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Dexamethasone with either granisetron or ondansetron for postoperative nausea and vomiting in laparoscopic surgery

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dc.contributor.author Dabbous A.S.
dc.contributor.author Jabbour-Khoury S.I.
dc.contributor.author Nasr V.G.
dc.contributor.author Moussa A.A.
dc.contributor.author Zbeidy R.A.
dc.contributor.author Khouzam N.E.
dc.contributor.author El-Khatib M.F.
dc.contributor.author Baraka A.S.
dc.contributor.editor
dc.date Feb-2010
dc.date.accessioned 2017-10-05T15:29:08Z
dc.date.available 2017-10-05T15:29:08Z
dc.date.issued 2010
dc.identifier
dc.identifier.isbn
dc.identifier.issn 05440440
dc.identifier.uri http://hdl.handle.net/10938/15114
dc.description.abstract In a prospective randomized double-blind study, we compared the effectiveness of dexamethasone 8 mg with either granisetron 1 mg or ondansetron 4 mg in the prevention of postoperative nausea and vomiting in patients undergoing laparoscopic surgery. Hundred ASA I and II patients scheduled for laparoscopic surgery were enrolled in the study and 84 patients completed it. Following induction of anesthesia, group I (n = 42) received granisetron 1 mg and dexamethasone 8 mg, group II (n = 42) received ondansetron 4 mg and dexamethasone 8 mg. Nausea and vomiting episodes, pain scores as well as side effects were recorded during the first hour and subsequently during the first 6 and 24 hours postoperatively. Satisfaction scores were obtained at discharge. There was no statistically significant difference between the 2 groups during the 1st 24 hours following surgery in regards to pain scores, satisfaction and side effects manifestations. At 0-1 hour interval, 100percent of patients in group I and 97.6percent in group II had no vomiting. Total response (no moderate or severe nausea and no rescue antiemetics) was 83.3percent in group I and 80.95percent in group II, and metoclopramide was used in 7.1percent of patients in both groups. At 1-6 hours interval, 97.6percent of patients in group I and 100percent in group II had no vomiting. Total response was 92.8percent in group I and 90.9percent in group II, and metoclopramide was used in 4.76percent of patients in group I and 2.38percent in group II. At 6-24 hours no vomiting occurred in 97.6percent of patients in group I and 100percent in group II. Total response was 95.2percent in both groups, and metoclopramide was used in 2.38percent of patients in both groups. In conclusion, the combination of dexamethasone 8 mg with either granisetron 1 mg or ondansetron 4 mg following induction of anesthesia in patients undergoing laparoscopic surgery showed no statistically significant difference in antiemetic efficacy with minimal side effects and excellent patient satisfaction.
dc.format.extent
dc.format.extent Pages: (565-570)
dc.language English
dc.relation.ispartof Publication Name: Middle East Journal of Anesthesiology; Publication Year: 2010; Volume: 20; no. 4; Pages: (565-570);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Dexamethasone with either granisetron or ondansetron for postoperative nausea and vomiting in laparoscopic surgery
dc.type Article
dc.contributor.affiliation Dabbous, A.S., Department of Anesthesiology, American University of Beirut-Medical Center, Beirut, Lebanon
dc.contributor.affiliation Jabbour-Khoury, S.I., Department of Anesthesiology, American University of Beirut-Medical Center, Beirut, Lebanon
dc.contributor.affiliation Nasr, V.G., Department of Anesthesiology, American University of Beirut-Medical Center, Beirut, Lebanon
dc.contributor.affiliation Moussa, A.A., Department of Anesthesiology, American University of Beirut-Medical Center, Beirut, Lebanon
dc.contributor.affiliation Zbeidy, R.A., Department of Anesthesiology, American University of Beirut-Medical Center, Beirut, Lebanon
