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Clinicovirologic analysis of hepatitis C infection in transfusion-dependent β-thalassemia major children

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dc.contributor.author Ragab L.
dc.contributor.author Helal S.
dc.contributor.author Zaghloul N.
dc.contributor.author El-Raziky M.
dc.contributor.author Afifi R.
dc.contributor.author Musallam K.M.
dc.contributor.author Taher A.T.
dc.contributor.editor
dc.date Apr-2010
dc.date.accessioned 2017-10-05T15:37:49Z
dc.date.available 2017-10-05T15:37:49Z
dc.date.issued 2010
dc.identifier 10.1111/j.1751-553X.2009.01155.x
dc.identifier.isbn
dc.identifier.issn 17515521
dc.identifier.uri http://hdl.handle.net/10938/15954
dc.description.abstract Regular blood transfusion puts β-thalassemia major patients at a higher risk of developing hepatic iron overload and hepatitis C virus (HCV) infection. The association between several transfusion-related factors and an increased risk of developing HCV viremia has been reported. The effect of HCV infection on liver damage in transfusion-dependent thalassemia patients has been poorly described. A sample of 100 Egyptian transfusion-dependent β-thalassemia major children were studied. Individual patients underwent full history taking, clinical examination and a panel of laboratory tests including HCV ribonucleic acid polymerase chain reaction (HCV-PCR) in blood samples. Liver biopsy was performed for 24 patients. HCV-PCR was positive in 64percent of patients. A statistically significant correlation was found between HCVPCR positivity (HCV viremia) and shorter inter-transfusion interval. There was a significant positive correlation between mean serum ferritin level and mean levels of alanine aminotransferase and aspartase aminotransferase. Histopathologic features of both chronic hepatitis and siderosis were present in 91.7percent of biopsy specimens, and fibrosis was present in 41.67percent. A higher risk of HCV viremia is noted with a shorter inter-transfusion interval. The reduced role of HCV infection in chronic liver injury in this group of patients may be surpassed by the associated effects of iron overload because of the chronic transfusion. However, the latter finding should be verified in larger studies. © 2009 Blackwell Publishing Ltd.
dc.format.extent
dc.format.extent Pages: (184-190)
dc.language English
dc.publisher MALDEN
dc.relation.ispartof Publication Name: International Journal of Laboratory Hematology; Publication Year: 2010; Volume: 32; no. 2; Pages: (184-190);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Clinicovirologic analysis of hepatitis C infection in transfusion-dependent β-thalassemia major children
dc.type Article
dc.contributor.affiliation Ragab, L., Department of Pediatrics, Faculty of Medicine, Cairo University, 34 Babel St., Dokki, Cairo, Egypt
dc.contributor.affiliation Helal, S., Department of Clinical Pathology, Cairo University, Cairo, Egypt
dc.contributor.affiliation Zaghloul, N., Department of Pediatrics, Faculty of Medicine, Cairo University, 34 Babel St., Dokki, Cairo, Egypt
dc.contributor.affiliation El-Raziky, M., Department of Pediatrics, Faculty of Medicine, Cairo University, 34 Babel St., Dokki, Cairo, Egypt
dc.contributor.affiliation Afifi, R., Department of Pediatrics, Faculty of Medicine, Cairo University, 34 Babel St., Dokki, Cairo, Egypt
dc.contributor.affiliation Musallam, K.M., Department of Internal Medicine, Hematology-Oncology Division, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Taher, A.T., Department of Internal Medicine, Hematology-Oncology Division, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.authorAddress Ragab, L.; Department of Pediatrics, Faculty of Medicine, Cairo University, 34 Babel St., Dokki, Cairo, Egypt; email: lragab@yahoo.com
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Internal Medicine; Division: Hematology-Oncology;
dc.contributor.authorDepartment Internal Medicine
dc.contributor.authorDivision Hematology-Oncology
dc.contributor.authorEmail lragab@yahoo.com
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Ragab, L
dc.contributor.authorInitials Helal, S
dc.contributor.authorInitials Zaghloul, N
dc.contributor.authorInitials El-Raziky, M
dc.contributor.authorInitials Afifi, R
dc.contributor.authorInitials Musallam, KM
dc.contributor.authorInitials Taher, AT
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Ragab, L (reprint author), Cairo Univ, Fac Med, Dept Pediat, 34 Babel St, Cairo, Egypt.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 8
dc.description.citedTotWOSCount 6
dc.description.citedWOSCount 6
dc.format.extentCount 7
dc.identifier.articleNo
dc.identifier.coden
dc.identifier.pubmedID 19389113
dc.identifier.scopusID 77953600625
dc.identifier.url
dc.publisher.address COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Int. J. Lab. Hematol.
