dc.contributor.author |
Lavallee G. |
dc.contributor.author |
Andelfinger G. |
dc.contributor.author |
Nadeau M. |
dc.contributor.author |
Lefebvre C. |
dc.contributor.author |
Nemer G. |
dc.contributor.author |
Horb M.E. |
dc.contributor.author |
Nemer M. |
dc.contributor.editor |
|
dc.date |
Nov-2006 |
dc.date.accessioned |
2017-10-05T15:30:58Z |
dc.date.available |
2017-10-05T15:30:58Z |
dc.date.issued |
2006 |
dc.identifier |
10.1038/sj.emboj.7601379 |
dc.identifier.isbn |
|
dc.identifier.issn |
02614189 |
dc.identifier.uri |
http://hdl.handle.net/10938/15312 |
dc.description.abstract |
In humans, congenital heart defects occur in 1-2percent of live birth, but the molecular mechanisms and causative genes remain unidentified in the majority of cases. We have uncovered a novel transcription pathway important for heart morphogenesis. We report that KLF13, a member of the Krüppel-like family of zinc-finger proteins, is expressed predominantly in the heart, binds evolutionarily conserved regulatory elements on cardiac promoters and activates cardiac transcription. KLF13 is conserved across species and knockdown of KLF13 in Xenopus embryos leads to atrial septal defects and hypotrabeculation similar to those observed in humans or mice with hypomorphic GATA-4 alleles. Physical and functional interaction with GATA-4, a dosage-sensitive cardiac regulator, provides a mechanistic explanation for KLF13 action in the heart. The data demonstrate that KLF13 is an important component of the transcription network required for heart development and suggest that KLF13 is a GATA-4 modifier; by analogy to other GATA-4 collaborators, mutations in KLF13 may be causative for congenital human heart disease. © 2006 European Molecular Biology Organization. All Rights Reserved. |
dc.format.extent |
|
dc.format.extent |
Pages: (5201-5213) |
dc.language |
English |
dc.relation.ispartof |
Publication Name: EMBO Journal; Publication Year: 2006; Volume: 25; no. 21; Pages: (5201-5213); |
dc.relation.ispartofseries |
|
dc.relation.uri |
|
dc.source |
Scopus |
dc.subject.other |
|
dc.title |
The Kruppel-like transcription factor KLF13 is a novel regulator of heart development |
dc.type |
Article |
dc.contributor.affiliation |
Lavallée, G., Institut de Recherches Cliniques de Montréal (IRCM), Montréal, Que., Canada, Université de Montréal, Montréal, Que., Canada |
dc.contributor.affiliation |
Andelfinger, G., Institut de Recherches Cliniques de Montréal (IRCM), Montréal, Que., Canada, Université de Montréal, Montréal, Que., Canada |
dc.contributor.affiliation |
Nadeau, M., Institut de Recherches Cliniques de Montréal (IRCM), Montréal, Que., Canada, Université de Montréal, Montréal, Que., Canada |
dc.contributor.affiliation |
Lefebvre, C., Institut de Recherches Cliniques de Montréal (IRCM), Montréal, Que., Canada, Université de Montréal, Montréal, Que., Canada |
dc.contributor.affiliation |
Nemer, G., Institut de Recherches Cliniques de Montréal (IRCM), Montréal, Que., Canada, Université de Montréal, Montréal, Que., Canada, Faculty of Medicine, American University of Beirut, Lebanon |
dc.contributor.affiliation |
Horb, M.E., Institut de Recherches Cliniques de Montréal (IRCM), Montréal, Que., Canada, Université de Montréal, Montréal, Que., Canada, Cardiac Growth and Differentiation Unit, Institut de Recherches Cliniques de Montréal (IRCM), 110, avenue des Pins Ouest, Montréal, Que. H2W1R7, Canada |
dc.contributor.affiliation |
Nemer, M., Institut de Recherches Cliniques de Montréal (IRCM), Montréal, Que., Canada, Université de Montréal, Montréal, Que., Canada, Cardiac Growth and Differentiation Unit, Institut de Recherches Cliniques de Montréal (IRCM), 110, avenue des Pins Ouest, Montréal, Que. H2W1R7, Canada |
dc.contributor.authorAddress |
