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Copper-adenine complex, a compound, with multi-biochemical targets and potential anti-cancer effect

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dc.contributor.author Hammud H.H.
dc.contributor.author Nemer G.
dc.contributor.author Sawma W.
dc.contributor.author Touma J.
dc.contributor.author Barnabe P.
dc.contributor.author Bou-Mouglabey Y.
dc.contributor.author Ghannoum A.
dc.contributor.author El-Hajjar J.
dc.contributor.author Usta J.
dc.contributor.editor
dc.date May-2008
dc.date.accessioned 2017-10-05T15:30:59Z
dc.date.available 2017-10-05T15:30:59Z
dc.date.issued 2008
dc.identifier 10.1016/j.cbi.2008.03.005
dc.identifier.isbn
dc.identifier.issn 00092797
dc.identifier.uri http://hdl.handle.net/10938/15314
dc.description.abstract A series of adenine-copper complexes (1-6) with various ligands (Cl-, SCN-, BF4- and acac [acetylacetonate ion]) have been synthesized and characterized by elemental analysis, infrared spectroscopy and thermal analysis. Among the six complexes only complex (1), Cu2(adenine)4Cl4·2EtOH (abbreviated as Cu-Ad), demonstrated some toxic effect on different cell lines. In vitro investigations of the biological effect of Cu-Ad complex have shown that it: (1) binds genomic DNA; (2) decreases significantly, the viability of cells in culture in a concentration (15-125 μM)-dependant manner; an estimated IC50 of: 45 μM with HepG2; 73 μM with C2C12; 103 μM with NIH3T3; and 108 μM with MCF7. Cu-Ad had no effect on A549 cells; (3) inhibits Taq polymerase-catalyzed reaction; (4) inhibits the binding of the transcription factor GATA-5 to labeled DNA probes; (5) inhibits mitochondrial NADH-UQ-reductase with an estimated IC50 of 2.8 nmol, but had no effect on succinate dehydrogenase activity; (6) increases reactive oxygen species (60percent) at 45 μM Cu-Ad; and (7) decreases ATP (80percent) at 50 μM Cu-Ad. The new compound Cu2(adenine)4Cl4·2EtOH (Cu-Ad), belongs to a class of copper-adenylate complexes that target many biochemical sites and with potential anti-cancer activity. © 2008 Elsevier Ireland Ltd. All rights reserved.
dc.format.extent
dc.format.extent Pages: (84-96)
dc.language English
dc.publisher CLARE
dc.relation.ispartof Publication Name: Chemico-Biological Interactions; Publication Year: 2008; Volume: 173; no. 2; Pages: (84-96);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Copper-adenine complex, a compound, with multi-biochemical targets and potential anti-cancer effect
dc.type Article
dc.contributor.affiliation Hammud, H.H., Beirut Arab University, Department of Chemistry, Beirut, Lebanon
dc.contributor.affiliation Nemer, G., American University of Beirut, Department of Biochemistry, School of Medicine, Abdul-Aziz Street, Hamra, Beirut, Lebanon
dc.contributor.affiliation Sawma, W., American University of Beirut, Department of Biochemistry, School of Medicine, Abdul-Aziz Street, Hamra, Beirut, Lebanon
dc.contributor.affiliation Touma, J., American University of Beirut, Department of Biochemistry, School of Medicine, Abdul-Aziz Street, Hamra, Beirut, Lebanon
dc.contributor.affiliation Barnabe, P., American University of Beirut, Department of Biochemistry, School of Medicine, Abdul-Aziz Street, Hamra, Beirut, Lebanon
dc.contributor.affiliation Bou-Mouglabey, Y., American University of Beirut, Department of Biochemistry, School of Medicine, Abdul-Aziz Street, Hamra, Beirut, Lebanon
dc.contributor.affiliation Ghannoum, A., Beirut Arab University, Department of Chemistry, Beirut, Lebanon
dc.contributor.affiliation El-Hajjar, J., American University of Beirut, Department of Biochemistry, School of Medicine, Abdul-Aziz Street, Hamra, Beirut, Lebanon
dc.contributor.affiliation Usta, J., American University of Beirut, Department of Biochemistry, School of Medicine, Abdul-Aziz Street, Hamra, Beirut, Lebanon
dc.contributor.authorAddress Usta, J.; American University of Beirut, Department of Biochemistry, School of Medicine, Abdul-Aziz Street, Hamra, Beirut, Lebanon; email: justa@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Biochemistry and Molecular Genetics;
dc.contributor.authorDepartment Biochemistry and Molecular Genetics
dc.contributor.authorDivision
dc.contributor.authorEmail justa@aub.edu.lb
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Hammud, HH
dc.contributor.authorInitials Nemer, G
dc.contributor.authorInitials Sawma, W
dc.contributor.authorInitials Touma, J
dc.contributor.authorInitials Barnabe, P
dc.contributor.authorInitials Bou-Mouglabey, Y
dc.contributor.authorInitials Ghannoum, A
dc.contributor.authorInitials El-Hajjar, J
dc.contributor.authorInitials Usta, J
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Usta, J (reprint author), Amer Univ Beirut, Dept Biochem, Sch Med, Abdul Aziz St, Beirut, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 18
dc.description.citedTotWOSCount 17
dc.description.citedWOSCount 17
dc.format.extentCount 13
dc.identifier.articleNo
dc.identifier.coden CBINA
dc.identifier.pubmedID 18452907
dc.identifier.scopusID 43049183307
dc.identifier.url
dc.publisher.address ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Chem.-Biol. Interact.
