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Supplementation of retrobulbar block with clonidine in vitreoretinal surgery: Effect on postoperative pain

Show simple item record Yazbeck-Karam V.G. Siddik-Sayyid S.M. Nader E.L.A. Barakat D.E. Karam H.S. Cherfane G.M. Hussein J.N.H. Aouad M.T.
dc.contributor.editor Aug-2011 2017-10-05T15:29:09Z 2017-10-05T15:29:09Z 2011
dc.identifier 10.1016/j.jclinane.2010.12.014
dc.identifier.issn 09528180
dc.description.abstract Study Objective: To evaluate the effect of clonidine when added to local anesthetics on duration of postoperative analgesia during retrobulbar block. Design: Prospective, randomized controlled trial. Setting: Operating room and Postanesthesia Care Unit of a university-affiliated hospital. Subjects: 80 ASA physical status 1, 2, and 3 patients undergoing vitreoretinal surgery with or without scleral buckling. Interventions: Patients in the control group (n = 40) received a retrobulbar block with 4.5 mL of lidocaine-bupivacaine and 0.5 mL of saline. Clonidine group patients (n = 40) received 4.5 mL of lidocaine-bupivacaine and 0.5 μg-kg of clonidine in a 0.5 mL volume. Measurements: The time to first analgesic request, frequency of postoperative pain, and number of postoperative analgesic requests per patient were assessed. Main Results: 37 patients in the control group (92.5percent) versus 24 patients (60percent) in the clonidine group reported pain postoperatively (P = 0.001), with a shorter time to first analgesic request noted in the control group (4.9 ± 3 vs 11.9 ± 5.3 hrs; P 0.001). The median number of postoperative analgesic requests per patient during the first 24 hours was higher in the control group than the clonidine group [2 (0-3) vs. 1 (0-3); P 0.001]. Conclusions: The addition of clonidine 0.5 μg-kg to the local anesthetics of a retrobulbar block for vitreoretinal surgery decreases the frequency of postoperative pain and prolongs the time of analgesia. © 2011 Elsevier Inc. All rights reserved.
dc.format.extent Pages: (393-397)
dc.language English
dc.publisher NEW YORK
dc.relation.ispartof Publication Name: Journal of Clinical Anesthesia; Publication Year: 2011; Volume: 23; no. 5; Pages: (393-397);
dc.source Scopus
dc.title Supplementation of retrobulbar block with clonidine in vitreoretinal surgery: Effect on postoperative pain
dc.type Conference Paper
dc.contributor.affiliation Yazbeck-Karam, V.G., Department of Anesthesiology, Rizk Hospital, Beirut, Lebanon, Department of Anesthesiology, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Siddik-Sayyid, S.M., Department of Anesthesiology, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Nader, E.L.A., Department of Anesthesiology, Rizk Hospital, Beirut, Lebanon
dc.contributor.affiliation Barakat, D.E., Department of Anesthesiology, Rizk Hospital, Beirut, Lebanon
dc.contributor.affiliation Karam, H.S., Department of Anesthesiology, Rizk Hospital, Beirut, Lebanon
dc.contributor.affiliation Cherfane, G.M., Department of Ophthalmology, Rizk Hospital, Beirut, Lebanon
dc.contributor.affiliation Hussein, J.N.H., Department of Ophthalmology, Rizk Hospital, Beirut, Lebanon
dc.contributor.affiliation Aouad, M.T., Department of Anesthesiology, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.authorAddress Aouad, M.T.; Department of Anesthesiology, American University of Beirut Medical Center, Beirut, Lebanon; email:
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Anesthesiology;
dc.contributor.authorDepartment Anesthesiology
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Yazbeck-Karam, VG
dc.contributor.authorInitials Siddik-Sayyid, SM
dc.contributor.authorInitials Nader, ELA
dc.contributor.authorInitials Barakat, DE
dc.contributor.authorInitials Karam, HS
dc.contributor.authorInitials Cherfane, GM
dc.contributor.authorInitials Hussein, JNH
dc.contributor.authorInitials Aouad, MT
dc.contributor.authorReprintAddress Aouad, MT (reprint author), Amer Univ Beirut, Med Ctr, Dept Anesthesiol, Beirut, Lebanon.
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited Barioni MFG, 2002, J CLIN ANESTH, V14, P140, DOI 10.1016-S0952-8180(01)00371-3; Bharti N, 2002, ANAESTH INTENS CARE, V30, P438; CANNON CS, 1992, BRIT J OPHTHALMOL, V76, P68, DOI 10.1136-bjo.76.2.68; Connelly NR, 1999, REGION ANESTH PAIN M, V24, P426, DOI 10.1016-S1098-7339(99)90009-3; Coppens M, 2002, Bull Soc Belge Ophtalmol, P27; Eisenach JC, 1996, ANESTHESIOLOGY, V85, P655, DOI 10.1097-00000542-199609000-00026; Falcó-Molmeneu E, 2007, Arch Soc Esp Oftalmol, V82, P147; Fekrat S, 2001, RETINA-J RET VIT DIS, V21, P627, DOI 10.1097-00006982-200112000-00010; Fernandez SA, 2009, BRIT J ANAESTH, V102, P216, DOI 10.1093-bja-aen369; Friedman DS, 2001, OPHTHALMOLOGY, V108, P519, DOI 10.1016-S0161-6420(00)00597-2; GAUMANN DM, 1992, ANESTH ANALG, V74, P719; HESSEMER V, 1990, KLIN MONATSBL AUGENH, V197, P470, DOI 10.1055-s-2008-1046314; JARROTT B, 1987, CLIN EXP PHARMACOL P, V14, P471, DOI 10.1111-j.1440-1681.1987.tb00999.x; Johnson RW, 2002, OPHTHALMIC ANAESTHESIA, P157; Jonas JB, 2000, AM J OPHTHALMOL, V129, P54; KUMAR A, 1992, ACTA ANAESTH SCAND, V36, P159; Kumar CM, 2006, ANN ACAD MED SINGAP, V35, P158; Madan R, 2001, ANESTH ANALG, V93, P1593, DOI 10.1097-00000539-200112000-00056; Mandelcorn M, 1999, CAN J OPHTHALMOL, V34, P281; McCartney CIL, 2007, REGION ANESTH PAIN M, V32, P330, DOI 10.1016-j.rapm.2007.02.010; Mjahed K, 1996, REGION ANESTH, V21, P569; Weindler J, 2000, EUR J OPHTHALMOL, V10, P248
dc.description.citedCount 2
dc.description.citedTotWOSCount 2
dc.description.citedWOSCount 2
dc.format.extentCount 5
dc.identifier.coden JCLBE
dc.identifier.pubmedID 21802630
dc.identifier.scopusID 79960967534
dc.publisher.address 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
dc.relation.ispartOfISOAbbr J. Clin. Anesth.
