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Comparison of three doses of epidural fentanyl followed by bupivacaine and fentanyl for labor analgesia

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dc.contributor.author Siddik-Sayyid S.M.
dc.contributor.author Taha S.K.
dc.contributor.author Azar M.S.
dc.contributor.author Hakki M.A.
dc.contributor.author Yaman R.A.
dc.contributor.author Baraka A.S.
dc.contributor.author Aouad M.T.
dc.contributor.editor
dc.date Oct-2008
dc.date.accessioned 2017-10-05T15:29:26Z
dc.date.available 2017-10-05T15:29:26Z
dc.date.issued 2008
dc.identifier 10.1111/j.1399-6576.2008.01765.x
dc.identifier.isbn
dc.identifier.issn 00015172
dc.identifier.uri http://hdl.handle.net/10938/15265
dc.description.abstract Background: Epidural fentanyl 100 μg after lidocaine-epinephrine test dose has been shown to provide adequate analgesia in early labor. This investigation determines the effect of three different bolus doses of epidural fentanyl on duration and quality of analgesia during early first stage of labor. Methods: In this prospective, double-blind study, 103 laboring nulliparous at cervical dilation 5 cm were enrolled. After an epidural test dose of lidocaine (60 mg) with epinephrine (15 μg), parturients received, randomly, bolus of epidural fentanyl 50, 75, or 100 μg, followed by a continuous infusion of epidural bupivacaine 0.0625percent and fentanyl 3 μg-ml at a rate of 10 ml-h. Pain scores and maternal sedation, pruritus, nausea, and vomiting were recorded 10, 20, and 30 min after fentanyl, and every 30 min thereafter until first request for additional analgesia. Results: Adequate analgesia was achieved in 87percent (28-32), 94percent (35-38), and 94percent (31-33) in the fentanyl 50, 75, and 100 μg groups within 20 min. Mean duration of analgesia before re-dosing was significantly longer in fentanyl 100 and 75 μg groups (185.6±82.9 and 188.5±82.2 min, respectively) as compared with fentanyl 50 μg group (133.6±46.2 min, P0.016). There was no difference in the incidence of maternal side effects or neonatal Apgar scores among the three groups. Conclusion: After a test dose of lidocaine-epinephrine, the three epidural fentanyl doses produced similar effective labor analgesia. However, epidural fentanyl 75 μg followed by epidural infusion of dilute bupivacaine and fentanyl produced longer duration of analgesia than fentanyl 50 μg followed by the same infusion, with no further prolongation when the dose of fentanyl was increased up to 100 μg. © 2008 The Authors.
dc.format.extent
dc.format.extent Pages: (1285-1290)
dc.language English
dc.publisher MALDEN
dc.relation.ispartof Publication Name: Acta Anaesthesiologica Scandinavica; Publication Year: 2008; Volume: 52; no. 9; Pages: (1285-1290);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Comparison of three doses of epidural fentanyl followed by bupivacaine and fentanyl for labor analgesia
dc.type Article
dc.contributor.affiliation Siddik-Sayyid, S.M., Department of Anesthesiology, American University of Beirut-Medical Center, Beirut, Lebanon
dc.contributor.affiliation Taha, S.K., Department of Anesthesiology, American University of Beirut-Medical Center, Beirut, Lebanon
dc.contributor.affiliation Azar, M.S., Department of Anesthesiology, American University of Beirut-Medical Center, Beirut, Lebanon
dc.contributor.affiliation Hakki, M.A., Department of Anesthesiology, American University of Beirut-Medical Center, Beirut, Lebanon
dc.contributor.affiliation Yaman, R.A., Department of Anesthesiology, American University of Beirut-Medical Center, Beirut, Lebanon
dc.contributor.affiliation Baraka, A.S., Department of Anesthesiology, American University of Beirut-Medical Center, Beirut, Lebanon
dc.contributor.affiliation Aouad, M.T., Department of Anesthesiology, American University of Beirut, P.O.Box 11-0236, Beirut, Lebanon, Department of Anesthesiology, American University of Beirut-Medical Center, Beirut, Lebanon
dc.contributor.authorAddress Aouad, M. T.; Department of Anesthesiology, American University of Beirut, P.O.Box 11-0236, Beirut, Lebanon; email: mm01@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Anesthesiology;
dc.contributor.authorDepartment Anesthesiology
dc.contributor.authorDivision
dc.contributor.authorEmail mm01@aub.edu.lb
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Siddik-Sayyid, SM