dc.relation.ispartOfIssue 2
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Chemico-Biological Interactions
dc.relation.ispartofPubTitleAbbr Chem.-Biol. Interact.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 173
dc.source.ID WOS:000256578700002
dc.type.publication Journal
dc.subject.otherAuthKeyword Copper-adenine
dc.subject.otherAuthKeyword GATA-5
dc.subject.otherAuthKeyword HepG2
dc.subject.otherAuthKeyword PCR
dc.subject.otherAuthKeyword TbX20
dc.subject.otherAuthKeyword WND
dc.subject.otherChemCAS adenine, 22177-51-1, 2922-28-3, 73-24-5
dc.subject.otherChemCAS adenosine triphosphate, 15237-44-2, 56-65-5, 987-65-5
dc.subject.otherChemCAS chloride, 16887-00-6
dc.subject.otherChemCAS reduced nicotinamide adenine dinucleotide dehydrogenase (ubiquinone), 9028-04-0
dc.subject.otherChemCAS succinate dehydrogenase, 9002-02-2, 9028-10-8
dc.subject.otherChemCAS thiocyanate, 302-04-5
dc.subject.otherChemCAS Adenine, 73-24-5
dc.subject.otherChemCAS Adenosine Triphosphate, 56-65-5
dc.subject.otherChemCAS Antineoplastic Agents
dc.subject.otherChemCAS Copper, 7440-50-8
dc.subject.otherChemCAS Electron Transport Complex I, EC 1.6.5.3
dc.subject.otherChemCAS GATA5 Transcription Factor
dc.subject.otherChemCAS Organometallic Compounds
dc.subject.otherChemCAS Reactive Oxygen Species
dc.subject.otherChemCAS Succinate Dehydrogenase, EC 1.3.99.1
dc.subject.otherChemCAS Taq Polymerase, EC 2.7.7.-
dc.subject.otherIndex adenine
dc.subject.otherIndex adenosine triphosphate
dc.subject.otherIndex chloride
dc.subject.otherIndex copper adenine complex
dc.subject.otherIndex copper complex
dc.subject.otherIndex reduced nicotinamide adenine dinucleotide dehydrogenase (ubiquinone)
dc.subject.otherIndex succinate dehydrogenase
dc.subject.otherIndex Taq polymerase
dc.subject.otherIndex thiocyanate
dc.subject.otherIndex transcription factor GATA 5
dc.subject.otherIndex animal cell
dc.subject.otherIndex antineoplastic activity
dc.subject.otherIndex article
dc.subject.otherIndex cell strain 3T3
dc.subject.otherIndex cell strain HepG2
dc.subject.otherIndex cell strain MCF 7
dc.subject.otherIndex cell viability
dc.subject.otherIndex controlled study
dc.subject.otherIndex DNA probe
dc.subject.otherIndex drug cytotoxicity
dc.subject.otherIndex drug DNA binding
dc.subject.otherIndex drug synthesis
dc.subject.otherIndex enzyme activity
dc.subject.otherIndex human
dc.subject.otherIndex human cell
dc.subject.otherIndex infrared spectroscopy
dc.subject.otherIndex nonhuman
dc.subject.otherIndex thermal analysis
dc.subject.otherIndex Adenine
dc.subject.otherIndex Adenosine Triphosphate
dc.subject.otherIndex Antineoplastic Agents
dc.subject.otherIndex Calorimetry, Differential Scanning
dc.subject.otherIndex Cell Line, Tumor
dc.subject.otherIndex Cell Survival
dc.subject.otherIndex Copper
dc.subject.otherIndex Electron Transport Complex I
dc.subject.otherIndex Electrophoretic Mobility Shift Assay
dc.subject.otherIndex GATA5 Transcription Factor
dc.subject.otherIndex Humans
dc.subject.otherIndex Inhibitory Concentration 50
dc.subject.otherIndex Organometallic Compounds
dc.subject.otherIndex Reactive Oxygen Species
dc.subject.otherIndex Spectrophotometry, Ultraviolet
dc.subject.otherIndex Spectroscopy, Fourier Transform Infrared
dc.subject.otherIndex Succinate Dehydrogenase
dc.subject.otherIndex Taq Polymerase
dc.subject.otherIndex Thermogravimetry
dc.subject.otherKeywordPlus PROTEIN-KINASE-C
dc.subject.otherKeywordPlus NUCLEIC-ACID CONSTITUENTS
dc.subject.otherKeywordPlus SELENOCOMPOUNDS INDUCE
dc.subject.otherKeywordPlus PREBIOTIC CATALYSIS
dc.subject.otherKeywordPlus ANTITUMOR-ACTIVITY
dc.subject.otherKeywordPlus CRYSTAL-STRUCTURE
dc.subject.otherKeywordPlus METAL-IONS
dc.subject.otherKeywordPlus X-RAY
dc.subject.otherKeywordPlus DNA
dc.subject.otherKeywordPlus ENZYME
dc.subject.otherWOS Biochemistry and Molecular Biology
dc.subject.otherWOS Pharmacology and Pharmacy
dc.subject.otherWOS Toxicology


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