
dc.contributor.author Zbeide R.A.
dc.contributor.author Shehade J.-M.A.
dc.contributor.author Al Alami A.A.
dc.contributor.author Mokadem F.H.
dc.contributor.author Abdallah F.W.
dc.contributor.author Baraka A.S.
dc.contributor.author Aouad M.T.
dc.contributor.editor
dc.date Oct-2009
dc.date.accessioned 2017-10-05T15:29:06Z
dc.date.available 2017-10-05T15:29:06Z
dc.date.issued 2009
dc.identifier 10.1213/ane.0b013e3181b2bd6b
dc.identifier.isbn
dc.identifier.issn 00032999
dc.identifier.uri http://hdl.handle.net/10938/15096
dc.description.abstract BACKGROUND: Hypotension after spinal anesthesia for cesarean delivery is common. Previous studies have demonstrated that a crystalloid fluid coload (rapid administration of a fluid bolus starting at the time of intrathecal injection) is superior to the conventional crystalloid preload (fluid administered before the intrathecal injection) for preventing hypotension. Colloid preload provides a sustained increase in central blood volume. We hypothesized that, in contrast to crystalloid, a colloid preload may be more effective than colloid coload for reducing the incidence of spinal anesthesia-induced hypotension. METHODS: In this double-blind study, 178 patients were randomly assigned to receive a preload of 500 mL of hydroxyethyl starch over a period of 15-20 min before initiation of spinal anesthesia (n = 90) or an identical fluid bolus of hydroxyethyl starch starting at the time of identification of cerebrospinal fluid (n = 88). Vasopressors (ephedrine or phenylephrine) were administered if systolic arterial blood pressure decreased less than 80percent of the baseline pressure and 100 mm Hg, or with smaller decreases in blood pressure if accompanied by nausea, vomiting, or dizziness. The primary outcome was the incidence of hypotension (defined as the administration of at least one dose of vasopressor). RESULTS: There was no significant difference between the groups in the incidence of hypotension (68percent in preload group and 75percent in coload group, 95percent confidence interval of difference -6percent-20percent; P = 0.28), doses of ephedrine and phenylephrine, and number of vasopressor unit doses. The incidence of severe hypotension (systolic blood pressure 80 mm Hg) was 16percent in the preload group and 22percent in the coload group (P = 0.30). There were no differences in the incidence of nausea and-or vomiting, or neonatal outcome between the groups. CONCLUSION: There was no difference in the incidence of hypotension in women who received colloid administration before the initiation of spinal anesthesia compared with at the time of initiation of anesthesia. Both modalities are inefficient as single interventions to prevent hypotension. © 2009 by International Anesthesia Research Society.
dc.format.extent
dc.format.extent Pages: (1219-1224)
dc.language English
dc.publisher PHILADELPHIA
dc.relation.ispartof Publication Name: Anesthesia and Analgesia; Publication Year: 2009; Volume: 109; no. 4; Pages: (1219-1224);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title A randomized trial comparing colloid preload to coload during spinal anesthesia for elective cesarean delivery
dc.type Article
dc.contributor.affiliation Siddik-Sayyid, S.M., Department of Anesthesiology, American University of Beirut Medical Center, PO Box 11-0236, Beirut, Lebanon
dc.contributor.affiliation Nasr, V.G., Department of Anesthesiology, American University of Beirut Medical Center, PO Box 11-0236, Beirut, Lebanon
dc.contributor.affiliation Taha, S.K., Department of Anesthesiology, American University of Beirut Medical Center, PO Box 11-0236, Beirut, Lebanon
dc.contributor.affiliation Zbeide, R.A., Department of Anesthesiology, American University of Beirut Medical Center, PO Box 11-0236, Beirut, Lebanon
