AUB ScholarWorks

Redefining thalassemia as a hypercoagulable state

Show simple item record

dc.contributor.author Cappellini M.D.
dc.contributor.author Motta I.
dc.contributor.author Musallam K.M.
dc.contributor.author Taher A.T.
dc.contributor.editor Vichinsky E.P.Neufeld E.J.
dc.date Aug-2010
dc.date.accessioned 2017-10-05T15:37:53Z
dc.date.available 2017-10-05T15:37:53Z
dc.date.issued 2010
dc.identifier 10.1111/j.1749-6632.2010.05548.x
dc.identifier.isbn 9.7815733178e+012
dc.identifier.issn 00778923
dc.identifier.uri http://hdl.handle.net/10938/16006
dc.description.abstract As the life expectancy of β-thalassemia patients has markedly improved over the last decade, several new complications are being recognized. The presence of a high incidence of thromboembolic events, mainly in thalassemia intermedia patients, has led to the identification of a hypercoagulable state in thalassemia. In this review, the molecular and cellular mechanisms leading to hypercoagulability in thalassemia are highlighted, and the current clinical experience is summarized. Recommendations for thrombosis prophylaxis are also discussed. © 2010 New York Academy of Sciences.
dc.format.extent
dc.format.extent Pages: (231-236)
dc.language English
dc.publisher OXFORD
dc.relation.ispartof Publication Name: Annals of the New York Academy of Sciences; Publication Year: 2010; Volume: 1202; Pages: (231-236);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Redefining thalassemia as a hypercoagulable state
dc.type Conference Paper
dc.contributor.affiliation Cappellini, M.D., Universitá di Milano, Policlinico Foundation IRCCS, Milan, Italy
dc.contributor.affiliation Motta, I., Universitá di Milano, Policlinico Foundation IRCCS, Milan, Italy
dc.contributor.affiliation Musallam, K.M., Hematology-Oncology Division, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Taher, A.T., Hematology-Oncology Division, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.authorAddress Cappellini, M. D.; Universitá di Milano, Fondazione Ospedale Maggiore Policlinico, Mangiagalli, Regina Elena IRCCS, Milan, Italy; email: maria.cappellini@unimi.it
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Internal Medicine; Division: Hematology-Oncology;
dc.contributor.authorDepartment Internal Medicine
dc.contributor.authorDivision Hematology-Oncology
dc.contributor.authorEmail maria.cappellini@unimi.it
dc.contributor.faculty Faculty of Medicine
dc.contributor.authorInitials Cappellini, MD
dc.contributor.authorInitials Motta, I
dc.contributor.authorInitials Musallam, KM
dc.contributor.authorInitials Taher, AT
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Cappellini, MD (reprint author), Univ Milan, Fdn Osped Maggiore Policlin Mangiagalli Regina El, Milan, Italy.