AUB ScholarWorks

Upper gastrointestinal bleeding in patients with acute coronary syndromes: Clinical predictors and prophylactic role of proton pump inhibitors

Show simple item record

dc.contributor.author Barada K.
dc.contributor.author Karrowni W.
dc.contributor.author Abdallah M.
dc.contributor.author Shamseddeen W.
dc.contributor.author Sharara A.I.
dc.contributor.author Dakik H.A.
dc.contributor.editor
dc.date Apr-2008
dc.date.accessioned 2017-10-05T15:37:35Z
dc.date.available 2017-10-05T15:37:35Z
dc.date.issued 2008
dc.identifier 10.1097/MCG.0b013e31802e63ff
dc.identifier.isbn
dc.identifier.issn 01920790
dc.identifier.uri http://hdl.handle.net/10938/15807
dc.description.abstract OBJECTIVES: To determine the risk and the clinical predictors of in-hospital upper gastrointestinal (UGI) bleeding in patients with acute coronary syndromes (ACS), and to study the prophylactic role of proton pump inhibitors (PPI) in this setting. BACKGROUND: Patients with ACS are usually treated by a combination of antiplatelet, antithrombotic and thrombolytic medications, thereby increasing the risk of bleeding. STUDY: A retrospective study of 1023 patients hospitalized with ACS at the American University of Beirut Medical Center from September 2001 to November 2005. The main outcome measurements were the incidence of in-hospital UGI bleeding and its predictors; the utilization rate of PPI and its determinants. RESULTS: Seven patients developed in-hospital UGI bleeding (0.7percent) and 2 had major bleeding (0.2percent). All required blood transfusion and none died in the hospital. Significant predictors of UGI bleeding were prior history of UGI bleeding or peptic ulcer disease (P0.01), creatinine 2 mg-dL (P=0.01), and home intake of aspirin, clopidogrel (P0.05), or nonsteroidal anti-inflammatory drugs (P0.05). Sixty-nine percent of patients received PPI during their hospital stay. There was no significant difference in the incidence of UGI bleeding between patients receiving and those not receiving PPI (0.7percent vs. 0.6percent, P= 0.88). CONCLUSIONS: The risk of UGI bleeding is relatively low in patients hospitalized with ACS and does not appear to be significantly reduced by the use of PPI. The utilization rate of PPI was relatively high. Better patient selection and risk stratification for the prophylactic use of PPI are warranted. © 2008 Lippincott Williams and Wilkins, Inc.
dc.format.extent
dc.format.extent Pages: (368-372)
dc.language English
dc.relation.ispartof Publication Name: Journal of Clinical Gastroenterology; Publication Year: 2008; Volume: 42; no. 4; Pages: (368-372);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Upper gastrointestinal bleeding in patients with acute coronary syndromes: Clinical predictors and prophylactic role of proton pump inhibitors
dc.type Article
dc.contributor.affiliation Barada, K., Department of Internal Medicine, American University of Beirut, Lebanon
dc.contributor.affiliation Karrowni, W., Department of Internal Medicine, American University of Beirut, Lebanon
dc.contributor.affiliation Abdallah, M., Department of Internal Medicine, American University of Beirut, Lebanon
dc.contributor.affiliation Shamseddeen, W., Department of Internal Medicine, American University of Beirut, Lebanon
dc.contributor.affiliation Sharara, A.I., Department of Internal Medicine, American University of Beirut, Lebanon
dc.contributor.affiliation Dakik, H.A., Department of Internal Medicine, American University of Beirut, Lebanon, American University of Beirut, PO Box 11-0236-A38, Beirut, Lebanon
dc.contributor.authorAddress Dakik, H. A.; American University of Beirut, PO Box 11-0236-A38, Beirut, Lebanon; email: hd01@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Internal Medicine;
dc.contributor.authorDepartment Internal Medicine
dc.contributor.authorDivision
dc.contributor.authorEmail
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited
dc.description.citedCount 30
dc.description.citedTotWOSCount
dc.description.citedWOSCount
dc.format.extentCount 5
dc.identifier.articleNo
dc.identifier.coden JCGAD
dc.identifier.pubmedID 18277903
dc.identifier.scopusID 41349123763
dc.identifier.url
dc.publisher.address
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr
dc.relation.ispartOfIssue 4
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Journal of Clinical Gastroenterology
dc.relation.ispartofPubTitleAbbr J. Clin. Gastroenterol.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 42
dc.source.ID
dc.type.publication Journal
dc.subject.otherAuthKeyword Acute coronary syndromes
dc.subject.otherAuthKeyword Gastrointestinal bleeding
dc.subject.otherAuthKeyword Proton pump inhibitors
dc.subject.otherChemCAS acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1
dc.subject.otherChemCAS clopidogrel, 113665-84-2, 120202-66-6, 90055-48-4, 94188-84-8
dc.subject.otherChemCAS omeprazole, 73590-58-6, 95510-70-6
dc.subject.otherChemCAS rabeprazole, 117976-89-3, 117976-90-6
dc.subject.otherChemCAS 2-Pyridinylmethylsulfinylbenzimidazoles
dc.subject.otherChemCAS Fibrinolytic Agents
dc.subject.otherChemCAS Omeprazole, 73590-58-6
dc.subject.otherChemCAS Proton Pump Inhibitors
dc.subject.otherChemCAS Proton-Translocating ATPases, EC 3.6.3.14
dc.subject.otherChemCAS rabeprazole, 117976-90-6
dc.subject.otherIndex acetylsalicylic acid
dc.subject.otherIndex clopidogrel
dc.subject.otherIndex nonsteroid antiinflammatory agent
dc.subject.otherIndex omeprazole
dc.subject.otherIndex rabeprazole
dc.subject.otherIndex acute coronary syndrome
dc.subject.otherIndex adult
dc.subject.otherIndex aged
dc.subject.otherIndex article
dc.subject.otherIndex blood transfusion
dc.subject.otherIndex female
dc.subject.otherIndex health hazard
dc.subject.otherIndex human
dc.subject.otherIndex incidence
dc.subject.otherIndex major clinical study
dc.subject.otherIndex male
dc.subject.otherIndex peptic ulcer
dc.subject.otherIndex priority journal
dc.subject.otherIndex prophylaxis
dc.subject.otherIndex upper gastrointestinal bleeding
dc.subject.otherIndex 2-Pyridinylmethylsulfinylbenzimidazoles
dc.subject.otherIndex Acute Coronary Syndrome
dc.subject.otherIndex Aged
dc.subject.otherIndex Female
dc.subject.otherIndex Fibrinolytic Agents
dc.subject.otherIndex Follow-Up Studies
dc.subject.otherIndex Gastrointestinal Hemorrhage
dc.subject.otherIndex Humans
dc.subject.otherIndex Lebanon
dc.subject.otherIndex Male
dc.subject.otherIndex Middle Aged
dc.subject.otherIndex Omeprazole
dc.subject.otherIndex Prognosis
dc.subject.otherIndex Proton Pump Inhibitors
dc.subject.otherIndex Proton-Translocating ATPases
dc.subject.otherIndex Retrospective Studies
dc.subject.otherIndex Risk Factors
dc.subject.otherKeywordPlus
dc.subject.otherWOS


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search AUB ScholarWorks


Browse

My Account