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GATA4 in Heart Development and Disease

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dc.contributor.author Nemer G.
dc.contributor.author Nemer M.
dc.contributor.editor
dc.date 2010
dc.date.accessioned 2017-10-05T15:30:55Z
dc.date.available 2017-10-05T15:30:55Z
dc.date.issued 2010
dc.identifier 10.1016/B978-0-12-381332-9.00027-X
dc.identifier.isbn 9.7801238133e+012
dc.identifier.issn
dc.identifier.uri http://hdl.handle.net/10938/15281
dc.description.abstract This chapter discusses the role of GATA4 in the heart development and disease. GATA proteins are expressed in a cell- and temporal-specific manner. Their essential roles in early development are well established and include lineage differentiation, as well as cell survival and proliferation. For example, in plants, GATA proteins are involved in flower development, whereas in C. elegans, fish and mammals, the different GATA proteins are crucial for lineage specification and organ development. This is well characterized in C. elegans, where the Elt and END proteins are involved in the commitment of cells into the endodermal lineage whereas the MED proteins are involved in specification of the mesendodermal cells. This role in lineage commitment is crucial for the evolution of metazoans, where compartmentalization via cell layer formation is a major event. GATA proteins also play essential roles throughout the lifecycle of the various organisms as they act as sensor-effectors of external threats and stimuli, and thus contribute to the inner defense mechanism of the cell. This particular role is conserved during evolution from fungi to higher vertebrates. For example, a protein plays an essential role in nitrogen metabolism in Aspergillus nidulans (Wilson and Arst Jr, 1998), and GATA proteins NIL1 and GLN3 are crucial regulators of carbon and nitrogen metabolism in Saccharomyces cerevisiae (Kuruvilla et al., 2001). As will be discussed in this chapter, mammalian GATA proteins play an important role in cardiac stress responses, and are critical regulators of cell survival. © 2010 Elsevier Inc. All rights reserved.
dc.format.extent
dc.format.extent Pages: (599-616)
dc.language English
dc.publisher Elsevier Inc.;
dc.relation.ispartof Publication Name: Heart Development and Regeneration; Publication Year: 2010; Pages: (599-616);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title GATA4 in Heart Development and Disease
dc.type Book Chapter
dc.contributor.affiliation Nemer, G., Research Unit in Cardiac Growth and Differentiation, Institut de recherches cliniques de Montréal (IRCM), Montréal, QC H2W 1R7, Canada, Department of Biochemistry, American University of Beirut, Lebanon
dc.contributor.affiliation Nemer, M., University of Ottawa, Laboratory of Cardiac Growth and Differentiation, Department of Biochemistry, Microbiology and Immunology, Ottawa, ON, K1N 6N5, Canada
dc.contributor.authorAddress Nemer, G.; Research Unit in Cardiac Growth and Differentiation, Institut de recherches cliniques de Montréal (IRCM), Montréal, QC H2W 1R7, Canada
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Biochemistry and Molecular Genetics;
dc.contributor.authorDepartment Biochemistry and Molecular Genetics
dc.contributor.authorDivision
dc.contributor.authorEmail
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited
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dc.identifier.scopusID 84858856836
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dc.relation.ispartofPubTitle Heart Development and Regeneration
dc.relation.ispartofPubTitleAbbr Heart Dev. and Regen.
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dc.type.publication Book
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dc.subject.otherChemCAS
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