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Tax ubiquitylation and sumoylation control critical cytoplasmic and nuclear steps of NF-κB activation

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dc.contributor.author Nasr R.
dc.contributor.author Chiari E.
dc.contributor.author El-Sabban M.
dc.contributor.author Mahieux R.
dc.contributor.author Kfoury Y.
dc.contributor.author Abdulhay M.
dc.contributor.author Yazbeck V.
dc.contributor.author Hermine O.
dc.contributor.author De The H.
dc.contributor.author Pique C.
dc.contributor.author Bazarbachi A.
dc.contributor.editor
dc.date May-2006
dc.date.accessioned 2017-10-05T15:37:17Z
dc.date.available 2017-10-05T15:37:17Z
dc.date.issued 2006
dc.identifier 10.1182/blood-2005-09-3572
dc.identifier.isbn
dc.identifier.issn 00064971
dc.identifier.uri http://hdl.handle.net/10938/15602
dc.description.abstract The Tax oncoprotein plays a crucial role in the proliferation and transformation of human T-cell leukemia virus type I (HTLV-I)-infected T lymphocytes through various mechanisms, including activation of the nuclear factor (NF)-κB pathway. We found that cytoplasmic ubiquitylation of Tax C-terminal lysines is critical for Tax binding to the IkappaB kinase complex and subsequent nuclear translocation of RelA. Conversely, we demonstrate that the same lysines are sumoylated in the nucleus, an event required for the formation of RelA-p300-enriched Tax nuclear bodies and full NF-κB transcriptional activation. In contrast, Tax ubiquitylation and sumoylation are dispensable for its activation of cyclic adenosine monophosphate response element binding protein (CREB)-dependent genes. Thus, ubiquitylation and sumoylation of the same residues of Tax regulate 2 essential steps controlling NF-κB activation, demonstrating how these post-translational modifications can cooperate to promote Tax-induced transformation. © 2006 by The American Society of Hematology.
dc.format.extent
dc.format.extent Pages: (4021-4029)
dc.language English
dc.publisher WASHINGTON
dc.relation.ispartof Publication Name: Blood; Publication Year: 2006; Volume: 107; no. 10; Pages: (4021-4029);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Tax ubiquitylation and sumoylation control critical cytoplasmic and nuclear steps of NF-κB activation
dc.type Article
dc.contributor.affiliation Nasr, R.
dc.contributor.affiliation Chiari, E.
dc.contributor.affiliation El-Sabban, M.
dc.contributor.affiliation Mahieux, R.
dc.contributor.affiliation Kfoury, Y.
dc.contributor.affiliation Abdulhay, M.
dc.contributor.affiliation Yazbeck, V.
dc.contributor.affiliation Hermine, O.
dc.contributor.affiliation De Thé, H.
dc.contributor.affiliation Pique, C., CNRS UMR 7151, Hôpital St. Louis, 1 av. C. Vellefaux, 75475 Paris Cedex 10, France
dc.contributor.affiliation Bazarbachi, A., Department of Internal Medicine, American University of Beirut, PO Box 113-6044, Beirut, Lebanon
dc.contributor.authorAddress Pique, C.; CNRS UMR 7151, Hôpital St. Louis, 1 av. C. Vellefaux, 75475 Paris Cedex 10, France; email: pique@chu-stlouis.fr
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Internal Medicine;
dc.contributor.authorDepartment Internal Medicine
dc.contributor.authorDivision
dc.contributor.authorEmail pique@chu-stlouis.fr; bazarbac@aub.edu.lb
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Nasr, R
dc.contributor.authorInitials Chiari, E
dc.contributor.authorInitials El-Sabban, M
dc.contributor.authorInitials Mahieux, R
dc.contributor.authorInitials Kfoury, Y
dc.contributor.authorInitials Abdulhay, M
dc.contributor.authorInitials Yazbeck, V
dc.contributor.authorInitials Hermine, O
dc.contributor.authorInitials de The, H
dc.contributor.authorInitials Pique, C
dc.contributor.authorInitials Bazarbachi, A
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Pique, C (reprint author), Amer Univ Beirut, Dept Internal Med, POB 113-6044, Beirut, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 58
dc.description.citedTotWOSCount 59
dc.description.citedWOSCount 58
dc.format.extentCount 9
dc.identifier.articleNo
dc.identifier.coden BLOOA
dc.identifier.pubmedID 16424386
dc.identifier.scopusID 33646575937
dc.identifier.url
dc.publisher.address 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Blood
dc.relation.ispartOfIssue 10
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Blood
dc.relation.ispartofPubTitleAbbr Blood
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 107
dc.source.ID WOS:000237584500038
dc.type.publication Journal
dc.subject.otherAuthKeyword
dc.subject.otherChemCAS cyclic AMP responsive element binding protein binding protein, 190209-80-4
dc.subject.otherChemCAS Gene Products, tax
dc.subject.otherChemCAS Lysine, 56-87-1
dc.subject.otherChemCAS NF-kappa B
dc.subject.otherChemCAS Ubiquitin
dc.subject.otherIndex cyclic AMP responsive element binding protein binding protein
dc.subject.otherIndex immunoglobulin enhancer binding protein
dc.subject.otherIndex lysine derivative
dc.subject.otherIndex Tax protein
dc.subject.otherIndex transcription factor RelA
dc.subject.otherIndex article
dc.subject.otherIndex carboxy terminal sequence
dc.subject.otherIndex controlled study
dc.subject.otherIndex cytoplasm
dc.subject.otherIndex human
dc.subject.otherIndex human cell
dc.subject.otherIndex immunoprecipitation
dc.subject.otherIndex priority journal
dc.subject.otherIndex protein binding
dc.subject.otherIndex protein function
dc.subject.otherIndex protein processing
dc.subject.otherIndex transcription initiation
dc.subject.otherIndex ubiquitination
dc.subject.otherIndex Binding Sites
dc.subject.otherIndex Cell Nucleus
dc.subject.otherIndex Cytoplasm
dc.subject.otherIndex Gene Products, tax
dc.subject.otherIndex HTLV-I Infections
dc.subject.otherIndex Humans
dc.subject.otherIndex Jurkat Cells
dc.subject.otherIndex Lysine
dc.subject.otherIndex Mutagenesis
dc.subject.otherIndex NF-kappa B
dc.subject.otherIndex Plasmids
dc.subject.otherIndex Trans-Activation (Genetics)
dc.subject.otherIndex Translocation, Genetic
dc.subject.otherIndex Ubiquitin
dc.subject.otherKeywordPlus VIRUS TYPE-1 TAX
dc.subject.otherKeywordPlus BINDING-PROTEIN
dc.subject.otherKeywordPlus UBIQUITIN
dc.subject.otherKeywordPlus TRANSFORMATION
dc.subject.otherKeywordPlus MECHANISMS
dc.subject.otherKeywordPlus MUTANTS
dc.subject.otherKeywordPlus SUMO-1
dc.subject.otherKeywordPlus GAMMA
dc.subject.otherKeywordPlus P300
dc.subject.otherWOS Hematology


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