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The Kruppel-like transcription factor KLF13 is a novel regulator of heart development

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dc.contributor.author Lavallee G.
dc.contributor.author Andelfinger G.
dc.contributor.author Nadeau M.
dc.contributor.author Lefebvre C.
dc.contributor.author Nemer G.
dc.contributor.author Horb M.E.
dc.contributor.author Nemer M.
dc.contributor.editor
dc.date Nov-2006
dc.date.accessioned 2017-10-05T15:30:58Z
dc.date.available 2017-10-05T15:30:58Z
dc.date.issued 2006
dc.identifier 10.1038/sj.emboj.7601379
dc.identifier.isbn
dc.identifier.issn 02614189
dc.identifier.uri http://hdl.handle.net/10938/15312
dc.description.abstract In humans, congenital heart defects occur in 1-2percent of live birth, but the molecular mechanisms and causative genes remain unidentified in the majority of cases. We have uncovered a novel transcription pathway important for heart morphogenesis. We report that KLF13, a member of the Krüppel-like family of zinc-finger proteins, is expressed predominantly in the heart, binds evolutionarily conserved regulatory elements on cardiac promoters and activates cardiac transcription. KLF13 is conserved across species and knockdown of KLF13 in Xenopus embryos leads to atrial septal defects and hypotrabeculation similar to those observed in humans or mice with hypomorphic GATA-4 alleles. Physical and functional interaction with GATA-4, a dosage-sensitive cardiac regulator, provides a mechanistic explanation for KLF13 action in the heart. The data demonstrate that KLF13 is an important component of the transcription network required for heart development and suggest that KLF13 is a GATA-4 modifier; by analogy to other GATA-4 collaborators, mutations in KLF13 may be causative for congenital human heart disease. © 2006 European Molecular Biology Organization. All Rights Reserved.
dc.format.extent
dc.format.extent Pages: (5201-5213)
dc.language English
dc.relation.ispartof Publication Name: EMBO Journal; Publication Year: 2006; Volume: 25; no. 21; Pages: (5201-5213);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title The Kruppel-like transcription factor KLF13 is a novel regulator of heart development
dc.type Article
dc.contributor.affiliation Lavallée, G., Institut de Recherches Cliniques de Montréal (IRCM), Montréal, Que., Canada, Université de Montréal, Montréal, Que., Canada
dc.contributor.affiliation Andelfinger, G., Institut de Recherches Cliniques de Montréal (IRCM), Montréal, Que., Canada, Université de Montréal, Montréal, Que., Canada
dc.contributor.affiliation Nadeau, M., Institut de Recherches Cliniques de Montréal (IRCM), Montréal, Que., Canada, Université de Montréal, Montréal, Que., Canada
dc.contributor.affiliation Lefebvre, C., Institut de Recherches Cliniques de Montréal (IRCM), Montréal, Que., Canada, Université de Montréal, Montréal, Que., Canada
dc.contributor.affiliation Nemer, G., Institut de Recherches Cliniques de Montréal (IRCM), Montréal, Que., Canada, Université de Montréal, Montréal, Que., Canada, Faculty of Medicine, American University of Beirut, Lebanon
dc.contributor.affiliation Horb, M.E., Institut de Recherches Cliniques de Montréal (IRCM), Montréal, Que., Canada, Université de Montréal, Montréal, Que., Canada, Cardiac Growth and Differentiation Unit, Institut de Recherches Cliniques de Montréal (IRCM), 110, avenue des Pins Ouest, Montréal, Que. H2W1R7, Canada
dc.contributor.affiliation Nemer, M., Institut de Recherches Cliniques de Montréal (IRCM), Montréal, Que., Canada, Université de Montréal, Montréal, Que., Canada, Cardiac Growth and Differentiation Unit, Institut de Recherches Cliniques de Montréal (IRCM), 110, avenue des Pins Ouest, Montréal, Que. H2W1R7, Canada
dc.contributor.authorAddress Horb, M.E.; Cardiac Growth and Differentiation Unit, Institut de Recherches Cliniques de Montréal (IRCM), 110, avenue des Pins Ouest, Montréal, Que. H2W1R7, Canada; email: marko.horb@ircm.qc.ca
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Biochemistry and Molecular Genetics;
dc.contributor.authorDepartment Biochemistry and Molecular Genetics
dc.contributor.authorDivision
dc.contributor.authorEmail
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited
dc.description.citedCount 24
dc.description.citedTotWOSCount
dc.description.citedWOSCount
dc.format.extentCount 13
dc.identifier.articleNo
dc.identifier.coden EMJOD
dc.identifier.pubmedID 17053787
dc.identifier.scopusID 33750489724
dc.identifier.url
dc.publisher.address
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr
dc.relation.ispartOfIssue 21
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle EMBO Journal
dc.relation.ispartofPubTitleAbbr EMBO J.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 25
dc.source.ID
dc.type.publication Journal
dc.subject.otherAuthKeyword ANP
dc.subject.otherAuthKeyword BNP
dc.subject.otherAuthKeyword Cardiac transcription
dc.subject.otherAuthKeyword GATA-4
dc.subject.otherAuthKeyword Xenopus
dc.subject.otherChemCAS GATA4 protein, Xenopus
dc.subject.otherChemCAS GATA4 Transcription Factor
dc.subject.otherChemCAS Kruppel-Like Transcription Factors
dc.subject.otherChemCAS Xenopus Proteins
dc.subject.otherIndex protein KLF13
dc.subject.otherIndex transcription factor GATA 4
dc.subject.otherIndex unclassified drug
dc.subject.otherIndex zinc finger protein
dc.subject.otherIndex article
dc.subject.otherIndex embryo
dc.subject.otherIndex heart atrium septum defect
dc.subject.otherIndex heart development
dc.subject.otherIndex morphogenesis
dc.subject.otherIndex nonhuman
dc.subject.otherIndex priority journal
dc.subject.otherIndex protein protein interaction
dc.subject.otherIndex Xenopus
dc.subject.otherIndex Alleles
dc.subject.otherIndex Animals
dc.subject.otherIndex GATA4 Transcription Factor
dc.subject.otherIndex Gene Dosage
dc.subject.otherIndex Gene Expression Regulation, Developmental
dc.subject.otherIndex Heart
dc.subject.otherIndex Heart Septal Defects, Atrial
dc.subject.otherIndex Humans
dc.subject.otherIndex Kruppel-Like Transcription Factors
dc.subject.otherIndex Mice
dc.subject.otherIndex Mutation
dc.subject.otherIndex Myocardium
dc.subject.otherIndex NIH 3T3 Cells
dc.subject.otherIndex Transcription, Genetic
dc.subject.otherIndex Xenopus laevis
dc.subject.otherIndex Xenopus Proteins
dc.subject.otherKeywordPlus
dc.subject.otherWOS


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