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Penicillamine revisited: Historic overview and review of the clinical uses and cutaneous adverse effects

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dc.contributor.author Ishak R.
dc.contributor.author Abbas O.
dc.contributor.editor
dc.date Jun-2013
dc.date.accessioned 2017-10-05T15:32:49Z
dc.date.available 2017-10-05T15:32:49Z
dc.date.issued 2013
dc.identifier 10.1007/s40257-013-0022-z
dc.identifier.isbn
dc.identifier.issn 11750561
dc.identifier.uri http://hdl.handle.net/10938/15419
dc.description.abstract Penicillamine is a well-known heavy metal chelator, classically used in the treatment of Wilson disease, rheumatoid arthritis, and cystinuria. From a dermatologic standpoint, penicillamine was found to be useful in the treatment of systemic sclerosis. The successful therapeutic uses of penicillamine have been hindered by its numerous adverse effects, both cutaneous and extra-cutaneous. It is a unique drug since it provokes a diversity of dermatologic manifestations that include (1) acute hypersensitivity reactions, (2) dermopathies characterized by elastic fiber abnormalities including elastosis perforans serpiginosa and pseudo-pseudoxanthoma elasticum, (3) autoimmune disorders such as pemphigus and penicillamine-induced lupus erythematosus-like syndrome, and (4) miscellaneous dermatoses that result from undefined mechanisms. These cutaneous adverse effects may correlate with the dosage and duration of penicillamine therapy as well as the disease being treated. © 2013 Springer International Publishing Switzerland.
dc.format.extent
dc.format.extent Pages: (223-233)
dc.language English
dc.publisher AUCKLAND
dc.relation.ispartof Publication Name: American Journal of Clinical Dermatology; Publication Year: 2013; Volume: 14; no. 3; Pages: (223-233);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Penicillamine revisited: Historic overview and review of the clinical uses and cutaneous adverse effects
dc.type Review
dc.contributor.affiliation Ishak, R., Department of Dermatology, American University of Beirut Medical Center, Riad El Solh-Beirut, Beirut 1107 2020, Lebanon
dc.contributor.affiliation Abbas, O., Department of Dermatology, American University of Beirut Medical Center, Riad El Solh-Beirut, Beirut 1107 2020, Lebanon
dc.contributor.authorAddress Abbas, O.; Department of Dermatology, American University of Beirut Medical Center, Riad El Solh-Beirut, Beirut 1107 2020, Lebanon; email: oa09@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Dermatology;
dc.contributor.authorDepartment Dermatology
dc.contributor.authorDivision
dc.contributor.authorEmail oa09@aub.edu.lb
dc.contributor.faculty Faculty of Medicine
dc.contributor.authorInitials Ishak, R
dc.contributor.authorInitials Abbas, O
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Abbas, O (reprint author), Amer Univ Beirut, Dept Dermatol, Med Ctr, POB 11-0236, Beirut 11072020, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 4
dc.description.citedTotWOSCount 6
dc.description.citedWOSCount 5
dc.format.extentCount 11
dc.identifier.articleNo
dc.identifier.coden AJCDC
dc.identifier.pubmedID 23605177
dc.identifier.scopusID 84878749327
dc.identifier.url
dc.publisher.address 41 CENTORIAN DR, PRIVATE BAG 65901, MAIRANGI BAY, AUCKLAND 1311, NEW ZEALAND
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Am. J. Clin. Dermatol.
