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Assessing neuro-systemic and behavioral components in the pathophysiology of blast-related brain injury

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dc.contributor.author Kobeissy F.
dc.contributor.author Mondello S.
dc.contributor.author Tumer N.
dc.contributor.author Toklu H.Z.
dc.contributor.author Whidden M.A.
dc.contributor.author Kirichenko N.
dc.contributor.author Zhang Z.
dc.contributor.author Prima V.
dc.contributor.author Yassin W.
dc.contributor.author Anagli J.
dc.contributor.author Chandra N.
dc.contributor.author Svetlov S.
dc.contributor.author Wang K.K.W.
dc.contributor.editor
dc.date 2013
dc.date.accessioned 2017-10-05T15:30:58Z
dc.date.available 2017-10-05T15:30:58Z
dc.date.issued 2013
dc.identifier 10.3389/fneur.2013.00186
dc.identifier.isbn
dc.identifier.issn 16642295
dc.identifier.uri http://hdl.handle.net/10938/15305
dc.description.abstract Among the U.S. military personnel, blast injury is among the leading causes of brain injury. During the past decade, it has become apparent that even blast injury as a form of mild traumatic brain injury (mTBI) may lead to multiple different adverse outcomes, such as neuropsychiatric symptoms and long-term cognitive disability. Blast injury is characterized by blast overpressure, blast duration, and blast impulse. While the blast injuries of a victim close to the explosion will be severe, majority of victims are usually at a distance leading to milder form described as mild blast TBI (mbTBI). A major feature of mbTBI is its complex manifestation occurring in concert at different organ levels involving systemic, cerebral, neuronal, and neuropsychiatric responses; some of which are shared with other forms of brain trauma such as acute brain injury and other neuropsychiatric disorders such as post-traumatic stress disorder. The pathophysiology of blast injury exposure involves complex cascades of chronic psychological stress, autonomic dysfunction, and neuro-systemic inflammation. These factors render blast injury as an arduous challenge in terms of diagnosis and treatment as well as identification of sensitive and specific biomarkers distinguishing mTBI from other non-TBI pathologies and from neuropsychiatric disorders with similar symptoms. This is due to the distinct but shared and partially identified biochemical pathways and neuro-histopathological changes that might be linked to behavioral deficits observed. Taken together, this article aims to provide an overview of the current status of the cellular and pathological mechanisms involved in blast overpressure injury and argues for the urgent need to identify potential biomarkers that can hint at the different mechanisms involved. © 2013 Kobeissy, Mondello, Tümer, Toklu, Whidden, Kirichenko, Zhang, Prima, Yassin, Anagli, Chandra, Svetlov and Wang.
dc.format.extent
dc.language English
dc.relation.ispartof Publication Name: Frontiers in Neurology; Publication Year: 2013; Volume: 41947;
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Assessing neuro-systemic and behavioral components in the pathophysiology of blast-related brain injury
dc.type Article
dc.contributor.affiliation Kobeissy, F., Department of Psychiatry, Center of Neuroproteomics and Biomarker Research, University of Florida, Gainesville, FL, United States, Department of Biochemistry and Molecular Genetics, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Mondello, S., Department of Neurosciences, University of Messina, Messina, Italy
dc.contributor.affiliation Tümer, N., Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, University of Florida, Gainesville, FL, United States, Department of Pharmacology and Therapeutics, University of Florida, Gainesville, FL, United States
dc.contributor.affiliation Toklu, H.Z., Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, University of Florida, Gainesville, FL, United States, Department of Pharmacology and Therapeutics, University of Florida, Gainesville, FL, United States, Department of Pharmacology, Marmara University, Istanbul, Turkey
dc.contributor.affiliation Whidden, M.A., Department of Kinesiology, West Chester University, West Chester, PA, United States
dc.contributor.affiliation Kirichenko, N., Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, University of Florida, Gainesville, FL, United States, Department of Pharmacology and Therapeutics, University of Florida, Gainesville, FL, United States
dc.contributor.affiliation Zhang, Z., Department of Psychiatry, Center of Neuroproteomics and Biomarker Research, University of Florida, Gainesville, FL, United States
dc.contributor.affiliation Prima, V., Banyan Laboratory, Banyan Biomarkers, Inc., Alachua, FL, United States
dc.contributor.affiliation Yassin, W., Department of Neuropsychiatry, Kyoto University, Kyoto, Japan
dc.contributor.affiliation Anagli, J., Banyan Laboratory, Banyan Biomarkers, Inc., Alachua, FL, United States
dc.contributor.affiliation Chandra, N., Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, United States
dc.contributor.affiliation Svetlov, S., Banyan Laboratory, Banyan Biomarkers, Inc., Alachua, FL, United States
dc.contributor.affiliation Wang, K.K.W., Department of Psychiatry, Center of Neuroproteomics and Biomarker Research, University of Florida, Gainesville, FL, United States
dc.contributor.authorAddress Kobeissy, F.; Firas Kobeissy and Kevin K. W. Wang, Department of Psychiatry, University of Florida, 100 S Newell Drive Room L4-100, Gainesville, FL 32611, United States; email: firasko@gmail.com
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Biochemistry and Molecular Genetics;
dc.contributor.authorDepartment Biochemistry and Molecular Genetics
dc.contributor.authorDivision
dc.contributor.authorEmail
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited
dc.description.citedCount 2
dc.description.citedTotWOSCount
dc.description.citedWOSCount
dc.format.extentCount 1
dc.identifier.articleNo Article 186
dc.identifier.coden
dc.identifier.pubmedID
dc.identifier.scopusID 84889680931
dc.identifier.url
dc.publisher.address
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr
dc.relation.ispartOfIssue
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Frontiers in Neurology
dc.relation.ispartofPubTitleAbbr Front. Neurol.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 41947
dc.source.ID
dc.type.publication Journal
dc.subject.otherAuthKeyword biomarkers
dc.subject.otherAuthKeyword Blast injury
dc.subject.otherAuthKeyword Blast overpressure
dc.subject.otherAuthKeyword Brain injury
dc.subject.otherAuthKeyword Mild TBI
dc.subject.otherAuthKeyword Neuropsychiatry
dc.subject.otherAuthKeyword Neurotrauma
dc.subject.otherAuthKeyword PTSD
dc.subject.otherChemCAS
dc.subject.otherIndex biological marker
dc.subject.otherIndex article
dc.subject.otherIndex autonomic dysfunction
dc.subject.otherIndex biomechanics
dc.subject.otherIndex blast injury
dc.subject.otherIndex blood brain barrier
dc.subject.otherIndex cognitive defect
dc.subject.otherIndex comorbidity
dc.subject.otherIndex disease model
dc.subject.otherIndex disease severity
dc.subject.otherIndex exposure
dc.subject.otherIndex human
dc.subject.otherIndex mental disease
dc.subject.otherIndex mental stress
dc.subject.otherIndex nerve cell lesion
dc.subject.otherIndex nervous system inflammation
dc.subject.otherIndex neurologic disease
dc.subject.otherIndex neuropathology
dc.subject.otherIndex nonhuman
dc.subject.otherIndex oxidative stress
dc.subject.otherIndex pathophysiology
dc.subject.otherIndex posttraumatic stress disorder
dc.subject.otherIndex traumatic brain injury
dc.subject.otherKeywordPlus
dc.subject.otherWOS


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