AUB ScholarWorks

Vitamin D: A growing perspective

Show simple item record Kimball S. Fuleihan G.E.-H. Vieth R.
dc.contributor.editor Jul-2008 2017-10-05T15:37:34Z 2017-10-05T15:37:34Z 2008
dc.identifier 10.1080/10408360802165295
dc.identifier.issn 10408363
dc.description.abstract Vitamin D deficiency has been widely reported in all age groups in recent years. Rickets has never been eradicated in developed countries, and it most commonly affects children from recent immigrant groups. There is much evidence that current vitamin D guidelines for the neonatal period, 5-10 μ g (200-400 IU)-day, prevent rickets at the typical calcium intakes in developed countries. The annual incidence of vitamin D-deficiency rickets in developed countries ranges between 2.9 and 7.5 cases per 100,000 children. The prevalence of vitamin D deficiency in mothers and their neonates is remarkable, and the results of one study suggest that third-trimester 25-hydroxyvitamin D (25(OH)D) is associated with fetal bone mineral accrual that may affect prepubertal bone mass accumulation. Beyond infancy, the evidence indicates that 5 μ g (200 IU)-day of vitamin D has little effect on vitamin D status as measured by the serum 25(OH)D concentration. Two randomized clinical trials show that higher vitamin D intake improves one-year gain in bone density in adolescent girls. The functions of vitamin D extend beyond bone to include immune system regulation and anti-proliferative effects on cells. Early life vitamin D inadequacy is implicated in the risk of bone disease, autoimmune disease, and certain cancers later in life; however, long-term interventional studies do not exist to validate the widespread implementation of greater vitamin D consumption. Here we review the available data concerning vitamin D status and health effects of vitamin D in pregnancy through to and including adolescence. Copyright © 2008 Informa Healthcare USA, Inc.
dc.format.extent Pages: (339-414)
dc.language English
dc.publisher LONDON
dc.relation.ispartof Publication Name: Critical Reviews in Clinical Laboratory Sciences; Publication Year: 2008; Volume: 45; no. 4; Pages: (339-414);
dc.source Scopus
dc.title Vitamin D: A growing perspective
dc.type Review
dc.contributor.affiliation Kimball, S., Department of Nutritional Sciences, University of Toronto, Toronto, ON, Canada, Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada, Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Box 34, 60 Murray St., Toronto, ON M5T 3L9, Canada
dc.contributor.affiliation Fuleihan, G.E.-H., Calcium Metabolism and Osteoporosis Program, American University of Beirut-Medical Center, Beirut, Lebanon
dc.contributor.affiliation Vieth, R., Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada, Departments of Nutritional Sciences, Laboratory Medicine and Pathology, University of Toronto, Toronto, ON, Canada
dc.contributor.authorAddress Kimball, S.; Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Box 34, 60 Murray St., Toronto, ON M5T 3L9, Canada; email:
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Internal Medicine;
dc.contributor.authorDepartment Internal Medicine
dc.contributor.faculty Faculty of Medicine
dc.contributor.authorInitials Kimball, S
dc.contributor.authorInitials Fuleihan, GEH
dc.contributor.authorInitials Vieth, R
dc.contributor.authorReprintAddress Kimball, S (reprint author), Mt Sinai Hosp, Dept Pathol and Lab Med, 60 Murray St,Box 34,Room 3-416, Toronto, ON M5T 3L9, Canada.
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 61
dc.description.citedTotWOSCount 46
dc.description.citedWOSCount 45
dc.format.extentCount 76
dc.identifier.coden CRCLB
dc.identifier.pubmedID 18568854
dc.identifier.scopusID 45849141252
dc.relation.ispartOfISOAbbr Crit. Rev. Clin. Lab. Sci.
dc.relation.ispartOfIssue 4
dc.relation.ispartofPubTitle Critical Reviews in Clinical Laboratory Sciences
dc.relation.ispartofPubTitleAbbr Crit. Rev. Clin. Lab. Sci.
dc.relation.ispartOfVolume 45
dc.source.ID WOS:000257385500001
dc.type.publication Journal
dc.subject.otherAuthKeyword 1,25-dihydroxyvitamin D
dc.subject.otherAuthKeyword 25-hydroxyvitamin D
dc.subject.otherAuthKeyword Adolescence
dc.subject.otherAuthKeyword Childhood
dc.subject.otherAuthKeyword Growth
dc.subject.otherAuthKeyword Pregnancy
dc.subject.otherAuthKeyword Puberty
dc.subject.otherAuthKeyword Vitamin D
dc.subject.otherChemCAS 25 hydroxyvitamin D, 64719-49-9
dc.subject.otherChemCAS calcitriol, 32222-06-3, 32511-63-0, 66772-14-3
dc.subject.otherChemCAS colecalciferol, 1406-16-2, 67-97-0
dc.subject.otherChemCAS ergocalciferol, 50-14-6, 50809-47-7, 8042-78-2
dc.subject.otherChemCAS Vitamin D, 1406-16-2
dc.subject.otherIndex 25 hydroxyvitamin D
dc.subject.otherIndex calcitriol
dc.subject.otherIndex colecalciferol
dc.subject.otherIndex ergocalciferol
dc.subject.otherIndex vitamin D
dc.subject.otherIndex autoimmune disease
dc.subject.otherIndex bone mass
dc.subject.otherIndex bone mineral
dc.subject.otherIndex bone mineralization
dc.subject.otherIndex breast feeding
dc.subject.otherIndex calcium homeostasis
dc.subject.otherIndex calcium intake
dc.subject.otherIndex drug mechanism
dc.subject.otherIndex hormonal regulation
dc.subject.otherIndex human
dc.subject.otherIndex immunoregulation
dc.subject.otherIndex lactation
dc.subject.otherIndex nutritional status
dc.subject.otherIndex pregnancy
dc.subject.otherIndex prevalence
dc.subject.otherIndex priority journal
dc.subject.otherIndex review
dc.subject.otherIndex rickets
dc.subject.otherIndex sun exposure
dc.subject.otherIndex vitamin D deficiency
dc.subject.otherIndex vitamin D metabolism
dc.subject.otherIndex vitamin intake
dc.subject.otherIndex vitamin supplementation
dc.subject.otherIndex Adolescent
dc.subject.otherIndex Bone Development
dc.subject.otherIndex Child
dc.subject.otherIndex Child, Preschool
dc.subject.otherIndex Female
dc.subject.otherIndex Humans
dc.subject.otherIndex Infant
dc.subject.otherIndex Infant, Newborn
dc.subject.otherIndex Male
dc.subject.otherIndex Models, Biological
dc.subject.otherIndex Pregnancy
dc.subject.otherIndex Vitamin D
dc.subject.otherIndex Vitamin D Deficiency
dc.subject.otherKeywordPlus BONE-MINERAL DENSITY
dc.subject.otherKeywordPlus D-BINDING-PROTEIN
dc.subject.otherKeywordPlus PREGNANT ASIAN WOMEN
dc.subject.otherKeywordPlus GROWTH-FACTOR-I
dc.subject.otherKeywordPlus D-RECEPTOR GENE
dc.subject.otherKeywordPlus BREAST-FED INFANTS
dc.subject.otherKeywordPlus SERUM 1,25-DIHYDROXYVITAMIN-D LEVELS
dc.subject.otherKeywordPlus SYSTEMIC-LUPUS-ERYTHE
dc.subject.otherWOS Medical Laboratory Technology

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