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Treatment of pachydermoperiostosis pachydermia with botulinum toxin type A

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dc.contributor.author Ghosn S.
dc.contributor.author Uthman I.
dc.contributor.author Dahdah M.
dc.contributor.author Kibbi A.G.
dc.contributor.author Rubeiz N.
dc.contributor.editor
dc.date Dec-2010
dc.date.accessioned 2017-10-05T15:37:51Z
dc.date.available 2017-10-05T15:37:51Z
dc.date.issued 2010
dc.identifier 10.1016/j.jaad.2009.08.067
dc.identifier.isbn
dc.identifier.issn 01909622
dc.identifier.uri http://hdl.handle.net/10938/15975
dc.description.abstract Background: Pachydermoperiostosis (PDP) is a rare hereditary disorder characterized by digital clubbing, periostosis, and pachydermia. Pachydermia results in leonine facies, a major cause of cosmetic and functional morbidity in these patients. Its treatment is usually surgical. So far, no medical treatment has been suggested to alleviate this morbidity. Objective: We sought to assess the role of botulinum toxin type A (BTX-A) in improving the cosmetic appearance of pachydermia in patients with PDP. Methods: Three patients with PDP were treated with BTX-A for their leonine facies. A total of 70 to 80 U were used to treat the upper third of the face. Photographs were taken at baseline and at 2 and 6 weeks after the injections. The patients were followed up periodically for at least 6 months. Wrinkle severity was assessed at relaxation using the 4-point facial wrinkle scale at baseline, week 6, and month 6. In addition, a subjective assessment of the improvement of the extent and depth of the facial rhytides-furrows over the upper third of the face was performed by the same investigator at week 6 and month 6. Results: Using the subjective assessment of the improvement of wrinkles, all 3 patients exhibited a fair to excellent response at week 6 that started manifesting 1 week after the BTX-A treatment. All patients demonstrated a residual effect 6 months after the treatment. One patient exhibited a mild exacerbation of his ptosis. Limitations: Major limitations were the small number of patients and the administration of BTX-A injections and assessment of their response by a single unblinded physician. Conclusion: BTX-A is a simple procedure that may be of value in temporarily improving the cosmetic appearance of pachydermia in patients with PDP. © 2009 by the American Academy of Dermatology, Inc.
dc.format.extent
dc.format.extent Pages: (1036-1041)
dc.language English
dc.publisher NEW YORK
dc.relation.ispartof Publication Name: Journal of the American Academy of Dermatology; Publication Year: 2010; Volume: 63; no. 6; Pages: (1036-1041);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Treatment of pachydermoperiostosis pachydermia with botulinum toxin type A
dc.type Article
dc.contributor.affiliation Ghosn, S., Department of Dermatology, American University, Beirut Medical Center, Riad El Solh St, Beirut, Lebanon
dc.contributor.affiliation Uthman, I., Department of Internal Medicine, Division of Rheumatology, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Dahdah, M., Department of Dermatology, American University, Beirut Medical Center, Riad El Solh St, Beirut, Lebanon
dc.contributor.affiliation Kibbi, A.G., Department of Dermatology, American University, Beirut Medical Center, Riad El Solh St, Beirut, Lebanon
dc.contributor.affiliation Rubeiz, N., Department of Dermatology, American University, Beirut Medical Center, Riad El Solh St, Beirut, Lebanon
dc.contributor.authorAddress Rubeiz, N.; Department of Dermatology, American University, Beirut Medical Center, Riad El Solh St, Beirut, Lebanon; email: nrgrubeiz@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Internal Medicine; Division: Rheumatology;
dc.contributor.authorDepartment Internal Medicine
dc.contributor.authorDivision Rheumatology