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited Ataga KI, 2007, BRIT J HAEMATOL, V139, P3, DOI 10.1111-j.1365-2141.2007.06740.x; Atichartakarn V, 2002, BRIT J HAEMATOL, V118, P893, DOI 10.1046-j.1365-2141.2002.03711.x; Atichartakarn V, 2003, INT J HEMATOL, V77, P299, DOI 10.1007-BF02983790; BORENSTAINBENYASHAR V, 1993, AM J HEMATOL, V44, P63; Pignatti CB, 1998, ACTA HAEMATOL-BASEL, V99, P76; Borgna-Pignatti C, 2004, HAEMATOLOGICA, V89, P1187; Butthep P, 1997, SE ASIAN J TROP MED, V28, p141A; BUTTHEP P, 1995, THROMB HAEMOSTASIS, V74, P1045; Butthep P, 2002, AM J HEMATOL, V70, P100, DOI 10.1002-ajh.10101; Cappellini MD, 2005, ANN NY ACAD SCI, V1054, P317, DOI 10.1196-annals.1345.039; Cappellini MD, 2000, BRIT J HAEMATOL, V111, P467, DOI 10.1046-j.1365-2141.2000.02376.x; CARLOS TM, 1994, BLOOD, V84, P2068; Chen SQ, 1996, AM J PHYSIOL-HEART C, V270, pH1951; DELPRINCIPE D, 1993, BRIT J HAEMATOL, V84, P111; ELDOR A, 1991, BLOOD, V77, P1749; ELDOR A, 1989, AM J HEMATOL, V32, P94, DOI 10.1002-ajh.2830320204; Gillis S, 1999, HAEMATOLOGICA, V84, P959; Giordano P, 1998, BRIT J HAEMATOL, V102, P903, DOI 10.1046-j.1365-2141.1998.00853.x; Habib A, 2008, HAEMATOL-HEMATOL J, V93, P941, DOI 10.3324-haematol.12460; Helley D, 1996, THROMB HAEMOSTASIS, V76, P322; HERSHKO C, 1978, BRIT J HAEMATOL, V40, P255, DOI 10.1111-j.1365-2141.1978.tb03662.x; Hovav T, 1999, BRIT J HAEMATOL, V106, P178; Iolascon A, 2001, HAEMATOLOGICA, V86, P1112; Karimi M, 2005, J PEDIAT HEMATOL ONC, V27, P380, DOI 10.1097-01.mph.0000174386.13109.28; Kuypers FA, 2004, CELL MOL BIOL, V50, P147; LOGOTHET.J, 1972, NEUROLOGY, V22, P294; Manfre L, 1999, AM J ROENTGENOL, V173, P1477; Manning JT, 1998, HUM NATURE-INT BIOS, V9, P53, DOI 10.1007-s12110-998-1011-4; MICHAELI J, 1992, ACTA HAEMATOL-BASEL, V87, P71; Ruf A, 1997, BRIT J HAEMATOL, V98, P51, DOI 10.1046-j.1365-2141.1997.1502965.x; Rund D, 2005, NEW ENGL J MED, V353, P1135, DOI 10.1056-NEJMra050436; SHINAR E, 1989, J CLIN INVEST, V83, P404, DOI 10.1172-JCI113898; SONAKUL D, 1980, Southeast Asian Journal of Tropical Medicine and Public Health, V11, P516; SUMIYOSHI A, 1992, J TROP MED PUBLIC S2, V23, P29; Taher A, 2006, THROMB HAEMOSTASIS, V96, P488, DOI 10.1160-TH06-05-0267; Taher A, 2006, BLOOD CELL MOL DIS, V37, P12, DOI 10.1016-j.bcmd.2006.04.005; Taher AT, 2008, BLOOD REV, V22, P283, DOI 10.1016-j.blre.2008.04.001; Taher AT, 2010, J THROMB HAEMOST, V8, P54, DOI 10.1111-j.1538-7836.2009.03651.x; Tavazzi D, 2001, BRIT J HAEMATOL, V112, P48, DOI 10.1046-j.1365-2141.2001.02482.x; Tripodi A, 2009, HAEMATOL-HEMATOL J, V94, P1520, DOI 10.3324-haematol.2009.010546; VANTEUNENBROEK A, 1989, NETH J MED, V35, P123; Weatherall DJ, 2001, THALASSAEMIA SYNDROM; WINICHAGOON P, 1981, Southeast Asian Journal of Tropical Medicine and Public Health, V12, P556; Zalloua PA, 2003, THROMB HAEMOSTASIS, V89, P767; ZURLO MG, 1989, LANCET, V2, P27
dc.description.citedCount 31
dc.description.citedTotWOSCount 29
dc.description.citedWOSCount 29
dc.format.extentCount 6
dc.identifier.articleNo
dc.identifier.coden ANYAA
dc.identifier.pubmedID 20712798
dc.identifier.scopusID 77955894491
dc.identifier.url
dc.publisher.address 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXEN, ENGLAND
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting New York Acad Sci
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Ann.NY Acad.Sci.
