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Comparison of the systemic levels of inflammatory markers after percutaneous coronary intervention with bare metal versus sirolimus-eluting stents

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dc.contributor.author Rebeiz A.G.
dc.contributor.author Zoghbi E.
dc.contributor.author Harb R.
dc.contributor.author Youhanna S.
dc.contributor.author Skouri H.N.
dc.contributor.author Dimassi A.
dc.contributor.author Abou-Nader G.
dc.contributor.author Nasrallah A.
dc.contributor.author Sawaya J.
dc.contributor.author Gharzuddine W.
dc.contributor.author Alam S.
dc.contributor.editor
dc.date Apr-2009
dc.date.accessioned 2017-10-05T15:37:38Z
dc.date.available 2017-10-05T15:37:38Z
dc.date.issued 2009
dc.identifier 10.1111/j.1540-8183.2009.00429.x
dc.identifier.isbn
dc.identifier.issn 08964327
dc.identifier.uri http://hdl.handle.net/10938/15842
dc.description.abstract Background: Percutaneous coronary intervention (PCI) with bare metal stent (BMS) deployment causes plaque disruption and a rise in systemic levels of C-reactive protein (CRP), interleukin (IL)-6, and monocyte chemoattractant protein (MCP)-1. Our aim is to study whether PCI with sirolimus-eluting stent (SES) use attenuates this response. Methods: Patients with stable angina undergoing single-vessel PCI were enrolled in a randomized, open-label fashion into a BMS group or an SES group. Blood samples were drawn pre-PCI, 24 hours post-PCI, and 30 days post-PCI. Systemic concentrations of CRP, IL-6, and MCP-1 were measured at all time points. Results: In total, 41 patients were enrolled (21 in the BMS group and 20 in the SES group). The baseline plasma concentrations of all markers were comparable between groups. At 24 hours, the mean plasma CRP concentration in the SES group was 20.21 mg-dL versus 8.95 mg-dL in the BMS group (P = 0.15). The mean plasma IL-6 concentration at 24 hours was 25.41 pg-mL in the SES group versus 17.44 pg-mL in the BMS group (P = 0.17). The mean plasma MCP-1 concentration at 24 hours was 382.38 pg-mL in the SES group versus 329.04 pg-mL in the BMS group (P = 0.2). At 30 days, plasma concentrations of all three markers decreased to similar values between groups. Conclusions: The use of SES did not inhibit the rise in systemic concentrations of CRP, IL-6, and MCP-1 at 24 hours or 30 days post-PCI, compared with BMS. Moreover, at 24 hours, there was a trend for higher systemic levels of all proinflammatory markers in the SES group compared with the BMS cohort. ©2009, Wiley Periodicals, Inc.
dc.format.extent
dc.format.extent Pages: (169-174)
dc.language English
dc.publisher MALDEN
dc.relation.ispartof Publication Name: Journal of Interventional Cardiology; Publication Year: 2009; Volume: 22; no. 2; Pages: (169-174);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Comparison of the systemic levels of inflammatory markers after percutaneous coronary intervention with bare metal versus sirolimus-eluting stents
dc.type Article
dc.contributor.affiliation Rebeiz, A.G., American University, Beirut Medical Center, Division of Cardiology, Beirut, Lebanon, American University, Beirut Medical Center, P.O. Box 20C, Beirut, Lebanon
dc.contributor.affiliation Zoghbi, E., American University, Beirut Medical Center, Division of Cardiology, Beirut, Lebanon
dc.contributor.affiliation Harb, R., American University, Beirut Medical Center, Division of Cardiology, Beirut, Lebanon
dc.contributor.affiliation Youhanna, S., American University, Beirut Medical Center, Division of Cardiology, Beirut, Lebanon
dc.contributor.affiliation Skouri, H.N., American University, Beirut Medical Center, Division of Cardiology, Beirut, Lebanon
dc.contributor.affiliation Dimassi, A., American University, Beirut Medical Center, Division of Cardiology, Beirut, Lebanon
dc.contributor.affiliation Abou-Nader, G., American University, Beirut Medical Center, Division of Cardiology, Beirut, Lebanon
dc.contributor.affiliation Nasrallah, A., American University, Beirut Medical Center, Division of Cardiology, Beirut, Lebanon