dc.contributor.affiliation Khouzam, N.E., Department of Anesthesiology, American University of Beirut-Medical Center, Beirut, Lebanon
dc.contributor.affiliation El-Khatib, M.F., Department of Anesthesiology, American University of Beirut-Medical Center, Beirut, Lebanon
dc.contributor.affiliation Baraka, A.S., Department of Anesthesiology, American University of Beirut-Medical Center, Beirut, Lebanon
dc.contributor.authorAddress Dabbous, A. S.; Department of Anesthesiology, American University of Beirut, P.O. Box: 11-0236, Beirut 1107-2020, Lebanon; email: ad00@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Anesthesiology;
dc.contributor.authorDepartment Anesthesiology
dc.contributor.authorDivision
dc.contributor.authorEmail
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited
dc.description.citedCount 3
dc.description.citedTotWOSCount
dc.description.citedWOSCount
dc.format.extentCount 6
dc.identifier.articleNo
dc.identifier.coden
dc.identifier.pubmedID 20394255
dc.identifier.scopusID 77950448011
dc.identifier.url
dc.publisher.address
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr
dc.relation.ispartOfIssue 4
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Middle East Journal of Anesthesiology
dc.relation.ispartofPubTitleAbbr Middle East J. Anesthiol.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 20
dc.source.ID
dc.type.publication Journal
dc.subject.otherAuthKeyword Dexamethasone
dc.subject.otherAuthKeyword Granisetron
dc.subject.otherAuthKeyword Laparoscopy
dc.subject.otherAuthKeyword Ondansetron
dc.subject.otherAuthKeyword Postoperative nausea and vomiting
dc.subject.otherChemCAS dexamethasone, 50-02-2
dc.subject.otherChemCAS granisetron, 107007-99-8, 109889-09-0
dc.subject.otherChemCAS metoclopramide, 12707-59-4, 2576-84-3, 364-62-5, 7232-21-5
dc.subject.otherChemCAS ondansetron, 103639-04-9, 116002-70-1, 99614-01-4
dc.subject.otherChemCAS Antiemetics
dc.subject.otherChemCAS Dexamethasone, 50-02-2
dc.subject.otherChemCAS Granisetron, 109889-09-0
dc.subject.otherChemCAS Metoclopramide, 364-62-5
dc.subject.otherChemCAS Ondansetron, 99614-02-5
dc.subject.otherIndex antiemetic agent
dc.subject.otherIndex dexamethasone
dc.subject.otherIndex granisetron
dc.subject.otherIndex metoclopramide
dc.subject.otherIndex ondansetron
dc.subject.otherIndex adult
dc.subject.otherIndex article
dc.subject.otherIndex clinical trial
dc.subject.otherIndex comparative study
dc.subject.otherIndex controlled clinical trial
dc.subject.otherIndex controlled study
dc.subject.otherIndex double blind procedure
dc.subject.otherIndex drug combination
dc.subject.otherIndex female
dc.subject.otherIndex hospitalization
dc.subject.otherIndex human
dc.subject.otherIndex laparoscopy
dc.subject.otherIndex male
dc.subject.otherIndex methodology
dc.subject.otherIndex middle aged
dc.subject.otherIndex patient satisfaction
dc.subject.otherIndex postoperative nausea and vomiting
dc.subject.otherIndex prospective study
dc.subject.otherIndex randomized controlled trial
dc.subject.otherIndex treatment outcome
dc.subject.otherIndex Adult
dc.subject.otherIndex Antiemetics
dc.subject.otherIndex Dexamethasone
dc.subject.otherIndex Double-Blind Method
dc.subject.otherIndex Drug Therapy, Combination
dc.subject.otherIndex Female
dc.subject.otherIndex Granisetron
dc.subject.otherIndex Humans
dc.subject.otherIndex Laparoscopy
dc.subject.otherIndex Male
dc.subject.otherIndex Metoclopramide
dc.subject.otherIndex Middle Aged
dc.subject.otherIndex Ondansetron
dc.subject.otherIndex Patient Satisfaction
dc.subject.otherIndex Postoperative Nausea and Vomiting
dc.subject.otherIndex Prospective Studies
dc.subject.otherIndex Severity of Illness Index
dc.subject.otherIndex Treatment Outcome
dc.subject.otherKeywordPlus
dc.subject.otherWOS


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