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Involvement of substance P, CGRP and histamine in the hyperalgesia and cytokine upregulation induced by intraplantar injection of capsaicin in rats

Show simple item record Massaad C.A. Safieh-Garabedian B. Poole S. Atweh S.F. Jabbur S.J. Saade N.E.
dc.contributor.editor Aug-2004 2017-10-05T15:37:17Z 2017-10-05T15:37:17Z 2004
dc.identifier 10.1016/j.jneuroim.2004.05.007
dc.identifier.issn 01655728
dc.description.abstract Intraplantar ( injection of small doses of capsaicin has been shown to produce hyperalgesia and upregulation of the levels of proinflammatory cytokines. The present work aimed at investigating the possible mediation of these effects by sensory neuropeptides and mast cells. Various groups of rats received injection of capsaicin alone or preceded by the injection of antagonists to substance P (SP), calcitonin gene-related protein (CGRP) and histamine (H1, H2) or the mast cell blocker ketotifen. All pretreatments prevented, in a dose-related manner, the capsaicin-induced hyperalgesia. The SP, H2 antagonists and ketotifen prevented the upregulation of all cytokines and nerve growth factor (NGF) levels, while the CGRP and H1 antagonists showed only attenuation of the NGF level. © 2004 Elsevier B.V. All rights reserved.
dc.format.extent Pages: (171-182)
dc.language English
dc.publisher AMSTERDAM
dc.relation.ispartof Publication Name: Journal of Neuroimmunology; Publication Year: 2004; Volume: 153; no. 41641; Pages: (171-182);
dc.source Scopus
dc.title Involvement of substance P, CGRP and histamine in the hyperalgesia and cytokine upregulation induced by intraplantar injection of capsaicin in rats
dc.type Article
dc.contributor.affiliation Massaad, C.A., Neuroscience Program, Faculties of Med. and Arts and Sci., American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Safieh-Garabedian, B., Neuroscience Program, Faculties of Med. and Arts and Sci., American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Poole, S., Division of Endocrinology, Natl. Inst. Biol. Std. and Contr., Blanche Ln., S. Mimms, Herts En6 3QG, Potters Bar, United Kingdom
dc.contributor.affiliation Atweh, S.F., Neuroscience Program, Faculties of Med. and Arts and Sci., American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Jabbur, S.J., Neuroscience Program, Faculties of Med. and Arts and Sci., American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Saadé, N.E., Neuroscience Program, Faculties of Med. and Arts and Sci., American University of Beirut, Beirut, Lebanon, Department of Human Morphology, Faculty of Medicine, Amer. Univ. Beirut, Riad El S., Beirut, Lebanon
dc.contributor.authorAddress Saadé, N.E.; Department of Human Morphology, Faculty of Medicine, Amer. Univ. Beirut, Riad El S., Beirut, Lebanon; email:
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Internal Medicine; Division: Neurology;
dc.contributor.authorDepartment Internal Medicine
dc.contributor.authorDivision Neurology
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Massaad, CA
dc.contributor.authorInitials Safieh-Garabedian, B
dc.contributor.authorInitials Poole, S
dc.contributor.authorInitials Atweh, SF
dc.contributor.authorInitials Jabbur, SJ
dc.contributor.authorInitials Saade, NE
dc.contributor.authorReprintAddress Saade, NE (reprint author), Amer Univ Beirut, Fac Med, Dept Human Morphol, Neurosci Program, Beirut 11072020, Lebanon.
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 25
dc.description.citedTotWOSCount 27
dc.description.citedWOSCount 21
dc.format.extentCount 12
dc.identifier.coden JNRID
dc.identifier.pubmedID 15265675
dc.identifier.scopusID 3242687155
dc.publisher.address PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
dc.relation.ispartOfISOAbbr J. Neuroimmunol.
dc.relation.ispartOfIssue 41641
dc.relation.ispartofPubTitle Journal of Neuroimmunology
dc.relation.ispartofPubTitleAbbr J. Neuroimmunol.