dc.contributor.affiliation Sawaya, J., American University, Beirut Medical Center, Division of Cardiology, Beirut, Lebanon
dc.contributor.affiliation Gharzuddine, W., American University, Beirut Medical Center, Division of Cardiology, Beirut, Lebanon
dc.contributor.affiliation Alam, S., American University, Beirut Medical Center, Division of Cardiology, Beirut, Lebanon
dc.contributor.authorAddress Rebeiz, A. G.; American University, Beirut Medical Center, P.O. Box 20C, Beirut, Lebanon; email: ar20@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Internal Medicine; Division: Cardiology;
dc.contributor.authorDepartment Internal Medicine
dc.contributor.authorDivision Cardiology
dc.contributor.authorEmail ar20@aub.edu.lb
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Rebeiz, AG
dc.contributor.authorInitials Zoghbi, E
dc.contributor.authorInitials Harb, R
dc.contributor.authorInitials Youhanna, S
dc.contributor.authorInitials Skouri, HN
dc.contributor.authorInitials Dimassi, A
dc.contributor.authorInitials Abou-Nader, G
dc.contributor.authorInitials Nasrallah, A
dc.contributor.authorInitials Sawaya, J
dc.contributor.authorInitials Gharzuddine, W
dc.contributor.authorInitials Alam, S
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Rebeiz, AG (reprint author), Amer Univ Beirut, Med Ctr, Div Cardiol, POB 20C, Beirut, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 8
dc.description.citedTotWOSCount 7
dc.description.citedWOSCount 6
dc.format.extentCount 6
dc.identifier.articleNo
dc.identifier.coden JICAF
dc.identifier.pubmedID 19245380
dc.identifier.scopusID 64149129351
dc.identifier.url
dc.publisher.address COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr J. Interv. Cardiol.
dc.relation.ispartOfIssue 2
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Journal of Interventional Cardiology
dc.relation.ispartofPubTitleAbbr J. Intervent. Cardiol.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 22
dc.source.ID WOS:000264885100013
dc.type.publication Journal
dc.subject.otherAuthKeyword
dc.subject.otherChemCAS C reactive protein, 9007-41-4
dc.subject.otherChemCAS rapamycin, 53123-88-9
dc.subject.otherChemCAS C-Reactive Protein, 9007-41-4
dc.subject.otherChemCAS Chemokine CCL2
dc.subject.otherChemCAS Immunosuppressive Agents
dc.subject.otherChemCAS Interleukin-6
dc.subject.otherChemCAS Sirolimus, 53123-88-9
dc.subject.otherIndex C reactive protein
dc.subject.otherIndex interleukin 6
dc.subject.otherIndex monocyte chemotactic protein 1
dc.subject.otherIndex rapamycin
dc.subject.otherIndex adult
dc.subject.otherIndex article
dc.subject.otherIndex bare metal stent
dc.subject.otherIndex blood analysis
dc.subject.otherIndex clinical article
dc.subject.otherIndex clinical trial
dc.subject.otherIndex controlled clinical trial
dc.subject.otherIndex controlled study
dc.subject.otherIndex drug eluting stent
dc.subject.otherIndex female
dc.subject.otherIndex human
dc.subject.otherIndex male
dc.subject.otherIndex percutaneous coronary intervention
dc.subject.otherIndex priority journal
dc.subject.otherIndex protein blood level
dc.subject.otherIndex randomized controlled trial
dc.subject.otherIndex single blind procedure
dc.subject.otherIndex stable angina pectoris
dc.subject.otherIndex Aged
dc.subject.otherIndex Angina Pectoris
dc.subject.otherIndex Angioplasty, Transluminal, Percutaneous Coronary
dc.subject.otherIndex C-Reactive Protein
dc.subject.otherIndex Chemokine CCL2
dc.subject.otherIndex Coronary Stenosis
dc.subject.otherIndex Female
dc.subject.otherIndex Humans
dc.subject.otherIndex Immunosuppressive Agents
dc.subject.otherIndex Interleukin-6
dc.subject.otherIndex Male
dc.subject.otherIndex Middle Aged
dc.subject.otherIndex Sirolimus
dc.subject.otherIndex Stents
dc.subject.otherKeywordPlus ARTERY-DISEASE
dc.subject.otherKeywordPlus RAPAMYCIN
dc.subject.otherKeywordPlus ANGIOPLASTY
dc.subject.otherKeywordPlus EXPRESSION
dc.subject.otherKeywordPlus RESTENOSIS
dc.subject.otherWOS Cardiac and Cardiovascular Systems


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