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Multimodal analgesia to prevent propofol-induced pain: Pretreatment with remifentanil and lidocaine versus remifentanil or lidocaine alone

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dc.contributor.author Aouad M.T.
dc.contributor.author Siddik-Sayyid S.M.
dc.contributor.author Al-Alami A.A.
dc.contributor.author Baraka A.S.
dc.contributor.editor
dc.date Jun-2007
dc.date.accessioned 2017-10-05T15:29:24Z
dc.date.available 2017-10-05T15:29:24Z
dc.date.issued 2007
dc.identifier 10.1213/01.ane.0000261520.34879.09
dc.identifier.isbn
dc.identifier.issn 00032999
dc.identifier.uri http://hdl.handle.net/10938/15246
dc.description.abstract BACKGROUND: Propofol is well-known for its pain on injection. Premixture with lidocaine or pretreatment with remifentanil reduces injection pain. A multimodal approach might offer additional mitigation of propofol injection pain. METHODS: In a randomized, prospective, double-blind study of 156 patients, we compared the incidence and severity of propofol pain among three groups. Patients in the lidocaine group (n = 54) received 2percent lidocaine premixed with propofol (40 mg lidocaine in 180 mg propofol). Patients in the remifentanil group (n = 50), received pretreatment with remifentanil 2 μg·kg IV over 30 s. Patients in the combination group (n = 52) received both lidocaine and remifentanil. RESULTS: A significant decrease in the overall incidence of propofol pain at induction was achieved in the combination group (9.6percent) compared with that in the remifentanil group (36percent) and the lidocaine group (35percent) (P = 0.003). The incidence of severe and moderate pain was also significantly different in the combination group (0percent), compared with that in the remifentanil (18percent) and lidocaine groups (12.9percent) (P 0.02). Similar, statistically significant differences among the three groups were achieved concerning recalled pain in the postanesthesia care unit. CONCLUSIONS: The combination of two different analgesic modalities, remifentanil and lidocaine completely abolishes moderate and severe pain associated with propofol injection, and significantly reduces the incidence of mild pain when compared with each drug used alone. © 2007 by International Anesthesia Research Society.
dc.format.extent
dc.format.extent Pages: (1540-1544)
dc.language English
dc.relation.ispartof Publication Name: Anesthesia and Analgesia; Publication Year: 2007; Volume: 104; no. 6; Pages: (1540-1544);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Multimodal analgesia to prevent propofol-induced pain: Pretreatment with remifentanil and lidocaine versus remifentanil or lidocaine alone
dc.type Article
dc.contributor.affiliation Aouad, M.T., Department of Anesthesiology, American University, Beirut Medical Center, Beirut, Lebanon, Department of Anesthesiology, American University, Beirut Medical Center, P. O. Box 11 0236, Beirut, Lebanon
dc.contributor.affiliation Siddik-Sayyid, S.M., Department of Anesthesiology, American University, Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Al-Alami, A.A., Department of Anesthesiology, American University, Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Baraka, A.S., Department of Anesthesiology, American University, Beirut Medical Center, Beirut, Lebanon
dc.contributor.authorAddress Aouad, M.T.; Department of Anesthesiology, American University, Beirut Medical Center, P. O. Box 11 0236, Beirut, Lebanon; email: mm01@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Anesthesiology;
dc.contributor.authorDepartment Anesthesiology
dc.contributor.authorDivision
dc.contributor.authorEmail
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited
dc.description.citedCount 18
dc.description.citedTotWOSCount
dc.description.citedWOSCount
dc.format.extentCount 5
dc.identifier.articleNo
dc.identifier.coden AACRA
dc.identifier.pubmedID 17513655
dc.identifier.scopusID 34249000360
dc.identifier.url
dc.publisher.address
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr
dc.relation.ispartOfIssue 6
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Anesthesia and Analgesia
dc.relation.ispartofPubTitleAbbr Anesth. Analg.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 104
dc.source.ID
dc.type.publication Journal
dc.subject.otherAuthKeyword
dc.subject.otherChemCAS lidocaine, 137-58-6, 24847-67-4, 56934-02-2, 73-78-9
dc.subject.otherChemCAS propofol, 2078-54-8
dc.subject.otherChemCAS remifentanil, 132539-07-2
dc.subject.otherChemCAS Lidocaine, 137-58-6
dc.subject.otherChemCAS Piperidines
dc.subject.otherChemCAS Propofol, 2078-54-8
dc.subject.otherChemCAS remifentanil, 132875-61-7
dc.subject.otherIndex lidocaine
dc.subject.otherIndex propofol
dc.subject.otherIndex remifentanil
dc.subject.otherIndex adult
dc.subject.otherIndex analgesia
dc.subject.otherIndex article
dc.subject.otherIndex clinical trial
dc.subject.otherIndex controlled clinical trial
dc.subject.otherIndex controlled study
dc.subject.otherIndex double blind procedure
dc.subject.otherIndex drug use
dc.subject.otherIndex female
dc.subject.otherIndex human
dc.subject.otherIndex incidence
dc.subject.otherIndex major clinical study
dc.subject.otherIndex male
dc.subject.otherIndex pain
dc.subject.otherIndex postoperative pain
dc.subject.otherIndex priority journal
dc.subject.otherIndex prospective study
dc.subject.otherIndex randomized controlled trial
dc.subject.otherIndex statistical significance
dc.subject.otherIndex Adult
dc.subject.otherIndex Double-Blind Method
dc.subject.otherIndex Drug Therapy, Combination
dc.subject.otherIndex Female
dc.subject.otherIndex Humans
dc.subject.otherIndex Injections, Intravenous
dc.subject.otherIndex Lidocaine
dc.subject.otherIndex Male
dc.subject.otherIndex Middle Aged
dc.subject.otherIndex Pain
dc.subject.otherIndex Pain Measurement
dc.subject.otherIndex Piperidines
dc.subject.otherIndex Propofol
dc.subject.otherIndex Prospective Studies
dc.subject.otherKeywordPlus
dc.subject.otherWOS


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