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An optimised patient-specific approach to administration of contrast agent for CT pulmonary angiography

Show simple item record Saade C. Bourne R. El-Merhi F. Somanathan A. Chakraborty D. Brennan P.
dc.contributor.editor Nov-2013 2017-10-05T15:33:37Z 2017-10-05T15:33:37Z 2013
dc.identifier 10.1007/s00330-013-2919-6
dc.identifier.issn 09387994
dc.description.abstract Objectives: To investigate pulmonary vasculature opacification during CTPA using an optimised patient-specific protocol for administering contrast agent. Methods: CTPA was performed on 200 patients with suspected PE. Patients were assigned to two protocol groups: protocol A, fixed 80 ml contrast agent; protocol B used a patient-specific approach. The mean cross-sectional opacification profile of 8 central and 11 peripheral pulmonary arteries and veins was measured and the arteriovenous contrast ratio (AVCR) calculated. Protocols were compared using Mann-Whitney U non-parametric statistics. Jack-knife alternative free-response receiver-operating characteristic (JAFROC) analyses assessed diagnostic efficacy. Interobserver variations were investigated using kappa methods. Results: A number of pulmonary arteries demonstrated increases in opacification (P 0.03) for protocol B compared to A, whilst opacification in the heart and veins was reduced in protocol B (P = 0.05). Increased AVCR in protocol B compared with A was observed at all anatomic locations (P 0.0002). Increased JAFROC (P 0.0002) and kappa variation were observed with protocol B (κ = 0.78) compared to A (κ = 0.25). Mean contrast volume was reduced in protocol B (33 ± 9 ml) compared to A (80 ± 1 ml). Conclusions: Significant improvements in visualisation of the pulmonary vasculature can be achieved with a low volume of contrast agent using injection timing based on a patient-specific contrast formula. © 2013 European Society of Radiology.
dc.format.extent Pages: (3205-3212)
dc.language English
dc.publisher NEW YORK
dc.relation.ispartof Publication Name: European Radiology; Publication Year: 2013; Volume: 23; no. 11; Pages: (3205-3212);
dc.source Scopus
dc.title An optimised patient-specific approach to administration of contrast agent for CT pulmonary angiography
dc.type Article
dc.contributor.affiliation Saade, C., Department of Radiology, Royal Prince Alfred Hospital, Missenden Rd, Camperdown, Sydney, NSW 2050, Australia, Department of Radiology, American University of Beirut Medical Center, PO Box: 11-0236, Riad El Solh, Beirut 1107 2020, Lebanon, Discipline of Medical Radiation Sciences, University of Sydney, Lidcombe, NSW 2141, Australia
dc.contributor.affiliation Bourne, R., Discipline of Medical Radiation Sciences, University of Sydney, Lidcombe, NSW 2141, Australia
dc.contributor.affiliation El-Merhi, F., Department of Radiology, American University of Beirut Medical Center, PO Box: 11-0236, Riad El Solh, Beirut 1107 2020, Lebanon
dc.contributor.affiliation Somanathan, A., Discipline of Medical Radiation Sciences, Saint George Hospital, University of Sydney, Sydney, NSW 2141, Australia
dc.contributor.affiliation Chakraborty, D., Medical Image Interpretation Assessment Laboratory, University of Pittsburgh, Presby South Tower, 200 Lothrop Street, Pittsburgh, PA 15213, United States
dc.contributor.affiliation Brennan, P., Discipline of Medical Radiation Sciences, University of Sydney, Lidcombe, NSW 2141, Australia
dc.contributor.authorAddress Saade, C.; Department of Radiology, Royal Prince Alfred Hospital, Missenden Rd, Camperdown, Sydney, NSW 2050, Australia; email:
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Diagnostic Radiology;
dc.contributor.authorDepartment Diagnostic Radiology
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Saade, C
dc.contributor.authorInitials Bourne, R
dc.contributor.authorInitials El-Merhi, F
dc.contributor.authorInitials Somanathan, A
dc.contributor.authorInitials Chakraborty, D
dc.contributor.authorInitials Brennan, P
dc.contributor.authorReprintAddress Saade, C (reprint author), Royal Prince Alfred Hosp, Dept Radiol, Missenden Rd, Sydney, NSW 2050, Australia.
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 1
dc.description.citedTotWOSCount 1
dc.description.citedWOSCount 1
dc.format.extentCount 8
dc.identifier.coden EURAE
dc.identifier.pubmedID 23732690
dc.identifier.scopusID 84885949587
dc.publisher.address 233 SPRING ST, NEW YORK, NY 10013 USA
dc.relation.ispartOfISOAbbr Eur. Radiol.
dc.relation.ispartOfIssue 11
dc.relation.ispartofPubTitle European Radiology
dc.relation.ispartofPubTitleAbbr Eur. Radiol.
dc.relation.ispartOfVolume 23
dc.source.ID WOS:000325466900033
dc.type.publication Journal
dc.subject.otherAuthKeyword Cardiovascular dynamics
dc.subject.otherAuthKeyword Computed tomography angiography
dc.subject.otherAuthKeyword Contrast volume
dc.subject.otherAuthKeyword Pulmonary embolism
dc.subject.otherAuthKeyword Pulmonary vasculature
dc.subject.otherChemCAS ioversol, 87771-40-2
dc.subject.otherIndex contrast medium
dc.subject.otherIndex ioversol
dc.subject.otherIndex adult
dc.subject.otherIndex aged
dc.subject.otherIndex article
dc.subject.otherIndex clinical protocol
dc.subject.otherIndex computed tomographic angiography
dc.subject.otherIndex computed tomography scanner
dc.subject.otherIndex female
dc.subject.otherIndex human
dc.subject.otherIndex lung angiography
dc.subject.otherIndex lung blood vessel
dc.subject.otherIndex lung embolism
dc.subject.otherIndex major clinical study
dc.subject.otherIndex male
dc.subject.otherIndex priority journal
dc.subject.otherIndex pulmonary artery
dc.subject.otherIndex pulmonary vein
dc.subject.otherIndex Angiography
dc.subject.otherIndex Contrast Media
dc.subject.otherIndex Female
dc.subject.otherIndex Humans
dc.subject.otherIndex Injections
dc.subject.otherIndex Male
dc.subject.otherIndex Middle Aged
dc.subject.otherIndex Pulmonary Artery
dc.subject.otherIndex Pulmonary Embolism
dc.subject.otherIndex Pulmonary Veins
dc.subject.otherIndex Retrospective Studies
dc.subject.otherIndex Tomography, X-Ray Computed
dc.subject.otherKeywordPlus MULTIDETECTOR ROW CT
dc.subject.otherKeywordPlus BODY-SURFACE AREA
dc.subject.otherKeywordPlus DUAL-ENERGY CT
dc.subject.otherKeywordPlus SPIRAL CT
dc.subject.otherKeywordPlus COMPUTED-TOMOGRAPHY
dc.subject.otherKeywordPlus IMAGE QUALITY
dc.subject.otherKeywordPlus VASCULAR ENHANCEMENT
dc.subject.otherKeywordPlus INJECTION PROTOCOLS
dc.subject.otherKeywordPlus AORTIC ENHANCEMENT
dc.subject.otherKeywordPlus POWER INJECTOR
dc.subject.otherWOS Radiology, Nuclear Medicine and Medical Imaging

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