dc.relation.ispartOfVolume 153
dc.source.ID WOS:000223362700024
dc.type.publication Journal
dc.subject.otherAuthKeyword calcitonin gene-related peptide
dc.subject.otherAuthKeyword Capsaicin
dc.subject.otherAuthKeyword capsaicin sensitive primary afferents
dc.subject.otherAuthKeyword CGRP
dc.subject.otherAuthKeyword CSPA
dc.subject.otherAuthKeyword Cytokines
dc.subject.otherAuthKeyword ELISA
dc.subject.otherAuthKeyword enzyme-linked immunosorbant assay
dc.subject.otherAuthKeyword hot plate
dc.subject.otherAuthKeyword HP
dc.subject.otherAuthKeyword IL
dc.subject.otherAuthKeyword interleukin
dc.subject.otherAuthKeyword Mast cells
dc.subject.otherAuthKeyword nerve growth factor
dc.subject.otherAuthKeyword Neurogenic inflammation
dc.subject.otherAuthKeyword Neuropeptides
dc.subject.otherAuthKeyword NG
dc.subject.otherChemCAS calcitonin gene related peptide, 83652-28-2
dc.subject.otherChemCAS capsaicin, 404-86-4
dc.subject.otherChemCAS histamine, 51-45-6, 56-92-8, 93443-21-1
dc.subject.otherChemCAS ketotifen, 34580-13-7
dc.subject.otherChemCAS nerve growth factor, 9061-61-4
dc.subject.otherChemCAS promethazine, 58-33-3, 60-87-7
dc.subject.otherChemCAS ranitidine, 66357-35-5, 66357-59-3
dc.subject.otherChemCAS spantide, 91224-37-2
dc.subject.otherChemCAS substance P, 33507-63-0
dc.subject.otherChemCAS Analgesics
dc.subject.otherChemCAS Calcitonin Gene-Related Peptide, 83652-28-2
dc.subject.otherChemCAS Capsaicin, 404-86-4
dc.subject.otherChemCAS Cytokines
dc.subject.otherChemCAS Histamine Antagonists
dc.subject.otherChemCAS Histamine, 51-45-6
dc.subject.otherChemCAS Nerve Growth Factor, 9061-61-4
dc.subject.otherChemCAS spantide II, 129176-97-2
dc.subject.otherChemCAS Substance P, 33507-63-0
dc.subject.otherIndex calcitonin gene related peptide
dc.subject.otherIndex calcitonin gene related peptide derivative
dc.subject.otherIndex capsaicin
dc.subject.otherIndex cytokine
dc.subject.otherIndex histamine
dc.subject.otherIndex histamine H2 receptor antagonist
dc.subject.otherIndex interleukin 1beta
dc.subject.otherIndex interleukin 6
dc.subject.otherIndex ketotifen
dc.subject.otherIndex nerve growth factor
dc.subject.otherIndex neuropeptide
dc.subject.otherIndex promethazine
dc.subject.otherIndex ranitidine
dc.subject.otherIndex spantide
dc.subject.otherIndex substance P
dc.subject.otherIndex substance P antagonist
dc.subject.otherIndex tumor necrosis factor alpha
dc.subject.otherIndex animal experiment
dc.subject.otherIndex animal model
dc.subject.otherIndex animal tissue
dc.subject.otherIndex article
dc.subject.otherIndex controlled study
dc.subject.otherIndex dose response
dc.subject.otherIndex down regulation
dc.subject.otherIndex drug effect
dc.subject.otherIndex enzyme linked immunosorbent assay
dc.subject.otherIndex hyperalgesia
dc.subject.otherIndex mast cell
dc.subject.otherIndex nonhuman
dc.subject.otherIndex priority journal
dc.subject.otherIndex upregulation
dc.subject.otherIndex Analgesics
dc.subject.otherIndex Animals
dc.subject.otherIndex Behavior, Animal
dc.subject.otherIndex Calcitonin Gene-Related Peptide
dc.subject.otherIndex Capsaicin
dc.subject.otherIndex Cytokines
dc.subject.otherIndex Dose-Response Relationship, Drug
dc.subject.otherIndex Drug Interactions
dc.subject.otherIndex Histamine
dc.subject.otherIndex Histamine Antagonists
dc.subject.otherIndex Hyperalgesia
dc.subject.otherIndex Injections, Spinal
dc.subject.otherIndex Nerve Growth Factor
dc.subject.otherIndex Pain Measurement
dc.subject.otherIndex Rats
dc.subject.otherIndex Rats, Sprague-Dawley
dc.subject.otherIndex Reaction Time
dc.subject.otherIndex Substance P
dc.subject.otherIndex Time Factors
dc.subject.otherIndex Up-Regulation
dc.subject.otherKeywordPlus GENE-RELATED PEPTIDE
dc.subject.otherKeywordPlus NERVE GROWTH-FACTOR
dc.subject.otherKeywordPlus MAST-CELLS
dc.subject.otherKeywordPlus SPANTIDE-II
dc.subject.otherKeywordPlus NEUROGENIC INFLAMMATION
dc.subject.otherKeywordPlus TACHYKININ ANTAGONIST
dc.subject.otherKeywordPlus PROSTAGLANDIN E-2
dc.subject.otherKeywordPlus SAPHENOUS NERVE
dc.subject.otherKeywordPlus IN-VITRO
dc.subject.otherKeywordPlus NEUROPEPTIDES
dc.subject.otherWOS Immunology
dc.subject.otherWOS Neurosciences

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