Horb, M.E.; Cardiac Growth and Differentiation Unit, Institut de Recherches Cliniques de Montréal (IRCM), 110, avenue des Pins Ouest, Montréal, Que. H2W1R7, Canada; email: marko.horb@ircm.qc.ca |
dc.contributor.authorCorporate |
University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Biochemistry and Molecular Genetics; |
dc.contributor.authorDepartment |
Biochemistry and Molecular Genetics |
dc.contributor.authorDivision |
|
dc.contributor.authorEmail |
|
dc.contributor.authorFaculty |
Faculty of Medicine |
dc.contributor.authorInitials |
|
dc.contributor.authorOrcidID |
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dc.contributor.authorReprintAddress |
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dc.contributor.authorResearcherID |
|
dc.contributor.authorUniversity |
American University of Beirut Medical Center |
dc.description.cited |
|
dc.description.citedCount |
24 |
dc.description.citedTotWOSCount |
|
dc.description.citedWOSCount |
|
dc.format.extentCount |
13 |
dc.identifier.articleNo |
|
dc.identifier.coden |
EMJOD |
dc.identifier.pubmedID |
17053787 |
dc.identifier.scopusID |
33750489724 |
dc.identifier.url |
|
dc.publisher.address |
|
dc.relation.ispartofConference |
|
dc.relation.ispartofConferenceCode |
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dc.relation.ispartofConferenceDate |
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dc.relation.ispartofConferenceHosting |
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dc.relation.ispartofConferenceLoc |
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dc.relation.ispartofConferenceSponsor |
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dc.relation.ispartofConferenceTitle |
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dc.relation.ispartofFundingAgency |
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dc.relation.ispartOfISOAbbr |
|
dc.relation.ispartOfIssue |
21 |
dc.relation.ispartOfPart |
|
dc.relation.ispartofPubTitle |
EMBO Journal |
dc.relation.ispartofPubTitleAbbr |
EMBO J. |
dc.relation.ispartOfSpecialIssue |
|
dc.relation.ispartOfSuppl |
|
dc.relation.ispartOfVolume |
25 |
dc.source.ID |
|
dc.type.publication |
Journal |
dc.subject.otherAuthKeyword |
ANP |
dc.subject.otherAuthKeyword |
BNP |
dc.subject.otherAuthKeyword |
Cardiac transcription |
dc.subject.otherAuthKeyword |
GATA-4 |
dc.subject.otherAuthKeyword |
Xenopus |
dc.subject.otherChemCAS |
GATA4 protein, Xenopus |
dc.subject.otherChemCAS |
GATA4 Transcription Factor |
dc.subject.otherChemCAS |
Kruppel-Like Transcription Factors |
dc.subject.otherChemCAS |
Xenopus Proteins |
dc.subject.otherIndex |
protein KLF13 |
dc.subject.otherIndex |
transcription factor GATA 4 |
dc.subject.otherIndex |
unclassified drug |
dc.subject.otherIndex |
zinc finger protein |
dc.subject.otherIndex |
article |
dc.subject.otherIndex |
embryo |
dc.subject.otherIndex |
heart atrium septum defect |
dc.subject.otherIndex |
heart development |
dc.subject.otherIndex |
morphogenesis |
dc.subject.otherIndex |
nonhuman |
dc.subject.otherIndex |
priority journal |
dc.subject.otherIndex |
protein protein interaction |
dc.subject.otherIndex |
Xenopus |
dc.subject.otherIndex |
Alleles |
dc.subject.otherIndex |
Animals |
dc.subject.otherIndex |
GATA4 Transcription Factor |
dc.subject.otherIndex |
Gene Dosage |
dc.subject.otherIndex |
Gene Expression Regulation, Developmental |
dc.subject.otherIndex |
Heart |
dc.subject.otherIndex |
Heart Septal Defects, Atrial |
dc.subject.otherIndex |
Humans |
dc.subject.otherIndex |
Kruppel-Like Transcription Factors |
dc.subject.otherIndex |
Mice |
dc.subject.otherIndex |
Mutation |
dc.subject.otherIndex |
Myocardium |
dc.subject.otherIndex |
NIH 3T3 Cells |
dc.subject.otherIndex |
Transcription, Genetic |
dc.subject.otherIndex |
Xenopus laevis |
dc.subject.otherIndex |
Xenopus Proteins |
dc.subject.otherKeywordPlus |
|
dc.subject.otherWOS |
|