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Correlation Between Cerebral and Mixed Venous Oxygen Saturation During Moderate Versus Tepid Hypothermic Hemodiluted Cardiopulmonary Bypass

Show simple item record Baraka A. Naufal M. El-Khatib M.
dc.contributor.editor Dec-2006 2017-10-05T15:29:21Z 2017-10-05T15:29:21Z 2006
dc.identifier 10.1053/j.jvca.2005.04.015
dc.identifier.issn 10530770
dc.description.abstract Objective: This study was undertaken to compare cerebral oxygen saturation (RsO2) and mixed venous oxygen saturation (SvO2) in patients undergoing moderate and tepid hypothermic hemodiluted cardiopulmonary bypass (CPB). Design: Prospective study. Settings: University hospital operating room. Participants: Fourteen patients undergoing elective coronary artery bypass graft surgery using hypothermic hemodiluted CPB. Interventions: During moderate (28°-30°C) and tepid hypothermic (33°-34°C) hemodiluted CPB, RsO2 and SvO2 were continuously monitored with a cerebral oximeter via a surface electrode placed on the patient's forehead and with the mixed venous oximeter integrated in the CPB machine, respectively. Measurements and Main Results: Mean ± standard deviation of RsO2, SvO2, PaCO2, and hematocrit were determined prebypass and during moderate and tepid hypothermic phases of CPB while maintaining pump flow at 2.4 L-min-m2 and mean arterial pressure in the 60- to 70-mmHg range. Compared with a prebypass value of 76.0percent ± 9.6percent, RsO2 was significantly decreased during moderate hypothermia to 58.9percent ± 6.4percent and increased to 66.4percent ± 6.7percent after slow rewarming to tepid hypothermia. In contrast, compared with a prebypass value of 78.6percent ± 3.3percent, SvO2 significantly increased to 84.9percent ± 3.6percent during moderate hypothermia and decreased to 74.1percent ± 5.6percent during tepid hypothermia. During moderate hypothermia, there was poor agreement between RsO2 and SvO2 with a gradient of 26percent; however, during tepid hypothermia, there was a strong agreement between RsO2 and SvO2 with a gradient of 6percent. The temperature-uncorrected PaCO2 was maintained at the normocapnic level throughout the study, whereas the temperature-corrected PaCO2 was significantly lower during the moderate hypothermic phase (26.8 ± 3.1 mmHg) compared with the tepid hypothermic phase (38.9 ± 3.7 mmHg) of CPB. There was a significant and positive correlation between RsO2 and temperature-corrected PaCO2 during hypothermia. Conclusions: During moderate hypothermic hemodiluted CPB, there was a significant increase of SvO2 associated with a paradoxic decrease of RsO2 that was attributed to the low temperature-corrected PaCO2 values. During tepid CPB after slow rewarming, regional cerebral oxygen saturation was increased in association with an increase with the temperature-corrected PaCO2 values. The results show that during hypothermic hemodiluted CPB using the alpha-stat strategy for carbon dioxide homeostasis, cerebral oxygen saturation is significantly higher during tepid than moderate hypothermia. © 2006 Elsevier Inc. All rights reserved.
dc.format.extent Pages: (819-825)
dc.language English
dc.publisher PHILADELPHIA
dc.relation.ispartof Publication Name: Journal of Cardiothoracic and Vascular Anesthesia; Publication Year: 2006; Volume: 20; no. 6; Pages: (819-825);
dc.source Scopus
dc.title Correlation Between Cerebral and Mixed Venous Oxygen Saturation During Moderate Versus Tepid Hypothermic Hemodiluted Cardiopulmonary Bypass
dc.type Article
dc.contributor.affiliation Baraka, A., Department of Anesthesiology, School of Medicine, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Naufal, M., Department of Anesthesiology, School of Medicine, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation El-Khatib, M., Department of Anesthesiology, School of Medicine, American University of Beirut, Beirut, Lebanon
dc.contributor.authorAddress Baraka, A.; Department of Anesthesiology, School of Medicine, American University of Beirut, Beirut, Lebanon; email:
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Anesthesiology;
dc.contributor.authorDepartment Anesthesiology
dc.contributor.faculty Faculty of Medicine
dc.contributor.authorInitials Baraka, A
dc.contributor.authorInitials Naufal, M
dc.contributor.authorInitials El-Khatib, M
dc.contributor.authorReprintAddress Baraka, A (reprint author), Amer Univ Beirut, Dept Anesthesiol, Sch Med, POB 11-0236, Beirut, Lebanon.
