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Predictors of bone mineral density in patients on hemodialysis

Show simple item record Zayour D. Daouk M. Medawar W. Salamoun M. El-Hajj Fuleihan G.
dc.contributor.editor Jun-2004 2017-10-05T15:37:16Z 2017-10-05T15:37:16Z 2004
dc.identifier 10.1016/j.transproceed.2004.05.069
dc.identifier.issn 00411345
dc.description.abstract Renal osteodystrophy is a universal complication of uremia. Renal failure patients are at risk for low bone mineral density (BMD) and fractures. Parathyroid hormone (PTH) plays a pivotal role in the pathophysiology of uremic bone disease. Histomorphometric studies suggest that the maintenance of PTH levels between two and four times the upper limit of normal is associated with the lowest prevalence of two common forms of osteodystrophy: osteitis fibrosa cystica and adynamic bone disease. The purpose of this study was to investigate whether the above recommendation for PTH levels in dialysis patients corresponds to a more optimal BMD with a special emphasis on diabetic versus nondiabetic subjects. Twenty-eight patients with chronic renal failure on hemodialysis underwent measurement of PTH levels, as well as BMD at the lumbar spine, hip, and forearm. They were divided into three groups based on the mean PTH level over the 5 years prior to having BMD measured. Osteoporosis was diagnosed in 55percent of men and 87percent of women on dialysis. Predictors of BMD were gender, duration on hemodialysis, and diabetes. Our study supports the histomorphometry-based studies suggesting that the maintenance of intact PTH levels two to four times the upper limit of normal may be associated with better skeletal health in uremic patients on hemodialysis, and that the diabetic subgroup is at particular risk for low BMD.
dc.format.extent Pages: (1297-1301)
dc.language English
dc.publisher NEW YORK
dc.relation.ispartof Publication Name: Transplantation Proceedings; Publication Year: 2004; Volume: 36; no. 5; Pages: (1297-1301);
dc.source Scopus
dc.title Predictors of bone mineral density in patients on hemodialysis
dc.type Article
dc.contributor.affiliation Zayour, D., Calcium Metab. Osteoporosis Prog., Department of Internal Medicine, Amer. Univ. of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Daouk, M., Division of Nephrology, Department of Internal Medicine, Amer. Univ. of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Medawar, W., Division of Nephrology, Department of Internal Medicine, Amer. Univ. of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Salamoun, M., Calcium Metab. Osteoporosis Prog., Department of Internal Medicine, Amer. Univ. of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation El-Hajj Fuleihan, G., Calcium Metab. Osteoporosis Prog., Department of Internal Medicine, Amer. Univ. of Beirut Medical Center, Beirut, Lebanon, Amer. Univ. of Beirut Medical Center, Bliss Street, Beirut, Lebanon
dc.contributor.authorAddress El-Hajj Fuleihan, G.; Amer. Univ. of Beirut Medical Center, Bliss Street, Beirut, Lebanon; email:
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Internal Medicine;
dc.contributor.authorDepartment Internal Medicine
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Zayour, D
dc.contributor.authorInitials Daouk, M
dc.contributor.authorInitials Medawar, W
dc.contributor.authorInitials Salamoun, M
dc.contributor.authorInitials Fuleihan, GE
dc.contributor.authorReprintAddress Fuleihan, GE (reprint author), Amer Univ Beirut, Med Ctr, Dept Internal Med, Calcium Metab and Osteoporosis Program, Bliss St, Beirut, Lebanon.
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 22
dc.description.citedTotWOSCount 25
dc.description.citedWOSCount 22
dc.format.extentCount 5
dc.identifier.coden TRPPA
dc.identifier.pubmedID 15251316
dc.identifier.scopusID 3142606742
dc.publisher.address 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
dc.relation.ispartOfISOAbbr Transplant. Proc.
dc.relation.ispartOfIssue 5
dc.relation.ispartofPubTitle Transplantation Proceedings
dc.relation.ispartofPubTitleAbbr Transplant. Proc.
dc.relation.ispartOfVolume 36
dc.source.ID WOS:000222713000020
dc.type.publication Journal
dc.subject.otherChemCAS parathyroid hormone, 12584-96-2, 68893-82-3, 9002-64-6
dc.subject.otherIndex parathyroid hormone
dc.subject.otherIndex adult
dc.subject.otherIndex aged
dc.subject.otherIndex article
dc.subject.otherIndex bone density
dc.subject.otherIndex bone mineral
dc.subject.otherIndex clinical article
dc.subject.otherIndex comparative study
dc.subject.otherIndex controlled study
dc.subject.otherIndex correlation analysis
dc.subject.otherIndex diabetes mellitus
dc.subject.otherIndex disease association
dc.subject.otherIndex female
dc.subject.otherIndex hemodialysis
dc.subject.otherIndex high risk population
dc.subject.otherIndex hip
dc.subject.otherIndex hormone determination
dc.subject.otherIndex human
dc.subject.otherIndex kidney failure
dc.subject.otherIndex lumbar spine
dc.subject.otherIndex male
dc.subject.otherIndex medical assessment
dc.subject.otherIndex morphometrics
dc.subject.otherIndex osteoporosis
dc.subject.otherIndex patient selection
dc.subject.otherIndex prediction
dc.subject.otherIndex priority journal
dc.subject.otherIndex sex difference
dc.subject.otherIndex uremia
dc.subject.otherIndex Adult
dc.subject.otherIndex Aged
dc.subject.otherIndex Aged, 80 and over
dc.subject.otherIndex Bone Density
dc.subject.otherIndex Diabetic Nephropathies
dc.subject.otherIndex Female
dc.subject.otherIndex Humans
dc.subject.otherIndex Kidney Failure, Chronic
dc.subject.otherIndex Male
dc.subject.otherIndex Middle Aged
dc.subject.otherIndex Renal Dialysis
dc.subject.otherIndex Renal Osteodystrophy
dc.subject.otherKeywordPlus SERUM PARATHYROID-HORMONE
dc.subject.otherKeywordPlus CHRONIC-RENAL-FAILURE
dc.subject.otherKeywordPlus DIALYSIS PATIENTS
dc.subject.otherKeywordPlus OSTEODYSTROPHY
dc.subject.otherKeywordPlus FRACTURE
dc.subject.otherKeywordPlus DISEASE
dc.subject.otherKeywordPlus ABSORPTIOMETRY
dc.subject.otherKeywordPlus OSTEOPOROSIS
dc.subject.otherKeywordPlus TURNOVER
dc.subject.otherKeywordPlus ALUMINUM
dc.subject.otherWOS Immunology
dc.subject.otherWOS Surgery
dc.subject.otherWOS Transplantation

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