dc.relation.ispartOfIssue 2
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle International Journal of Laboratory Hematology
dc.relation.ispartofPubTitleAbbr Int. J. Lab. Hematol.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 32
dc.source.ID WOS:000274817800007
dc.type.publication Journal
dc.subject.otherAuthKeyword Aminotransferase
dc.subject.otherAuthKeyword Fibrosis
dc.subject.otherAuthKeyword Hepatitis C
dc.subject.otherAuthKeyword Siderosis
dc.subject.otherAuthKeyword Thalassemia
dc.subject.otherAuthKeyword Transfusion
dc.subject.otherChemCAS alanine aminotransferase, 9000-86-6, 9014-30-6
dc.subject.otherChemCAS aspartate aminotransferase, 9000-97-9
dc.subject.otherChemCAS ferritin, 9007-73-2
dc.subject.otherIndex alanine aminotransferase
dc.subject.otherIndex aspartate aminotransferase
dc.subject.otherIndex ferritin
dc.subject.otherIndex virus RNA
dc.subject.otherIndex adolescent
dc.subject.otherIndex adult
dc.subject.otherIndex alanine aminotransferase blood level
dc.subject.otherIndex anamnesis
dc.subject.otherIndex article
dc.subject.otherIndex aspartate aminotransferase blood level
dc.subject.otherIndex blood sampling
dc.subject.otherIndex blood transfusion
dc.subject.otherIndex child
dc.subject.otherIndex chronic hepatitis
dc.subject.otherIndex clinical examination
dc.subject.otherIndex comorbidity
dc.subject.otherIndex controlled study
dc.subject.otherIndex correlational study
dc.subject.otherIndex Egypt
dc.subject.otherIndex female
dc.subject.otherIndex ferritin blood level
dc.subject.otherIndex hepatitis C
dc.subject.otherIndex Hepatitis C virus
dc.subject.otherIndex histopathology
dc.subject.otherIndex human
dc.subject.otherIndex infection risk
dc.subject.otherIndex iron overload
dc.subject.otherIndex laboratory test
dc.subject.otherIndex liver biopsy
dc.subject.otherIndex liver injury
dc.subject.otherIndex major clinical study
dc.subject.otherIndex male
dc.subject.otherIndex nonhuman
dc.subject.otherIndex pediatrics
dc.subject.otherIndex polymerase chain reaction
dc.subject.otherIndex preschool child
dc.subject.otherIndex priority journal
dc.subject.otherIndex school child
dc.subject.otherIndex siderosis
dc.subject.otherIndex statistical significance
dc.subject.otherIndex thalassemia major
dc.subject.otherIndex viremia
dc.subject.otherIndex Adolescent
dc.subject.otherIndex beta-Thalassemia
dc.subject.otherIndex Blood Transfusion
dc.subject.otherIndex Child
dc.subject.otherIndex Child, Preschool
dc.subject.otherIndex Female
dc.subject.otherIndex Hepacivirus
dc.subject.otherIndex Hepatitis C
dc.subject.otherIndex Humans
dc.subject.otherIndex Laboratory Techniques and Procedures
dc.subject.otherIndex Male
dc.subject.otherKeywordPlus VIRUS-INFECTION
dc.subject.otherKeywordPlus HIGH PREVALENCE
dc.subject.otherKeywordPlus RISK-FACTORS
dc.subject.otherKeywordPlus LIVER
dc.subject.otherKeywordPlus EGYPT
dc.subject.otherKeywordPlus ASSAY
dc.subject.otherKeywordPlus SEROPOSITIVITY
dc.subject.otherKeywordPlus POPULATION
dc.subject.otherKeywordPlus ANTIBODIES
dc.subject.otherKeywordPlus COMMUNITY
dc.subject.otherWOS Hematology


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