dc.contributor.authorInitials Taha, SK
dc.contributor.authorInitials Azar, MS
dc.contributor.authorInitials Hakki, MA
dc.contributor.authorInitials Yaman, RA
dc.contributor.authorInitials Baraka, AS
dc.contributor.authorInitials Aouad, MT
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Aouad, MT (reprint author), Amer Univ Beirut, Dept Anesthesiol, Med Ctr, POB 11-0236, Beirut, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited Beilin Y, 2005, ANESTHESIOLOGY, V103, P1211, DOI 10.1097-00000542-200512010-00016; BREEN TW, 1993, ANESTH ANALG, V77, P919; Bromage P R, 1965, Acta Anaesthesiol Scand Suppl, V16, P55; Capogna G, 2003, ANESTH ANALG, V96, P1178, DOI 10.1213-01.ANE.0000054003.03645.CF; CARRIE LES, 1981, ANAESTHESIA, V36, P965, DOI 10.1111-j.1365-2044.1981.tb08658.x; CHANEY MA, 1995, CAN J ANAESTH, V42, P891; Connelly NR, 2001, ANESTH ANALG, V93, P1001, DOI 10.1097-00000539-200110000-00041; Connelly NR, 2000, ANESTH ANALG, V91, P374, DOI 10.1097-00000539-200008000-00026; Connelly NR, 2003, ANESTH ANALG, V96, P1799, DOI 10.1213-01.ANE.0000061583.77068.0B; Gaiser RR, 2000, REGION ANESTH PAIN M, V25, P223, DOI 10.1016-S1098-7339(00)90002-6; HALONEN PM, 1993, ACTA ANAESTH SCAND, V37, P774; HUGHES SC, 1984, ANESTH ANALG, V63, P319; JUSTINS DM, 1982, BRIT J ANAESTH, V54, P409, DOI 10.1093-bja-54.4.409; Roelants F, 2006, ANESTH ANALG, V103, P1534, DOI 10.1213-01.ane.0000244595.03322.52; Vercauteren M, 1997, PHARMACOL BIOCHEM BE, V58, P237, DOI 10.1016-S0091-3057(97)00011-7; VERTOMMEN JD, 1991, ANESTHESIOLOGY, V74, P809, DOI 10.1097-00000542-199105000-00002; Wong CA, 2004, INT J OBSTET ANESTH, V13, P19, DOI 10.1016-S0959-289X(03)00106-7
dc.description.citedCount 6
dc.description.citedTotWOSCount 5
dc.description.citedWOSCount 5
dc.format.extentCount 6
dc.identifier.articleNo
dc.identifier.coden AANEA
dc.identifier.pubmedID 18823470
dc.identifier.scopusID 51749083041
dc.identifier.url
dc.publisher.address COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Acta Anaesthesiol. Scand.
dc.relation.ispartOfIssue 9
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Acta Anaesthesiologica Scandinavica
dc.relation.ispartofPubTitleAbbr Acta Anaesthesiol. Scand.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 52
dc.source.ID WOS:000259215600016
dc.type.publication Journal
dc.subject.otherAuthKeyword
dc.subject.otherChemCAS adrenalin, 51-43-4, 55-31-2, 6912-68-1
dc.subject.otherChemCAS bupivacaine, 18010-40-7, 2180-92-9, 55750-21-5
dc.subject.otherChemCAS fentanyl, 437-38-7
dc.subject.otherChemCAS lidocaine, 137-58-6, 24847-67-4, 56934-02-2, 73-78-9
dc.subject.otherChemCAS Bupivacaine, 2180-92-9
dc.subject.otherChemCAS Fentanyl, 437-38-7
dc.subject.otherIndex adrenalin
dc.subject.otherIndex bupivacaine
dc.subject.otherIndex fentanyl
dc.subject.otherIndex lidocaine
dc.subject.otherIndex adult
dc.subject.otherIndex Apgar score
dc.subject.otherIndex article
dc.subject.otherIndex body height
dc.subject.otherIndex body weight
dc.subject.otherIndex bothersomeness
dc.subject.otherIndex controlled study
dc.subject.otherIndex disease severity
dc.subject.otherIndex drowsiness
dc.subject.otherIndex epidural catheter
dc.subject.otherIndex female
dc.subject.otherIndex human
dc.subject.otherIndex incidence
dc.subject.otherIndex Kaplan Meier method
dc.subject.otherIndex major clinical study
dc.subject.otherIndex nausea and vomiting
dc.subject.otherIndex nullipara
dc.subject.otherIndex obstetric analgesia
dc.subject.otherIndex pain
dc.subject.otherIndex priority journal
dc.subject.otherIndex prospective study
dc.subject.otherIndex pruritus
dc.subject.otherIndex scoring system
dc.subject.otherIndex sedation
dc.subject.otherIndex side effect
dc.subject.otherIndex somnolence
dc.subject.otherIndex uterine cervix dilatation
dc.subject.otherIndex Adult
dc.subject.otherIndex Analgesia, Epidural
dc.subject.otherIndex Analgesia, Obstetrical
dc.subject.otherIndex Bupivacaine
dc.subject.otherIndex Dose-Response Relationship, Drug
dc.subject.otherIndex Female
dc.subject.otherIndex Fentanyl
dc.subject.otherIndex Humans
dc.subject.otherIndex Mothers
dc.subject.otherIndex Pain
dc.subject.otherIndex Pregnancy
dc.subject.otherIndex Time Factors
dc.subject.otherKeywordPlus SUFENTANIL
dc.subject.otherKeywordPlus ANESTHESIA
dc.subject.otherKeywordPlus INFUSION
dc.subject.otherWOS Anesthesiology


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