dc.relation.ispartOfIssue 3
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle American Journal of Clinical Dermatology
dc.relation.ispartofPubTitleAbbr Am. J. Clin. Dermatol.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 14
dc.source.ID WOS:000319757000006
dc.type.publication Journal
dc.subject.otherAuthKeyword
dc.subject.otherChemCAS ceruloplasmin, 9031-37-2
dc.subject.otherChemCAS copper, 15158-11-9, 7440-50-8
dc.subject.otherChemCAS penicillamine, 2219-30-9, 52-67-5
dc.subject.otherChemCAS protein bcl 2, 219306-68-0
dc.subject.otherChemCAS Chelating Agents
dc.subject.otherChemCAS Penicillamine, GNN1DV99GX
dc.subject.otherIndex ceruloplasmin
dc.subject.otherIndex copper
dc.subject.otherIndex corticosteroid
dc.subject.otherIndex HLA A1 antigen
dc.subject.otherIndex HLA B8 antigen
dc.subject.otherIndex HLA DR1 antigen
dc.subject.otherIndex HLA DR3 antigen
dc.subject.otherIndex HLA DR4 antigen
dc.subject.otherIndex penicillamine
dc.subject.otherIndex protein bcl 2
dc.subject.otherIndex protein p53
dc.subject.otherIndex agranulocytosis
dc.subject.otherIndex anorexia
dc.subject.otherIndex antiangiogenic activity
dc.subject.otherIndex aplastic anemia
dc.subject.otherIndex apoptosis
dc.subject.otherIndex cystinuria
dc.subject.otherIndex dermatomyositis
dc.subject.otherIndex diarrhea
dc.subject.otherIndex diplopia
dc.subject.otherIndex drug contraindication
dc.subject.otherIndex drug induced disease
dc.subject.otherIndex drug withdrawal
dc.subject.otherIndex dyspepsia
dc.subject.otherIndex elastic fiber
dc.subject.otherIndex elastosis perforans serpiginosa
dc.subject.otherIndex eosinophilic fasciitis
dc.subject.otherIndex epidermolysis bullosa acquisita
dc.subject.otherIndex glioblastoma
dc.subject.otherIndex hematuria
dc.subject.otherIndex histopathology
dc.subject.otherIndex human
dc.subject.otherIndex leukopenia
dc.subject.otherIndex lichen planus
dc.subject.otherIndex low drug dose
dc.subject.otherIndex lupus like syndrome
dc.subject.otherIndex metastatic melanoma
dc.subject.otherIndex mucous membrane pemphigoid
dc.subject.otherIndex nausea
dc.subject.otherIndex nephritis
dc.subject.otherIndex nonhuman
dc.subject.otherIndex overall survival
dc.subject.otherIndex oxidative stress
dc.subject.otherIndex pemphigus
dc.subject.otherIndex photophobia
dc.subject.otherIndex primary biliary cirrhosis
dc.subject.otherIndex priority journal
dc.subject.otherIndex proteinuria
dc.subject.otherIndex pseudoxanthoma elasticum
dc.subject.otherIndex review
dc.subject.otherIndex rheumatoid arthritis
dc.subject.otherIndex scleroderma
dc.subject.otherIndex skin disease
dc.subject.otherIndex systemic sclerosis
dc.subject.otherIndex taste disorder
dc.subject.otherIndex thrombocytopenia
dc.subject.otherIndex vomiting
dc.subject.otherIndex Wilson disease
dc.subject.otherIndex Chelating Agents
dc.subject.otherIndex Humans
dc.subject.otherIndex Penicillamine
dc.subject.otherIndex Skin Diseases
dc.subject.otherKeywordPlus ELASTOSIS PERFORANS SERPIGINOSA
dc.subject.otherKeywordPlus DRUG-INDUCED PEMPHIGUS
dc.subject.otherKeywordPlus PSEUDO-PSEUDOXANTHOMA ELASTICUM
dc.subject.otherKeywordPlus PROGRESSIVE SYSTEMIC-SCLEROSIS
dc.subject.otherKeywordPlus PRIMARY BILIARY-CIRRHOSIS
dc.subject.otherKeywordPlus OF-THE-LITERATURE
dc.subject.otherKeywordPlus CONNECTIVE-TISSUE DISEASE
dc.subject.otherKeywordPlus INDUCED MYASTHENIA-GRAVIS
dc.subject.otherKeywordPlus MATERNAL D-PENICILLAMINE
dc.subject.otherKeywordPlus RHEUMAT
dc.subject.otherWOS Dermatology


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