dc.contributor.authorEmail
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Ghosn, S
dc.contributor.authorInitials Uthman, I
dc.contributor.authorInitials Dahdah, M
dc.contributor.authorInitials Kibbi, AG
dc.contributor.authorInitials Rubeiz, N
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Rubeiz, N (reprint author), Amer Univ Beirut, Med Ctr, Dept Dermatol, POB 11 0236, Beirut, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited Abitbol RJ, 2009, ARCH DERMATOL, V145, P13, DOI 10.1001-archdermatol.2008.546; Ballard HJ, 1998, CHINESE MED J-PEKING, V111, P945; Bhansali A, 2006, J Assoc Physicians India, V54, P340; Bruner S, 2007, HANDCHIR MIKROCHIR P, V39, P135, DOI 10.1055-s-2007-965017; Carruthers A, 2003, DERMATOL SURG, V29, P461, DOI 10.1046-j.1524-4725.2003.29114.x; Castori M, 2005, CLIN GENET, V68, P477, DOI 10.1111-j.1399-0004.00533.x; Chen W, 2009, BRIT J DERMATOL, V161, P674, DOI 10.1111-j.1365-2133.2009.09165.x; Ebrahimi A, 2010, J DERMATOL TREAT, V21, P80, DOI [10.1080-09546630902877907, 10.3109-09546630902877907]; George L, 2008, J DERMATOL TREAT, V19, P61, DOI 10.1080-09546630701389955; Moffat CE, 2009, EUR J VASC ENDOVASC, V38, P188, DOI 10.1016-j.ejvs.2009.03.016; Monteiro E, 2003, PLAST RECONSTR SURG, V112, P1189, DOI 10.1097-01.PRS.0000077234.32815.27; Okten A, 2007, CLIN RHEUMATOL, V26, P8, DOI 10.1007-s10067-005-1161-2; Seyhan T, 2005, DERMATOL SURG, V31, P1465; Stone AV, 2007, J ORTHOP RES, V25, P1658, DOI 10.1002-jor.20450; Uppal S, 2008, NAT GENET, V40, P789, DOI 10.1038-ng.153; Xiao ZB, 2009, AESTHET PLAST SURG, V33, P409, DOI 10.1007-s00266-009-9334-z; Zanchi M, 2008, J EUR ACAD DERMATOL, V22, P431, DOI 10.1111-j.1468-3083.2007.02457.x
dc.description.citedCount 5
dc.description.citedTotWOSCount 3
dc.description.citedWOSCount 1
dc.format.extentCount 6
dc.identifier.articleNo
dc.identifier.coden JAADD
dc.identifier.pubmedID 20933299
dc.identifier.scopusID 78650311387
dc.identifier.url
dc.publisher.address 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr J. Am. Acad. Dermatol.
dc.relation.ispartOfIssue 6
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Journal of the American Academy of Dermatology
dc.relation.ispartofPubTitleAbbr J. Am. Acad. Dermatol.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 63
dc.source.ID WOS:000284968100012
dc.type.publication Journal
dc.subject.otherAuthKeyword Botulinum toxin type A
dc.subject.otherAuthKeyword Leonine facies
dc.subject.otherAuthKeyword Pachydermia
dc.subject.otherAuthKeyword Pachydermoperiostosis
dc.subject.otherAuthKeyword Primary hypertropic osteoarthropathy
dc.subject.otherChemCAS botulinum toxin A, 93384-43-1
dc.subject.otherChemCAS Botulinum Toxins, Type A, 3.4.24.69
dc.subject.otherChemCAS Neuromuscular Agents
dc.subject.otherIndex botulinum toxin A
dc.subject.otherIndex adult
dc.subject.otherIndex article
dc.subject.otherIndex case report
dc.subject.otherIndex disease exacerbation
dc.subject.otherIndex esthetics
dc.subject.otherIndex human
dc.subject.otherIndex male
dc.subject.otherIndex pachydermoperiostosis pachydermia
dc.subject.otherIndex photography
dc.subject.otherIndex priority journal
dc.subject.otherIndex ptosis
dc.subject.otherIndex skin disease
dc.subject.otherIndex wrinkle
dc.subject.otherIndex Botulinum Toxins, Type A
dc.subject.otherIndex Cosmetic Techniques
dc.subject.otherIndex Forehead
dc.subject.otherIndex Humans
dc.subject.otherIndex Male
dc.subject.otherIndex Neuromuscular Agents
dc.subject.otherIndex Osteoarthropathy, Primary Hypertrophic
dc.subject.otherIndex Severity of Illness Index
dc.subject.otherIndex Skin Aging
dc.subject.otherIndex Young Adult
dc.subject.otherKeywordPlus PRIMARY HYPERTROPHIC OSTEOARTHROPATHY
dc.subject.otherKeywordPlus SOLENTE-GOLE-SYNDROME
dc.subject.otherKeywordPlus FRONTAL RHYTIDECTOMY
dc.subject.otherWOS Dermatology


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