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The effect of war stress on multiple sclerosis exacerbations and radiological disease activity

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dc.contributor.author Yamout B.
dc.contributor.author Itani S.
dc.contributor.author Hourany R.
dc.contributor.author Sibaii A.M.
dc.contributor.author Yaghi S.
dc.contributor.editor
dc.date Jan-2010
dc.date.accessioned 2017-10-05T15:37:45Z
dc.date.available 2017-10-05T15:37:45Z
dc.date.issued 2010
dc.identifier 10.1016/j.jns.2009.10.012
dc.identifier.isbn
dc.identifier.issn
dc.identifier.uri http://hdl.handle.net/10938/15933
dc.description.abstract Objective: The relationship between stressful life events and multiple sclerosis (MS) exacerbations or radiological disease activity is at best controversial. The aim of this study is to examine the relationship between exposure to war-related events incurred during the July 2006 Israeli-Lebanese war and clinical relapses and MRI disease activity among Lebanese MS patients. Methods: We studied a group of 216 patients with clinically definite relapsing remitting MS (RRMS), on whom clinical data was available for the war period and for the preceding and following year(s). The number of relapses was determined during the war period and during similar periods over a 3-year span. All patients with brain MRI during the war period had their scans reviewed for evidence of disease activity as defined by the presence of gadolinium enhancing (Gd+) lesions. A group of patients with brain MRI performed outside the war period was used for comparison. Results: The total number of relapses during the war period (n = 23) was significantly higher than during non-war periods (mean = 8.4, SD = 0.86) (p = 0.006). Of the 18 patients with brain MRI during the war, 5-7 with relapses and 1-11 without relapses had Gd+ lesions (p = 0.013). More patients had Gd+ lesions during the war period (33percent) compared to controls (13percent) (p = 0.075). Interpretation: Our study shows that exposure to war-related events is likely to lead to an increase in both clinical relapses and MRI disease activity in patients with MS. © 2009 Elsevier B.V. All rights reserved.
dc.format.extent
dc.format.extent Pages: (42-44)
dc.language English
dc.publisher AMSTERDAM
dc.relation.ispartof Publication Name: Journal of the Neurological Sciences; Publication Year: 2010; Volume: 288; no. 41641; Pages: (42-44);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title The effect of war stress on multiple sclerosis exacerbations and radiological disease activity
dc.type Article
dc.contributor.affiliation Yamout, B., Department of Internal Medicine, American University, Beirut - Medical Center, P.O. Box 11-0236, Riad El Solh 1107 2020, Beirut, Lebanon
dc.contributor.affiliation Itani, S., Department of Internal Medicine, American University, Beirut - Medical Center, P.O. Box 11-0236, Riad El Solh 1107 2020, Beirut, Lebanon
dc.contributor.affiliation Hourany, R., Department of Radiology, American University, Beirut - Medical Center, P.O. Box 11-0236, Riad El Solh 1107 2020, Beirut, Lebanon
dc.contributor.affiliation Sibaii, A.M., Department of Epidemiology and Population, American University, Beirut - Medical Center, P.O. Box 11-0236, Riad El Solh 1107 2020, Beirut, Lebanon
dc.contributor.affiliation Yaghi, S., Department of Internal Medicine, American University, Beirut - Medical Center, P.O. Box 11-0236, Riad El Solh 1107 2020, Beirut, Lebanon
dc.contributor.authorAddress Yaghi, S.; Department of Internal Medicine, American University, Beirut - Medical Center, P.O. Box 11-0236, Riad El Solh 1107 2020, Beirut, Lebanon; email: shadiyaghi@yahoo.com
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Internal Medicine; Division: Neurology;
dc.contributor.authorDepartment Internal Medicine
dc.contributor.authorDivision Neurology
dc.contributor.authorEmail shadiyaghi@yahoo.com
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Yamout, B
dc.contributor.authorInitials Itani, S
dc.contributor.authorInitials Hourany, R
dc.contributor.authorInitials Sibaii, AM
dc.contributor.authorInitials Yaghi, S
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Yaghi, S (reprint author), Amer Univ Beirut, Med Ctr, Dept Internal Med, POB 11-0236,Riad El Solh 1107, Beirut 2020, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 10
dc.description.citedTotWOSCount 8
dc.description.citedWOSCount 8
dc.format.extentCount 3
dc.identifier.articleNo
dc.identifier.coden JNSCA
dc.identifier.pubmedID 19892371
dc.identifier.scopusID 71049183467
dc.identifier.url
dc.publisher.address PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr J. Neurol. Sci.
dc.relation.ispartOfIssue 41641
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Journal of the Neurological Sciences
dc.relation.ispartofPubTitleAbbr J. Neurol. Sci.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 288
dc.source.ID WOS:000274042500005
dc.type.publication Journal
dc.subject.otherAuthKeyword Disease activity
dc.subject.otherAuthKeyword Exacerbations
dc.subject.otherAuthKeyword Gadolinium enhancement
dc.subject.otherAuthKeyword MRI
dc.subject.otherAuthKeyword Multiple sclerosis
dc.subject.otherAuthKeyword War stress
dc.subject.otherChemCAS gadolinium, 7440-54-2
dc.subject.otherChemCAS Contrast Media
dc.subject.otherChemCAS Gadolinium, 7440-54-2
dc.subject.otherChemCAS Interferons, 9008-11-1
dc.subject.otherIndex corticosteroid
dc.subject.otherIndex gadolinium
dc.subject.otherIndex adult
dc.subject.otherIndex article
dc.subject.otherIndex brain damage
dc.subject.otherIndex controlled study
dc.subject.otherIndex disease activity
dc.subject.otherIndex disease association
dc.subject.otherIndex disease exacerbation
dc.subject.otherIndex female
dc.subject.otherIndex human
dc.subject.otherIndex Lebanon
dc.subject.otherIndex life stress
dc.subject.otherIndex major clinical study
dc.subject.otherIndex male
dc.subject.otherIndex multiple sclerosis
dc.subject.otherIndex nuclear magnetic resonance imaging
dc.subject.otherIndex priority journal
dc.subject.otherIndex relapse
dc.subject.otherIndex war
dc.subject.otherIndex Adult
dc.subject.otherIndex Contrast Media
dc.subject.otherIndex Female
dc.subject.otherIndex Gadolinium
dc.subject.otherIndex Humans
dc.subject.otherIndex Interferons
dc.subject.otherIndex Lebanon
dc.subject.otherIndex Magnetic Resonance Imaging
dc.subject.otherIndex Male
dc.subject.otherIndex Middle Aged
dc.subject.otherIndex Multiple Sclerosis, Relapsing-Remitting
dc.subject.otherIndex Recurrence
dc.subject.otherIndex Stress, Psychological
dc.subject.otherIndex War
dc.subject.otherKeywordPlus BLOOD-BRAIN-BARRIER
dc.subject.otherKeywordPlus LIFE EVENTS
dc.subject.otherKeywordPlus MAST-CELLS
dc.subject.otherKeywordPlus PSYCHOLOGICAL STRESS
dc.subject.otherKeywordPlus DIAGNOSTIC-CRITERIA
dc.subject.otherKeywordPlus PROGRESSION
dc.subject.otherKeywordPlus RELAPSE
dc.subject.otherKeywordPlus IMPACT
dc.subject.otherKeywordPlus MRI
dc.subject.otherKeywordPlus MS
dc.subject.otherWOS Clinical Neurology
dc.subject.otherWOS Neurosciences


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