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Clinical characteristics of multiple sclerosis in Lebanon

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dc.contributor.author Yamout B.
dc.contributor.author Barada W.
dc.contributor.author Tohme R.A.
dc.contributor.author Mehio-Sibai A.
dc.contributor.author Khalifeh R.
dc.contributor.author El-Hajj T.
dc.contributor.editor
dc.date Jul-2008
dc.date.accessioned 2017-10-05T15:37:30Z
dc.date.available 2017-10-05T15:37:30Z
dc.date.issued 2008
dc.identifier 10.1016/j.jns.2008.02.009
dc.identifier.isbn
dc.identifier.issn
dc.identifier.uri http://hdl.handle.net/10938/15751
dc.description.abstract The epidemiologic, clinical, radiological and laboratory characterization of multiple sclerosis (MS) is very well documented in Caucasian and Japanese populations, but very little is known about MS in the Arab world. Such knowledge is becoming of paramount importance, with the recent advances in therapies, MRI techniques and other diagnostic procedures. We report a cohort of Lebanese MS patients, including details of their clinical and laboratory characteristics. The medical records of 202 patients fulfilling the Mc Donald's diagnostic criteria, and followed in our tertiary care center were reviewed. This cohort is highly representative of the disease in Lebanon where the number of MS patients is estimated to be between 1200 and 1700. The peak age of onset of MS in our cohort was in the third decade with 62.4percent of patients developing their first symptoms between 20 and 39 years. The female-male ratio was 1.8-1.0. A positive family history for MS was present in 5percent of patients. The most frequent presenting symptoms were brainstem-cerebellar (46.2percent) followed by sensory (42.5percent), motor (33.9percent) and visual (29.6percent). Of the total number of patients, 85.1percent had relapsing remitting MS at onset, and 7.9percent primary progressive MS. Benign MS defined as EDSS = 2.0 after 10 years from onset was present in 20percent of patients. The mean time from onset to secondary progressive MS was around 9 years. Visual, brainstem, and somatosensory evoked potentials were abnormal in 65.6percent, 27.8percent, and 50.7percent of patients tested respectively. Cerebrospinal fluid showed pleocytosis in 32.6percent, increased IgG synthesis in 45.2percent, positive oligoclonal bands in 40percent, and elevated protein in 34percent of patients tested. Although some of the clinical characteristics of our MS population were different compared to western series, the natural history of the disease was similar. © 2008 Elsevier B.V. All rights reserved.
dc.format.extent
dc.format.extent Pages: (88-93)
dc.language English
dc.publisher AMSTERDAM
dc.relation.ispartof Publication Name: Journal of the Neurological Sciences; Publication Year: 2008; Volume: 270; no. 41641; Pages: (88-93);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Clinical characteristics of multiple sclerosis in Lebanon
dc.type Article
dc.contributor.affiliation Yamout, B., Department of Internal Medicine, Neurology Division, Faculty of Medicine, American University of Beirut Medical Center, Lebanon
dc.contributor.affiliation Barada, W., Department of Internal Medicine, Neurology Division, Faculty of Medicine, American University of Beirut Medical Center, Lebanon
dc.contributor.affiliation Tohme, R.A., Department of Epidemiology and Population Health, Faculty of Health sciences, American University, Lebanon
dc.contributor.affiliation Mehio-Sibai, A., Department of Epidemiology and Population Health, Faculty of Health sciences, American University, Lebanon
dc.contributor.affiliation Khalifeh, R., Department of Internal Medicine, Neurology Division, Faculty of Medicine, American University of Beirut Medical Center, Lebanon
dc.contributor.affiliation El-Hajj, T., Department of Internal Medicine, Neurology Division, Faculty of Medicine, American University of Beirut Medical Center, Lebanon
dc.contributor.authorAddress Yamout, B.; Department of Internal Medicine, Neurology Division, Faculty of Medicine, American University of Beirut Medical CenterLebanon; email: yamoutba@idm.net.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Internal Medicine; Division: Neurology;
dc.contributor.authorDepartment Internal Medicine
dc.contributor.authorDivision Neurology
dc.contributor.authorEmail yamoutba@idm.net.lb
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Yamout, B
dc.contributor.authorInitials Barada, W
dc.contributor.authorInitials Tohme, RA
dc.contributor.authorInitials Mehio-Sibai, A
dc.contributor.authorInitials Khalifeh, R
dc.contributor.authorInitials El-Hajj, T
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Yamout, B (reprint author), Amer Univ Beirut, Med Ctr, Fac Med, Dept Internal Med,Neurol Div, Beirut, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 12
dc.description.citedTotWOSCount 12
dc.description.citedWOSCount 12
dc.format.extentCount 6
dc.identifier.articleNo
dc.identifier.coden JNSCA
dc.identifier.pubmedID 18367208
dc.identifier.scopusID 44649161456
dc.identifier.url
dc.publisher.address PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
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dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
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dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr J. Neurol. Sci.
