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Interpretation and use of FRAX in clinical practice

Show simple item record Kanis J.A. Hans D. Cooper C. Baim S. Bilezikian J.P. Binkley N. Cauley J.A. Compston J.E. Dawson-Hughes B. El-Hajj Fuleihan G. Johansson H. Leslie W.D. Lewiecki E.M. Luckey M. Oden A. Papapoulos S.E. Poiana C. Rizzoli R. Wahl D.A. McClo
dc.contributor.editor Sep-2011 2017-10-05T15:37:57Z 2017-10-05T15:37:57Z 2011
dc.identifier 10.1007/s00198-011-1713-z
dc.description.abstract Summary: The introduction of the WHO FRAX® algorithms has facilitated the assessment of fracture risk on the basis of fracture probability. Its use in fracture risk prediction has strengths, but also limitations of which the clinician should be aware and are the focus of this review Introduction: The International Osteoporosis Foundation (IOF) and the International Society for Clinical Densitometry (ISCD) appointed a joint Task Force to develop resource documents in order to make recommendations on how to improve FRAX and better inform clinicians who use FRAX. The Task Force met in November 2010 for 3 days to discuss these topics which form the focus of this review. Methods: This study reviews the resource documents and joint position statements of ISCD and IOF. Results: Details on the clinical risk factors currently used in FRAX are provided, and the reasons for the exclusion of others are provided. Recommendations are made for the development of surrogate models where country-specific FRAX models are not available. Conclusions: The wish list of clinicians for the modulation of FRAX is large, but in many instances, these wishes cannot presently be fulfilled; however, an explanation and understanding of the reasons may be helpful in translating the information provided by FRAX into clinical practice. © 2011 International Osteoporosis Foundation and National Osteoporosis Foundation.
dc.format.extent Pages: (2395-2411)
dc.language English
dc.publisher LONDON
dc.relation.ispartof Publication Name: Osteoporosis International; Publication Year: 2011; Volume: 22; no. 9; Pages: (2395-2411);
dc.source Scopus
dc.title Interpretation and use of FRAX in clinical practice
dc.type Article
dc.contributor.affiliation Kanis, J.A., WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX, United Kingdom
dc.contributor.affiliation Hans, D., Center of Bone Diseases, Bone and Joint Department, Lausanne University Hospital, Lausanne, Switzerland
dc.contributor.affiliation Cooper, C., MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, United Kingdom, NIHR Musculoskeletal Biomedical Research Unit, Institute of Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom
dc.contributor.affiliation Baim, S., Division of Endocrinology, University of Miami, Miller School of Medicine, Coral Gables, FL, United States
dc.contributor.affiliation Bilezikian, J.P., Columbia University, College of Physicians and Surgeons, New York, NY, United States
dc.contributor.affiliation Binkley, N., Osteoporosis Clinical Research Program, University of Wisconsin, Madison, WI, United States
dc.contributor.affiliation Cauley, J.A., Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, CA, United States
dc.contributor.affiliation Compston, J.E., Department of Medicine, Addenbrooke's Hospital, Cambridge University, Cambridge, United Kingdom
dc.contributor.affiliation Dawson-Hughes, B., Jean Mayer United States Department of Agriculture, Human Nutrition Research Center on Aging, Tufts University, Boston, MA, United States
dc.contributor.affiliation El-Hajj Fuleihan, G., WHO Collaborating Center for Metabolic Bone Disorders, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Johansson, H., Centre for Bone Research at the Sahlgrenska Academy, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
dc.contributor.affiliation Leslie, W.D., University of Manitoba, Winnipeg, MB, Canada
dc.contributor.affiliation Lewiecki, E.M., New Mexico Clinical Research and Osteoporosis Center, University of New Mexico, School of Medicine, Albuquerque, NM, United States
dc.contributor.affiliation Luckey, M., St. Barnabas Osteoporosis and Metabolic Bone Disease Center, Livingston, NJ, United States
dc.contributor.affiliation Oden, A., Centre for Bone Research at the Sahlgrenska Academy, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
dc.contributor.affiliation Papapoulos, S.E., Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, Netherlands
dc.contributor.affiliation Poiana, C., Department of Endocrinology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
dc.contributor.affiliation Rizzoli, R., Department of Rehabilitation and Geriatrics, Faculty of Medicine, Geneva University Hospitals, Geneva, Switzerland
dc.contributor.affiliation Wahl, D.A., International Osteoporosis Foundation, Nyon, Switzerland
dc.contributor.affiliation McCloskey, E.V., Academic Unit of Bone Metabolism, University of Sheffield, Sheffield, United Kingdom
dc.contributor.authorAddress Kanis, J.A.; WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX, United Kingdom; email:
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Internal Medicine;
dc.contributor.authorDepartment Internal Medicine
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Kanis, JA
dc.contributor.authorInitials Hans, D
dc.contributor.authorInitials Cooper, C
dc.contributor.authorInitials Baim, S
dc.contributor.authorInitials Bilezikian, JP
dc.contributor.authorInitials Binkley, N
dc.contributor.authorInitials Cauley, JA
dc.contributor.authorInitials Compston, JE
dc.contributor.authorInitials Dawson-Hughes, B
dc.contributor.authorInitials Fuleihan, GE
dc.contributor.authorInitials Johansson, H
dc.contributor.authorInitials Leslie, WD
dc.contributor.authorInitials Lewiecki, EM
dc.contributor.authorInitials Luckey, M
dc.contributor.authorInitials Oden, A
dc.contributor.authorInitials Papapoulos, SE
dc.contributor.authorInitials Poiana, C
dc.contributor.authorInitials Rizzoli, R
dc.contributor.authorInitials Wahl, DA
dc.contributor.authorInitials McCloskey, EV
dc.contributor.authorOrcidID Moayyeri, Alireza-0000-0002-9143-2161
dc.contributor.authorReprintAddress Kanis, JA (reprint author), Univ Sheffield, Sch Med, WHO Collaborating Ctr Metab Bone Dis, Beech Hill Rd, Sheffield S10 2RX, S Yorkshire, England.