dc.relation.ispartOfIssue 5
dc.relation.ispartofPubTitle Journal of Clinical Anesthesia
dc.relation.ispartofPubTitleAbbr J. Clin. Anesth.
dc.relation.ispartOfVolume 23
dc.source.ID WOS:000293940000008
dc.type.publication Journal
dc.subject.otherAuthKeyword Anesthesia, regional
dc.subject.otherAuthKeyword Clonidine
dc.subject.otherAuthKeyword Eye surgery
dc.subject.otherAuthKeyword Postoperative pain
dc.subject.otherAuthKeyword Retrobulbar block
dc.subject.otherAuthKeyword Vitreoretinal surgery
dc.subject.otherChemCAS bupivacaine, 18010-40-7, 2180-92-9, 55750-21-5
dc.subject.otherChemCAS clonidine, 4205-90-7, 4205-91-8, 57066-25-8
dc.subject.otherChemCAS diazepam, 439-14-5
dc.subject.otherChemCAS hyaluronidase, 488712-31-8, 9001-54-1, 9055-18-9
dc.subject.otherChemCAS lidocaine, 137-58-6, 24847-67-4, 56934-02-2, 73-78-9
dc.subject.otherChemCAS oxybuprocaine, 5987-82-6, 99-43-4
dc.subject.otherChemCAS Anesthetics, Combined
dc.subject.otherChemCAS Anesthetics, Local
dc.subject.otherChemCAS Bupivacaine, 2180-92-9
dc.subject.otherChemCAS Clonidine, 4205-90-7
dc.subject.otherChemCAS Lidocaine, 137-58-6
dc.subject.otherIndex bupivacaine
dc.subject.otherIndex clonidine
dc.subject.otherIndex diazepam
dc.subject.otherIndex hyaluronidase
dc.subject.otherIndex lidocaine
dc.subject.otherIndex local anesthetic agent
dc.subject.otherIndex oxybuprocaine
dc.subject.otherIndex add on therapy
dc.subject.otherIndex adult
dc.subject.otherIndex aged
dc.subject.otherIndex clinical article
dc.subject.otherIndex conference paper
dc.subject.otherIndex controlled study
dc.subject.otherIndex drug effect
dc.subject.otherIndex female
dc.subject.otherIndex human
dc.subject.otherIndex male
dc.subject.otherIndex morbidity
dc.subject.otherIndex operating room
dc.subject.otherIndex patient assessment
dc.subject.otherIndex patient satisfaction
dc.subject.otherIndex postoperative analgesia
dc.subject.otherIndex postoperative pain
dc.subject.otherIndex priority journal
dc.subject.otherIndex prospective study
dc.subject.otherIndex randomized controlled trial
dc.subject.otherIndex retrobulbar anesthesia
dc.subject.otherIndex sclera buckling procedure
dc.subject.otherIndex treatment duration
dc.subject.otherIndex university hospital
dc.subject.otherIndex vitreoretinal surgery
dc.subject.otherIndex Aged
dc.subject.otherIndex Anesthetics, Combined
dc.subject.otherIndex Anesthetics, Local
dc.subject.otherIndex Bupivacaine
dc.subject.otherIndex Clonidine
dc.subject.otherIndex Double-Blind Method
dc.subject.otherIndex Female
dc.subject.otherIndex Hospitals, University
dc.subject.otherIndex Humans
dc.subject.otherIndex Lidocaine
dc.subject.otherIndex Male
dc.subject.otherIndex Middle Aged
dc.subject.otherIndex Nerve Block
dc.subject.otherIndex Pain, Postoperative
dc.subject.otherIndex Prospective Studies
dc.subject.otherIndex Time Factors
dc.subject.otherIndex Vitreoretinal Surgery
dc.subject.otherKeywordPlus LOCAL-ANESTHETIC MIXTURE
dc.subject.otherKeywordPlus CATARACT-SURGERY
dc.subject.otherKeywordPlus PERIBULBAR BLOCK
dc.subject.otherKeywordPlus REGIONAL ANESTHESIA
dc.subject.otherKeywordPlus INTRAOCULAR SURGERY
dc.subject.otherKeywordPlus ORAL CLONIDINE
dc.subject.otherKeywordPlus LIDOCAINE
dc.subject.otherKeywordPlus PREMEDICATION
dc.subject.otherWOS Anesthesiology

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