dc.contributor.affiliation Shehade, J.-M.A., Department of Anesthesiology, American University of Beirut Medical Center, PO Box 11-0236, Beirut, Lebanon
dc.contributor.affiliation Al Alami, A.A., Department of Anesthesiology, American University of Beirut Medical Center, PO Box 11-0236, Beirut, Lebanon
dc.contributor.affiliation Mokadem, F.H., Department of Anesthesiology, American University of Beirut Medical Center, PO Box 11-0236, Beirut, Lebanon
dc.contributor.affiliation Abdallah, F.W., Department of Anesthesiology, American University of Beirut Medical Center, PO Box 11-0236, Beirut, Lebanon
dc.contributor.affiliation Baraka, A.S., Department of Anesthesiology, American University of Beirut Medical Center, PO Box 11-0236, Beirut, Lebanon
dc.contributor.affiliation Aouad, M.T., Department of Anesthesiology, American University of Beirut Medical Center, PO Box 11-0236, Beirut, Lebanon
dc.contributor.authorAddress Aouad, M. T.; Department of Anesthesiology, American University of Beirut Medical Center, PO Box 11-0236, Beirut, Lebanon; email: mm01@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Anesthesiology;
dc.contributor.authorDepartment Anesthesiology
dc.contributor.authorDivision
dc.contributor.authorEmail mm01@aub.edu.lb
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Siddik-Sayyid, SM
dc.contributor.authorInitials Nasr, VG
dc.contributor.authorInitials Taha, SK
dc.contributor.authorInitials Zbeide, RA
dc.contributor.authorInitials Shehade, JMA
dc.contributor.authorInitials Al Alami, AA
dc.contributor.authorInitials Mokadem, FH
dc.contributor.authorInitials Abdallah, FW
dc.contributor.authorInitials Baraka, AS
dc.contributor.authorInitials Aouad, MT
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Aouad, MT (reprint author), Amer Univ Beirut, Med Ctr, Dept Anesthesiol, POB 11-0236, Beirut, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited COVINO BG, 1994, HDB SPINAL ANESTHESI; Dyer RA, 2004, ANAESTH INTENS CARE, V32, P351; Husaini SW, 1998, INT J OBSTET ANESTH, V7, P76, DOI 10.1016-S0959-289X(98)90001-2; JACKSON R, 1995, BRIT J ANAESTH, V75, P262; Kamenik M, 2001, ANESTH ANALG, V92, P710; KARINEN J, 1995, BRIT J ANAESTH, V75, P531; Kee WDN, 2001, ANESTH ANALG, V93, P703; Kee WDN, 2005, ANESTHESIOLOGY, V103, P744, DOI 10.1097-00000542-200510000-00012; KESTIN IG, 1991, BRIT J ANAESTH, V66, P596, DOI 10.1093-bja-66.5.596; LAXENAIRE MC, 1994, ANN FR ANESTH, V13, P301, DOI 10.1016-S0750-7658(94)80038-3; MACLENNAN FM, 1987, ANAESTHESIA, V42, P141, DOI 10.1111-j.1365-2044.1987.tb02986.x; Mojica JL, 2002, ANESTH ANALG, V94, P432, DOI 10.1097-00000539-200202000-00039; MORGAN P, 1994, CAN J ANAESTH, V41, P404; Morgan PJ, 2001, ANESTH ANALG, V92, P997; Nishikawa Koichi, 2007, J Clin Monit Comput, V21, P125, DOI 10.1007-s10877-006-9066-4; Pouta AM, 1996, ANAESTHESIA, V51, P128, DOI 10.1111-j.1365-2044.1996.tb07698.x; Riley Edward T., 1995, Anesthesia and Analgesia, V81, P838, DOI 10.1097-00000539-199510000-00031; ROBSON S, 1989, ANAESTHESIA, V44, P475, DOI 10.1111-j.1365-2044.1989.tb11372.x; ROCKE DA, 1995, BRIT J ANAESTH, V75, P257; ROUT CC, 1993, ANESTHESIOLOGY, V79, P262, DOI 10.1097-00000542-199308000-00011; Thomas DG, 1996, BRIT J ANAESTH, V76, P61; Ueyama H, 1999, ANESTHESIOLOGY, V91, P1571, DOI 10.1097-00000542-199912000-00006; Vercauteren MP, 1996, BRIT J ANAESTH, V76, P731
dc.description.citedCount 28
dc.description.citedTotWOSCount 25
dc.description.citedWOSCount 21
dc.format.extentCount 6
dc.identifier.articleNo
dc.identifier.coden AACRA
dc.identifier.pubmedID 19641050
dc.identifier.scopusID 70349575946
dc.identifier.url
dc.publisher.address 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Anesth. Analg.