dc.contributor.authorResearcherID Moayyeri, Alireza-N-3332-2014
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 109
dc.description.citedTotWOSCount 91
dc.description.citedWOSCount 84
dc.format.extentCount 17
dc.identifier.coden OSINE
dc.identifier.pubmedID 21779818
dc.identifier.scopusID 80052313108
dc.publisher.address 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND
dc.relation.ispartOfISOAbbr Osteoporosis Int.
dc.relation.ispartOfIssue 9
dc.relation.ispartofPubTitle Osteoporosis International
dc.relation.ispartofPubTitleAbbr Osteoporosis Int.
dc.relation.ispartOfVolume 22
dc.source.ID WOS:000293636500001
dc.type.publication Journal
dc.subject.otherAuthKeyword Bone mineral density
dc.subject.otherAuthKeyword Clinical risk factors
dc.subject.otherAuthKeyword Fracture probability
dc.subject.otherAuthKeyword Risk assessment
dc.subject.otherChemCAS alcohol, 64-17-5
dc.subject.otherChemCAS beclometasone, 4419-39-0
dc.subject.otherChemCAS prednisolone, 50-24-8
dc.subject.otherIndex alcohol
dc.subject.otherIndex beclometasone
dc.subject.otherIndex prednisolone
dc.subject.otherIndex algorithm
dc.subject.otherIndex article
dc.subject.otherIndex bone density
dc.subject.otherIndex bone turnover
dc.subject.otherIndex calculation
dc.subject.otherIndex clinical practice
dc.subject.otherIndex computer program
dc.subject.otherIndex drug exposure
dc.subject.otherIndex evaluation
dc.subject.otherIndex falling
dc.subject.otherIndex female
dc.subject.otherIndex fracture
dc.subject.otherIndex human
dc.subject.otherIndex medical society
dc.subject.otherIndex prediction
dc.subject.otherIndex priority journal
dc.subject.otherIndex probability
dc.subject.otherIndex rheumatoid arthritis
dc.subject.otherIndex risk assessment
dc.subject.otherIndex risk factor
dc.subject.otherIndex secondary osteoporosis
dc.subject.otherIndex smoking
dc.subject.otherIndex Algorithms
dc.subject.otherIndex Bone Density
dc.subject.otherIndex Female
dc.subject.otherIndex Fractures, Bone
dc.subject.otherIndex Humans
dc.subject.otherIndex Male
dc.subject.otherIndex Models, Statistical
dc.subject.otherIndex Osteoporosis
dc.subject.otherIndex Practice Guidelines as Topic
dc.subject.otherIndex Risk Assessment
dc.subject.otherIndex Risk Factors
dc.subject.otherIndex World Health
dc.subject.otherIndex World Health Organization
dc.subject.otherKeywordPlus FRACTURE RISK-ASSESSMENT
dc.subject.otherKeywordPlus BONE-MINERAL DENSITY
dc.subject.otherKeywordPlus HIP FRACTURE
dc.subject.otherKeywordPlus OSTEOPOROTIC FRACTURES
dc.subject.otherKeywordPlus ORAL CORTICOSTEROIDS
dc.subject.otherKeywordPlus BIOCHEMICAL MARKERS
dc.subject.otherKeywordPlus VERTEBRAL FRACTURE
dc.subject.otherKeywordPlus ASSESSMENT-TOOL
dc.subject.otherKeywordPlus ELDERLY-WOMEN
dc.subject.otherWOS Endocrinology and Metabolism

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