dc.relation.ispartOfIssue 41641
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Journal of the Neurological Sciences
dc.relation.ispartofPubTitleAbbr J. Neurol. Sci.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 270
dc.source.ID WOS:000257486500014
dc.type.publication Journal
dc.subject.otherAuthKeyword Arab countries
dc.subject.otherAuthKeyword Epidemiology
dc.subject.otherAuthKeyword Lebanon
dc.subject.otherAuthKeyword Middle East
dc.subject.otherAuthKeyword Multiple sclerosis
dc.subject.otherAuthKeyword Natural history
dc.subject.otherChemCAS immunoglobulin G, 97794-27-9
dc.subject.otherIndex immunoglobulin G
dc.subject.otherIndex oligoclonal band
dc.subject.otherIndex adolescent
dc.subject.otherIndex adult
dc.subject.otherIndex article
dc.subject.otherIndex brain stem
dc.subject.otherIndex cerebellum
dc.subject.otherIndex cerebrospinal fluid
dc.subject.otherIndex child
dc.subject.otherIndex clinical feature
dc.subject.otherIndex evoked brain stem response
dc.subject.otherIndex evoked somatosensory response
dc.subject.otherIndex evoked visual response
dc.subject.otherIndex family history
dc.subject.otherIndex female
dc.subject.otherIndex human
dc.subject.otherIndex immunoglobulin production
dc.subject.otherIndex laboratory
dc.subject.otherIndex Lebanon
dc.subject.otherIndex major clinical study
dc.subject.otherIndex male
dc.subject.otherIndex medical record review
dc.subject.otherIndex motor dysfunction
dc.subject.otherIndex multiple sclerosis
dc.subject.otherIndex onset age
dc.subject.otherIndex pleocytosis
dc.subject.otherIndex priority journal
dc.subject.otherIndex recurrent disease
dc.subject.otherIndex remission
dc.subject.otherIndex sensory dysfunction
dc.subject.otherIndex sex ratio
dc.subject.otherIndex visual disorder
dc.subject.otherIndex Adolescent
dc.subject.otherIndex Adult
dc.subject.otherIndex Age Factors
dc.subject.otherIndex Child
dc.subject.otherIndex Child, Preschool
dc.subject.otherIndex Disability Evaluation
dc.subject.otherIndex Female
dc.subject.otherIndex Humans
dc.subject.otherIndex Infant
dc.subject.otherIndex Lebanon
dc.subject.otherIndex Male
dc.subject.otherIndex Middle Aged
dc.subject.otherIndex Multiple Sclerosis
dc.subject.otherIndex Neural Conduction
dc.subject.otherIndex Neurologic Examination
dc.subject.otherIndex Retrospective Studies
dc.subject.otherIndex Severity of Illness Index
dc.subject.otherKeywordPlus AGAROSE-GEL ELECTROPHORESIS
dc.subject.otherKeywordPlus CEREBROSPINAL-FLUID
dc.subject.otherKeywordPlus OLIGOCLONAL BANDS
dc.subject.otherKeywordPlus IGG-INDEX
dc.subject.otherKeywordPlus EVOKED-POTENTIALS
dc.subject.otherKeywordPlus NATURAL-HISTORY
dc.subject.otherKeywordPlus DIAGNOSIS
dc.subject.otherKeywordPlus DISABILITY
dc.subject.otherKeywordPlus CRITERIA
dc.subject.otherKeywordPlus DISEASE
dc.subject.otherWOS Clinical Neurology
dc.subject.otherWOS Neurosciences


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