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited BARAKA A, 1992, J CARDIOTHOR VASC AN, V1, P35; COOK DJ, 1996, J THORACIC CARDIOVAS, V111, P672; CZINN EA, 1995, ANESTH ANALG, V80, P492, DOI 10.1097-00000539-199503000-00010; Daubeney PEF, 1996, ANN THORAC SURG, V61, P930, DOI 10.1016-0003-4975(95)01186-2; Duebener LF, 2004, J CARDIOTHOR VASC AN, V18, P423, DOI 10.1053-j.jvca.2004.05.018; Edmonds HL, 1996, J CARDIOTHOR VASC AN, V10, P15, DOI 10.1016-S1053-0770(96)80174-1; Holzschuh M, 1997, NEUROL RES, V19, P246; JOBSISVANDERVLIET FF, 1985, ADV EXP MED BIOL, V191, P833; LARACH DR, 1988, ANESTHESIOLOGY, V69, P185, DOI 10.1097-00000542-198808000-00006; Lozano S, 2004, J CARDIOTHOR VASC AN, V18, P645, DOI 10.1053-j.jvca.2004.07.027; BLAND JM, 1986, LANCET, V1, P307; McLean RF, 1996, J CARDIOTHOR VASC AN, V10, P45, DOI 10.1016-S1053-0770(96)80178-9; MURKIN JM, 1987, ANESTH ANALG, V66, P825; Newman MF, 2001, NEW ENGL J MED, V344, P395, DOI 10.1056-NEJM200102083440601; RICHARD FM, 1996, J CARDIOTHOR VASC AN, V10, P45; Roach GW, 1996, NEW ENGL J MED, V335, P1857, DOI 10.1056-NEJM199612193352501; Samra SK, 1999, J NEUROSURG ANESTH, V11, P1, DOI 10.1097-00008506-199901000-00001; SHAABAN AM, 2004, ACTA ANAESTHESIOLOGI, V48, P837; Yao FSF, 2004, J CARDIOTHOR VASC AN, V18, P552, DOI 10.1053-j.jvca.2004.07.007; Yeh T, 2001, J THORAC CARDIOV SUR, V122, P192, DOI 10.1067-mtc.2001.113167
dc.description.citedCount 14
dc.description.citedTotWOSCount 12
dc.description.citedWOSCount 12
dc.format.extentCount 7
dc.identifier.coden JCVAE
dc.identifier.pubmedID 17138087
dc.identifier.scopusID 33751312276
dc.publisher.address 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
dc.relation.ispartOfISOAbbr J. Cardiothorac. Vasc. Anesth.
dc.relation.ispartOfIssue 6
dc.relation.ispartofPubTitle Journal of Cardiothoracic and Vascular Anesthesia
dc.relation.ispartofPubTitleAbbr J. Cardiothorac. Vasc. Anesth.
dc.relation.ispartOfVolume 20
dc.source.ID WOS:000242678400012
dc.type.publication Journal
dc.subject.otherAuthKeyword alpha-stat
dc.subject.otherAuthKeyword cardiopulmonary bypass
dc.subject.otherAuthKeyword cerebral oximetry
dc.subject.otherAuthKeyword hemodilution
dc.subject.otherAuthKeyword hypothermia
dc.subject.otherChemCAS Oxygen, 7782-44-7
dc.subject.otherIndex adult
dc.subject.otherIndex article
dc.subject.otherIndex cardiopulmonary bypass
dc.subject.otherIndex clinical article
dc.subject.otherIndex controlled study
dc.subject.otherIndex correlation analysis
dc.subject.otherIndex female
dc.subject.otherIndex flow rate
dc.subject.otherIndex hemodilution
dc.subject.otherIndex human
dc.subject.otherIndex hypothermia
dc.subject.otherIndex ischemic heart disease
dc.subject.otherIndex male
dc.subject.otherIndex operating room
dc.subject.otherIndex oximetry
dc.subject.otherIndex oxygen saturation
dc.subject.otherIndex priority journal
dc.subject.otherIndex standardization
dc.subject.otherIndex surface property
dc.subject.otherIndex temperature measurement
dc.subject.otherIndex university hospital
dc.subject.otherIndex Blood Pressure
dc.subject.otherIndex Body Temperature
dc.subject.otherIndex Cardiopulmonary Bypass
dc.subject.otherIndex Cerebrovascular Circulation
dc.subject.otherIndex Female
dc.subject.otherIndex Hematocrit
dc.subject.otherIndex Hemodilution
dc.subject.otherIndex Humans
dc.subject.otherIndex Hypothermia, Induced
dc.subject.otherIndex Male
dc.subject.otherIndex Middle Aged
dc.subject.otherIndex Monitoring, Intraoperative
dc.subject.otherIndex Oximetry
dc.subject.otherIndex Oxygen
dc.subject.otherIndex Prospective Studies
dc.subject.otherKeywordPlus NEAR-INFRARED SPECTROSCOPY
dc.subject.otherKeywordPlus CARDIAC-SURGERY
dc.subject.otherKeywordPlus METABOLISM
dc.subject.otherKeywordPlus OXIMETRY
dc.subject.otherKeywordPlus OUTCOMES
dc.subject.otherKeywordPlus BRAIN
dc.subject.otherKeywordPlus FLOW
dc.subject.otherWOS Anesthesiology
dc.subject.otherWOS Cardiac and Cardiovascular Systems
dc.subject.otherWOS Respiratory System
dc.subject.otherWOS Peripheral Vascular Disease

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