dc.relation.ispartOfIssue 4
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Anesthesia and Analgesia
dc.relation.ispartofPubTitleAbbr Anesth. Analg.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 109
dc.source.ID WOS:000270209100037
dc.type.publication Journal
dc.subject.otherAuthKeyword
dc.subject.otherChemCAS Ringer lactate solution, 8022-63-7
dc.subject.otherChemCAS bupivacaine, 18010-40-7, 2180-92-9, 55750-21-5
dc.subject.otherChemCAS ephedrine, 299-42-3, 50-98-6
dc.subject.otherChemCAS hetastarch, 9005-27-0
dc.subject.otherChemCAS metoclopramide, 12707-59-4, 2576-84-3, 364-62-5, 7232-21-5
dc.subject.otherChemCAS morphine, 52-26-6, 57-27-2
dc.subject.otherChemCAS oxytocin, 50-56-6, 54577-94-5
dc.subject.otherChemCAS phenylephrine, 532-38-7, 59-42-7, 61-76-7
dc.subject.otherChemCAS Colloids
dc.subject.otherChemCAS Ephedrine, 299-42-3
dc.subject.otherChemCAS Hetastarch, 9005-27-0
dc.subject.otherChemCAS Phenylephrine, 59-42-7
dc.subject.otherChemCAS Plasma Substitutes
dc.subject.otherChemCAS Vasoconstrictor Agents
dc.subject.otherIndex bupivacaine
dc.subject.otherIndex ephedrine
dc.subject.otherIndex hetastarch
dc.subject.otherIndex metoclopramide
dc.subject.otherIndex morphine
dc.subject.otherIndex oxytocin
dc.subject.otherIndex phenylephrine
dc.subject.otherIndex Ringer lactate solution
dc.subject.otherIndex ephedrine
dc.subject.otherIndex hetastarch
dc.subject.otherIndex phenylephrine
dc.subject.otherIndex plasma substitute
dc.subject.otherIndex vasoconstrictor agent
dc.subject.otherIndex adult
dc.subject.otherIndex anesthesia induction
dc.subject.otherIndex arterial pressure
dc.subject.otherIndex article
dc.subject.otherIndex blood volume
dc.subject.otherIndex cerebrospinal fluid
dc.subject.otherIndex cesarean section
dc.subject.otherIndex clinical trial
dc.subject.otherIndex colloid coload
dc.subject.otherIndex colloid preload
dc.subject.otherIndex comparative study
dc.subject.otherIndex control group
dc.subject.otherIndex controlled clinical trial
dc.subject.otherIndex controlled study
dc.subject.otherIndex crystalloid
dc.subject.otherIndex dizziness
dc.subject.otherIndex double blind procedure
dc.subject.otherIndex drug dosage form comparison
dc.subject.otherIndex drug efficacy
dc.subject.otherIndex elective surgery
dc.subject.otherIndex female
dc.subject.otherIndex fluid resuscitation
dc.subject.otherIndex gestational age
dc.subject.otherIndex human
dc.subject.otherIndex hypotension
dc.subject.otherIndex incidence
dc.subject.otherIndex major clinical study
dc.subject.otherIndex nausea
dc.subject.otherIndex outcome assessment
dc.subject.otherIndex priority journal
dc.subject.otherIndex randomized controlled trial
dc.subject.otherIndex spinal anesthesia
dc.subject.otherIndex systolic blood pressure
dc.subject.otherIndex vomiting
dc.subject.otherIndex blood pressure
dc.subject.otherIndex colloid
dc.subject.otherIndex drug administration
dc.subject.otherIndex elective surgery
dc.subject.otherIndex hypotension
dc.subject.otherIndex newborn
dc.subject.otherIndex pathophysiology
dc.subject.otherIndex postoperative nausea and vomiting
dc.subject.otherIndex pregnancy
dc.subject.otherIndex pregnancy outcome
dc.subject.otherIndex spinal anesthesia
dc.subject.otherIndex time
dc.subject.otherIndex treatment outcome
dc.subject.otherIndex Adult
dc.subject.otherIndex Anesthesia, Spinal
dc.subject.otherIndex Blood Pressure
dc.subject.otherIndex Blood Volume
dc.subject.otherIndex Cesarean Section
dc.subject.otherIndex Colloids
dc.subject.otherIndex Double-Blind Method
dc.subject.otherIndex Drug Administration Schedule
dc.subject.otherIndex Ephedrine
dc.subject.otherIndex Female
dc.subject.otherIndex Hetastarch
dc.subject.otherIndex Humans
dc.subject.otherIndex Hypotension
dc.subject.otherIndex Infant, Newborn
dc.subject.otherIndex Phenylephrine
dc.subject.otherIndex Plasma Substitutes
dc.subject.otherIndex Postoperative Nausea and Vomiting
dc.subject.otherIndex Pregnancy
dc.subject.otherIndex Pregnancy Outcome
dc.subject.otherIndex Surgical Procedures, Elective
dc.subject.otherIndex Time Factors
dc.subject.otherIndex Treatment Outcome
dc.subject.otherIndex Vasoconstrictor Agents
dc.subject.otherKeywordPlus LACTATED RINGERS SOLUTION
dc.subject.otherKeywordPlus EPIDURAL-ANESTHESIA
dc.subject.otherKeywordPlus CRYSTALLOID PRELOAD
dc.subject.otherKeywordPlus INDUCED HYPOTENSION
dc.subject.otherKeywordPlus CARDIAC-OUTPUT
dc.subject.otherKeywordPlus VOLUME PRELOAD
dc.subject.otherKeywordPlus BLOOD-VOLUME
dc.subject.otherKeywordPlus SECTION
dc.subject.otherKeywordPlus PREVENTION
dc.subject.otherKeywordPlus INFUSION
dc.subject.otherWOS Anesthesiology


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