dc.relation.ispartOfIssue
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Annals of the New York Academy of Sciences
dc.relation.ispartofPubTitleAbbr Ann. New York Acad. Sci.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 1202
dc.source.ID WOS:000283099600035
dc.type.publication Series
dc.subject.otherAuthKeyword hypercoagulability
dc.subject.otherAuthKeyword stroke
dc.subject.otherAuthKeyword thalassemia
dc.subject.otherAuthKeyword thromboembolism
dc.subject.otherChemCAS 5 aza 2' deoxycytidine, 2353-33-5
dc.subject.otherChemCAS endothelial leukocyte adhesion molecule 1, 128875-25-2
dc.subject.otherChemCAS hemoglobin F, 9034-63-3
dc.subject.otherChemCAS hydroxyurea, 127-07-1
dc.subject.otherChemCAS intercellular adhesion molecule 1, 126547-89-5
dc.subject.otherChemCAS nitric oxide, 10102-43-9
dc.subject.otherChemCAS prostacyclin, 35121-78-9, 61849-14-7
dc.subject.otherChemCAS spectrin, 12634-43-4
dc.subject.otherChemCAS thromboxane A2, 57576-52-0
dc.subject.otherChemCAS von Willebrand factor, 109319-16-6
dc.subject.otherIndex 5 aza 2' deoxycytidine
dc.subject.otherIndex ankyrin
dc.subject.otherIndex CD63 antigen
dc.subject.otherIndex endothelial leukocyte adhesion molecule 1
dc.subject.otherIndex erythrocyte band 3 protein
dc.subject.otherIndex hemoglobin F
dc.subject.otherIndex hydroxyurea
dc.subject.otherIndex intercellular adhesion molecule 1
dc.subject.otherIndex nitric oxide
dc.subject.otherIndex PADGEM protein
dc.subject.otherIndex prostacyclin
dc.subject.otherIndex spectrin
dc.subject.otherIndex thromboxane A2
dc.subject.otherIndex vascular cell adhesion molecule 1
dc.subject.otherIndex von Willebrand factor
dc.subject.otherIndex beta thalassemia
dc.subject.otherIndex blood transfusion
dc.subject.otherIndex conference paper
dc.subject.otherIndex erythrocyte
dc.subject.otherIndex follow up
dc.subject.otherIndex hemolysis
dc.subject.otherIndex human
dc.subject.otherIndex hypercoagulability
dc.subject.otherIndex sickle cell anemia
dc.subject.otherIndex splenectomy
dc.subject.otherIndex thrombocyte
dc.subject.otherIndex thrombocyte activation
dc.subject.otherIndex thrombocyte aggregation
dc.subject.otherIndex thrombocyte lifespan
dc.subject.otherIndex thromboembolism
dc.subject.otherIndex thrombosis
dc.subject.otherIndex urinary excretion
dc.subject.otherIndex Erythrocytes
dc.subject.otherIndex Humans
dc.subject.otherIndex Splenectomy
dc.subject.otherIndex Thalassemia
dc.subject.otherIndex Thrombophilia
dc.subject.otherKeywordPlus VIVO PLATELET ACTIVATION
dc.subject.otherKeywordPlus RED-BLOOD-CELLS
dc.subject.otherKeywordPlus BETA-THALASSEMIA
dc.subject.otherKeywordPlus THROMBOEMBOLIC EVENTS
dc.subject.otherKeywordPlus INTERMEDIA PATIENTS
dc.subject.otherKeywordPlus ENDOTHELIAL-CELLS
dc.subject.otherKeywordPlus MAJOR PATIENTS
dc.subject.otherKeywordPlus COMPLICATIONS
dc.subject.otherKeywordPlus ERYTHROCYTES
dc.subject.otherKeywordPlus SURVIVAL
dc.subject.otherWOS Hematology
dc.subject.otherWOS Multidisciplinary Sciences


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search AUB ScholarWorks


Browse

My Account